Review
Endocrinology & Metabolism
Dan Huang, Yunlu Guo, Xiaoyu Guan, Lijun Pan, Ziyu Zhu, Zeng'ai Chen, Rick M. Dijkhuizen, Marco Duering, Fang Yu, Johannes Boltze, Peiying Li
Summary: Cognitive impairment (CI) is a significant health concern in aging populations and is often associated with vascular cognitive impairment (VCI). Reduced cerebral blood flow (CBF) plays a critical role in the progression of VCI, and arterial spin labeling (ASL) is a non-invasive MRI technique that can accurately assess CBF. Recent advancements in ASL have improved its usability and led to an increased application in identifying high-risk VCI patients. ASL, when combined with other imaging modalities and biomarkers, shows great potential in early detection and prevention strategies for VCI.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Psychiatry
J. M. Batail, I. Corouge, B. Combes, C. Conan, M. Guillery-Sollier, M. Verin, P. Sauleau, F. Le Jeune, J. Y. Gauvrit, G. Robert, C. Barillot, J. C. Ferre, D. Drapier
Summary: This study investigated the neurovascular mechanisms underlying apathy in depression using neuroimaging techniques. The results showed a negative correlation between cerebral blood flow in the left anterior cingulate cortex (ACC) and the severity of apathy, highlighting the significance of this region in depressed individuals.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Review
Neurosciences
Ekaterina Lunkova, Guido Guberman, Alain Ptito, Rajeet Singh Saluja
Summary: This review discusses various imaging methods for concussion, including fMRI, SWI, dMRI, and ASL, highlighting their benefits and drawbacks. A multimodal approach is recommended for a comprehensive understanding of mild traumatic brain injury mechanisms.
HUMAN BRAIN MAPPING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sue Y. Yi, Brian R. Barnett, McKenzie J. Poetzel, Nicholas A. Stowe, John-Paul J. Yu
Summary: This study found that NAC treatment can improve early-life, sex-specific neural microstructural deficits, with significant effects observed in male Disc1 sv Delta 2 rats; however, the addition of chronic early-life stress weakens the ability of NAC to restore microstructural deficits.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rong Wang, Xueling Liu, Chong Sun, Bin Hu, Liqin Yang, Yiru Liu, Daoying Geng, Jie Lin, Yuxin Li
Summary: This study investigated neurovascular coupling changes and potential neural basis in patients with MELAS using rs-fMRI and ASL. The results showed dynamic alterations in neurovascular coupling from acute to chronic stage in MELAS patients, providing a novel insight into the pathogenesis of MELAS.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Neurosciences
Ying Xiong, Rong-Sheng Chen, Xing-Yu Wang, Xiao Li, Lin-Qi Dai, Ren-Qiang Yu
Summary: The study aimed to investigate the neurobiological features of adolescent patients with MDD. Results showed differences in CBF in various brain regions between MDD patients and healthy controls, which can aid in early diagnosis and intervention.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Giannina R. Iannotti, Isaure Nadin, Vladimira Ivanova, Quentin Tourdot, Agustina M. Lascano, Shahan Momjian, Karl L. Schaller, Karl O. Lovblad, Frederic Grouiller
Summary: This study validates the use of functional arterial spin-labeling (ASL) as a noninvasive tool for presurgical functional brain mapping. The results show that functional ASL is more spatially accurate than blood oxygen level?dependent (BOLD) imaging when compared to transcranial magnetic stimulation, making it a valuable supplementary technique for presurgical mapping.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Neurosciences
Michael A. Chappell, Flora A. Kennedy McConnell, Xavier Golay, Matthias Gunther, Juan A. Hernandez-Tamames, Matthias J. van Osch, Iris Asllani
Summary: The mismatch in spatial resolution of ASL MRI perfusion images and brain tissues leads to a partial volume effect (PVE), which confounds perfusion estimation. PVE influences brain perfusion studies, particularly when changes in perfusion coincide with alterations in brain structure. The application of PVE correction (PVEc) is limited and methodologies are inconsistent.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaoyuan Fan, Zhentao Zuo, Tianye Lin, Zhichao Lai, Hui You, Jianxun Qu, Juan Wei, Bao Liu, Feng Feng
Summary: The study aimed to investigate whether preoperative arterial spin labeling (ASL) MRI can predict cerebral hyperperfusion after carotid endarterectomy (CEA) in patients with carotid stenosis. The study found that ASL can non-invasively predict cerebral hyperperfusion after CEA in patients with carotid stenosis based on the presence of arterial transit artifacts (ATAs).
