Article
Pharmacology & Pharmacy
Patrycja Szumala, Adam Macierzanka
Summary: This review focuses on recent advancements in topical microemulsion systems related to the transport of active ingredients into the skin, including those with high molecular weight and high polarity. Permeation of therapeutic macromolecules can be increased by the correct design of the microemulsion.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Polymer Science
Sitah Alharthi, Zyta Maria Ziora, Gulam Mustafa, Pramila Chaubey, Ahmed Farag El Kirdasy, Ghallab Alotaibi
Summary: In this study, a microemulsion-based gel containing fi-caryophyllene, isopropyl myristate, Tween 80, and normal saline was prepared as a topical option for managing musculoskeletal pain and inflammation. The developed system showed better skin permeation, drug retention, pharmacokinetic profile, and pharmacodynamic outcome compared to the conventional product. This nanotechnology-based natural bioactive product with improved efficacy and drug loading can offer a better alternative for the management of musculoskeletal pain.
Article
Chemistry, Physical
Beibei Lu, Tianqi Liu, Hao Wang, Chengyu Wu, Hanjun Chen, Zhe Liu, Jiaheng Zhang
Summary: Transdermal drug delivery system has several advantages, and ionic liquids play an important role in transdermal drug delivery.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Multidisciplinary Sciences
M. Yasmin Begum, Riyaz Ali M. Osmani, Ali Alqahtani, Mohammed Ghazwani, Umme Hani, Hissana Ather, Akhtar Atiya, Mohamed Rahamathulla, Ayesha Siddiqua
Summary: This study developed stealth liposomes of CLB to reduce its side effects and increase drug accumulation in inflammation sites. The results showed that stealth liposomes significantly reduced inflammation and had extended drug bioavailability with lower toxicity.
Article
Pharmacology & Pharmacy
Lina Shen, Xiaolin Hou, Zhi Wang, Teng Guo, Zehui He, Shuyao Ruan, Zhenda Liu, Hang Ruan, Yongtai Zhang, Nianping Feng
Summary: Microemulsions can be used as a carrier to enhance the solubility and skin permeability of total flavones of Arisaematis rhizoma for transdermal delivery. By adding 1% sodium hyaluronate, transparent microemulsion-based hydrogels with pseudoplastic-fluid and shear-thinning characteristics were obtained. Nanoscale droplets of microemulsions migrate in the gel network, with their migration capacity and transdermal permeation flux negatively correlated with sodium hyaluronate concentration.
Article
Pharmacology & Pharmacy
Chutima Phechkrajang, Wichuda Phiphitphibunsuk, Rapee Sukthongchaikool, Nantana Nuchtavorn, Jiraporn Leanpolchareanchai
Summary: To address the low solubility of miconazole nitrate in water, miconazole-loaded microemulsions were developed for topical skin delivery. The optimal microemulsion containing PSM and ethanol at a ratio of 1:1 showed good drug permeation across pig skin and increased the inhibition of Candida albicans compared to cream. The microemulsion also exhibited favorable physicochemical stability.
Article
Nanoscience & Nanotechnology
Rahman Md Moshikur, Islam Md Shimul, Shihab Uddin, Rie Wakabayashi, Muhammad Moniruzzaman, Masahiro Goto
Summary: In this study, we synthesized 12 oil-miscible ionic liquid drugs and found that one formulation containing oleate had 2.6 times higher permeation ability than the traditional levamisole salt. Animal experiments showed that the levamisole ionic liquid had higher plasma concentration and longer elimination half-life compared to the levamisole salt. Additionally, the levamisole ionic liquid demonstrated excellent biocompatibility. Therefore, oil-miscible ionic liquid drugs provide a simple and scalable strategy for the design of effective transdermal drug delivery systems.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Khaled Shalaby
Summary: This study found that olive oil, as a vegetable oil, has good skin permeability. The acidity of olive oil affects skin permeability, with higher acidity resulting in stronger permeability. Highly acidic olive oil can improve epidermal permeability by weakening the skin barrier and stimulating cytokine secretion. Highly acidic olive oil is suitable for the formulation of cutaneous drug delivery systems.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Saratsanan Promjan, Prapaporn Boonme
Summary: This study validated a quantitative analysis method using high performance liquid chromatography (HPLC) for itraconazole (ITZ) in microemulsions (ME) and samples from a shed snakeskin permeation study. The method showed specificity, accuracy, precision, and sensitivity.
LATIN AMERICAN JOURNAL OF PHARMACY
(2022)
Article
Plant Sciences
Lucia Grifoni, Giulia Vanti, Maria Giuliana Vannucchi, Maria Camilla Bergonzi, Anna Rita Bilia
Summary: Microemulsions are versatile drug delivery systems that can be administered regardless of route. In this study, a microemulsion was formulated using glycerol (2.25%), Labrasol (20.25%), vitamin E acetate (2.50%), and water (75.00%). The microemulsion showed stable globules with a size of about 17 nm and had high potential for skin care applications due to its dermatological properties.
