Review
Nutrition & Dietetics
Helena Lahoda Brodska, Jiri Klempir, Jan Zavora, Pavel Kohout
Summary: Micronutrients are essential for basic metabolic reactions in the human body, and their abnormal levels have been linked to the etiopathogenesis and complications of neurological diseases.
Article
Cell Biology
Yingyao Shao, Sameer S. Bajikar, Harini P. Tirumala, Manuel Cantu Gutierrez, Joshua D. Wythe, Huda Y. Zoghbi
Summary: This study identified six putative noncoding regulatory elements of Mecp2, two of which are conserved in humans. Deletion of these elements altered RNA and protein levels and caused RTT- and MDS-like behavioral deficits in mice. These findings offer insight into Mecp2/MECP2 transcriptional regulation and suggest potential diagnostic and therapeutic targets for RTT or MDS.
GENES & DEVELOPMENT
(2021)
Article
Chemistry, Multidisciplinary
Francesca Roda, Silvia Picciolini, Valentina Mangolini, Alice Gualerzi, Pierfausto Seneci, Antonio Renda, Silvia Sesana, Francesca Re, Marzia Bedoni
Summary: Raman Spectroscopy (RS) is proposed as a valuable tool for characterizing liposomes (LPs) and evaluating their effectiveness and safety in treating neuroinflammation and microglial dysfunctions in Glioblastoma multiforme and Alzheimer's disease. The Raman spectra of different LP components contribute to the overall LP Raman fingerprint, making it possible to differentiate LPs with different functionalization patterns. Raman data analysis allows for the evaluation of LP synthesis efficacy using small sample amounts.
Article
Biochemistry & Molecular Biology
Riikka Lampinen, Veronika Gorova, Simone Avesani, Jeffrey R. Liddell, Elina Penttila, Tana Zavodna, Zdenek Krejcik, Juha-Matti Lehtola, Toni Saari, Juho Kalapudas, Sanna Hannonen, Heikki Lopponen, Jan Topinka, Anne M. Koivisto, Anthony R. White, Rosalba Giugno, Katja M. Kanninen
Summary: The biometal homeostasis in the olfactory mucosa cells of Alzheimer's disease (AD) patients is disturbed and correlated with the alterations in the brain. This provides new clues for the early diagnosis and treatment of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Behavioral Sciences
Mehar Sahu, Rahul Tripathi, Niraj Kumar Jha, Saurabh Kumar Jha, Rashmi K. Ambasta, Pravir Kumar
Summary: Sleep disorders are becoming more prevalent among the elderly population, especially those with neurodegenerative and neuropsychiatric disorders. This article reviews the mechanisms and effects of sleep dysfunction in these disorders, including disturbed circadian rhythm, gene regulation, brainwave perturbations, and ocular manifestations. Non-pharmacological treatments are gaining importance due to the limitations of pharmacological approaches.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Clinical Neurology
James Beharry, David Palmer, Teddy Wu, Duncan Wilson, Campbell Le Heron, Deborah Mason, Jon Reimers, John Fink, Roger Mulder, Roderick Duncan
Summary: A study at Christchurch Hospital in New Zealand found that FND patients accounted for a significant proportion of acute neurology admissions, with high healthcare resource utilization. Patients were mainly female with an average age of 40, and most had a hospital stay of around 3 days. The rate of acute inpatient admission for FND varied in different areas.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Review
Neurosciences
Judyta Juranek, Konark Mukherjee, Bernard Kordas, Michal Zalecki, Agnieszka Korytko, Kamila Zglejc-Waszak, Jaroslaw Szuszkiewicz, Marta Banach
Summary: This review discusses the role of RAGE in the nervous system and highlights the incomplete understanding of this signaling pathway. While some clinical trials have not shown the expected therapeutic efficacy, there is still hope for treating nervous system diseases through the use of different blocking agents.
