Article
Endocrinology & Metabolism
Yixuan He, Chirag M. Lakhani, Danielle Rasooly, Arjun K. Manrai, Ioanna Tzoulaki, Chirag J. Patel
Summary: The study established a polyexposure score (PXS) for type 2 diabetes and found that it provides modest incremental predictive value over traditional clinical risk factors. Adding PXS and polygenic risk score (PGS) improved T2D classification accuracy, indicating their potential usefulness in chronic disease risk prediction models.
Review
Endocrinology & Metabolism
Qing-Qing Tan, Xin-Yi Du, Chen-Lin Gao, Yong Xu
Summary: Individuals with higher Dietary Inflammatory Index (DII) scores have a higher risk of diabetes mellitus (DM), but further evidence from larger prospective studies in different countries is needed to clarify this association.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Farshad Teymoori, Hossein Farhadnejad, Ebrahim Mokhtari, Mohammad Hassan Sohouli, Nazanin Moslehi, Parvin Mirmiran, Fereidoun Azizi
Summary: This study found that greater adherence to empirical dietary inflammatory patterns and lifestyle inflammation scores was associated with a higher risk of diabetes, while no significant association was found between dietary inflammation scores and diabetes incident.
Article
Endocrinology & Metabolism
Andre Madsen, Bjorg Almas, Ingvild S. Bruserud, Ninnie Helen Bakken Oehme, Christopher Sivert Nielsen, Mathieu Roelants, Thomas Hundhausen, Marie Lindhardt Ljubicic, Robert Bjerknes, Gunnar Mellgren, Jorn Sagen, Petur B. Juliusson, Kristin Viste
Summary: Reference curves for biomarkers and corresponding z-scores were established in this study, providing an intuitive framework for clinical implementation in pediatric endocrinology. Associations between hormones, pubertal phenotype, and body mass index were examined, and it was found that they differed significantly between different subgroups stratified by puberty phenotype and BMI weight class. These findings contribute to the application of machine learning classification and covariate precision medicine for pediatric patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Abraham Shaked, Bao-Li Loza, Elisabet Van Loon, Kim M. Olthoff, Weihua Guan, Pamala A. Jacobson, Andrew Zhu, Claire E. Fishman, Hui Gao, William S. Oetting, Ajay K. Israni, Giuliano Testa, James Trotter, Goran Klintmalm, Maarten Naesens, Sumeet K. Asrani, Brendan J. Keating
Summary: T2D PRS can identify transplant candidates at high risk of PTDM, aiding in preemptive diabetes management and donor selection.
Review
Endocrinology & Metabolism
Amber M. M. Luckett, Michael N. N. Weedon, Gareth Hawkes, R. David Leslie, Richard A. A. Oram, Struan F. A. Grant
Summary: Iterative advances in understanding of the genetics of type 1 diabetes have led to the identification of over 70 genetic regions linked to disease risk, with the HLA class II region being the strongest contributor. Genetic data availability and reduced costs have facilitated the development of polygenic scores, which aggregate risk variants into a single number. These scores have utility in distinguishing between different types of diabetes and in identifying at-risk infants, but further research is needed in non-European populations to accurately develop polygenic scores for diverse ancestries. Implementation barriers mainly arise from a lack of guidance and knowledge on integrating polygenic scores with other biomarkers and clinical variables.
Review
Biochemistry & Molecular Biology
Agnieszka Zawada, Alicja Ewa Ratajczak, Anna Maria Rychter, Aleksandra Szymczak-Tomczak, Agnieszka Dobrowolska, Iwona Krela-Kazmierczak
Summary: Diabetes mellitus affects bone mineral density and fracture risk, but the impact of other medications remains unknown. Pharmacotherapy for diabetes should focus on preventing bone mineral disorders and improving treatment and quality of life for patients. Additionally, diabetes patients need to pay attention to osteoporosis prevention.
