Article
Food Science & Technology
Chunwei Li, Xiankang Fan, Yangying Sun, Changyu Zhou, Daodong Pan
Summary: Goose liver oil microcapsules prepared with konjac glucomannan and soybean protein isolate exhibited high encapsulation efficiency and improved thermal and oxidative stability compared to free goose liver oil. The microcapsules showed a smooth spherical surface morphology and homogeneous internal structure. They also demonstrated good gastric juice permeability and controlled release in the intestinal region.
Article
Plant Sciences
Elsinraju Devadasu, Rajagopal Subramanyam
Summary: Under iron-limiting conditions, the unicellular alga Chlamydomonas reinhardtii accumulates significant amounts of triacylglycerols (TAGs) that are mainly derived from chloroplast lipids. The iron stress triggers rapid accumulation of TAGs, potentially contributing to efficient production of algal biofuels.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Bo Wang, Boxuan Liang, Yuji Huang, Zhiming Li, Bingli Zhang, Jiaxin Du, Rongyi Ye, Hongyi Xian, Yanhong Deng, Jiancheng Xiu, Xingfen Yang, Sahoko Ichihara, Gaku Ichihara, Yizhou Zhong, Zhenlie Huang
Summary: Exposure to micro- and nanoplastics (MNPs) is common and recent studies have shown that they can exacerbate atherosclerosis. In this study, ApoE(-/-) mice were exposed to polystyrene nanoplastics (PS-NPs) and it was found that PS-NPs aggravate artery stiffness and promote atherosclerotic plaque formation. PS-NPs activate phagocytosis of M1-macrophage in the aorta, disrupt lipid metabolism, and increase long-chain acyl carnitines (LCACs). The accumulation of LCACs exacerbates PS-NP-induced atherosclerosis by upregulating MARCO.
Article
Optics
Haoyu Wei, Xin Liu, Xiang Hao, Edmund Y. Lam, Yifan Peng
Summary: We establish a universal least-sampling angular spectrum method for efficiently simulating off-axis diffraction with high accuracy. By converting off-axis diffraction to quasi-on-axis using the shifting property of Fourier transform and linking the angular spectrum to the transfer function, essential sampling requirements can be optimized and determined adaptively. Using a flexible matrix-based Fourier transform, we demonstrate significant speed improvement and the ability to compute ultra-large angles within seconds.
Article
Optics
Haoyu Wei, Xin Liu, Xiang Hao, Edmund Y. Lam, Yifan Peng
Summary: This article explores an efficient method for simulating off-axis diffraction and establishes a universal least-sampling angular spectrum method with high accuracy. By utilizing the shifting property of the Fourier transform to convert off-axis diffraction to quasi-on-axis and linking the angular spectrum to the transfer function, the necessary sampling requirements can be optimized and adaptively determined during computation. Using a flexible matrix-based Fourier transform, the off-axis point spread function of coded-aperture imaging systems is demonstrated, achieving a significant speed boost over the state of the art and enabling computation of ultra-large angles within seconds on a commercial computer. The applicability to high-frequency modulation is also investigated.
Article
Chemistry, Analytical
Huiwen Yu, Rasmus Bro, Neal B. Gallagher
Summary: In this paper, a new analysis method named PARASIAS is introduced for analyzing shifted higher-order tensor data by combining spectral transformation and the simple PARAFAC modeling. The proposed method has significant advantages in terms of model simplicity, convergence speed, robustness to shift changes in the data, the ability to impose non-negativity constraint on the shift mode, and the possibility of easily extending to data with multiple shift modes. However, the resolved profiles of the PARASIAS model are always slightly worse when the number of components in the data is larger than three and without using additional factors in the PARASIAS model. The reason for this is also discussed in this work.
ANALYTICA CHIMICA ACTA
(2023)
Article
Physics, Multidisciplinary
A. D. Corcoles, Maika Takita, Ken Inoue, Scott Lekuch, Zlatko K. Minev, Jerry M. Chow, Jay M. Gambetta
Summary: The research explored dynamic quantum circuits on superconducting-based quantum systems, involving the evolution of quantum state, periodic measurements, and concurrent processing of classical information. It demonstrated that the real-time quantum computing version can yield results comparable to classical asynchronous postprocessing methods.
PHYSICAL REVIEW LETTERS
(2021)
Article
Mathematics, Interdisciplinary Applications
Tieyu Zhao, Yingying Chi
Summary: This study investigates the discrete fractional Fourier transform and its extended definition, the multiweighted-type fractional Fourier transform, and proves its unitarity. By using basic functions for discussion, it is found that the effective weighting term of the M-WFRFT is only four terms, different from the M terms described in the definition. The analysis of program code reveals inaccuracies in previous works based on MATLAB for unitary verification.
