期刊
MICROBES AND INFECTION
卷 10, 期 3, 页码 302-312出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2007.12.007
关键词
herpes simplex virus; stromal keratitis; IL-23; IL-12; IFN-gamma; IL-17
资金
- NEI NIH HHS [R01 EY05093, R01 EY005093, R01 EY005093-24A1] Funding Source: Medline
Herpes simplex virus (HSV) infection of the cornea culminates in an immunopathological lesion (stromal keratitis - SK) that impairs vision. This report shows that HSV infection results in IL-23 up-regulation, but if this response fails to occur, as was noted in p19-/- mice, the severity of lesions, their incidence and the level of viral induced angiogenesis were significantly increased compared to wild-type (WT) animals (p < 0.05). The higher disease severity in p19-/- mice appeared to be the consequence of an increased IL-12 response that in turn led to the induction of higher numbers of IFN-gamma producing CD4(+)T cells, the principal orchestrators of SK. Our results indicate that the severity of HSV induced immunopathological lesions may be mainly the consequence of IL-12 driven Th1 T cell reactions rather than the action of IL-17 producing cells controlled by IL-23. (c) 2007 Elsevier Masson SAS. All rights reserved.
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