Article
Environmental Sciences
Deborah J. Watkins, John D. Meeker, Marcela Tamayo-Ortiz, Brisa N. Sanchez, Lourdes Schnaas, Karen E. Peterson, Martha Maria Tellez-Rojo
Summary: Research suggests that in utero phthalate exposure may have adverse effects on attention, particularly in adolescence. Future research is needed to investigate the long-term effects of in utero phthalate exposure on attention and ADHD in adolescence, as well as to identify potential mechanisms involved.
ENVIRONMENTAL RESEARCH
(2021)
Article
Environmental Sciences
Magda Bosch de Basea, Anne-Elie Carsin, Alicia Abellan, Ines Cobo, Aitana Lertxundi, Natalia Marin, Raquel Soler -Blasco, Jesus Ibarluzea, Martine Vrijheid, Jordi Sunyer, Maribel Casas, Judith Garcia-Aymerich
Summary: This study aimed to investigate the potential impact of gestational exposure to phthalates on lung function levels in children. The findings revealed that the gestational levels of phthalate metabolites were associated with lower forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) in children, particularly in early childhood. Significant associations were observed for MEP, MiBP, MBzP, and MnBP.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Hui Gao, Bei-bei Zhu, Kun Huang, Yuan-duo Zhu, Shuang-qin Yan, Xiao-yan Wu, Yan Han, Jie Sheng, Hui Cao, Peng Zhu, Fang-biao Tao
Summary: Exposure to phthalates during the first trimester of pregnancy is associated with increased risks of maternal metabolic syndrome components, with conflicting findings between phthalates and their metabolites needing careful interpretation.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Jian Zhang, Catherine Powell, Sunitha Meruvu, Ravi Sonkar, Mahua Choudhury
Summary: The study demonstrated that PQQ can attenuate metabolic aberrations induced by obesogens and high fat diet, especially in the presence of BBP. However, the effects of PQQ were more pronounced in male mice compared to female mice.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Environmental Sciences
Xiaoyue Zhang, Dana Boyd Barr, Anne L. Dunlop, Parinya Panuwet, Jeremy A. Sarnat, Grace E. Lee, Youran Tan, Elizabeth J. Corwin, Dean P. Jones, P. Barry Ryan, Donghai Liang
Summary: This study investigated the association between urinary phthalate levels and perturbations in biological pathways related to inflammation, oxidative stress, and endocrine disruption in pregnant women. The findings provide support for future targeted investigations into the molecular mechanisms underlying the adverse health outcomes associated with maternal phthalate exposure.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Environmental Sciences
Qi Zhong, Hui-li Liu, Hong Fu, Qin-shan Niu, Hua-bing Wu, Fen Huang
Summary: The evidence on the relationship between prenatal phthalates exposure and preterm birth is uncertain, with most associations not being statistically significant. Heterogeneity was mainly found in studies conducted in China and matrix collected at the first trimester of pregnancy. A multicenter cohort study with a consistent approach is recommended to unravel the complex associations of prenatal phthalates exposure with birth outcomes.
Article
Environmental Sciences
Seonyoung Park, Emily Zimmerman, Gredia Huerta-Montanez, Zaira Rosario-Pabon, Carmen M. Velez-Vega, Jose F. Cordero, Akram Alshwabekah, John D. Meeker, Deborah J. Watkins
Summary: Phthalates and phthalate replacements have been found to be associated with neurodevelopmental delays in children, with sex-specific differences. The study analyzed data from a birth cohort in Puerto Rico and found that mono-3-carboxypropyl phthalate (MCPP) was significantly associated with developmental delay across all domains. Additionally, di-2-ethylhexyl terephthalate (DEHTP), a recent phthalate replacement, showed differential associations with the adaptive and cognitive domains in boys compared to girls at 6 months of age.
