期刊
MICROBES AND INFECTION
卷 14, 期 2, 页码 140-147出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2011.08.018
关键词
Tollip; Innate immunity; Toll-like receptor; Phosphoinositides; Ubiquitin
资金
- American Heart Association
- Thomas F. Jeffress & Kate Jeffress Memorial Trust Foundation
The Toll-interacting protein (Tollip) is a critical regulator of Toll-like receptor (TLR)-mediated innate immune responses. Tollip modulates TLR signaling and membrane trafficking processes through its interaction with both proteins and phosphoinositides. Here, I discuss the multitasking role of Tollip associated with its modular architecture. (C) 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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