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Caiyu Zhuang, Julien Poublanc, Larissa Mcketton, Lakshmikumar Venkatraghavan, Olivia Sobczyk, James Duffin, Adrian P. Crawley, Joseph A. Fisher, Renhua Wu, David J. Mikulis
Summary: This study demonstrates that in both 1.5-s and 2.5-s PLD groups, the CVR values in the affected ROI were significantly lower than in the control ROI. Additionally, the CBF in the affected ROI was significantly lower compared to the control ROI in the 1.5-s PLD group, but not in the 2.5-s PLD group. In hemisphere-based analysis, CBF was significantly lower in the affected side compared to the control side in the 1.5-s PLD group, but not in the 2.5-s PLD group.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2021)
Article
Behavioral Sciences
Vita Cardinale, Traute Demirakca, Tobias Gradinger, Markus Sack, Matthias Ruf, Nikolaus Kleindienst, Marius Schmitz, Christian Schmahl, Ulf Baumgaertner, Gabriele Ende
Summary: ASL is a functional neuroimaging technique that has been used to investigate acute pain states, offering advantages for low-frequency designs. A study found that ASL can sensitively detect brain activation in healthy controls following mechanical painful stimulation, indicating its potential for studying acute pain in a single event paradigm.
BRAIN AND BEHAVIOR
(2022)
Article
Neurosciences
Meher R. Juttukonda, Binyin Li, Randa Almaktoum, Kimberly A. Stephens, Kathryn M. Yochim, Essa Yacoub, Randy L. Buckner, David H. Salat
Summary: ASL MRI data from HCP-A was used to study cerebral hemodynamics in typically aging adults, revealing that white matter CBF decreases and white matter ATT lengthens with age. Additionally, CBF is lower and ATTs are longer in white matter compared to gray matter across the adult lifespan. Furthermore, sex differences were observed with females showing shorter white matter ATTs than males.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xinyu Wang, Weiqiang Dou, Dong Dong, Xinyi Wang, Xueyu Chen, Kunjian Chen, Huimin Mao, Yu Guo, Chao Zhang
Summary: This study aimed to explore the feasibility of three-dimensional pseudo-continuous arterial-spin-labeling (tASL) in evaluating MCA recanalization. After recanalization, tASL provided good prognosis and was found to be an independent predictor of good clinical outcome.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Medicine, General & Internal
Tingting Zhang, Haijun Niu, Yawen Liu, Linkun Cai, Dong Liu, Erwei Zhao, Min Li, Wenjuan Liu, Jing Li, PengGang Qiao, Wei Zheng, Pengling Ren, Zhenchang Wang
Summary: This study investigated the effects of dobutamine on cerebral hemodynamics and found that dobutamine stress significantly decreased cerebral blood flow in the frontal lobe anterior circulation. Additionally, body mass index, resting systolic blood pressure, and basilar artery diameter were significantly associated with changes in frontal lobe cerebral blood flow.
Article
Nutrition & Dietetics
Nikoleta S. Stamataki, Shane Mckie, Corey Scott, Douwina Bosscher, Rebecca Elliott, John T. McLaughlin
Summary: Non-nutritive sweeteners have potential effects on brain function, especially stevia which showed a more robust and prolonged effect compared to other beverages. Sweet taste and calories both exert modulatory effects on the brain.
Article
Multidisciplinary Sciences
Wouter S. Hoogenboom, Joyce Q. Lu, Benjamin Musheyev, Lara Borg, Rebeca Janowicz, Stacey Pamlayne, Wei Hou, Tim Q. Duong
Summary: This study investigated the survival of critically ill COVID-19 patients who received prophylactic or therapeutic dose anticoagulation (AC) and found that the therapeutic AC group had a significantly higher death rate after 3 or more weeks of ICU stay. Acute kidney injury (AKI), age, lymphocyte count, and cardiovascular disease were identified as important risk factors for increased mortality.
Article
Medicine, General & Internal
Joyce Q. Lu, Justin Y. Lu, Weihao Wang, Yuhang Liu, Alexandra Buczek, Roman Fleysher, Wouter S. Hoogenboom, Wei Zhu, Wei Hou, Carlos J. Rodriguez, Tim Q. Duong
Summary: This study investigated the incidence of persistent acute cardiac injury (ACI) in COVID-19 survivors and identified clinical predictors of recovery. The results showed that ACI is common among COVID-19 survivors, and readily available patient data can accurately predict ACI recovery.
