期刊
METALLOMICS
卷 4, 期 8, 页码 739-750出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2mt20081c
关键词
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资金
- CEITEC [CZ.1.05/1.1.00/02.0068]
- CYTORES GA CR [P301/10/0356]
- NANOSEMED GA AV [KAN208130801]
- NanoBioTECell GA CR [102/11/1068]
Metallothioneins (MT) are a family of ubiquitous proteins, whose role is still discussed in numerous papers, but their affinity to some metal ions is undisputable. These cysteine-rich proteins are connected with antioxidant activity and protective effects on biomolecules against free radicals, especially reactive oxygen species. In this review, the connection between zinc(II) ions, reactive oxygen species, heavy metal ions and metallothioneins is demonstrated with respect to effect of these proteins on cell proliferation and a possible negative role in resistance to heavy metal-based and non-heavy metal-based drugs.
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