FRACTAL AND FRACTIONAL
(2021)
Review
Pharmacology & Pharmacy
Jianglian She, Tanwei Gu, Xiaoyan Pang, Yonghong Liu, Lan Tang, Xuefeng Zhou
Summary: This review provides an overview of natural products that can influence LXRs and FXR, serving as a reference for future research on novel LXRs and FXR agonists and antagonists, and attracting more professional scholars for in-depth discussions.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Tianci Zhou, Aram W. Harrow
Summary: A global quantum quench can be simulated using a quantum circuit with local unitary gates. The growth rate of entanglement is determined by the entanglement velocity, which is bounded by the finite light cone resulting from locality. The study shows that the unitary interactions achieving the maximal rate must remain unitary when the space and time directions are exchanged, known as dual unitarity. The results also indicate that maximal entanglement velocity is always accompanied by a specific pattern of entanglement, making the analysis of solvable models simpler.
Article
Chemistry, Multidisciplinary
Nasser S. Al-Shakliah, Adnan A. Kadi, Haya Aljohar, Haitham AlRabiah, Mohamed W. Attwa
Summary: Zorifertinib is a novel oral small molecule drug used for the treatment of non-small cell lung cancer. It inhibits the Epidermal Growth Factor Receptor and has good blood-brain barrier permeability for patients with EGFR mutations. This study investigated the in vitro and in vivo metabolism of Zorifertinib, as well as its reactive metabolites. Several metabolic pathways were identified, and various metabolites were detected. These findings provide valuable insights into the metabolism of Zorifertinib and contribute to a better understanding of its clinical use.
Article
Pharmacology & Pharmacy
Ting Hu, Yuan Sun, Zhuoling An
Summary: This study investigated the dose- and time-dependent manner of liver injury induced by moxifloxacin using a targeted metabolomics method. The results showed that moxifloxacin caused transient hepatotoxicity, with the most severe liver injury occurring after 7 days of continuous administration. Serum concentrations of fatty acyl carnitines, fatty acids, and dehydroepiandrosterone changed dynamically with the severity of moxifloxacin-related liver injury, suggesting their potential as biomarkers for predicting hepatotoxicity.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Physical
Ritesh Verma, Ankush Chauhan, Khalid Mujasam Batoo, Muhammad Hadi, Emad H. Raslan, Rajesh Kumar, Muhammad Farzik Ijaz, Abdulaziz K. Assaifan
Summary: The synthesis of vanadium-doped BCZT ceramic oxides was reported in this paper, confirming the existence of a solubility limit of V in BCZT ceramics. Analysis revealed the influence of crystal structure and formation of oxygen vacancies on the luminescence and electrical properties of the material.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Engineering, Electrical & Electronic
Luan Portella, Diego F. G. Coelho, Fabio M. Bayer, Arjuna Madanayake, Renato J. Cintra
Summary: This article presents a variant of transform scaling method to obtain DFT approximations of large blocksize. The proposed method scales up a given transformation successively, leading to different sizes of transformations. The authors fully introduce a 32(4)-point DFT approximation and provide a fast algorithm, arithmetic complexity assessment, and error analysis.
IEEE SIGNAL PROCESSING LETTERS
(2022)
Article
Mathematics
Firdous A. A. Shah, Aajaz A. A. Teali, Mawardi Bahri
Summary: The article introduces the Clifford-valued shearlet transform for representing Clifford-valued signals and investigates its fundamental properties and uncertainty principles.
JOURNAL OF MATHEMATICS
(2022)
Article
Multidisciplinary Sciences
Liang Zheng, Simone Cardaci, Livnat Jerby, Elaine D. MacKenzie, Marco Sciacovelli, T. Isaac Johnson, Edoardo Gaude, Ayala King, Joshua D. G. Leach, RuAngelie Edrada-Ebel, Ann Hedley, Nicholas A. Morrice, Gabriela Kalna, Karen Blyth, Eytan Ruppin, Christian Frezza, Eyal Gottlieb
NATURE COMMUNICATIONS
(2015)
Article
Multidisciplinary Sciences
Jiska van der Reest, Sergio Lilla, Liang Zheng, Sara Zanivan, Eyal Gottlieb
NATURE COMMUNICATIONS
(2018)
Article
Clinical Neurology
Fred Fack, Heidi Espedal, Olivier Keunen, Anna Golebiewska, Nina Obad, Patrick N. Harter, Michel Mittelbronn, Oliver Baehr, Astrid Weyerbrock, Linda Stuhr, Hrvoje Miletic, Per O. Sakariassen, Daniel Stieber, Cecilie B. Rygh, Morten Lund-Johansen, Liang Zheng, Eyal Gottlieb, Simone P. Niclou, Rolf Bjerkvig