Article
Multidisciplinary Sciences
Eric R. Muir, Saurav B. Chandra, Divya Narayanan, Vincent Zhang, Ike Zhang, Zhao Jiang, Jeffrey W. Kiel, Timothy Q. Duong
Summary: This study investigated the effects of chronic mild hyperoxia on retinal function and retinal and choroidal blood flow in a mouse model of glaucoma. The results showed that despite a progressive decline in blood flow, retinal function was improved in the mice treated with oxygen compared to the untreated mice.
Article
Clinical Neurology
Shen-Da Chang, Po-Chih Kuo, Karl Zilles, Tim Q. Duong, Simon B. Eickhoff, Andrew C. W. Huang, Arthur C. Tsai, Philip E. Cheng, Michelle Liou
Summary: This study empirically assessed the strength and duration of short-term effects induced by brain reactions to closing/opening the eyes on resting-state networks, and examined their association with cortisol levels. The results showed that opening the eyes had a short-term effect on conventional resting-state networks, with increased activity observed in time courses for approximately 60 seconds. Brain reactions to opening the eyes also affected the temporo-parietal lobes and limbic structures, leading to a prolonged decrease in activity. Additionally, there was a positive correlation between pre-scan cortisol levels and connectivity in the limbic structures under both conditions.
Article
Medicine, General & Internal
Benjamin Musheyev, Montek S. Boparai, Reona Kimura, Rebeca Janowicz, Stacey Pamlanye, Wei Hou, Tim Q. Duong
Summary: The medical specialty usage of COVID-19 survivors after hospital discharge was investigated in this study. The findings showed that a high incidence of persistent symptoms and medical specialty care needs were present in hospitalized COVID-19 survivors 1-24 months post-discharge. Some specialty care needs were COVID-19 related while others were associated with pre-existing medical conditions.
INTERNAL AND EMERGENCY MEDICINE
(2023)
Article
Multidisciplinary Sciences
Aaquib Q. Syed, Richard Adam, Thomas Ren, Jinyu Lu, Takouhie Maldjian, Tim Duong
Summary: Using extreme gradient boosting (XGBoost) with MRI and non-imaging data, it is possible to predict pathological complete response (pCR) after neoadjuvant chemotherapy. By analyzing texture features of DWI and DCE images, along with patient demographics and tumor data, pCR can be accurately predicted. The combination of MRI and non-MRI data from multiple treatment timepoints as inputs achieves the highest prediction accuracy.
Article
Multidisciplinary Sciences
Hongyi Dammu, Thomas Ren, Tim Q. Duong
Summary: The goal of this study was to use a novel deep-learning convolutional-neural-network (CNN) to predict pathological complete response (PCR), residual cancer burden (RCB), and progression-free survival (PFS) in breast cancer patients treated with neoadjuvant chemotherapy using longitudinal multiparametric MRI, demographics, and molecular subtypes as inputs. The results showed that the Integrated approach of CNN outperformed the Stack or Concatenation CNN, and the combination of MRI and non-MRI data performed better than either alone. The best model achieved an accuracy of 0.81 for PCR prediction, 0.80 for RCB prediction, and a mean absolute error of 24.6 months for PFS prediction.
Article
Medicine, General & Internal
Anna Eligulashvili, Megan Darrell, Carolyn Miller, Jeylin Lee, Seth Congdon, Jimmy S. Lee, Kevin Hsu, Judy Yee, Wei Hou, Marjan Islam, Tim Q. Duong
Summary: This study reports the symptoms and assessments of COVID-19 survivors up to five months post-acute infection. The results showed that many survivors experienced issues in pulmonary function, physical, emotional, and cognitive health. Furthermore, lung imaging abnormalities were more common than brain imaging abnormalities.
Review
Endocrinology & Metabolism
Tharun T. Alamuri, Sandhya Mahesh, Kevin Dell'Aquila, Taylor Jan Leong, Rebecca Jennings, Tim Q. Duong
Summary: SARS-CoV-2 infection may lead to endocrine dysfunction and dysregulation of blood sugar levels, causing diabetes mellitus. The relationship between COVID-19 and endocrine dysfunctions is still not completely understood. This review analyzed 27 publications on COVID-19 associated ketosis or diabetic ketoacidosis, suggesting that DKA in the setting of COVID-19 could increase the risk of death, especially in patients with new-onset diabetes. Larger studies with more specific variables are needed for better conclusions.
