期刊
MICROBES AND INFECTION
卷 12, 期 12-13, 页码 889-899出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2010.07.001
关键词
Biosynthesis; Chemokines; Cytokines; Hematin anhydride; Hemozoin; Innate immune response; Macrophages; Malaria; NLR; TLR
资金
- Canadian Institute of Health Research (CIHR)
- McGill University Faculty of Medicine
- Research Institute of the McGill University Health Centre
Malaria is an infectious disease caused by parasites of the genus Plasmodium This intraerythrocytic protozoan produces hemozoin (HZ) an insoluble crystalline metabolite resulting from the heme detoxification mechanism This review will focus on HZ biosynthesis and synthetic preparation but in particular on its effect on host s innate inflammatory responses (C) 2010 Institut Pasteur Published by Elsevier Masson SAS All rights reserved
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