Article
Multidisciplinary Sciences
Akl C. Fahed, Anthony A. Philippakis, Amit Khera
Summary: Polygenic scores can be used to identify individuals with high disease risk based on inherited DNA variations. This has the potential to enhance clinical trials by targeting individuals with higher risk for disease or increased likelihood of benefiting from treatment.
NATURE COMMUNICATIONS
(2022)
Review
Endocrinology & Metabolism
Eleonora de Klerk, Matthias Hebrok
Summary: Intraportal allogeneic cadaveric islet transplantation shows promise for Type I Diabetes patients, but is limited by issues like cadaveric islet availability and immunosuppressive drug dependence. Mesenchymal stem cell and human embryonic stem cell approaches are explored as alternatives, but still face challenges such as immune rejection. Protective immune strategies and innovative technologies are being developed to address these challenges.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Haruka Miyake, Ikuko Kashino, Akiko Nanri, Tetsuya Mizoue
Summary: Attention is increasingly being paid to the role of diet quality in preventing and managing non-communicable diseases. A scoring system for the traditional Japanese diet and its modified version has been developed, which can be used for diet quality assessments and epidemiological research.
Review
Nutrition & Dietetics
Andrea Da Porto, Alessandro Cavarape, GianLuca Colussi, Viviana Casarsa, Cristiana Catena, Leonardo A. Sechi
Summary: Polyphenols, with anti-inflammatory and antioxidant properties, are plant-derived compounds associated with the pathogenesis of type 2 diabetes. Dietary patterns rich in polyphenols have favorable effects on glucose metabolism and may help prevent type 2 diabetes.
Article
Multidisciplinary Sciences
George B. Busby, Scott Kulm, Alessandro Bolli, Jen Kintzle, Paolo Di Domenico, Giordano Botta
Summary: This study develops and validates ancestry-specific Polygenic Risk Scores (PRSs) for Coronary Artery Disease (CAD) and demonstrates their utility in different genetic ancestries. The use of this risk score improves the assessment of CAD and Atherosclerotic Cardiovascular Disease (ASCVD) risk, outlining a method for genetic-guided ASCVD prevention.
NATURE COMMUNICATIONS
(2023)
Article
Nutrition & Dietetics
Giovanna Esposito, Francesca Bravi, Diego Serraino, Fabio Parazzini, Anna Crispo, Livia S. A. Augustin, Eva Negri, Carlo La Vecchia, Federica Turati
Summary: The study found that following a diabetes risk reduction diet may reduce the risk of endometrial cancer. Combining high vegetable consumption with high adherence to the DRRD may offer additional benefits in preventing endometrial cancer.
Article
Multidisciplinary Sciences
Chi Kuen Wong, Enes Makalic, Gillian S. Dite, Lawrence Whiting, Nicholas M. Murphy, John L. Hopper, Richard Allman
Summary: Polygenic risk scores (PRSs) are a promising approach to accurately predict an individual's risk of developing disease. In this study, the researchers developed PRSs to predict different diseases using the stacked clumping and thresholding method and a variation called maximum clumping and thresholding method. They controlled for age and sex in their case-control training datasets and found that the maximum clumping and thresholding PRSs required fewer single-nucleotide polymorphisms but had similar discriminatory ability compared to the stacked clumping and thresholding PRSs.
Review
Nutrition & Dietetics
Mauro Finicelli, Anna Di Salle, Umberto Galderisi, Gianfranco Peluso
Summary: The Mediterranean Diet, originating from the eating practices of people living in the Mediterranean basin, has shown to have beneficial effects on health and specific diseases. Clinical trials have provided evidence of its anti-inflammatory, anti-oxidant properties, and its effectiveness in controlling waist circumference and obesity. Strict and long-lasting adherence to the diet, as well as the beneficial effects of specific components, are valuable insights for intervention improvements.