NEUROSCIENCE BULLETIN
(2022)
Review
Biochemistry & Molecular Biology
Raluca Ioana Teleanu, Adelina-Gabriela Niculescu, Eugenia Roza, Oana Vladacenco, Alexandru Mihai Grumezescu, Daniel Mihai Teleanu
Summary: This paper describes the role of neurotransmitters and their link to relevant neurological conditions. It also provides an overview of detection methods and considerations for modulating neurotransmitters to restore homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Environmental Sciences
Hong Cheng, Bobo Yang, Tao Ke, Shaojun Li, Xiaobo Yang, Michael Aschner, Pan Chen
Summary: Metals play important roles in physiological activities, but metal overload can lead to neurotoxicity by increasing reactive oxygen species and oxidative stress. Mitochondria, crucial for energy production, are major targets of metal toxicity, and dysfunction can disrupt brain function, causing neuronal cell death and neurological disorders.
Article
Behavioral Sciences
Kirti Agrawal, Pratik Chakraborty, Saikat Dewanjee, Saniya Arfin, Sabya Sachi Das, Abhijit Dey, Mahmoud Moustafa, Prabhu Chandra Mishra, Seid Mahdi Jafari, Niraj Kumar Jha, Saurabh Kumar Jha, Dhruv Kumar
Summary: Quercetin, a naturally occurring bioactive flavonoid, has shown therapeutic potential in preclinical tests against neurological disorders. Its protective role against oxidative stress and neuroinflammation make it a possible choice for treatment. However, the specific molecular targets of quercetin and its derivatives, such as nuclear receptors and proinflammatory mediators, are yet to be explored.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Review
Nutrition & Dietetics
Giorgia Sebastiani, Laura Almeida-Toledano, Mariona Serra-Delgado, Elisabet Navarro-Tapia, Sebastian Sailer, Olga Valverde, Oscar Garcia-Algar, Vicente Andreu-Fernandez
Summary: Research on neurological and neurodegenerative disorders has focused on molecular mechanisms to find potential drug targets. Catechins, particularly EGCG, have antioxidant, immunomodulatory, neuritogenic, and autophagic properties against neuroinflammation and neurodegenerative diseases. However, the efficacy of EGCG in humans remains controversial.
Review
Nutrition & Dietetics
Anastasiia V. Badaeva, Alexey B. Danilov, Paul Clayton, Alexey A. Moskalev, Alexander V. Karasev, Andrey F. Tarasevich, Yulia D. Vorobyeva, Viacheslav N. Novikov
Summary: Neuronutrition is a part of nutritional neuroscience that studies the effects of different dietary components on behavior and cognition. It also encompasses the use of various nutrients and diets to prevent and treat neurological disorders. This narrative review explores the current understanding of neuronutrition as a key concept for brain health and its potential application in the prevention and treatment of various disorders.
Review
Geriatrics & Gerontology
Yang Liu, Miao Wang, Xiao-Ou Hou, Li-Fang Hu
Summary: Microglia, as resident innate immune cells in the central nervous system, play an important role in neurological disorders. Mitophagy, as a critical mechanism for mitochondrial quality control and turnover, regulates the inflammatory response and phagocytic function of microglia. Dysfunction in mitochondria and mitophagy is associated with aging and neurological disorders.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Biying Liu, Dan Huang, Yunlu Guo, Xiaoqiong Sun, Caiyang Chen, Xiaozhu Zhai, Xia Jin, Hui Zhu, Peiying Li, Weifeng Yu
Summary: Neurological disorders after surgery in elderly patients, such as postoperative delirium and cognitive dysfunction, pose significant challenges and can lead to worsened functional outcomes and quality of life. Preventive measures and prompt treatment are crucial in reducing long-term risks and improving recovery.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Review
