期刊
METHODS
卷 64, 期 2, 页码 119-128出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ymeth.2013.07.025
关键词
Spectroscopy; Single cells; Nuclear magnetic resonance; Fluorescence microscopy; Atomic force microscopy
资金
- Showalter Trust Fund
- Intramural program of the National Institutes of Health (NIH), National Institute on Aging [NIH R21 AR064178]
The advancement of spectroscopy methods attained through increases in sensitivity, and often with the coupling of complementary techniques, has enabled real-time structure and function measurements of single cells. The purpose of this review is to illustrate, in light of advances, the strengths and the weaknesses of these methods. Included also is an assessment of the impact of the experimental setup and conditions of each method on cellular function and integrity. A particular emphasis is placed on noninvasive and nondestructive techniques for achieving single cell detection, including nuclear magnetic resonance, in addition to physical, optical, and vibrational methods. (C) 2013 Elsevier Inc. All rights reserved.
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