Article
Nutrition & Dietetics
Shaden Melhem, Sarah Steven, Roy Taylor, Ahmad Al-Mrabeh
Summary: Weight loss can significantly reduce cardiovascular risk, especially when accompanied by remission of diabetes. Changes in Leptin, adiponectin, GDF-15, and FGF-21 are related to weight loss rather than remission of diabetes. Normalization of 10-year cardiovascular risk and heart age is achievable after substantial dietary weight loss and remission of T2DM.
Review
Food Science & Technology
Marko Viskic, Luna Maslov Bandic, Ana-Marija Jagatic Korenika, Ana Jeromel
Summary: NMR is a fast and reproducible technique for analyzing the components and origin of wine, tracing the geographical origin and detecting chaptalization. However, the current sample preparation process is still time-consuming and expensive, requiring further improvements.
Article
Biochemistry & Molecular Biology
Katarina Simic, Nina Todorovic, Snezana Trifunovic, Zoran Miladinovic, Aleksandra Gavrilovic, Silvana Jovanovic, Natasa Avramovic, Dejan Godevac, Ljubodrag Vujisic, Vele Tesevic, Ljubica Tasic, Boris Mandic
Summary: Schizophrenia is a common mental disorder that significantly impairs patients' functioning and leads to premature death. There are gaps in the understanding and diagnosis of this disease, but personalized and precise approaches are needed for patients through customized medical treatment and reliable monitoring of treatment response. Metabolomic investigations of serum samples of Serbian patients with schizophrenia led to the identification of 26 metabolites/biomarkers for this disorder. These findings provide a good starting point for the establishment of a universal set of biomarkers for schizophrenia, including metabolites that are common among different ethnic and geographic origins.
Article
Biochemistry & Molecular Biology
R. Conde, R. Laires, L. G. Goncalves, A. Rizvi, C. Barroso, M. Villar, R. Macedo, M. J. Simoes, S. Gaddam, P. Lamosa, L. Puchades-Carrasco, A. Pineda-Lucena, A. B. Patel, S. C. Mande, S. Banerjee, M. Matzapetakis, A. Coelho
Summary: This study utilized Nuclear Magnetic Resonance based metabolomics to discover a signature of biomarkers for tuberculosis diagnosis. Six metabolites associated with TB infection were validated, in line with the recommendations of the World Health Organization.
BIOMEDICAL JOURNAL
(2022)
Article
Nutrition & Dietetics
Massimo Cirillo, Giancarlo Bilancio, Carmine Secondulfo, Gennaro Iesce, Carmela Ferrara, Oscar Terradura-Vagnarelli, Martino Laurenzi
Summary: The effects of alcohol intake on kidney function are still debated. This population-based study examined the association between alcohol intake and kidney function and mortality. The findings suggest a positive independent association between alcohol intake and kidney function, with moderate alcohol consumption associated with lower mortality rates.
Article
Chemistry, Applied
Gavin Duley, Laurence Dujourdy, Susanne Klein, Anna Werwein, Christina Spartz, Regis D. Gougeon, Dennis K. Taylor
Summary: Wine quality and character are influenced by terroir, with metabolomic techniques like NMR and ICP-MS being useful for characterization and fraud detection. The study found that ICP-MS data is most useful for determining the regionality of wines from different terroirs.
Article
Biochemistry & Molecular Biology
Antoinette O'Connor, Thomas K. Karikari, Teresa Poole, Nicholas J. Ashton, Juan Lantero Rodriguez, Ayesha Khatun, Imogen Swift, Amanda J. Heslegrave, Emily Abel, Elisha Chung, Philip S. J. Weston, Ivanna M. Pavisic, Natalie S. Ryan, Suzie Barker, Martin N. Rossor, James M. Polke, Chris Frost, Simon Mead, Kaj Blennow, Henrik Zetterberg, Nick C. Fox
Summary: Blood biomarker p-tau181 shows increased concentration in symptomatic and presymptomatic carriers of familial AD, with individual values able to differentiate carriers from non-carriers of the same age and sex. A fitted model suggests that p-tau181 concentrations were higher in mutation carriers than non-carriers from 16 years prior to estimated symptom onset.
MOLECULAR PSYCHIATRY
(2021)
Article
Chemistry, Applied
Anna Mascellani, Gokce Hoca, Marek Babisz, Pavel Krska, Pavel Kloucek, Jaroslav Havlik
Summary: Nuclear magnetic resonance spectroscopy was used to analyze a set of 917 Czech wines, resulting in the development of statistical models and machine learning methods with over 93% accuracy for wine classification based on color and residual sugar content. The study found Random Forest model to classify wine varieties with high correctness rates, supporting the use of chemometrics for predicting important features in wine.