Neurosciences
Jie Shao, Yunhui Liu, Dashuang Gao, Jie Tu, Fan Yang
Summary: Neural firing patterns play a critical role in various mental and neurological disorders, with T-type voltage-gated calcium channels implicated in conditions like depression and epilepsy. Burst firing varies in different brain areas, with distinct ionic mechanisms and physiological functions.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Chiara A. De Benedictis, Claudia Haffke, Simone Hagmeyer, Ann Katrin Sauer, Andreas M. Grabrucker
Summary: Research has shown that zinc ions play an essential role in brain function, with zinc transporters implicated in neurodegenerative disorders. This study identified ZIP4 expression in both rat neurons and astrocytes but predominantly in neurons, indicating a potential novel role in excitatory synapses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Neurosciences
Elisa L. Hill-Yardin, Andreas M. Grabrucker, Ashley E. Franks, Ruth Ann Luna, Mastura Monif
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Neurosciences
Janelle E. Stanton, Sigita Malijauskaite, Kieran McGourty, Andreas M. Grabrucker
Summary: Metal dyshomeostasis is a significant factor in neurological diseases such as Alzheimer's, Parkinson's, and Autism Spectrum Disorders. Metallomics studies have mainly focused on trace metal composition, but there is a growing awareness of the connections between metallome and other omes like microbiome and metabolome, which may contribute to individual pathologies. The gut-brain axis and inflammatory processes in ASD have been linked to changes in the microbiome, which are influenced by metallomics data.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Ann Katrin Sauer, Sigita Malijauskaite, Paula Meleady, Tobias M. Boeckers, Kieran McGourty, Andreas M. Grabrucker
Summary: The study reveals that zinc deficiency can cause morphological changes in GI development, affecting barrier permeability and pro-inflammatory pathways, leading to chronic systemic and neuroinflammation, and altering microbiota composition, resembling the characteristics found in ASD patients.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ann Katrin Sauer, Simone Hagmeyer, Andreas M. Grabrucker
Summary: Early life zinc deficiency is associated with Autism Spectrum Disorders (ASD), as shown by epidemiological studies and mouse models. Prenatal zinc deficiency can lead to gastrointestinal and immune system alterations, as well as abnormal synaptic signaling in the brain, which contribute to the neurobiological and behavioral abnormalities observed in ASD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Jason Thomas Duskey, Arianna Rinaldi, Ilaria Ottonelli, Riccardo Caraffi, Chiara Alessia De Benedictis, Ann Katrin Sauer, Giovanni Tosi, Maria Angela Vandelli, Barbara Ruozi, Andreas Martin Grabrucker
Summary: Nanomedicines offer a way to overcome major barriers in current cancer treatments.
Article
Medicine, General & Internal
Chiara A. De Benedictis, Sarah Trame, Lothar Rink, Andreas M. Grabrucker
Summary: This study investigated the zinc intake and bioavailability of over 250 women (both pregnant and non-pregnant) in Ireland and found that 58% of participants were at risk of inadequate zinc intake, with 29% potentially being zinc deficient. The low zinc intake was primarily a result of insufficient consumption of zinc-rich foods and relatively higher intake of foods rich in phytate, a major inhibitor of zinc uptake.
