Article
Immunology
Isaac Ssewanyana, John Rek, Isabel Rodriguez, Lindsey Wu, Emmanuel Arinaitwe, Joaniter I. Nankabirwa, James G. Beeson, Harriet Mayanja-Kizza, Philip J. Rosenthal, Grant Dorsey, Moses R. Kamya, Chris Drakeley, Bryan Greenhouse, Kevin K. A. Tetteh
Summary: The study revealed that the decay rate of total IgG following infection decreased with age during declining malaria transmission, and the increase in avidity index post-infection was largely due to the rapid loss of non-avid total IgG. Further research is needed to understand the functional differences between IgG1 and IgG3 to determine their role in protective immunity to malaria.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Rebeca Santano, Rocio Rubio, Berta Grau-Pujol, Valdemiro Escola, Osvaldo Muchisse, Inocencia Cuamba, Marta Vidal, Pau Cistero, Gemma Ruiz-Olalla, Ruth Aguilar, Maria Demontis, Jose Carlos Jamine, Anelsio Cossa, Charfudin Sacoor, Jorge Cano, Luis Izquierdo, Chetan E. Chitnis, Ross L. Coppel, Virander Chauhan, David Cavanagh, Sheetij Dutta, Evelina Angov, Deepak Gaur, Lisette van Lieshout, Bin Zhan, Jose Munoz, Gemma Moncunill, Carlota Dobano
Summary: Co-infection with Plasmodium falciparum and helminths leads to higher levels of total IgE and antigen-specific IgG, indicating a broader immune response, potentially due to a more permissive immune environment in the host. Co-infection or co-exposure to Plasmodium falciparum and helminths is positively correlated, resulting in increased antibody responses. Children with co-infections may exhibit higher Plasmodium falciparum parasitemia.
MICROBIOLOGY SPECTRUM
(2021)
Article
Chemistry, Applied
Natalia Ukleja-Sokolowska, Kinga Lis, Magdalena Zbikowska-Gotz, Rafal Adamczak, Zbigniew Bartuzi
Summary: The study found that the levels of IgG and IgE, as well as the concentrations of IL-25, IL-33, and TSLP, did not affect the nature or severity of clinical symptoms in patients with shrimp allergy. There was also no correlation between the concentrations of IL-25, IL-33, and TSLP and the age or sex of the participants.
FOOD AND AGRICULTURAL IMMUNOLOGY
(2021)
Article
Political Science
Tor A. Benjaminsen, Boubacar Ba
Summary: Violent clashes between Fulani and Dogon have escalated in central Mali, with the Malian army sponsoring and training a Dogon militia that has attacked Fulani villages, leading to counterattacks. Internal conflicts within Fulani and Dogon societies have also emerged.
Review
Immunology
Larissa Nogueira Almeida, Ann-Katrin Clauder, Lingzhang Meng, Marc Ehlers, Sergio Arce, Rudolf Armin Manz
Summary: MHC haplotypes play a crucial role in the development of autoimmune diseases, modulating autoreactive B cell responses and facilitating the production of pathogenic IgG autoantibodies with reduced pathogenicity.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Kevin K. Esoh, Tobias O. Apinjoh, Steven G. Nyanjom, Ambroise Wonkam, Emile R. Chimusa, Lucas Amenga-Etego, Alfred Amambua-Ngwa, Eric A. Achidi
Summary: Genetic association studies rely on defining underlying populations, which can be confounded by population structure. A study in Cameroon revealed fine-scale genetic structure and longstanding sympatric differentiation among ethnic groups. Selection signatures in HLA and HBB genes confirmed natural selection and balancing selection in African populations, shaping genomes of Cameroonian populations.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Selma Belhimeur, Sylvie Briquet, Roger Peronet, Jennifer Pham, Pierre-Henri Commere, Pauline Formaglio, Rogerio Amino, Artur Scherf, Olivier Silvie, Salaheddine Mecheri
Summary: Plasmodium sporozoites (SPZ) migrate to the liver before infecting hepatocytes. IL-6 production in the liver has been shown to be detrimental for the parasite growth and contributes to long-lasting immune protection. This study explores how the parasite itself encodes for murine IL-6 and its effects on parasite virulence.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pediatrics
Omid Reza Zekavat, Elham Nikpendar, Sezaneh Haghpanah, Negin Shokrgozar, Seyed Javad Dehghani, Nargess Arandi
Summary: This study explored the connection between post-chemotherapy allergic manifestations in pediatric ALL patients and the levels of IgE and IL-4. The results showed that IgE and IL-4 levels increased following chemotherapy, and the increase was more significant in patients with atopy compared to those without it.
Article
Rheumatology
Sho Fujimoto, Yojiro Arinobu, Kohta Miyawaki, Masahiro Ayano, Hiroki Mitoma, Yasutaka Kimoto, Nobuyuki Ono, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro
Summary: This study examined the role of basophils and anti-double-stranded DNA (dsDNA) IgE in the pathogenesis of SLE using human samples. The results showed that the serum levels of anti-dsDNA IgE in SLE patients were correlated with disease activity. Basophils were found to promote B cell differentiation through dsDNA-specific IgE, similar to the process observed in mouse models.