Review
Environmental Sciences
Amol Hirke, Bincy Varghese, Shruti Varade, Ramu Adela
Summary: Prenatal exposure to certain endocrine-disrupting chemicals, such as perfluorooctanoic acid (PFOA), perfluoro octane sulfonic acid (PFOS), perfluononanoic acid (PFNA), and mono-ethyl phthalate (MEP), is associated with an increased risk of gestational hypertension (GH) and preeclampsia (PE). However, exposure to bisphenol A during pregnancy does not show a significant association with the risk of PE. More research is needed to confirm these findings, as the evidence for most of these associations is limited.
ENVIRONMENTAL POLLUTION
(2023)
Article
Biochemical Research Methods
Manuela Grimaldi, Carmen Marino, Michela Buonocore, Angelo Santoro, Eduardo Sommella, Fabrizio Merciai, Emanuela Salviati, Arianna De Rosa, Tommaso Nuzzo, Francesco Errico, Pietro Campiglia, Alessandro Usiello, Anna Maria D'Ursi
Summary: Originally believed to be present only in bacteria and invertebrates, D-amino acids have also been found in mammalian tissues. Depletion of D-Asp in the brain has been shown to influence amino acid pathways and metabolites related to brain development and function.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Environmental Sciences
Delnia Ahmadpour, Sakina Mhaouty-Kodja, Valerie Grange-Messent
Summary: Exposure to low doses of DEHP or an environmental phthalate mixture was found to increase BBB permeability, affect glial activation and neuroinflammation in specific brain regions. This suggests that exposure to endocrine disruptors like phthalates may pose a risk to cerebrovascular function.
Article
Pharmacology & Pharmacy
Chongyang Huang, Hehua Lei, Chaoyang Liu, Yulan Wang
Summary: In this study, the metabolic effects of Cyadox were evaluated using comprehensive methods. The results showed dose-dependent alterations in the metabolism of urine, kidney, plasma, and liver. Gene expressions in the liver were also affected by high dose Cyadox treatment, with differentially expressed genes involved in xenobiotic metabolism, lipid metabolism, energy metabolism, nucleic acid metabolism, inflammatory response, and oxidative stress.
Article
Biochemistry & Molecular Biology
Yu Hasegawa, Zhichao Zhang, Ameer Y. Taha, John P. Capitanio, Melissa D. Bauman, Mari S. Golub, Judy Van de Water, Catherine A. VandeVoort, Cheryl K. Walker, Carolyn M. Slupsky
Summary: Maternal gestational obesity affects the metabolism of both mothers and offspring, leading to larger birth size, altered behaviors, and emotional responses. These changes are correlated with phosphorylation of enzymes in brain signaling pathways and the concentration of maternal plasma betaine.
Article
Environmental Sciences
Andrea L. Deierlein, Haotian Wu, Allan C. Just, Allison J. Kupsco, Joseph M. Braun, Emily Oken, Diana C. Soria-Contreras, Alejandra Cantoral, Ma Luisa Pizano, Nia McRae, Martha M. Tellez-Rojo, Robert O. Wright, Andrea A. Baccarelli
Summary: The study found that prenatal exposure to phthalates was negatively associated with gestational weight gain and positively associated with long-term changes in maternal weight. Further investigation is needed to understand how phthalates influence body composition and whether they contribute to the development of obesity and other cardiometabolic diseases in women.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Laura Sienas, Catherine Albright, Yu Ni, Adam Szpiro, Nicole R. Bush, Christine Loftus, Kurunthachalam Kannan, Frances Tylavsky, Catherine J. Karr, Kaja Z. LeWinn, Sheela Sathyanarayana
Summary: This study examined the association between prenatal phthalate exposure and late preterm birth (LPTB), and found that phthalates may be associated with an increased risk of spontaneous LPTB.
Article
Environmental Sciences
P. A. Bommarito, B. M. Welch, A. P. Keil, G. P. Baker, D. E. Cantonwine, T. F. McElrath, K. K. Ferguson
Summary: While fetal growth is regulated, it is sensitive to environmental exposures during pregnancy. In this study, joint exposure to organophosphate esters (OPEs) and phthalates was associated with lower odds of delivering large-for-gestational-age (LGA) babies. Associations with LGA may indicate specific impacts of these exposures on the higher end of the birth weight spectrum. Further research is needed to understand the nuances in associations between consumer product chemical mixtures and fetal growth.