Article
Chemistry, Medicinal
Irene Carolina Luna-Canales, Norma Laura Delgado-Buenrostro, Irasema Chirino, Guadalupe Nava-Arzaluz, Elizabeth Pinon-Segundo, Graciela Martinez-Cruz, Adriana Ganem-Rondero
Summary: Objective: The objective of this study was to formulate a microemulsion with high loading capacity for curcumin and promote its penetration into the skin with the aim of enhancing its therapeutic effects. Methods: Curcumin was formulated in microemulsions based on oleic acid, Tween((R)) 80, and Transcutol((R)) HP. The microemulsions were characterized and their skin permeation properties were evaluated. Results: Nine stable microemulsions were prepared and the one with the highest loading capacity (60 mg/mL) showed effective penetration into the viable epidermis, with a total amount of curcumin found in the receptor medium at 24 h of 10.17 +/- 9.7 μg/cm². Conclusion: The inclusion of curcumin in a microemulsion enables its passage into and through the skin, with a preferential accumulation in the viable epidermis.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2023)
Article
Chemistry, Applied
Yuhang Xu, Ye Cai, Yun Meng, Long Wu, Jingbao Chen, Wenxuan Cao, Xiaoqin Chu
Summary: This study compared the differences between liposome and microemulsion in transdermal delivery of ibuprofen and found that liposome was superior. The transdermal mechanism was investigated using Fourier transform infrared spectroscopy, differential scanning calorimetry, and other methods.
JOURNAL OF MICROENCAPSULATION
(2022)
Article
Chemistry, Multidisciplinary
Mar Calzado-Delgado, M. Olga Guerrero-Perez, King Lun Yeung
Summary: The article describes two drug delivery systems for topical administration of vitamin C. The electrospun PVA nanofiber carrier releases vitamin C in bursts, while the PVA nanofiber-molecular capsule delivers vitamin C at a constant rate. Both systems protect vitamin C and provide increased heat stability.
Article
Pharmacology & Pharmacy
Amitkumar Virani, Vinam Puri, Hana Mohd, Bozena Michniak-Kohn
Summary: The present study aimed to evaluate the transdermal delivery of Oxcarbazepine (OXC) from microemulsions using different penetration enhancers. The results showed that all penetration enhancers improved the rate of permeation of OXC compared to the control. Microemulsions prepared using cineole, Tween 80 and Transcutol P (TRC) were shown to provide the best penetration enhancement for OXC.
Article
Pharmacology & Pharmacy
Simone Braga Carneiro, Taina Kreutz, Renata Pereira Limberger, Helder Ferreira Teixeira, Valdir Florencio da Veiga Junior, Leticia Scherer Koester
Summary: Nanoemulsions and nanostructured lipid carriers prepared by high-pressure homogenization showed potential for the skin delivery of dillapiole, a compound with anti-inflammatory activity, extracted from the leaves of Piper aduncum.
Review
Instruments & Instrumentation
Nidhi Aggarwal, Sachin, Bushra Nabi, Sumit Aggarwal, Sanjula Baboota, Javed Ali
Summary: Despite the benefits of HAART for AIDS patients, managing HIV infections remains a global health challenge. The inability of ARV drugs to cross the BBB has limited their effectiveness, but nano-based drug delivery strategies have shown promise in improving drug penetration and targeting viral reservoirs in the brain, offering a potential solution for treating NeuroAIDS.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Polymer Science
Annu, Sanjula Baboota, Javed Ali
Summary: The study successfully optimized chitosan nanoparticles for nasal delivery to enhance the bioavailability of lurasidone hydrochloride, showing potential in improving drug release and nasal permeation.
Article
Instruments & Instrumentation
Tausif Alam, Mohd Asif Ansari, Sanjula Baboota, Javed Ali
Summary: The study successfully improved the oral bioavailability of isradipine through optimizing the formulation of nanostructured lipid carriers, presenting a promising strategy for long-term management of hypertension. Additionally, the nanostructured lipid carrier of isradipine demonstrated effective cardioprotection in a rat model of myocardial infarction.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Ajay Singh, Zeba Maqsood, Mohammad Kashif Iqubal, Javed Ali, Sanjula Baboota
Summary: Wound healing is a complex process that involves the restoration of injured tissue. Nanocarriers have shown promising results in accelerating wound healing.
CURRENT DRUG DELIVERY
(2022)
Article
Biochemical Research Methods
Dheeraj Kataria, Ameeduzzafar Zafar, Javed Ali, Karishma Khatoon, Saba Khan, Syed Sarim Imam, Mohd Yasir, Asgar Ali
Summary: The optimized nanostructured lipid carriers (NLCs) of the antihypertensive drug lacidipine (LAC) showed nanometric size, high entrapment efficiency, and drug loading, leading to significantly improved drug release and intestinal permeation, ultimately resulting in higher oral bioavailability and antihypertensive effect compared to LAC-dispersion.
ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
(2022)
Article
Chemistry, Inorganic & Nuclear
Happy Garg, Saurabh Mittal, Muhammad Usama Ashhar, Shobhit Kumar, Shweta Dang, Kuldeep Nigam, Javed Ali, Sanjula Baboota
Summary: The study developed paroxetine-loaded SNEDDS to increase oral bioavailability. Optimized SNEDDS exhibited good particle morphology and transmittance. Results from permeability and behavioral studies demonstrated the enhanced therapeutic effects of paroxetine-loaded SNEDDS. Pharmacokinetic studies showed higher oral bioavailability of paroxetine SNEDDS.
