Article
Oncology
Carmen Aguilar-Gurrieri, Ana Barajas, Carla Rovirosa, Raquel Ortiz, Victor Urrea, Nuria de la Iglesia, Bonaventura Clotet, Julia Blanco, Jorge Carrillo
Summary: Neoantigens are tumor-specific antigens that can elicit a specific immune response. They have potential for the development of personalized cancer vaccines. The presentation of neoantigens to T cells is influenced by vaccine delivery strategies, including the use of specific linkers. The efficiency of neoantigen processing and presentation by MHC-I molecules can be improved with alanine-based linkers.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Chemistry, Multidisciplinary
Jie Zhang, Biao Fan, Guoliang Cao, Wenping Huang, Fuhao Jia, Guangjun Nie, Hai Wang
Summary: This study developed a personalized DC-mimicking nanovaccine for stimulating TAAs-specific T cell populations. By inducing BMDCs maturation and delivering TAAs through nanostructures, the nanoDCs efficiently generated potent antigen-specific T cell responses, leading to inhibition of tumor growth and metastases formation.
ADVANCED MATERIALS
(2022)
Review
Immunology
Bharathi Karunakaran, Raghav Gupta, Pranav Patel, Sagar Salave, Amit Sharma, Dhruv Desai, Derajram Benival, Nagavendra Kommineni
Summary: Lipid-based vaccine delivery systems have attracted significant interest due to their ability to protect antigens from enzymatic degradation by encapsulating them in vesicles. The particulate form of lipid-based nanocarriers stimulates immune responses, making them ideal antigen carriers. These nanocarriers can be tailored to achieve desired characteristics through lipid composition modification and appropriate preparation methods, enhancing their effectiveness as vaccine delivery carriers.
Review
Chemistry, Multidisciplinary
Fei Wang, Aftab Ullah, Xuelian Fan, Zhou Xu, Rongling Zong, Xuewen Wang, Gang Chen
Summary: An appropriate delivery system can enhance the immune effects of antigens against infections or tumors. Targeting vaccine delivery systems to APCs is a promising strategy for provoking potent immune responses.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Immunology
Ger T. Rijkers, Nynke Weterings, Andres Obregon-Henao, Michaela Lepolder, Taru S. Dutt, Frans J. van Overveld, Marcela Henao-Tamayo
Summary: Infection with SARS-CoV-2 leads to the pandemic disease COVID-19, but effective vaccines such as mRNA and viral vector vaccines have been developed to control the spread. These vaccines can induce immune-related side effects like allergic reactions and thrombosis events, especially in rare cases.
Review
Immunology
Takumi Kawasaki, Moe Ikegawa, Taro Kawai
Summary: The lungs have an immune defense mechanism that uses various cells to eliminate harmful pathogens and activate T cell immune response. In addition to immune cells, other lung cells also participate in antigen presentation and T cell activation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Ashkan Safavi, Amirhosein Kefayat, Elham Mahdevar, Fatemeh Ghahremani, Navid Nezafat, Mohammad Hossein Modarressi
Summary: The study demonstrated that prophylactic co-immunization with multiepitope DNA and peptide cancer vaccines can significantly enhance the immune response against breast cancer, leading to reduced tumor volume and increased survival time in tumor-bearing mice. Further experiments are needed to evaluate their efficacy from different angles.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Review
Immunology
Karolina D. Witt
Summary: MHC class I antigen processing is a less recognized area in nonviral host-pathogen interactions, involving immunology and cell biology. This review focuses on the MHC-I antigen processing pathway and alternative sources of antigens, particularly in the context of Mycobacterium tuberculosis (Mtb) as an intracellular pathogen. It explores how Mtb manipulates host immunity for survival and proposes directions for MHC-I-focused approaches in developing vaccines against tuberculosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Carolina Johnstone, Elena Chaves-Pozo
Summary: This review focuses on the essential components of antigen processing and presentation (APP) in teleost fish and the increasing evidence related to the modulation of APP and autophagy during pathogen infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Ichwaku Rastogi, Douglas G. McNeel
Summary: DNA vaccines have shown limited immunogenicity in human clinical trials. B cells, not DCs, are the primary antigen-presenting cells for DNA-encoded antigens. B cells can translate the encoded antigens, but DCs are required for activating CD8 T cells. Further study of B cells as APCs is important for improving the efficacy of DNA vaccines.
Article
Immunology
Adrian Rice, Mohit Verma, Emily Voigt, Peter Battisti, Sam Beaver, Sierra Reed, Kyle Dinkins, Shivani Mody, Lise Zakin, Shiho Tanaka, Brett Morimoto, C. Anders Olson, Elizabeth Gabitzsch, Jeffrey T. Safrit, Patricia Spilman, Corey Casper, Patrick Soon-Shiong
Summary: The study assessed the enhanced immune responses in CD-1 mice by heterologous vaccination with two different nucleic acid-based COVID-19 vaccines. It was found that one vaccine showed better T-cell and humoral responses, and the sera from vaccinated mice exhibited high neutralizing activity against various strains of the virus.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Lucia Biscari, Ma Carmen Maza, Cecilia Farre, Cintia Daniela Kaufman, Sebastian Amigorena, Manuel Fresno, Nuria Girones, Andres Alloatti
Summary: Antigen cross-presentation is an essential mechanism for dendritic cells and other antigen-presenting cells to activate CD8(+) T cells and induce cytotoxic responses against infected or cancer cells. The protein Sec22b plays a crucial role in this process by coordinating the recruitment of the transporter associated with antigen processing protein and the peptide loading complex. Silencing Sec22b in dendritic cells impairs antigen cross-presentation and leads to deficient priming of CD8(+) T cells, reduced control of tumor growth, and resistance to anti-checkpoint immunotherapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Xiaoqing Shi, Jiage Ding, Yanyan Zheng, Jiawe Wang, Navid Sobhani, Praveen Neeli, Gang Wang, Junnian Zheng, Dafei Chai
Summary: PLGA/PEI-HMGB1/GPC3 vaccine induced a strong and long-lasting CTL effect, inhibiting the progression and re-attack of hepatocellular carcinoma.