ENVIRONMENTAL HEALTH
(2021)
Article
Pharmacology & Pharmacy
Suramya Waidyanatha, Sherry R. Black, Chad R. Blystone, Purvi R. Patel, Scott L. Watso, Rodney W. Snyder, Timothy R. Fennell
Article
Toxicology
Suramya Waidyanatha, Sherry R. Black, Purvi R. Patel, Cynthia V. Rider, Scott L. Watson, Rodney W. Snyder, Timothy R. Fennell
TOXICOLOGY LETTERS
(2020)
Article
Pharmacology & Pharmacy
Suramya Waidyanatha, Sherry R. Black, Purvi R. Patel, Scott L. Watson, Rodney W. Snyder, Vicki Sutherland, Jason Stanko, Timothy R. Fennell
Review
Microbiology
Reza Ghanbari, Ali Teimoori, Anahita Sadeghi, Ashraf Mohamadkhani, Sama Rezasoltani, Ebrahim Asadi, Abolghasem Jouyban, Susan C. J. Sumner
FUTURE MICROBIOLOGY
(2020)
Article
Toxicology
Ninell P. Mortensen, Maria Moreno Caffaro, Purvi R. Patel, Rodney W. Snyder, Scott L. Watson, Shyam Aravamudhan, Stephanie A. Montgomery, Timothy Lefever, Susan J. Sumner, Timothy R. Fennell
Summary: This study found that orally administered Al2O3 NP interfered with brain biochemistry in juvenile rats, leading to changes in neurotransmitter/metabolite concentrations.
JOURNAL OF APPLIED TOXICOLOGY
(2021)
Article
Chemistry, Medicinal
Sanju Narayanan, Shaobin Wang, Vineetha Vasukuttan, Ravi Kumar Vyas Devambatla, Donghua Dai, Chunyang Jin, Rodney Snyder, Lucas Laudermilk, Scott P. Runyon, Rangan Maitra
Summary: A small-molecule agonist of the apelin receptor has been identified for in vivo investigation in a mouse model of diet-induced obesity (DIO) and metabolic syndrome, showing efficacy in improving multiple symptoms such as weight loss, reduced food intake, improved glucose utilization, and decreased liver steatosis.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Genetics & Heredity
Shuang Li, Yuanyuan Li, Blake R. Rushing, Sarah E. Harris, Susan L. McRitchie, Janice C. Jones, Daniel Dominguez, Susan J. Sumner, Henrik G. Dohlman
Summary: The study investigates the distinct roles of G protein subunits in transmitting glucose signals. Gpa2 primarily regulates carbohydrate metabolism, while Asc1 is involved in amino acid metabolism, with both contributing to purine metabolism. The integrated approach used in this study sheds light on complex G protein and metabolic signaling networks.
Article
Chemistry, Multidisciplinary
Ninell P. Mortensen, Maria Moreno Caffaro, Shyam Aravamudhan, Lakshmi Beeravalli, Sharmista Prattipati, Rodney W. Snyder, Scott L. Watson, Purvi R. Patel, Frank X. Weber, Stephanie A. Montgomery, Susan J. Sumner, Timothy R. Fennell
Summary: Oral exposure to nanoparticles during early life may lead to intestinal uptake and an increase in immune cells, potentially causing irritation or low-grade inflammation. The long-term impact of increased immune cells in the intestinal tract during early life is unknown.
Article
Toxicology
Ninell P. Mortensen, Rodney W. Snyder, Wimal Pathmasiri, Maria Moreno Caffaro, Susan J. Sumner, Timothy R. Fennell
Summary: The study found that the size of multiwalled carbon nanotubes (MWCNTs) has a significant impact on their biodistribution and perturbation of endogenous metabolite profiles. While all MWCNTs were observed in the liver, different-sized MWCNTs showed variations in distribution in other tissues. The perturbation of endogenous metabolite profiles was more profound at Day 7, indicating a delayed biological response to MWCNTs.
