Article
Optics
Ming-Che Chan, Qi-Xin Liu, Ankur Gogoi, Wei-Hsun Wang, Chin-Yu Lin, Guan-Yu Zhuo
Summary: In this work, a novel strategy based on the SHG signals of first-order modulation (1M) is presented to enhance the image contrast/SNR in SHG-LSM. By using 1M signal for image acquisition, the image contrast is increased by more than a factor of two and the image acquisition time is shortened by a factor of 2.5.
OPTICS AND LASERS IN ENGINEERING
(2023)
Article
Engineering, Electrical & Electronic
Stefan R. Anton, Rosa M. Martinez-Ojeda, Radu Hristu, George A. Stanciu, Antonela Toma, Cosmin K. Banica, Enrique J. Fernandez, Mikko J. Huttunen, Juan M. Bueno, Stefan G. Stanciu
Summary: Second Harmonic Generation Microscopy (SHG) is a valuable tool for non-invasively identifying and monitoring changes in collagen structures of tissues. However, the interpretation of SHG data can be challenging, hindering its clinical translation. This study explores the use of Deep Learning models to automatically detect corneal edema in SHG images with promising results, potentially paving the way for precision diagnostics of the cornea with Deep-Learning assisted SHG imaging.
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
(2023)
Article
Optics
Zilong Zhang, Yuan Gao, Xiangjia Li, Xin Wang, Suyi Zhao, Qiang Liu, Changming Zhao
Summary: Nonlinear frequency conversion of structured beams, specifically the intracavity second harmonic generation (SHG), has been investigated theoretically and experimentally. The results show that the SHG of transverse mode locking (TML) beams can carry more information compared to coherent and incoherent superposed states. Various rarely observed SHG beam patterns have been obtained, showcasing the potential applications in optical 3D printing, optical trapping of particles, and free-space optical communication.
ADVANCED PHOTONICS
(2022)
Article
Physics, Multidisciplinary
Abiramy Karunendiran, Kamdin Mirsanaye, Bryan A. Stewart, Virginijus Barzda
Summary: Polarimetric second harmonic generation microscopy is a label-free imaging technique used to study molecular organization in striated muscle structure. By examining the influence of myosin organization on imaging response, it provides insight into how myosin filament structure affects second harmonic properties.
FRONTIERS IN PHYSICS
(2022)
Article
Optics
Rosa M. Martinez-Ojeda, Carlos Hernandez-Garcia, Juan M. Bueno
Summary: This study proposes using radially polarized beams to improve the quality of SHG microscopy images, which has been shown to increase the efficiency of SHG processes and image quality, particularly for deep imaging.
OPTICS COMMUNICATIONS
(2021)
Article
Optics
Gia Quyet Ngo, Emad Najafidehaghani, Ziyang Gan, Sara Khazaee, Malte Per Siems, Antony George, Erik P. Schartner, Stefan Nolte, Heike Ebendorff-Heidepriem, Thomas Pertsch, Alessandro Tuniz, Markus A. Schmidt, Ulf Peschel, Andrey Turchanin, Falk Eilenberger
Summary: This study demonstrates a method to achieve second-harmonic generation in functionalized optical fibers by directly growing highly nonlinear MoS2 monolayers on the fiber's core. The approach is scalable and can be generalized to other materials and waveguide systems.
Article
Biochemical Research Methods
Leonardo Uribe Castano, Kamdin Mirsanaye, Lukas Kontenis, Serguei Krouglov, Edvardas Zurauskas, Roya Navab, Kazuhiro Yasufuku, Ming-Sound Tsao, Margarete K. Akens, Brian C. Wilson, Virginijus Barzda
Summary: We used wide-field second harmonic generation (SHG) microscopy and non-linear Stokes polarimetry to quickly investigate the ultrastructural characteristics of large sample areas in thin histology sections. By obtaining the Stokes vector components for SHG from polarimetric measurements, we were able to construct images of polarimetric parameters and determine the ultrastructural characteristics of achiral and chiral nonlinear susceptibility tensor components ratios and cylindrical axis orientation in fibrillar materials. This imaging technique was applied to examine lung tumor margins, revealing reduced SHG intensity, increased achiral susceptibility ratio values, and preferential orientation of collagen strands along the tumor border.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Materials Science, Multidisciplinary
Xuejian Dong, Shixiang Wang, Kaishun Guo, Zhixiang Chen, Bo Wu, Jing Guan, Fengqin Liu, Yingying Ren, Hongliang Liu, Qingming Lu, Yuechen Jia, Feng Chen
Summary: This article reports on the frequency doubling properties of femtosecond laser direct-written lithium triborate cladding waveguides. The guiding properties of these waveguides are experimentally characterized, and maximum conversion efficiency values of 4.8% and 8.6% are achieved for frequency doubling processes of 1064 -> 532 nm and 1560 -> 780 nm, respectively, in the fabricated depressed-cladding waveguides at room temperature. Our results suggest the potential applications of the fs-laser direct writing technique as well as LBO waveguides in constructing compact frequency converters.