Review
Immunology
Narjes Yektaeian, Abdorrasoul Malekpour, Amir Atapour, Tahereh Davoodi, Gholamreza Hatam
Summary: Toxoplasma gondii is a protozoan parasite causing toxoplasmosis, transmitted through various routes and infecting warm-blooded animals. DNA vaccines are considered as a successful approach against the parasite, inducing suitable immune response and protection.
MICROBIAL PATHOGENESIS
(2021)
Article
Immunology
Sk Injamamul Islam, Saloa Sanjida, Sheikh Sunzid Ahmed, Mazen Almehmadi, Mamdouh Allahyani, Abdulelah Aljuaid, Ahad Amer Alsaiari, Mustafa Halawi
Summary: Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is a serious health issue worldwide. A reverse vaccine candidate was designed based on core proteomics analysis and immune epitopes. The candidate demonstrated strong binding affinity with TLR4, MHC-I, and MHC-II receptors. Immune simulation predicted its efficacy, suggesting it as a viable treatment option for Chagas disease.
Review
Genetics & Heredity
Yousuke Takahama, Izumi Ohigashi, Shigeo Murata, Keiji Tanaka
Article
Immunology
Anca Apavaloaei, Sylvie Brochu, Mengqi Dong, Alexandre Rouette, Marie-Pierre Hardy, Geno Villafano, Shigeo Murata, Heather J. Melichar, Claude Perreault
JOURNAL OF IMMUNOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Takuya Tomita, Shoshiro Hirayama, Yasuyuki Sakurai, Yuki Ohte, Hidehito Yoshihara, Yasushi Saeki, Jun Hamazaki, Shigeo Murata
MOLECULAR AND CELLULAR BIOLOGY
(2019)
Article
Immunology
Seiji Obi, Chikako Shimokawa, Mizuki Katsuura, Alex Olia, Takashi Imai, Kazutomo Suzue, Hajime Hisaeda
PARASITE IMMUNOLOGY
(2020)
Article
Cell Biology
Takashi Imai, Yukinori Takahashi
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Chikako Shimokawa, Tamotsu Kato, Tadashi Takeuchi, Noriyasu Ohshima, Takao Furuki, Yoshiaki Ohtsu, Kazutomo Suzue, Takashi Imai, Seiji Obi, Alex Olia, Takashi Izumi, Minoru Sakurai, Hirokazu Arakawa, Hiroshi Ohno, Hajime Hisaeda
NATURE COMMUNICATIONS
(2020)
Article
Parasitology
Alex Olia, Chikako Shimokawa, Takashi Imai, Kazutomo Suzue, Hajime Hisaeda
PARASITOLOGY INTERNATIONAL
(2020)
Article
Immunology
Takashi Imai, Kazutomo Suzue, Ha Ngo-Thanh, Chikako Shimokawa, Hajime Hisaeda
Article
Parasitology
Ha Ngo-Thanh, Tsutomu Sasaki, Kazutomo Suzue, Hideaki Yokoo, Koji Isoda, Wataru Kamitani, Chikako Shimokawa, Hajime Hisaeda, Takashi Imai
INTERNATIONAL JOURNAL FOR PARASITOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Rafael Baptista, Sumana Bhowmick, Jianying Shen, Luis A. J. Mur
Summary: In this study, a molecular reverse docking approach was used to predict interactions between 53 selected anti-mycobacterial natural products and known druggable mycobacterial targets. Results showed that certain compounds had significantly higher binding free energies against PknB and DprE1 targets, suggesting their potential use in drug optimization research.
Article
Biochemistry & Molecular Biology
Shinji Sakamoto, Dania Mallah, Destynie J. Medeiros, Eisuke Dohi, Takashi Imai, Indigo V. L. Rose, Ken Matoba, Xiaolei Zhu, Atsushi Kamiya, Shin-ichi Kano
Summary: Chronic stress can lead to immune changes and inflammation, impacting neuropathology and behavioral abnormalities related to psychiatric disorders like depression. The role of circulating EVs and associated miRNAs in CSDS susceptibility suggests a potential link to pro-inflammatory mechanisms underlying stress-induced neurobehavioral outcomes.
Article
Immunology
Takashi Imai
Summary: This study investigated the impact of single amino acid deletion in the target antigen of plasmid DNA vaccines on vaccine efficacy, with results showing that minor modifications could enhance the efficacy of DNA vaccines against tumors or infectious diseases.
Editorial Material
Immunology
Takashi Imai
Article
Medicine, General & Internal
Olayemi Adeniyi, Rafael Baptista, Sumana Bhowmick, Alan Cookson, Robert J. Nash, Ana Winters, Jianying Shen, Luis A. J. Mur
Summary: This study identified quercitrin as the active compound in Alchornea cordifolia Mull. Arg. that exhibits significant anti-sickling activity and can alter the metabolome of HbSS erythrocytes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Takashi Imai, Ha Ngo-Thanh, Kazutomo Suzue, Aoi Shimo, Akihiro Nakamura, Yutaka Horiuchi, Hajime Hisaeda, Takashi Murakami
Summary: This study aims to develop a malaria vaccine that provides cross-strain protection. Results showed that inoculation of mice with a heterologous live-vaccine prevented the development of experimental cerebral malaria (ECM) and protected the blood-organ barriers from infection. The immune response induced by the live vaccine included cross-reactive antibodies and IL-10-mediated host protection against ECM.