JOURNAL OF CLUSTER SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Ashif Iqubal, Mohammad Kashif Iqubal, Sumit Sharma, Mohd Wasim, Mohamed A. Alfaleh, Shadab Md, Sanjula Baboota, Javed Ali, Syed Ehtaishamul Haque
Summary: Radiotherapy is commonly used to treat glioblastoma and other types of cancers, but it can cause neuroinflammation and cognitive dysfunction. Various drugs and nanocarrier systems have been explored to mitigate these side effects, but limitations still exist. Therefore, researchers are investigating the neuroprotective potential and mechanisms of other natural products and miRNAs.
Article
Pharmacology & Pharmacy
Saleha Rehman, Bushra Nabi, Amaan Javed, Tahira Khan, Ashif Iqubal, Mohammad Javed Ansari, Sanjula Baboota, Javed Ali
Summary: This research evaluated the improvement of antipsychotic activity for managing schizophrenia through paliperidone-loaded lipid nanoconstruct (PPD-LNC). The findings showed that PPD-LNC had high safety in Neuro-2a cells and significantly improved relative bioavailability in the brain compared to a drug suspension. Furthermore, PPD-LNC reduced extrapyramidal side effects and exhibited anti-inflammatory and antioxidant effects.
Article
Pharmacology & Pharmacy
Muhammad Usama Ashhar, Preeti Vyas, Divya Vohora, Pravat Kumar Sahoo, Kuldeep Nigam, Shweta Dang, Javed Ali, Sanjula Baboota
Summary: The study aimed to relieve oxidative stress in Parkinson's disease using intranasal delivery of nanoemulsion loaded with Bromocriptine Mesylate (BRM) and Glutathione (GSH). The results showed that the nanoemulsion had higher permeation and significant antioxidant activity compared to suspension. Treatment with the nanoemulsion significantly enhanced GSH, SOD, and CAT levels while reducing TBARS levels, IL-6, and TNF-alpha. Histopathological studies confirmed the neuroprotective effect of the nanoemulsion. Pharmacokinetic study revealed sustained release of BRM and GSH in the brain. Overall, the BRM and GSH loaded nanoemulsion showed potential for efficient management of PD.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Sabna Kotta, Abdul Wadood Khan, Shahid H. Ansari, Rakesh Kumar Sharma, Y. T. Kamal, Hibah Mubarak Aldawsari, Nabil Abdulhafiz Alhakamy, Sanjula Baboota, Javed Ali
Summary: The development of a nanoemulsion formulation of efavirenz has shown promising results in improving drug permeability and bioavailability, addressing the challenges of inaccurate dosing in pediatric antiretroviral therapy for HIV infection. The formulation has demonstrated an effective dose adjustable formulation for HIV therapy, especially in pediatric population.
INTERNATIONAL JOURNAL OF PHARMACOLOGY
(2022)
Article
Chemistry, Analytical
Saurabh Mittal, Javed Ali, Sanjula Baboota
Summary: Temozolomide and resveratrol have synergistic effects in treating glioblastoma, and a newly developed HPLC method allows for simultaneous assessment of both compounds with high precision and accuracy.
JOURNAL OF AOAC INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Farheen Fatima Qizilbash, Muhammad Usama Ashhar, Ameeduzzafar Zafar, Zufika Qamar, Annu, Javed Ali, Sanjula Baboota, Mohammed M. Ghoneim, Sultan Alshehri, Asgar Ali
Summary: In this study, a thymoquinone-enriched naringenin-loaded nanostructured lipid carrier was developed for nasal delivery in the treatment of depression. The optimized carrier exhibited excellent drug release and permeation properties, leading to improved therapeutic effect compared to traditional suspension and marketed formulation.
Article
Pharmacology & Pharmacy
Ali Sartaj, Annu, Meraj Alam, Largee Biswas, Mohammad Shahar Yar, Showkat Rasool Mir, Anita Kamra Verma, Sanjula Baboota, Javed Ali
Summary: This research investigated the potential of dual drug-loaded nanostructure lipidic carriers (NLCs) of green tea extract and Ribociclib in the treatment of breast cancer. In vitro and in vivo studies were conducted to evaluate the drug release, bioavailability, and therapeutic efficacy of the prepared NLCs. The results demonstrated controlled drug release, increased bioavailability, and promising therapeutic potential.
JOURNAL OF DRUG TARGETING
(2022)
Editorial Material
Pharmacology & Pharmacy
Marcio Rodrigues, Javed Ali, Gilberto Alves
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Nupur Shrivastava, Ankit Parikh, Rikeshwer Prasad Dewangan, Largee Biswas, Anita Kamra Verma, Saurabh Mittal, Javed Ali, Sanjay Garg, Sanjula Baboota
Summary: The optimized solid self-nanoemulsifying drug delivery system shows promising anti-cancer effects and significantly improves drug bioavailability and therapeutic efficacy.