Article
Chemistry, Multidisciplinary
Yann Foucaud, Bertrand Siboulet, Magali Duvail, Alban Jonchere, Olivier Diat, Rodolphe Vuilleumier, Jean-Francois Dufreche
Summary: A breakthrough method has been developed to predict and interpret SHG signal at the atomic level, showing the significant impact of bulk quadrupole contribution in the SHG response. The experimental results are in unprecedented agreement with the simulated responses.
Article
Engineering, Electrical & Electronic
Hauke Conradi, Almontaserbillah Hakmi, Moritz Kleinert, Lars Liebermeister, David de Felipe, Madeleine Weigel, Martin Kresse, Crispin Zawadzki, Bjoern Globisch, Norbert Keil, Ronald Freund, Martin Schell
Summary: In this study, second harmonic generation from 1550 to 775 nm was demonstrated in a polymer photonic integrated circuit via the hybrid integration of a periodically poled lithium niobate crystal. Fiber to fiber conversion efficiencies were found to be 0.03%/W for a continuous wave laser source and 100%/W for a femtosecond laser source. Additionally, third and fourth harmonic light at 517 and 388 nm was observed.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Chenshuang Zhang, Fangrui Lin, Yong Zhang, Haozhi Yang, Danying Lin, Jun He, Changrui Liao, Xiaoyu Weng, Liwei Liu, Yiping Wang, Bin Yu, Junle Qu
Summary: MSIM-SHG is a novel approach that combines second-harmonic generation (SHG) with multifocal structured illumination microscopy (MSIM) to achieve super-resolution imaging. It has wide applications in imaging material molecules and quantifying collagen fiber alignment, showing potential for clinical diagnosis and biological research.
Article
Chemistry, Physical
Hong-Xin Tang, Rui-Biao Fu, Zu-Ju Ma, Xin-Tao Wu
Summary: A new tungsten oxyfluoride crystal, K2(H2O)WO3F2, with O/F orientationally order has been successfully synthesized. The distorted [WO4F2] octahedra in this crystal are induced by trigonal [K2(H2O)]2+ motifs into an oriented arrangement. K2(H2O)WO3F2 exhibits the strongest phase-matching SHG response and the highest laser damage threshold among reported transition-metal oxyfluorides, which is attributed to the uniform alignment of the distorted [WO4F2] octahedra.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Optics
Supriya Sundareswaran, Srinivasan Karuppannan
Summary: The stable Form-I and metastable Form-II polymorphs of vanillin were successfully separated through nucleation control with selected templates. Both polymorphs exhibit good thermal stability and high SHG efficiency, making them promising for nonlinear optical applications.
OPTICS AND LASER TECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Qianting Xu, Youchao Liu, Qingchen Wu, Linxi Hou, Yanqiang Li, Lina Li, Zheshuai Lin, Sangen Zhao, Junhua Luo
Summary: A new chiral trithiocyanate compound, K-4(HC3N3S3)(2)·H2O, is reported to have strong second-harmonic generation and high birefringence in comparison with the commercial NLO crystal beta-BaB2O4. The enhanced optical properties of K-4(HC3N3S3)(2)·H2O are attributed to the highly pi-conjugated [HC3N3S3](2-) rings.
SCIENCE CHINA-MATERIALS
(2023)
Article
Chemistry, Physical
Aamir Mushtaq, Liam Clink, Mohamed Yaseen Noor, Conrad Kuz, Emma DeAngelis, Ryan Siebenaller, Adam Fisher, Darpan Verma, Roberto C. Myers, Benjamin S. Conner, Michael A. Susner, Enam Chowdhury
Summary: The nonlinear optical behavior of Cu0.33In1.30P2S6 bulk heterostructure was studied. Large two-photon induced nonlinear absorptions and self-defocusing were observed using the Z-scan technique. These observations can be utilized for designing optoelectronic and ultrafast photonic devices.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Physics, Applied
Subir Das, Yun-Yu Hsu, Ying-Rue Kao, Bao-Yu Hsieh, Fu-Jen Kao
Summary: In this study, a synchronous time delay technique is presented to control the illuminating laser pulses and the generation of ultrasonic waves for visualizing the ultrasound waveform through the Schlieren imaging method. The proposed technique allows for two-dimensional mapping of the ultrasound waveform in a temporally evolved manner, and the critical physical parameters such as the speed and spatial pulse length of the ultrasonic waves can be visualized and calculated through image analysis.
