期刊
METALS AND MATERIALS INTERNATIONAL
卷 18, 期 2, 页码 243-247出版社
KOREAN INST METALS MATERIALS
DOI: 10.1007/s12540-012-2007-5
关键词
biomaterials; casting; mechanical properties; bone; compression test
资金
- KIST [2E21950, 2E22710]
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [2010-0028287]
- Seoul Development Institute, Republic of Korea [SS100008]
The purposes of this preliminary study were to investigate the effect of increased Ca contents (5-10 wt% Ca) in Mg-Ca alloy on the mechanical properties and osseous healing rate in a standard rat defect model. Mechanical tests were performed using a compression system followed by qualitative histological analysis using the hemotoxylin and eosin (H&E) staining method and quantitative reverse transcriptase polymerase chain reaction (reverse transcriptase PCR). Mg-Ca alloy degraded fast in vivo while displaying a high level of the bone formation markersOC and ALP. Favorablemechanical strength properties were displayed as Ca content increased from 5 wt% to 10 wt% to show its potential to be considered as a load bearing implant material. The resultfrom this study suggests that the developed Mg-Ca alloy has the potential to serve as a biocompatible load bearing implant material that is degradable and possibly osteoconductive.
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