Article
Health Care Sciences & Services
Karen O. B. Appiah, Kamlesh Khunti, Benjamin M. Kelly, Aidan Q. Innes, Zhining Liao, Michael Dymond, Robert G. Middleton, Thomas W. Wainwright, Thomas Yates, Francesco Zaccardi
Summary: This study aimed to develop risk scores of preoperative patient factors and patient-reported outcome measures (PROMs) as predictors of patient-rated satisfaction and improvement following hip and knee replacements. Analysis of prospectively collected patient data showed that preoperative PROMs were closely related to surgical outcomes. Prediction models were developed to predict dissatisfaction and lack of improvement following surgery based on easily accessible preoperative patient factors and PROMs.
JOURNAL OF EVALUATION IN CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Tatiana Plekhanova, Alex Rowlands, Melanie J. Davies, Andrew P. Hall, Tom Yates, Charlotte L. Edwardson
Summary: The aim of this study was to evaluate the validity of an automated sleep detection algorithm applied to data from three accelerometers. The results showed that the sleep estimates obtained from the accelerometers were generally comparable to the results from polysomnography, except for wake after sleep onset.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Kieran F. Docherty, John J. V. McMurray, Brian L. Claggett, Zi Michael Miao, Kirkwood F. Adams, Alexandra Arias-Mendoza, John G. F. Cleland, Rafael Diaz, Luis E. Echeverria Correa, G. Michael Felker, Candida Fonseca, Jing Li, Marco Metra, Karen Sliwa-Hahnle, Scott D. Solomon, Hans J. Vandekerckhove, Dragos Vinereanu, Adriaan A. Voors, Stephen B. Heitner, Stuart Kupfer, Fady I. Malik, Lisa Meng, John R. Teerlink
Summary: This study aimed to examine the effect of omecamtiv mecarbil in heart failure patients according to the NT-proBNP levels. The results showed that omecamtiv mecarbil had a greater benefit in patients with higher baseline NT-proBNP levels, especially those without atrial fibrillation/flutter.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Robert J. H. Miller, Derek S. Chew, Lei Qin, Nowell M. Fine, Jieling Chen, John J. V. McMurray, Jonathan G. Howlett, Phil McEwan
Summary: This study compares the cost-effectiveness of immediate and 12-month delayed initiation of dapagliflozin treatment in patients with a history of hospitalization for heart failure from different healthcare perspectives. Using a decision-analytic Markov model, the study found that immediate initiation of dapagliflozin reduces heart failure events and cardiovascular mortality. Immediate initiation of dapagliflozin provides greater clinical benefits and should be considered standard of care.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Letter
Cardiac & Cardiovascular Systems
Jawad H. Butt, Scott D. Solomon, John J. V. McMurray
Article
Cardiac & Cardiovascular Systems
Leanne Mooney, Colette E. Jackson, Carly Adamson, Alex McConnachie, Paul Welsh, Rachel C. Myles, John J. V. McMurray, Pardeep S. Jhund, Mark C. Petrie, Ninian N. Lang
Summary: Circulating levels of interleukin-6 may identify patients at greater risk of adverse outcomes following hospitalization with heart failure with preserved ejection fraction.
CIRCULATION-HEART FAILURE
(2023)
Review
Cardiac & Cardiovascular Systems
Ewa A. Jankowska, Tomas Andersson, Claudia Kaiser-Albers, Biykem Bozkurt, Ovidiu Chioncel, Andrew J. S. Coats, Loreena Hill, Friedrich Koehler, Lars H. Lund, Theresa McDonagh, Marco Metra, Clemens Mittmann, Wilfried Mullens, Uwe Siebert, Scott D. Solomon, Maurizio Volterrani, John J. V. McMurray
Summary: Despite the rapid development of therapies and tools for heart failure (HF), everyday management in clinical practice remains suboptimal. A workshop convened by the European Society of Cardiology (ESC) identified barriers, such as the complexity of HF and its treatment, financial constraints, failure to meet patient needs, suboptimal outpatient management, and fragmented healthcare systems. Ongoing initiatives and proposed actions aim to address these barriers and improve patient outcomes.
Article
Endocrinology & Metabolism
Sharmin Shabnam, Sophia Abner, Clare L. Gillies, Melanie J. Davies, Terry Dex, Kamlesh Khunti, David R. Webb, Francesco Zaccardi, Samuel Seidu
Summary: The study found that delayed treatment intensification increases the risk of cardiovascular disease and complications in patients with suboptimal glycaemia, especially in those under the age of 65.