Article
Agriculture, Multidisciplinary
Yi-Yu Chen, Meng-Si Li, Meng Liu, Xiao Yun, Fei Huan, Qing-Mei Liu, Min-Jie Cao, Gui-Xia Chen, Dong Lai, Guang-Ming Liu
Summary: The study identified linear epitopes of Sarcoplasmic calcium-binding protein (Scy p 4) that play a significant role in the binding capacity of immunoglobulin G (IgG) and immunoglobulin E (IgE). These linear epitopes were able to inhibit the binding of Scy p 4 to sensitized serum, highlighting their potential diagnostic and food processing applications in shellfish allergy. The findings contribute to a better understanding of the relationship between the structure and allergenicity of Scy p 4.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Sarah Thomas, Juliane E. E. Fiebig, Eva-Maria Kuhn, Dominik S. S. Mayer, Sebastian Filbeck, Werner Schmitz, Markus Krischke, Roswitha Gropp, Thomas D. D. Mueller
Summary: Interleukin-4 (IL-4) and Interleukin-13 (IL-13) play key roles in atopic diseases by coordinating T-helper cell differentiation and inducing immunoglobulin class switch. IL-4 antagonists, including Pitrakinra, have been evaluated as potential therapeutic alternatives to neutralizing antibodies for treating asthma. This study explores the use of glycoengineering and chemical attachment strategies to improve the effectiveness and proteolytic stability of IL-4 antagonists.
Article
Medicine, General & Internal
Nicolle Rakanidis Machado, Beatriz Oliveira Fagundes, Lorena Abreu Fernandes, Augusto Cesar Penalva de Oliveira, Youko Nukui, Jorge Casseb, Fernando Roberto Machado Cunha, Luiz Henrique da Silva Nali, Sabri Saeed Sanabani, Jefferson Russo Victor
Summary: This study found that IgG obtained from HAM/TSP and ATLL patients can differentially modulate the cytokine production by human T and B cells, and elicit distinct effects on target populations.
FRONTIERS IN MEDICINE
(2023)
Article
Immunology
Lidia Sans-de San Nicolas, Ignasi Figueras-Nart, Irene Garcia-Jimenez, Montserrat Bonfill-Orti, Antonio Guilabert, Laia Curto-Barredo, Marta Bertolin-Colilla, Marta Ferran, Esther Serra-Baldrich, Ramon M. Pujol, Luis F. Santamaria-Babi
Summary: This study found that memory T cells from AD patients sensitized to house dust mite produce IL-31, and the production of IL-31 is related to the clinical features of the patients. The production of IL-31 is associated with patient's pruritus intensity, plasma CCL27 levels, and periostin levels. By measuring the levels of sp IgE and total IgE, IL-31 production and related clinical phenotypes can be further determined.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Celia Dechavanne, Odilon Nouatin, Rafiou Adamou, Sofie Edslev, Anita Hansen, Florian Meurisse, Ibrahim Sadissou, Erasme Gbaguidi, Jacqueline Milet, Gilles Cottrell, Laure Gineau, Audrey Sabbagh, Achille Massougbodji, Kabirou Moutairou, Eduardo A. Donadi, Edgardo D. Carosella, Philippe Moreau, Ed Remarque, Michael Theisen, Nathalie Rouas-Freiss, Andre Garcia, Benoit Favier, David Courtin
Summary: Placental malaria may increase susceptibility of infants to malaria. Infants born to women with placental malaria are more likely to develop symptomatic malaria and have lower expression of inhibitory receptor LILRB2. Additionally, these infants may have impaired immune response during active infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Infectious Diseases
Catalina Tovar Acero, Javier Ramirez-Montoya, Maria Camila Velasco, Paula A. Aviles-Vergara, Dina Ricardo-Caldera, Miquel Duran-Frigola, Gustavo Quintero, Myriam Elena Cantero, Juan Rivera-Correa, Ana Rodriguez, Maria Fernanda Yasnot-Acosta
Summary: This study evaluated the cytokine profile of P. vivax malaria patients and identified several cytokines and chemokines that are associated with disease severity. These molecules could potentially serve as biomarkers for severity in P. vivax malaria.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Parasitology
