Article
Immunology
Yunjia Shi, Xindi Chen, Jingyan Shu, Yang Liu, Yong Zhang, Qianghua Lv, Jianfeng Wang, Xuming Deng, Hongtao Liu, Jiazhang Qiu
Summary: The study found that harmine can inhibit the infection caused by Salmonella, by suppressing the secretion and expression of the bacterium's virulence factor T3SS, thus reducing the severity of the infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
German Pozdeev, Aalap Mogre, Charles J. Dorman
Summary: DNA gyrase, composed of GyrA and GyrB subunits, plays a crucial role in bacterial physiology. The positioning of gyrase genes can affect various functions within the bacteria, with a particular impact on virulence genes like SPI-2. Understanding the significance of gene arrangements in bacteria can provide insights into genome evolution and the sensitivity of certain genes to disruptions in DNA topology.
MOLECULAR MICROBIOLOGY
(2021)
Article
Microbiology
Yunjia Shi, Zeyu Sun, Yang Liu, Jingyan Shu, Yong Zhang, Qianghua Lv, Jianfeng Wang, Xuming Deng, Hongtao Liu, Jiazhang Qiu
Summary: The serious problem of bacterial drug resistance has led to the development of antivirulence agents. This study found that fraxetin inhibits the invasion of Salmonella Typhimurium by inhibiting the transcription of the type III secretion system (T3SS), and it has been demonstrated to be effective in protecting mice against Salmonella infection.
MICROBIOLOGY SPECTRUM
(2022)
Article
Food Science & Technology
Rui Dong, Xiaojie Qin, Shoukui He, Xiujuan Zhou, Yan Cui, Chunlei Shi, Yiping He, Xianming Shi
Summary: The study revealed that DsrA plays a crucial role in promoting oxidative stress resistance in S. Typhimurium by regulating the expression of antioxidant enzymes and maintaining intracellular redox balance.
Article
Microbiology
Jingyan Shu, Hongtao Liu, Yang Liu, Xindi Chen, Yu Yu, Qianghua Lv, Jianfeng Wang, Xuming Deng, Zhimin Guo, Jiazhang Qiu
Summary: Tannic acid (TA) has been shown to improve survival rates and alleviate cecal pathological lesions in S. Typhimurium-infected mice, while inhibiting bacterial invasion of HeLa cells. TA may exert its anti-infection effects by controlling the expression of key genes in the T3SS.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qingjie Li, Lianping Wang, Jingwen Xu, Shuang Liu, Zeyu Song, Tingting Chen, Xuming Deng, Jianfeng Wang, Qianghua Lv
Summary: In this study, the compound quercitrin was found to inhibit the invasion of S. Typhimurium into host cells and reduce host cell damage. It directly inhibited the function of T3SS, providing a potential antibiotic alternative against S. Typhimurium infection.
Article
Microbiology
Yu Han, Yu Li, Zhiwei Zeng, Wenjing Li, Saixiang Feng, Weisheng Cao
Summary: This study explores the resistance mechanism and activity of the antimicrobial peptide MccY against Salmonella strains. The deletion of Ton system genes resulted in resistance to MccY and mutants showed increased susceptibility to MccY under a low-iron condition. MccY may decrease the virulence of S. Typhimurium by altering multiple physiological properties.
MICROBIOLOGY SPECTRUM
(2022)
Article
Chemistry, Analytical
Han Du, Xu Zhang, Mingru Yao, Qingli Yang, Wei Wu
Summary: This study successfully constructed aptamer-guided luminous microspheres using carbon dots fluorescence, which can efficiently recognize and detect Salmonella enterica serovar Typhimurium. The method shows high sensitivity and has broad application prospects.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Microbiology
Selwan Hamed, Riham M. Shawky, Mohamed Emara, James M. Slauch, Christopher Rao
Summary: HilE, originally thought to be a repressor of SPI-1 gene expression, was found to also function as an activator under specific growth conditions involving acetate and nutrients. The mechanism behind this remains unknown, but the involvement of the Rcs system in mediating this response has been identified. This study sheds new light on SPI-1 gene regulation and highlights the complexity of HilE's role in gene expression.
Article
Microbiology
Stephanie Paulini, Florian D. Fabiani, Anna S. Weiss, Ana Laura Moldoveanu, Sophie Helaine, Baerbel Stecher, Kirsten Jung
Summary: Pyruvate, the simplest of the alpha-keto acids, plays a crucial role in the metabolic pathways of bacteria and eukaryotes. This study identified two specific transporters, BtsT and CstA, in Salmonella enterica serovar Typhimurium, which are important for pyruvate uptake and have significant effects on bacterial survival, infection, and persistence.
Article
Microbiology
Jiwon Baek, Hyunjin Yoon
Summary: Cyclic di-GMP is a signaling molecule that controls the transition between motile and nonmotile lifestyles in bacteria. It regulates biofilm formation and dispersal, and it can alter carbon metabolic pathways in Salmonella enterica serovar Typhimurium.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
R. Kavi Bharathi, C. S. Srinandan, N. Sai Subramanian
Summary: This study investigates the cooperative ability and matrix sharing between specialist and generalist strains during biofilm formation. The results show that the matrix aids in survival during antibiotic, chlorine, and predatory stress, and possible sharing of the matrix occurs in co-culture.
Article
Microbiology
Seul Kim, Eunsuk Kim, Hyunjin Yoon
Summary: Salmonella alters cellular processes to improve intracellular fitness during host infection by rewiring cellular transcriptional regulation through alternative sigma factors such as rpoS. Deprivation of outer membrane protein YcfR in Salmonella Typhimurium leads to decreased intracellular survival and downregulation of SPI-2 genes, which is abolished in the absence of rpoS. RpoS-associated stress responses in Salmonella due to impaired envelope integrity may reciprocally downregulate the expression of SPI-2 genes to reduce its virulence.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Yuan Yuan, Yara Seif, Kevin Rychel, Reo Yoo, Siddharth Chauhan, Saugat Poudel, Tahani Al-bulushi, Bernhard O. Palsson, Anand Sastry
Summary: By combining pan-genome and transcriptomic analytics, variations in transcriptional regulatory networks across six strains of Salmonella enterica serovar Typhimurium were revealed.
Article
Food Science & Technology
Hui Li, Keren Agyekumwaa Addo, Yi-gang Yu, Xing-long Xiao
Summary: The study investigated the influence of cuminaldehyde (CUM) on cell membrane and genomic DNA of Salmonella enterica serovar Typhimurium (S. Typhimurium), and revealed its antibacterial mechanism. CUM could bind to bacterial membrane proteins and change its structure and conformation, leading to the leakage of intracellular substances and the destruction of cell integrity. DNA interaction analysis showed that CUM bound to genomic DNA through groove mode, affecting the normal functioning of S. Typhimurium.