Metallostasis and amyloid β-degrading enzymes

Drug Development Based on the Metals Hypothesis of Alzheimer's Disease

(2017) Ashley I. Bush   JOURNAL OF ALZHEIMERS DISEASE

PBT2 Rapidly Improves Cognition in Alzheimer's Disease: Additional Phase II Analyses

(2017) Noel G. Faux et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuronal Calcium Signaling, Mitochondrial Dysfunction, and Alzheimer's Disease

(2017) Charlene Supnet et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid-β Peptide and Oligomers in the Brain and Cerebrospinal Fluid of Aged Canines

(2017) Elizabeth Head et al.   JOURNAL OF ALZHEIMERS DISEASE

A potential role for zinc alterations in the pathogenesis of Alzheimer's disease

(2012) Ganna Lyubartseva et al.   BIOFACTORS

Metal ions affect insulin-degrading enzyme activity

(2012) Giuseppe Grasso et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

The distribution profile and oxidation states of biometals in APP transgenic mouse brain: dyshomeostasis with age and as a function of the development of Alzheimer's disease

(2012) Huajian Wang et al.   Metallomics

Genetic Inhibition of Solute-Linked Carrier 39 Family Transporter 1 Ameliorates Aβ Pathology in a Drosophila Model of Alzheimer's Disease

(2012) Minglin Lang et al.   PLoS Genetics

The Inorganic Perspective of Nerve Growth Factor: Interactions of Cu2+ and Zn2+ with the N-Terminus Fragment of Nerve Growth Factor Encompassing the Recognition Domain of the TrkA Receptor

(2011) Alessio Travaglia et al.   CHEMISTRY-A EUROPEAN JOURNAL

Copper(I) and Copper(II) Inhibit Aβ Peptides Proteolysis by Insulin-Degrading Enzyme Differently: Implications for Metallostasis Alteration in Alzheimer’s Disease

(2011) Giuseppe Grasso et al.   CHEMISTRY-A EUROPEAN JOURNAL

Copper(II) interaction with amyloid-β: Affinity and speciation

(2011) Giuseppe Arena et al.   COORDINATION CHEMISTRY REVIEWS

Affinity of Cu+for the Copper-Binding Domain of the Amyloid-β Peptide of Alzheimer’s Disease

(2011) Heather A. Feaga et al.   INORGANIC CHEMISTRY

Zn2+’s Ability to Alter the Distribution of Cu2+among the Available Binding Sites of Aβ(1–16)-Polyethylenglycol-ylated Peptide: Implications in Alzheimer’s Disease

(2011) Chiara A. Damante et al.   INORGANIC CHEMISTRY

Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer’s disease?

(2011) Natalia N. Nalivaeva et al.   JOURNAL OF NEUROCHEMISTRY

Role of metal dyshomeostasis in Alzheimer's disease

(2011) David J. Bonda et al.   Metallomics

In vitro Pb exposure disturbs the balance between Aβ production and elimination: The role of AβPP and neprilysin

(2011) Hui Huang et al.   NEUROTOXICOLOGY

Oxidative Stress and Cell Membranes in the Pathogenesis of Alzheimer's Disease

(2011) Paul H. Axelsen et al.   PHYSIOLOGY

Metal Ionophore Treatment Restores Dendritic Spine Density and Synaptic Protein Levels in a Mouse Model of Alzheimer's Disease

(2011) Paul A. Adlard et al.   PLoS One

The Monomer State of Beta-Amyloid: Where the Alzheimer's Disease Protein Meets Physiology

(2011) M.L. Giuffrida et al.   REVIEWS IN THE NEUROSCIENCES

Degradation of Soluble and Fibrillar Amyloid β-Protein by Matrix Metalloproteinase (MT1-MMP)in Vitro

(2010) Mei-Chen Liao et al.   BIOCHEMISTRY

Effect of a Deficiency of Ceruloplasmin Copper in Blood Plasma on Copper Metabolism in the Brain

(2010) P. S. Babich et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Protein Conformational Pathology in Alzheimers and Other Neurodegenerative Diseases; New Targets for Therapy

(2010) E. Zerovnik   Current Alzheimer Research

Targeted Hydrolysis of Beta-Amyloid with Engineered Antibody Fragments

(2010) S. Kasturirangan et al.   Current Alzheimer Research

Novel drug targets based on metallobiology of Alzheimer's disease

(2010) Sanghamitra Bandyopadhyay et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Modulation of Aβ42 fibrillogenesis by glycosaminoglycan structure

(2010) Juan José Valle-Delgado et al.   FASEB JOURNAL

The enhancement of amyloid precursor protein and β-site amyloid cleavage enzyme 1 interaction: Amyloid-β production with aging

(2010) Zou   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Matrix Metalloproteinase 2 (MMP-2) Degrades Soluble Vasculotropic Amyloid-β E22Q and L34V Mutants, Delaying Their Toxicity for Human Brain Microvascular Endothelial Cells

(2010) Mar Hernandez-Guillamon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cognitive Loss in Zinc Transporter-3 Knock-Out Mice: A Phenocopy for the Synaptic and Memory Deficits of Alzheimer's Disease?

