期刊
MICROBES AND INFECTION
卷 14, 期 10, 页码 796-810出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2012.04.007
关键词
Apicomplexa; Kinase inhibitor; Hidden Markov model; Protein classification; Drug target; Kinome
资金
- Japan Society for the Promotion of Science (JSPS) through the WPI-IFReC Research Program
- Kakenhi grant
- Kishimoto Foundation
- ETHZ-JST Japanese-Swiss Cooperative Program
- Spanish Ministry of Science and Innovation [BFU2009-09168]
- INSERM
- EPFL
- FP6 (SIGMAL and ANTIMAL projects, BioMalPar Network of Excellence)
- European Commission
- CNRS
- FP7 programmes MALSIG and PIROVAC
Protein phosphorylation plays a fundamental role in the biology of apicomplexan parasites. Many apicomplexan protein kinases are substantially different from their mammalian orthologues, and thus constitute a landscape of potential drug targets. Here, we integrate genomic, biochemical, genetic and evolutionary information to provide an integrated and up-to-date analysis of twelve apicomplexan kinomes. All kinome sequences are available through the Kinomer database. (C) 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据