DIABETES OBESITY & METABOLISM
(2023)
Article
Medicine, General & Internal
Justin Y. Lu, Jack Wilson, Wei Hou, Roman Fleysher, Betsy C. Herold, Kevan C. Herold, Tim Q. Duong
Summary: This study compared the incidences and risk factors of new-onset persistent type-2 diabetes in COVID-19 patients to those in influenza patients. It was found that the incidence of type-2 diabetes was higher in COVID-19 patients compared to influenza patients. The risk of developing persistent type-2 diabetes was also higher in hospitalized COVID-19 patients compared to non-hospitalized COVID-19 patients and hospitalized influenza patients.
Article
Endocrinology & Metabolism
Alexander Y. Y. Xu, Stephen H. H. Wang, Tim Q. Q. Duong
Summary: This study aimed to investigate the incidence of new-onset diabetes in patients with prediabetes after COVID-19 and compared it with those not infected. The study found that hospitalized patients with prediabetes and COVID-19 had a higher incidence of in-hospital and post-infection diabetes compared to those without COVID-19. Critical illness, in-hospital steroid treatment, SARS-CoV-2 infection, and HbA1c were significant predictors of in-hospital diabetes.
BMJ OPEN DIABETES RESEARCH & CARE
(2023)
Article
Medicine, General & Internal
Beiyi Shen, Wei Hou, Zhao Jiang, Haifang Li, Adam J. J. Singer, Mahsa Hoshmand-Kochi, Almas Abbasi, Samantha Glass, Henry C. C. Thode, Jeffrey Levsky, Michael Lipton, Tim Q. Q. Duong
Summary: This study analyzed the temporal characteristics of lung chest X-ray (CXR) scores in COVID-19 patients during hospitalization and their correlation with other clinical variables and outcomes. The results showed that CXR scores have the potential to provide prognosis, guide treatment, and monitor disease progression in COVID-19 patients.
Article
Hematology
Avery Feit, Moshe Gordon, Tharun T. Alamuri, Wei Hou, William B. Mitchell, Deepa Manwani, Tim Q. Duong
Summary: This study examined whether patients with sickle cell disease (SCD) had increased risk of worse long-term outcomes and healthcare utilization 2.5 years after SARS-CoV-2 infection. The results showed that SCD patients with SARS-CoV-2 infection did not have additional risk of worse long-term outcomes compared to matched controls of SCD patients not infected by SARS-CoV-2.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2023)
Article
Peripheral Vascular Disease
Vincent Zhang, Molly Fisher, Wei Hou, Lili Zhang, Tim Q. Duong
Summary: The incidence of new-onset persistent hypertension in patients with COVID-19 is higher than those with influenza, indicating a significant health burden associated with COVID-19.
Article
Rheumatology
Jai Mehrotra-Varma, Anand Kumthekar, Sonya Henry, Roman Fleysher, Wei Hou, Tim Q. Duong
Summary: This retrospective study examined the clinical outcomes of 361 patients with rheumatoid arthritis (RA) who were infected with COVID-19. The results showed that patients with RA and COVID-19 had higher rates of hospitalization, critical illness, and mortality compared to patients with RA without COVID-19. However, these adverse outcomes were not directly attributed to RA itself, but rather to age and preexisting medical conditions.
ACR OPEN RHEUMATOLOGY
(2023)
Article
Biochemical Research Methods
K. Ramki, G. Thiruppathi, Selva Kumar Ramasamy, P. Sundararaj, P. Sakthivel
Summary: A chromone-based ratiometric fluorescent probe L2 was developed for the selective detection of Hg(II) in a semiaqueous solution. The probe exhibited enhanced fluorescence in its aggregated state and even higher fluorescence when chelated with Hg(II). The probe demonstrated high sensitivity and specificity for Hg(II) detection and was successfully applied for imaging Hg(II) in a living model.
Article
Biochemical Research Methods
Qun Zhang, Rui Yang, Gang Liu, Shiyan Jiang, Jiarui Wang, Juqiang Lin, Tingyin Wang, Jing Wang, Zufang Huang
Summary: This research aims to develop a cost-effective and portable method for measuring creatinine levels using the enhanced Tyndall effect phenomenon. The method offers a promising solution for monitoring renal healthcare in resource-limited settings.