ACTA NEUROPATHOLOGICA
(2015)
Article
Biochemistry & Molecular Biology
Jaclyn S. Long, Diane Crighton, James O'Prey, Gillian MacKay, Liang Zheng, Timothy M. Palmer, Eyal Gottlieb, Kevin M. Ryan
Article
Multidisciplinary Sciences
Oliver D. K. Maddocks, Celia R. Berkers, Susan M. Mason, Liang Zheng, Karen Blyth, Eyal Gottlieb, Karen H. Vousden
Article
Multidisciplinary Sciences
Joanna Kaplon, Liang Zheng, Katrin Meissl, Barbara Chaneton, Vitaly A. Selivanov, Gillian Mackay, Sjoerd H. van der Burg, Elizabeth M. E. Verdegaal, Marta Cascante, Tomer Shlomi, Eyal Gottlieb, Daniel S. Peeper
Article
Multidisciplinary Sciences
Mathias T. Rosenfeldt, Jim O'Prey, Jennifer P. Morton, Colin Nixon, Gillian MacKay, Agata Mrowinska, Amy Au, Taranjit Singh Rai, Liang Zheng, Rachel Ridgway, Peter D. Adams, Kurt I. Anderson, Eyal Gottlieb, Owen J. Sansom, Kevin M. Ryan
Article
Multidisciplinary Sciences
G. M. Tannahill, A. M. Curtis, J. Adamik, E. M. Palsson-McDermott, A. F. McGettrick, G. Goel, C. Frezza, N. J. Bernard, B. Kelly, N. H. Foley, L. Zheng, A. Gardet, Z. Tong, S. S. Jany, S. C. Corr, M. Haneklaus, B. E. Caffrey, K. Pierce, S. Walmsley, F. C. Beasley, E. Cummins, V. Nizet, M. Whyte, C. T. Taylor, H. Lin, S. L. Masters, E. Gottlieb, V. P. Kelly, C. Clish, P. E. Auron, R. J. Xavier, L. A. J. O'Neill
Article
Biochemistry & Molecular Biology
Lijuan Du, Fan Yang, Houshun Fang, Huiying Sun, Yao Chen, Yan Xu, Hui Li, Liang Zheng, Bin-Bing S. Zhou
Article
Cell Biology
Ting Li, Lili Song, Yingwen Zhang, Yali Han, Zhiyan Zhan, Zhou Xv, Yang Li, Yuejia Tang, Yi Yang, Siqi Wang, Shanshan Li, Liang Zheng, Yanxin Li, Yijin Gao
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Article
Urology & Nephrology
Yunze Xu, Wen Kong, Ming Cao, Jieying Wang, Zaoyu Wang, Liang Zheng, Xiaoyu Wu, Rongrong Cheng, Wei He, Bo Yang, Baijun Dong, Jiahua Pan, Yonghui Chen, Jiwei Huang, Chen Jiang, Wei Zhai, Fangzhou Li, Ruohua Chen, Xiang Zhou, Guangyu Wu, Xiaochuan Geng, Jiasheng Chen, Huimin An, Yichu Yuan, Tianyuan Xu, Dongning Chen, Dengqiang Lin, Lieyu Xu, Kangbo Huang, Ling Peng, Yanfei Yu, Shengcheng Tai, Honggang Qi, Kai Luo, Xiaonan Kang, Hang Wang, Yiran Huang, Jin Zhang, Wei Xue
Summary: This retrospective multicenter analysis showed that immune checkpoint inhibitor plus tyrosine kinase inhibitor combination therapy had better treatment response than bevacizumab plus erlotinib combination therapy in patients with FH-deficient RCC, providing evidence for the treatment of this rare cancer.
Article
Multidisciplinary Sciences
Fangming Liu, Xiaochen Gai, Yuting Wu, Baohui Zhang, Xiaoyu Wu, Rongrong Cheng, Bufu Tang, Kezhuo Shang, Na Zhao, Weiwei Deng, Jie Chen, Zhengyi Zhang, Song Gu, Liang Zheng, Hongbing Zhang
Summary: This study reveals the oncogenic role of CTNNB1 gain-of-function mutations in liver cancer development and identifies the beta-catenin/AKT2/CAD signaling cascade as a potential therapeutic target for this type of liver cancer.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Medicine, Research & Experimental
Liang Zheng, Zi-Ran Zhu, Tal Sneh, Wei-Tuo Zhang, Zao-Yu Wang, Guang-Yu Wu, Wei He, Hong-Gang Qi, Hang Wang, Xiao-Yu Wu, Jonatan Fernandez-Garcia, Ifat Abramovich, Yun-Ze Xu, Jin Zhang, Eyal Gottlieb
Summary: Germline or somatic loss-of-function mutations of fumarate hydratase (FH) predispose patients to an aggressive form of renal cell carcinoma (RCC). Noninvasive plasma biomarkers, succinyl-adenosine and succinic-cysteine, were identified as excellent plasma biomarkers for early diagnosis of FH-deficient RCC. These biomarkers can also be used for monitoring treatment efficacy and identifying recurrent or metastatic tumors.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Cell Biology
Yi Yang, Lili Song, Xia Huang, Yanan Feng, Yingwen Zhang, Yanfeng Liu, Shanshan Li, Zhiyan Zhan, Liang Zheng, Haizhong Feng, Yanxin Li
Summary: The study reveals that the purine synthesis enzymes PRPS1/2 play critical roles in pluripotent stem cell stemness and survival. Knockout of PRPS1 leads to DNA damage and apoptosis in PSCs, while depletion of PRPS2 attenuates stemness and promotes differentiation in PSCs.
Article
Oncology
Liang Zheng, Elaine D. MacKenzie, Saadia A. Karim, Ann Hedley, Karen Blyth, Gabriela Kalna, David G. Watson, Peter Szlosarek, Christian Frezza, Eyal Gottlieb
CANCER & METABOLISM
(2013)