APPLIED PHYSICS LETTERS
(2022)
Review
Food Science & Technology
Aditi Sengupta, Ishita Chakraborty, G. Indira, Nirmal Mazumder
Summary: The interaction between starch and lipid leads to complexes that have various applications in the food industry. These complexes can affect the texture, quality, and other characteristics of food products. Various techniques can be used to study the structural, thermal, and chemical properties of these starch-lipid complexes.
FOOD REVIEWS INTERNATIONAL
(2023)
Review
Biotechnology & Applied Microbiology
Soumyabrata Banik, Ashwini Uchil, Tenzin Kalsang, Sanjiban Chakrabarty, Md. Azahar Ali, Pornsak Srisungsitthisunti, Krishna Kishore Mahato, Salvatore Surdo, Nirmal Mazumder
Summary: Microfluidics revolutionizes cellular biology research by providing control over the physicochemical environment and enabling high-throughput cellular analysis. The introduction of PDMS as a structural material has made microfluidic technology more accessible and widely applicable in various biological fields. This review emphasizes the innovative applications of PDMS-based microfluidic systems in pre-clinical biological research, enhancing sensitivity and diagnostic effectiveness in cell-based assays.
CRITICAL REVIEWS IN BIOTECHNOLOGY
(2023)
Review
Environmental Sciences
I Chakraborty, S. Banik, R. Biswas, T. Yamamoto, H. Noothalapati, N. Mazumder
Summary: The increasing demand and use of plastics have led to the concentration of microplastics in water bodies, posing threats to aquatic life and human health. Various water sources, including fresh, marine, and sewage, have been found to contain microplastics. Raman spectroscopy has been proven to be an essential tool in identifying the chemical composition of microplastics in water sources.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Kuheli Das, Manasa G. Shetty, Sindhoora K. Melanthota, Babitha K. Sundara, Sudeshna Kar, Chiara Massera, Eugenio Garribba, Amitabha Datta, Nirmal Mazumder
Summary: A new mononuclear Mn(III) derivative was synthesized and characterized. The central Mn atom is hexa-coordinated via the NNOO donor sites of the Schiff base precursor and two water molecules, resulting in a distorted octahedral geometry. The cytotoxic activity of the derivative was evaluated, and it exhibited a better activity against MCF-7 cells compared to SiHa and fibroblast cells.
Review
Pharmacology & Pharmacy
Upama Das, Soumyabrata Banik, Sharmila Sajankila Nadumane, Shweta Chakrabarti, Dharshini Gopal, Shama Prasada Kabekkodu, Pornsak Srisungsitthisunti, Nirmal Mazumder, Rajib Biswas
Summary: Cancer is a devastating disease and early diagnosis remains a challenge. Recently, circulating tumor cells (CTCs) have been extensively studied for their potential in detecting metastasis. Nanomaterial-based strategies have emerged as promising tools for early and rapid examination of tumor cells. This review provides a comprehensive overview of different nanotechnological methodologies and their application in cancer research, including the detection, isolation, and analysis of CTCs. State-of-the-art implementations, future challenges, and recommendations are also discussed.
Article
Physics, Applied
F. S-S Chien, A. Herawati, C-M Ho, H-L Hsiao, T-S Lim, C. R. Wang, K-K Ng, S. Das, F-J Kao, M-C Wu
Summary: The photon-induced deactivation of traps in MAPbI(3) has a significant impact on charge relaxation behavior. Through analyzing steady-state and time-resolved photoluminescence spectroscopy, it was found that three types of traps (T-L, T-H, and T-GB) in MAPbI(3) films can be deactivated by photons. Different thresholds were observed for the deactivation of these traps, with T-L and T-H having low and high energy thresholds, respectively, while T-GB had a lower energy threshold. The deactivation of these traps led to changes in photoluminescence quantum yield and recombination time.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2023)
Review
Biotechnology & Applied Microbiology
Nag Pooja, Ishita Chakraborty, Md. Hafizur Rahman, Nirmal Mazumder
Summary: Durability and affordability are the main reasons for the popularity of plastic, but their inability to degrade poses a significant threat to the environment and human health. Bioplastics, derived from renewable biomass, offer a promising alternative with lower carbon footprint and reduced greenhouse gas emissions. This review compares the biodegradation rates of potential bioplastics from various sources, highlighting their potential as replacements for conventional plastics.