(2010) P. A. Adlard et al.   JOURNAL OF NEUROSCIENCE

The use of mass spectrometry to study amyloid-β peptides

(2010) Giuseppe Grasso   MASS SPECTROMETRY REVIEWS

Effect of transition metals in synaptic damage induced by amyloid beta peptide

(2010) R.M. Uranga et al.   NEUROSCIENCE

Design of small molecules that target metal-A  species and regulate metal-induced A  aggregation and neurotoxicity

(2010) J.-S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

New evidence on iron, copper accumulation and zinc depletion and its correlation with DNA integrity in aging human brain regions

(2010) T.SSathyanarayana Rao et al.   Indian Journal of Psychiatry

Endothelin-Converting Enzyme-2 Is Increased in Alzheimer’s Disease and Up-Regulated by Aβ

(2009) Jennifer C. Palmer et al.   AMERICAN JOURNAL OF PATHOLOGY

High-Throughput Analysis of Alzheimer’s β-Amyloid Aggregation Using a Microfluidic Self-Assembly of Monomersf

(2009) Joon Seok Lee et al.   ANALYTICAL CHEMISTRY

Alzheimer's Disease: From Pathology to Therapeutic Approaches

(2009) Roland Jakob-Roetne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mammalian Zinc Transporters: Nutritional and Physiologic Regulation

(2009) Louis A. Lichten et al.   Annual Review of Nutrition

Kinetic analysis of product release and metal ions in a metallonuclease

(2009) Fuqian Xie et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Characterization of the vaccinia virus D10 decapping enzyme provides evidence for a two-metal-ion mechanism

(2009) Marie F. Soulière et al.   BIOCHEMICAL JOURNAL

The Second Cu(II)-Binding Site in a Proton-Rich Environment Interferes with the Aggregation of Amyloid-β(1−40) into Amyloid Fibrils

(2009) Sangmi Jun et al.   BIOCHEMISTRY

The M17 Leucine Aminopeptidase of the Malaria ParasitePlasmodium falciparum: Importance of Active Site Metal Ions in the Binding of Substrates and Inhibitors

(2009) Selma Maric et al.   BIOCHEMISTRY

Bacillus d-stereospecific metallo-amidohydrolase: Active-site metal-ion substitution changes substrate specificity

(2009) Jiro Arima et al.   BIOCHIMIE

Calcium dyshomeostasis in white matter pathology

(2009) Carlos Matute   CELL CALCIUM

GEPT Extract Reduces Aβ Deposition by Regulating the Balance Between Production and Degradation of Aβ in APPV717I Transgenic Mice

(2009) Jinzhou Tian et al.   Current Alzheimer Research

Metal Loading Capacity of Aβ N-Terminus: a Combined Potentiometric and Spectroscopic Study of Zinc(II) Complexes with Aβ(1−16), Its Short or Mutated Peptide Fragments and Its Polyethylene Glycol−ylated Analogue

(2009) Chiara A. Damante et al.   INORGANIC CHEMISTRY

Zinc Ion-induced Domain Organization in Metallo-β-lactamases

(2009) Nathalie Selevsek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron binding effects on the kinetic stability and unfolding energetics of a thermophilic phenylalanine hydroxylase from Chloroflexus aurantiacus

(2009) Angel Luis Pey et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Intracellular calcium signalling in Alzheimer’s disease

(2009) Marina Hermes et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The proteolytic activity of insulin-degrading enzyme: a mass spectrometry study

(2009) Giuseppe Grasso et al.   JOURNAL OF MASS SPECTROMETRY

Site-Activated Multifunctional Chelator with Acetylcholinesterase and Neuroprotective−Neurorestorative Moieties for Alzheimer’s Therapy

(2009) Hailin Zheng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Poly-N-methylated Amyloid β-Peptide (Aβ) C-Terminal Fragments Reduce Aβ Toxicity in Vitro and inDrosophila melanogaster

(2009) Partha Pratim Bose et al.   JOURNAL OF MEDICINAL CHEMISTRY

Restored degradation of the Alzheimer’s amyloid-β peptide by targeting amyloid formation

(2009) Peter J. Crouch et al.   JOURNAL OF NEUROCHEMISTRY

The amyloid hypothesis for Alzheimer’s disease: a critical reappraisal

(2009) John Hardy   JOURNAL OF NEUROCHEMISTRY

Amyloid Deposition and Influx Transporter Expression at the Blood-Brain Barrier Increase in Normal Aging