Article
Medicine, General & Internal
Zhenqiu Liu, Ci Song, Chen Suo, Hong Fan, Tiejun Zhang, Li Jin, Xingdong Chen
Summary: This study found that low-to-moderate drinking may be inversely associated with the risk of hepatocellular carcinoma (HCC) in low-risk populations, largely driven by wine drinking. However, in high-risk populations of HCC, such as men and older people, abstaining from drinking alcohol is recommended.
Article
Geriatrics & Gerontology
Pankaja Desai, Kristin R. Krueger, Carlos Mendes de Leon, Robert S. Wilson, Denis A. Evans, Kumar B. Rajan
Summary: This study investigates the impact of depressive symptoms and glial fibrillary acid protein (GFAP) concentrations on cognitive functioning. The results show that depressive symptoms and high GFAP concentrations contribute to cognitive decline, while depressive symptoms and low GFAP concentrations have a smaller effect.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Joao P. P. Vieira, Filip Ottosson, Amra Jujic, Vladimir Denisov, Martin Magnusson, Olle Melander, Joao M. N. Duarte
Summary: Combining LC-MS and NMR techniques improves the discrimination of metabolic disease development, including those induced by a high-fat diet. The study confirms that metabolic pathways in mice affected by high-fat diet also impact diabetes in humans.
Article
Biochemistry & Molecular Biology
Alexandros Tzachristas, Marilena E. Dasenaki, Reza Aalizadeh, Nikolaos S. Thomaidis, Charalampos Proestos
Summary: Wine metabolomics is a powerful discipline for assessing wine authenticity by exploring multiple classes of compounds in the wine matrix simultaneously. This study developed a targeted metabolomics methodology to discriminate between two Greek grape varieties and identified a total of 86 compounds using a suspect screening workflow. Chemometric techniques were used to build an accurate and robust model for variety discrimination.
Article
Clinical Neurology
Jun Xiao, Liangwan Chen, Olle Melander, Marju Orho-Melander, Jan Nilsson, Yan Borne, Gunnar Engstrom
Summary: VIM is positively associated with the incidence of stroke, especially in individuals with carotid plaque, indicating a potentially stronger risk for stroke in this population. Further studies are needed to confirm and understand the observed associations.
Article
Medical Laboratory Technology
Rasmus Bo Hasselbalch, Bashir Alaour, Jonas Henrik Kristensen, Liam S. Couch, Thomas E. Kaier, Ture Lange Nielsen, Louis Lind Plesner, Nina Strandkjaer, Morten Schou, Casper Rydahl, Jens P. Goetze, Henning Bundgaard, Michael Marber, Kasper Karmark Iversen
Summary: This study compared the concentration and prognostic ability of high sensitivity cardiac troponin T (hs-cTnT) and I (hs-cTnI) and cardiac myosin-binding protein C (cMyC) among stable hemodialysis patients. The results showed that hs-cTnT concentration was above the 99th percentile in almost all patients, while cMyC and hs-cTnI had lower proportions. High concentrations of hs-cTnT and hs-cTnI were associated with increased mortality risk, but cMyC concentration was not. These findings are important for the management of hemodialysis patients.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Clinical Neurology
Anelia Dietmann, Elena Wenz, Julia van Der Meer, Maya Ringli, Jan D. Warncke, Ellen Edwards, Markus H. Schmidt, Corrado A. Bernasconi, Arto Nirkko, Mathias Strub, Silvia Miano, Mauro Manconi, Jens Acker, Sigrid von Manitius, Christian R. Baumann, Philip O. Valko, Bahtiyar Yilmaz, Andreas-David Brunner, Athina Tzovara, Zhongxing Zhang, Carlo R. Largiader, Mehdi Tafti, Daniela Latorre, Federica Sallusto, Ramin Khatami, Claudio L. A. Bassetti
Summary: The SPHYNCS study aims to investigate the clinical presentation, pathophysiology, and long-term course of Narcolepsy type 1 (NT1) and the narcoleptic borderland (NBL) disorders, in order to validate new and reevaluate established markers for the characterization of NBL and facilitate the diagnostic process. The study involves multiple Swiss sleep centers and will prospectively enroll over 500 patients with excessive daytime sleepiness, hypersomnia, or suspected disorders of hypersomnolence, with the goal of improving understanding, diagnosis, and management of these conditions.
JOURNAL OF SLEEP RESEARCH
(2021)
Article
Clinical Neurology
Andrea Du Preez, Sophie Lefevre-Arbogast, Vikki Houghton, Chiara de Lucia, Dorrain Y. Low, Catherine Helmer, Catherine Feart, Cecile Delcourt, Cecile Proust-Lima, Merce Pallas, Silvie R. Ruigrok, Barbara Altendorfer, Raul Gonzalez-Dominguez, Alex Sanchez-Pla, Mireia Urpi-Sarda, Cristina Andres-Lacueva, Ludwig Aigner, Paul J. Lucassen, Aniko Korosi, Claudine Manach, Cecilia Samieri, Sandrine Thuret
Summary: Diet and exercise can influence neurogenesis prior to the onset of cognitive decline and dementia, with changes in hippocampal neurogenesis potentially serving as biomarkers for future risk of CD and dementia. Apoptosis plays a key role in mediating the effects of diet and exercise on cognitive decline.