IRISH JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Food Science & Technology
Luciana Azevedo, Mateus Sa M. Serafim, Vinicius G. Maltarollo, Andreas M. Grabrucker, Daniel Granato
Summary: This study proposes a multidisciplinary and cross-sectoral approach to design functional foods by linking atherosclerosis biomarkers, potential bioactive compounds, and food technology. Computational methods can be used to predict the bioactivity of phenolic compounds, and combined with chemical analyses and mathematical models, novel sources of bioactive compounds can be discovered. The integration of food science/technology, nutrition, and structure-and ligand-based approaches supports the design of tailor-made functional foods/nutraceuticals for interventions related to cardiovascular and metabolic diseases.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sigita Malijauskaite, Ann Katrin Sauer, Seamus E. Hickey, Marco Franzoni, Andreas M. Grabrucker, Kieran McGourty
Summary: This study used omics approaches to compare genetic and non-genetic mouse models of autism spectrum disorders (ASD) and identified a common protein network related to synaptic vesicle release and recycling. The findings suggest that abnormal synaptic vesicle dynamics and function may be a key neurobiological factor contributing to shared behavioral abnormalities in ASD.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Anna Blazewicz, Andreas M. Grabrucker
Summary: Metals have been recognized to impact our body's physiology for hundreds of years. Recently, a link between abnormal metal levels and neuropsychiatric illnesses such as schizophrenia and autism spectrum disorders (ASDs) has been discovered. This review summarizes past and current research on the cellular and molecular mechanisms of toxic metals, focusing on ASD-related activities such as inflammation/immune activation, mitochondrial dysfunction, oxidative stress, impairment of axonal myelination, and synapse formation and function. The competition with essential metals may explain why both the presence of certain toxic metals and the absence of certain essential metals are risk factors for ASD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Aisling M. Ross, Rachel M. Cahalane, Darragh R. Walsh, Andreas M. Grabrucker, Lynnette Marcar, John J. E. Mulvihill
Summary: This study investigated the effects of nanoparticles (NPs) with different materials, sizes, and concentrations on cell barrier integrity and cell viability. The results showed that the properties of NPs in realistic media were the best predictor of cell response. Additionally, the zeta potential of NPs was found to significantly correlate with NP permeability and changes in cell viability. NPs with a physiological-based zeta potential of -12 mV demonstrated good cell barrier penetration without considerable changes in cell viability.
Review
Biochemistry & Molecular Biology
Sakshi Hans, Alexandra Karadimou, John J. E. Mulvihill, Andreas M. Grabrucker, Ioannis Zabetakis
Summary: Neurodegenerative diseases, including Alzheimer's disease, are characterized by progressive loss of brain function. Dietary intake of macro- and micro-nutrients, particularly lipids, can significantly affect cognitive function. Although the importance of functional foods in preventing cardiovascular disease is well-documented, their significance for central nervous system health and neurodegenerative diseases is less recognized. The composition of the gut microbiome affects cognitive health, and dietary lipids have been shown to influence gut health.
Review
Health Care Sciences & Services
Neluwa-Liyanage R. Indika, Richard E. Frye, Daniel A. Rossignol, Susan C. Owens, Udara D. Senarathne, Andreas M. Grabrucker, Rasika Perera, Marielle P. K. J. Engelen, Nicolaas E. P. Deutz
Summary: Children with autism spectrum disorder may have nutritional deficiencies due to various factors and supplementing vitamins, minerals, and cofactors can be beneficial for their metabolic pathways and neurotransmitter functioning. Some vitamins can be administered at higher doses than usual to yield effects beyond their enzyme cofactor role. The interrelationships between these nutrients can also be leveraged for synergistic effects. This review discusses the evidence, rationale, and prospects for using vitamins, minerals, and cofactors in autism spectrum disorder.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Genetics & Heredity
Ausra Matuleviciene, Kamile Siauryte, Els Kuiper, Andreas M. Grabrucker
Summary: This review summarizes the gastrointestinal (GI) problems in Phelan-McDermid syndrome (PMS) and addresses the fundamental questions regarding the occurrence, types, consequences, and treatment of GI problems in individuals with PMS. The findings highlight the detrimental effect of GI problems on the health of PMS individuals and the significant burden they pose for their families, emphasizing the need for evaluation and care recommendations.
EUROPEAN JOURNAL OF MEDICAL GENETICS
(2023)
Review
Chemistry, Medicinal
Ewa Dudzinska, Andreas M. Grabrucker, Pawel Kwiatkowski, Robert Sitarz, Monika Sienkiewicz
Summary: Visceral stimuli from the digestive tract are transmitted to the brain via nerves, causing overreaction in the brain of irritable bowel syndrome (IBS) patients. Stress and dysbiosis can lead to inflammation and gastrointestinal hypersensitivity. Treating IBS involves reducing visceral hypersensitivity and regulating the intestinal microbiota.