JOURNAL OF APPLIED TOXICOLOGY
(2022)
Article
Orthopedics
B. R. Rushing, S. McRitchie, L. Arbeeva, A. E. Nelson, M. A. Azcarate-Peril, Y-Y Li, Y. Qian, W. Pathmasiri, S. C. J. Sumner, R. F. Loeser
Summary: This exploratory study aimed to investigate the links between gut microbial composition, gut metabolome, and individuals with obesity and osteoarthritis. The results indicated that adults with obesity and knee plus hand OA have distinct fecal metabolomes characterized by increased products of proteolysis and perturbations in leukotriene metabolism. Logistic regression models identified significant predictors of OA status related to gut microbiota and leaky gut syndrome when combined with rRNA-seq data.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Toxicology
Ninell P. Mortensen, Wimal Pathmasiri, Rodney W. Snyder, Maria Moreno Caffaro, Scott L. Watson, Purvi R. Patel, Lakshmi Beeravalli, Sharmista Prattipati, Shyam Aravamudhan, Susan J. Sumner, Timothy R. Fennell
Summary: This study investigates the effects of early life exposure to orally ingested TiO2 NP. The findings suggest that these nanoparticles can impact cardiac and neurobehavioral performance, neurotransmitters concentration in brain tissue, and the biochemical profiles of plasma. Furthermore, female pups are more likely to experience adverse outcomes compared to male pups.
PARTICLE AND FIBRE TOXICOLOGY
(2022)
Article
Chemistry, Medicinal
Allison Zarkin, Rajwana Jahan, Rajendra Uprety, Yanan Zhang, Charles McElhinny, Rodney Snyder, Elaine Gay, Gabriel Jewula, Heather Bool, Stewart D. Clark, Scott Runyon
Summary: Activation of the NPS receptor system has various physiological effects, while a newly discovered compound, 14b, demonstrates potent NPS receptor antagonist activity by effectively blocking NPS-induced locomotor activity in mice. This compound shows potential for further exploration of the pharmacological functions of the NPS receptor system.
Article
Chemistry, Medicinal
Thuy Nguyen, Ann M. M. Decker, Rodney W. W. Snyder, Emma C. C. Tonetti, Thomas F. F. Gamage, Yanan Zhang
Summary: This study reveals the important structural regions for NPBWR1 agonism and successfully develops stable and potent peptidomimetic agonists targeting NPBWR1.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Dehui Zhang, Ann M. Decker, Kristen Woodhouse, Rodney Snyder, Purvi Patel, Danni L. Harris, Yuan -Xiang Tao, Jun-Xu Li, Yanan Zhang
Summary: The blockade of LPA5 by isoquinolone derivatives showed promising potential as analgesics, with good in vitro potency, selectivity, metabolic stability, and brain permeability, indicating that these compounds could effectively attenuate nociceptive hypersensitivity.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Andrology
Emily Houle, YuanYuan Li, Madison Schroder, Susan L. McRitchie, Tayyab Rahil, Cynthia K. Sites, Susan Jenkins Sumner, J. Richard Pilsner
Summary: Infertility is defined as the inability to achieve pregnancy within 12 months of regular unprotected sexual intercourse and affects 15% of couples worldwide. This pilot study aimed to identify novel biomarkers in seminal plasma that can accurately predict male reproductive health and couples' reproductive success. Using untargeted metabolomics, the study found associations between the internal exposome of seminal plasma and semen quality, as well as live birth outcomes in participants undergoing assisted reproductive technology. These findings suggest that seminal plasma is a promising matrix to study the influence of internal exposome on reproductive health outcomes. Future research is needed to validate these findings with a larger sample size.
SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE
(2023)