Review
Optics
Gagan Raju, Nirmal Mazumder
Summary: Optical microscopy has been hindered in its biological applicability due to the limited penetration depth, but researchers have proposed various methods to address this, including designing novel probes and using adaptive optics (AO) technology. Through AO paradigms, techniques such as direct and indirect wavefront sensing have been developed to detect and rectify wavefront deformations and aberrations. Additionally, algorithmic post-processing without mechanical feedback has been used to correct optical patterns. Sensorless AO enables reliable optical imaging through thick biological tissue. This review highlights the latest advancements in AO-based optical microscopy techniques for depth-resolved imaging and discusses their potential in biomedical applications.
Article
Polymer Science
Ishita Chakraborty, Indira Govindaraju, Steffi Kunnel, Vishwanath Managuli, Nirmal Mazumder
Summary: This study investigated the effect of storage time and temperature on the retrogradation of rice starch. The results showed that increasing storage time and decreasing temperature increased the degree of retrogradation, which in turn affected the formation of resistant starch and alterations in thermal and rheological properties.
Article
Engineering, Biomedical
K. U. Spandana, Bhagesh Basavraj Hunakunti, Aymeric Le Gratiet, Ankur Gogoi, Nirmal Mazumder
Summary: Simulating the light scattering properties and studying the microstructural information of SARS-CoV-2 can help understand the virology of the coronavirus and develop effective detection strategies.
LASERS IN MEDICAL SCIENCE
(2023)
Article
Materials Science, Multidisciplinary
Jayur Tisso, Surajit Konwer, Gazi A. Ahmed, Nirmal Mazumder, Ankur Gogoi
Summary: This study investigates the photoluminescent properties of diatom frustules using spectroscopy and theoretical calculations. The role of various defects and impurity groups in the photoluminescence of diatom frustules is analyzed.
BULLETIN OF MATERIALS SCIENCE
(2023)
Article
Food Science & Technology
Mridula Sunder, Kamalesh D. Mumbrekar, Nirmal Mazumder
Summary: Starch, a common carbohydrate found in various foods, can be modified through chemical, enzymatic, and physical methods such as gamma radiation to enhance its industrial applications. Gamma radiation alters the physicochemical properties of starch and improves its performance.
CURRENT RESEARCH IN FOOD SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Thripthi Ananda, Ankita Modi, Ishita Chakraborty, Vishwanath Managuli, Chiranjay Mukhopadhyay, Nirmal Mazumder
Summary: This review discusses the concept and major pathogens of hospital-acquired infections (HAIs). Due to the increasing antibacterial resistance, nanotechnology offers new solutions for detecting and treating bacterial infections. The paper also focuses on the HAI situation in India and highlights the significant initiatives taken by medical bodies and hospitals in raising awareness and providing training.
BIOENGINEERING-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Vishwa Jyoti Baruah, Rasana Paul, Dhrubajyoti Gogoi, Nirmal Mazumder, Subrata Chakraborty, Aparoopa Das, Tapan Kumar Mondal, Bhaswati Sarmah
Summary: This study aimed to explore the potential biomedical applications of plant-based natural compounds derived from Thumbai (Leucas aspera) using a multi-omics approach. Nine compounds were identified as potential candidates based on their pharmacokinetics parameters. Target fishing techniques revealed renin receptor (ATP6AP2) and thymidylate kinase (DTYMK) as potential targets. Network biology approaches validated the functional, biochemical, and clinical relevance of these targets. Molecular modeling, pharmacophore approaches, and molecular dynamics simulation were used to investigate the target-ligand interaction and stability. Isololiolide and 4-hydroxy-2-methoxycinnamaldehyde were identified as lead molecules with the best binding affinity against the two potential protein targets. These natural lead products may have medical applications in various neurodegenerative, genetic, and developmental disorders, as well as potential diagnostic and therapeutic applications in transplantation-related pathogenesis, autoimmune diseases, and other immunological disorders.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biochemical Research Methods
K. Ramki, G. Thiruppathi, Selva Kumar Ramasamy, P. Sundararaj, P. Sakthivel
Summary: A chromone-based ratiometric fluorescent probe L2 was developed for the selective detection of Hg(II) in a semiaqueous solution. The probe exhibited enhanced fluorescence in its aggregated state and even higher fluorescence when chelated with Hg(II). The probe demonstrated high sensitivity and specificity for Hg(II) detection and was successfully applied for imaging Hg(II) in a living model.
Article
Biochemical Research Methods
Qun Zhang, Rui Yang, Gang Liu, Shiyan Jiang, Jiarui Wang, Juqiang Lin, Tingyin Wang, Jing Wang, Zufang Huang
Summary: This research aims to develop a cost-effective and portable method for measuring creatinine levels using the enhanced Tyndall effect phenomenon. The method offers a promising solution for monitoring renal healthcare in resource-limited settings.