(2009) Gerald D. Silverberg et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

 -Amyloid Monomers Are Neuroprotective

(2009) M. L. Giuffrida et al.   JOURNAL OF NEUROSCIENCE

Matrix Metalloprotease-9 Inhibition Improves Amyloid  -Mediated Cognitive Impairment and Neurotoxicity in Mice

(2009) H. Mizoguchi et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Bioimaging of metals in brain tissue by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) and metallomics

(2009) J. Sabine Becker et al.   Metallomics

Nanoparticle–chelator conjugates as inhibitors of amyloid-β aggregation and neurotoxicity: A novel therapeutic approach for Alzheimer disease

(2009) Gang Liu et al.   NEUROSCIENCE LETTERS

Small-Molecule Activators of Insulin-Degrading Enzyme Discovered through High-Throughput Compound Screening

(2009) Christelle Cabrol et al.   PLoS One

Increasing Cu bioavailability inhibits A  oligomers and tau phosphorylation

(2009) P. J. Crouch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small-Molecule Fluorescent Sensors for Investigating Zinc Metalloneurochemistry

(2008) Elizabeth M. Nolan et al.   ACCOUNTS OF CHEMICAL RESEARCH

Influence of Multiple Metal Ions on β-Amyloid Aggregation and Dissociation on a Solid Surface†

(2008) Jungki Ryu et al.   BIOCHEMISTRY

How the binding and degrading capabilities of insulin degrading enzyme are affected by ubiquitin

(2008) Giuseppe Grasso et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

SYMPOSIUM: Clearance of Aβ from the Brain in Alzheimer's Disease: Aβ-Degrading Enzymes in Alzheimer's Disease

(2008) James Scott Miners et al.   BRAIN PATHOLOGY

Evoking plasmin for β-amyloid clearance

(2008) Jian Zhao et al.   CELL RESEARCH

Amyloid β-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin

(2008) E. Malito et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

From Presenilinase to γ-Secretase, Cleave to Capacitate

(2008) Weiming Xia   Current Alzheimer Research

Amyloid-Degrading Enzymes as Therapeutic Targets in Alzheimers Disease

(2008) Natalia Nalivaeva et al.   Current Alzheimer Research

Neprilysin and Amyloid Beta Peptide Degradation

(2008) Louis Hersh et al.   Current Alzheimer Research

Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-β peptide

(2008) Peter Faller et al.   DALTON TRANSACTIONS

Enzyme solid-state support assays: a surface plasmon resonance and mass spectrometry coupled study of immobilized insulin degrading enzyme

(2008) Giuseppe Grasso et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

The Metal Loading Ability of β-Amyloid N-Terminus: A Combined Potentiometric and Spectroscopic Study of Copper(II) Complexes with β-Amyloid(1−16), Its Short or Mutated Peptide Fragments, and Its Polyethylene Glycol (PEG)-ylated Analogue

(2008) Chiara A. Damante et al.   INORGANIC CHEMISTRY

Activation of epidermal growth factor receptor by metal-ligand complexes decreases levels of extracellular amyloid beta peptide

(2008) Katherine A. Price et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Reassessing the amyloid cascade hypothesis of Alzheimer's disease

(2008) Sanjay W. Pimplikar   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The AβCs of Aβ-cleaving Proteases

(2008) Malcolm A. Leissring   JOURNAL OF BIOLOGICAL CHEMISTRY

The Anti-neurodegeneration Drug Clioquinol Inhibits the Aging-associated Protein CLK-1

(2008) Ying Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mono- (Ag, Hg) and di- (Cu, Hg) valent metal ions effects on the activity of jack bean urease. Probing the modes of metal binding to the enzyme

(2008) Barbara Krajewska   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Somatostatin: A Novel Substrate and a Modulator of Insulin-Degrading Enzyme Activity

(2008) Chiara Ciaccio et al.   JOURNAL OF MOLECULAR BIOLOGY

Peripherally expressed neprilysin reduces brain amyloid burden: A novel approach for treating Alzheimer's disease

(2008) Hanjun Guan et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Therapeutics for Alzheimer’s disease based on the metal hypothesis

(2008) Ashley I. Bush et al.   Neurotherapeutics

Amyloid-  overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

(2008) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clioquinol inhibits peroxide-mediated toxicity through up-regulation of phosphoinositol-3-kinase and inhibition of p53 activity

(2007) Gulay Filiz et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Zinc and copper modulate Alzheimer Aβ levels in human cerebrospinal fluid

(2007) Dorothea Strozyk et al.   NEUROBIOLOGY OF AGING