Mariama K. Cherif, Guillaume S. Sanou, Edith C. Bougouma, Amidou Diarra, Alphonse Ouedraogo, Amagana Dolo, Marita Troye-Blomberg, David R. Cavanagh, Michael Theisen, David Modiano, Sodiomon B. Sirima, Issa Nebie
Review
Parasitology
Charles Arama, Bakary Maiga, Amagana Dolo, Bourema Kouriba, Boubacar Traore, Peter D. Crompton, Susan K. Pierce, Marita Troye-Blomberg, Louis H. Miller, Ogobara K. Doumbo
Article
Cell Biology
Ioana Bujila, Evelin Schwarzer, Oleksii Skorokhod, Jessica M. Weidner, Marita Troye-Blomberg, Ann-Kristin Ostlund Farrants
CELLULAR MICROBIOLOGY
(2016)
Article
Immunology
Marianne Guenot, Severine Loizon, Jennifer Howard, Giulia Costa, David A. Baker, Shaneel Y. Mohabeer, Marita Troye-Blomberg, Jean-Francois Moreau, Julie Dechanet-Merville, Odile Mercereau-Puijalon, Maria Mamani-Matsuda, Charlotte Behr
INFECTION AND IMMUNITY
(2015)
Article
Infectious Diseases
Jennifer M. G. Shelton, Patrick Corran, Paul Risley, Nilupa Silva, Christina Hubbart, Anna Jeffreys, Kate Rowlands, Rachel Craik, Victoria Cornelius, Meike Hensmann, Sile Molloy, Nuno Sepulveda, Taane G. Clark, Gavin Band, Geraldine M. Clarke, Christopher C. A. Spencer, Angeliki Kerasidou, Susana Campino, Sarah Auburn, Adama Tall, Alioune Badara Ly, Odile Mercereau-Puijalon, Anavaj Sakuntabhai, Abdoulaye Djimde, Boubacar Maiga, Ousmane Toure, Ogobara K. Doumbo, Amagana Dolo, Marita Troye-Blomberg, Valentina D. Mangano, Frederica Verra, David Modiano, Edith Bougouma, Sodiomon B. Sirima, Muntaser Ibrahim, Ayman Hussain, Nahid Eid, Abier Elzein, Hiba Mohammed, Ahmed Elhassan, Ibrahim Elhassan, Thomas N. Williams, Carolyne Ndila, Alexander Macharia, Kevin Marsh, Alphaxard Manjurano, Hugh Reyburn, Martha Lemnge, Deus Ishengoma, Richard Carter, Nadira Karunaweera, Deepika Fernando, Rajika Dewasurendra, Christopher J. Drakeley, Eleanor M. Riley, Dominic P. Kwiatkowski, Kirk A. Rockett
Article
Multidisciplinary Sciences
Odilon Nouatin, Komi Gbedande, Samad Ibitokou, Bertin Vianou, Parfait Houngbegnon, Sem Ezinmegnon, Sophie Borgella, Carine Akplogan, Gilles Cottrell, Stefania Varani, Achille Massougbodji, Kabirou Moutairou, Marita Troye-Blomberg, Philippe Deloron, Adrian J. F. Luty, Nadine Fievet
Article
Immunology
Charles Arama, Jeff Skinner, Didier Doumtabe, Silvia Portugal, Tuan M. Tran, Aarti Jain, Boubacar Traore, Ogobara K. Doumbo, David Huw Davies, Marita Troye-Blomberg, Amagana Dolo, Philip L. Felgner, Peter D. Crompton
OPEN FORUM INFECTIOUS DISEASES
(2015)
Article
Parasitology
Ratchanok Kumsiri, Marita Troye-Blomberg, Kovit Pattanapanyasat, Srivicha Krudsood, Yaowapa Maneerat
Article
Infectious Diseases
Mariama Cherif, Daniel Amoako-Sakyi, Amagana Dolo, Jan-Olov Pearson, Ben Gyan, Dorcas Obiri-Yeboah, Issa Nebie, Sodiomon B. Sirima, Ogobara Doumbo, Marita Troye-Blomberg, Maiga Bakary
Article
Multidisciplinary Sciences
Victor Yman, Michael T. White, Josea Rono, Bruno Arca, Faith H. Osier, Marita Troye-Blomberg, Stephanie Bostrom, Raffaele Ronca, Ingegerd Rooth, Anna Farnert
SCIENTIFIC REPORTS
(2016)
Article
Medicine, General & Internal
Manijeh Vafa Homann, S. Noushin Emami, Victor Yman, Christine Stenstrom, Klara Sonden, Hanna Ramstrom, Mattias Karlsson, Muhammad Asghar, Anna Farnert
Article
Immunology
Akira Kaneko, Luis F. Chaves, George Taleo, Morris Kalkoa, Rie Isozumi, Renu Wickremasinghe, Hedvig Perlmann, Satoru Takeo, Takafumi Tsuboi, Shin-Ichiro Tachibana, Masatsugu Kimura, Anders Bjoerkman, Marita Troye-Blomberg, Kazuyuki Tanabe, Chris Drakeley
INFECTION AND IMMUNITY
(2014)
Review
Medicine, General & Internal
C. Arama, M. Troye-Blomberg
JOURNAL OF INTERNAL MEDICINE
(2014)
Article
Infectious Diseases
Anna Farnert, Victor Yman, Manijeh Vafa Homann, Grace Wandell, Leah Mhoja, Marita Johansson, Salome Jesaja, Johanna Sandlund, Kazuyuki Tanabe, Ulf Hammar, Matteo Bottai, Zulfiqarali G. Premji, Anders Bjorkman, Ingegerd Rooth
Review
Immunology
Marita Troye-Blomberg, Charles Arama, Jaclyn Quin, Ioana Bujila, Ann-Kristin Ostlund Farrants
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2020)