ALZHEIMERS & DEMENTIA
(2022)
Article
Geriatrics & Gerontology
Lucia Camacho-Barcia, Jesus Garcia-Gavilan, Miguel angel Martinez-Gonzalez, Fernando Fernandez-Aranda, Serena Galie, Dolores Corella, Aida Cuenca-Royo, Dora Romaguera, Jesus Vioque, angel M. Alonso-Gomez, Julia Warnberg, J. Alfredo Martinez, Luis Serra-Majem, Ramon Estruch, M. Rosa Bernal-Lopez, Jose Lapetra, Xavier Pinto, Josep A. Tur, Antonio Garcia-Rios, Aurora Bueno-Cavanillas, Miguel Delgado-Rodriguez, Pilar Matia-Martin, Lidia Daimiel, Vicente Martin-Sanchez, Josep Vidal, Clotilde Vazquez, Emilio Ros, Miguel Ruiz Canela, Jose Sorli, Rafael De La Torre, Jadwiga Konieczna, Alejandro Oncina-Canovas, Lucas Tojal-Sierra, Jessica Perez-Lopez, Itziar Abete, Almudena Sanchez-Villegas, Rosa Casas, Araceli Munoz-Garach, Jose Manuel Santos-Lozano, Cristina Bouzas, Cristina Razquin, Raul Martinez-Lacruz, Olga Castaner, Aina M. Yanez, Rafael Valls-Enguix, Maria Concepcion Bello-Mora, Javier Basterra-Gortari, Josep Basora, Jordi Salas-Salvado, Monica Bullo
Summary: The study aimed to assess the association between dietary vitamin K intake changes and cognitive function. The results showed that an increase in dietary vitamin K intake was associated with better cognitive function scores.
Article
Nutrition & Dietetics
Giorgio Gargari, Valentina Taverniti, Cristian Del Bo', Stefano Bernardi, Nicole Hidalgo-Liberona, Tomas Merono, Cristina Andres-Lacueva, Paul A. Kroon, Antonio Cherubini, Patrizia Riso, Simone Guglielmetti
Summary: This study demonstrates that older subjects with higher bacterial DNAemia can benefit from a polyphenol-rich diet. Bacterial DNAemia may be a useful marker for identifying populations that could benefit more from a protective dietary intervention.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Nutrition & Dietetics
Jesus F. Garcia-Gavilan, Indira Paz-Graniel, Nancy Babio, Dora Romaguera, Jose Alfredo Martinez, Vicente Martin, Maria Angeles Martinez, Jadwiga Konieczna, Miguel Ruiz-Canela, Jose Antonio de Paz Fernandez, Albert Goday, Miguel Angel Martinez-Gonzalez, Monica Bullo, Jordi Salas-Salvado
Summary: This study found that a high pro-inflammatory diet, as measured by the M-DIS, is associated with lower bone mineral density in a senior Mediterranean population with metabolic syndrome.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Nutrition & Dietetics
Jananee Muralidharan, Christopher Papandreou, Maria T. Soria-Florido, Aleix Sala-Vila, Gemma Blanchart, Ramon Estruch, Miguel A. Martinez-Gonzalez, Dolores Corella, Emilio Ros, Miguel Ruiz-Canela, Montse Fito, Jordi Salas-Salvado, Monica Bullo
Summary: The study found interrelations between indicators of inflammation and both blood cell membrane fatty acid composition and HDL structure/functional parameters in a Mediterranean population at high CVD risk.
JOURNAL OF NUTRITION
(2022)
Article
Neurosciences
Oriol Busquets, Marina Carrasco, Triana Espinosa-Jimenez, Miren Ettcheto, Ester Verdaguer, Carme Auladell, Monica Bullo, Antoni Camins, Montserrat Pinent, Esther Rodriguez-Gallego, Jaume Folch
Summary: The study aimed to evaluate the protective effects of short-term GSPE pre-treatment in the hippocampus of rats against prolonged feeding with cafeteria diet. Results showed that GSPE was able to protect against cellular damage through AKT activation and promote mitochondrial function maintenance. Additionally, GSPE decreased inflammatory activation and reduced reactivity of astrocytes.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Oriol Busquets, Triana Espinosa-Jimenez, Miren Ettcheto, Jordi Olloquequi, Monica Bullo, Eva Carro, Jose Luis Cantero, Gemma Casadesus, Jaume Folch, Ester Verdaguer, Carme Auladell, Antoni Camins
Summary: This study induced chronic metabolic stress by feeding a high-fat diet and studied the effects of JNK1 and JNK3 loss of function on cognition. The results showed that JNK3 loss led to increased body weight and decreased cognitive capacity, while JNK1 loss promoted normal or heightened energetic metabolism and preserved cognitive function.
MOLECULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Alessandro Atzeni, Thomaz F. S. Bastiaanssen, John F. Cryan, Francisco J. Tinahones, Jesus Vioque, Dolores Corella, Montserrat Fito, Josep Vidal, Isabel Moreno-Indias, Ana M. Gomez-Perez, Laura Torres-Collado, Oscar Coltell, Olga Castaner, Monica Bullo, Jordi Salas-Salvado
Summary: This study identified specific taxonomic and functional fecal microbiota signatures associated with insulin resistance in a non-diabetic population with overweight/obesity at high cardiovascular risk. The findings suggest that tailoring therapies based on specific fecal microbiota profiles could be a potential strategy to improve insulin sensitivity.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Daniel Canueto, Reza M. Salek, Monica Bullo, Xavier Correig, Nicolau Canellas
Summary: The quality of automatic metabolite profiling in NMR datasets from complex matrices can be affected by various sources of variability and low-intensity signals. This study demonstrates that by optimizing the analysis and modeling of signal parameters, better profiling quality indicators can be obtained, maximizing the performance of automatic profiling.
Review
Nutrition & Dietetics
Raul Sanchez-Gimenez, Wahiba Ahmed-Khodja, Yesica Molina, Oscar M. Peiro, Gil Bonet, Anna Carrasquer, George A. Fragkiadakis, Monica Bullo, Alfredo Bardaji, Christopher Papandreou
Summary: Gut microbiota-derived metabolites, including trimethylamine N-oxide, bile acids, and branched-chain amino acids, are associated with adverse cardiovascular events and cardiovascular disease.
Article
Psychiatry
Theresa Wimberley, Henriette T. Horsdal, Isabell Brikell, Thomas M. Laursen, Aske Astrup, Giuseppe Fanelli, Janita Bralten, Geert Poelmans, Veerle Van Gils, Willemijn J. Jansen, Stephanie J. B. Vos, Valerie Bertaina-Anglade, Lucia Camacho-Barcia, Bernat Mora-Maltas, Fernando Fernandez-Aranda, Monica B. Bonet, Jordi Salas-Salvado, Barbara Franke, Soren Dalsgaard
Summary: This study found associations between type 2 diabetes mellitus (T2DM) and various neurodegenerative and psychiatric disorders, suggesting shared etiology and biological mechanisms.
Article
Nutrition & Dietetics
Nil Novau-Ferre, Melina Rojas, Laia Gutierrez-Tordera, Pierre Arcelin, Jaume Folch, Christopher Papandreou, Monica Bullo
Summary: This study found associations between lipoprotein subfractions and telomere length, TERT, and WRAP53 expression. Medium and small-sized HDL particles were negatively associated with telomere length, TERT, and WRAP53 expression, while large HDL particles were only negatively associated with WRAP53 expression. These results suggest the importance of considering lipoprotein profiles in assessing the risk of chronic diseases.
Article
Biochemistry & Molecular Biology
Triana Espinosa-Jimenez, Amanda Cano, Elena Sanchez-Lopez, Jordi Olloquequi, Jaume Folch, Monica Bullo, Ester Verdaguer, Carme Auladell, Caterina Pont, Diego Munoz-Torrero, Antoni Parcerisas, Antoni Camins, Miren Ettcheto
Summary: This study evaluated the effects of a synthesized inhibitor called RHE-HUP on APP/PS1 mice, a familial AD mouse model challenged by high-fat diet to simulate a T2DM-like condition. Results showed that RHE-HUP reduced the main hallmarks of AD, including Tau hyperphosphorylation, A beta(42) peptide levels, and plaque formation. Additionally, it decreased inflammation, increased synaptic proteins and neurotrophic factors, leading to memory improvement. Importantly, these improvements were observed at a central level without peripheral modifications induced by HFD consumption.
CELL AND BIOSCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Raul Sanchez-Gimenez, Oscar M. Peiro, Gil Bonet, Anna Carrasquer, George A. Fragkiadakis, Monica Bullo, Christopher Papandreou, Alfredo Bardaji
Summary: This study aimed to examine the relationship between tricarboxylic acid (TCA) cycle metabolites and the risk of cardiovascular events and mortality after acute coronary syndrome (ACS), and to evaluate the mediating role of renal function in these associations. The results showed positive associations between certain metabolites and the risk of major adverse cardiovascular events (MACE) and all-cause mortality. However, these associations became non-significant after adjusting for estimated glomerular filtration rate (eGFR), indicating the strong mediating effect of eGFR.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