DIABETES OBESITY & METABOLISM
(2023)
Letter
Endocrinology & Metabolism
Melanie J. Davies, Amra Ciric Alibegovic, Pranav Kelkar, Uffe Christian Braae, Anders Boeck Jensen
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Sharmin Shabnam, Clare L. Gillies, Melanie J. Davies, Terry Dex, Eka Melson, Kamlesh Khunti, David R. Webb, Francesco Zaccardi, Samuel Seidu
Summary: This study aims to identify factors associated with treatment inertia in patients with type 2 diabetes mellitus who have recently started on basal insulin. The study found that older age, female gender, longer duration of T2DM, living in deprived areas, smoking, presence of comorbidities, and use of certain medications were all associated with a delayed intensification of treatment. Interventions to overcome therapeutic inertia should be implemented at both patient and healthcare professional level.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Cardiac & Cardiovascular Systems
Toru Kondo, Xiaowen Wang, Mingming Yang, Pardeep S. Jhund, Brian L. Claggett, Muthiah Vaduganathan, Adrian F. Hernandez, Carolyn S. P. Lam, Silvio E. Inzucchi, Felipe A. Martinez, Rudolf A. de Boer, Mikhail N. Kosiborod, Akshay S. Desai, Lars Kober, Piotr Ponikowski, Marc S. Sabatine, Anna Maria Langkilde, Magnus Petersson, Natalia Zaozerska, Erasmus Bachus, Scott D. Solomon, John J. V. Mcmurray
Summary: The efficacy and safety of dapagliflozin were consistent across global regions despite geographic differences in patient characteristics, background treatment, and event rates.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Shingo Matsumoto, Toru Kondo, Pardeep S. Jhund, Ross T. Campbell, Karl Swedberg, Dirk J. van Veldhuisen, Stuart J. Pocock, Bertram Pitt, Faiez Zannad, John J. V. McMurray
Summary: This study evaluated the safety and efficacy of eplerenone according to the duration of heart failure with reduced ejection fraction (HFrEF). The results showed that the benefits of eplerenone were consistent regardless of HFrEF duration, with the longest-duration group experiencing the greatest absolute benefit.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Matthew M. Y. Lee, Toru Kondo, Ross T. Campbell, Mark C. Petrie, Naveed Sattar, Scott D. Solomon, Muthiah Vaduganathan, Pardeep S. Jhund, John J. Mcmurray
Summary: This meta-analysis evaluates the safety and efficacy of renin-angiotensin system (RAS) blockers in the treatment of COVID-19. The results suggest that ACE inhibitors and ARBs can be continued in non-severe patients, but initiation of RAS blockers may be harmful in critically ill patients.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
John Ostrominski, B. Claggett, M. Packer, M. Pfeffer, C. Lam, M. Zile, A. Desai, P. Jhund, M. Lefkowitz, J. Mcmurray, S. Solomon, M. Vaduganathan
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Meeting Abstract
Endocrinology & Metabolism
M. Vaduganathan, S. E. Inzucchi, B. L. Claggett, I. Kulac, R. A. de Boer, A. S. Desai, K. F. Docherty, A. F. Hernandez, M. N. Kosiborod, P. S. Jhund, C. S. P. Lam, F. A. Martinez, S. J. Shah, J. J. V. McMurray, S. D. Solomon
Article
Endocrinology & Metabolism
Emilie Steinbach, Davide Masi, Agnes Ribeiro, Patricia Serradas, Tiphaine Le Roy, Karine Clement
Summary: The study of the gut microbiome is crucial for understanding and treating metabolic diseases. While research on the fecal microbiome has provided valuable insights, relying solely on this may not be enough to draw comprehensive conclusions. The microbiome in the proximal part of the small intestine may play a significant role in metabolic regulation, but further exploration is needed due to limited accessibility.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Evangelia Chavdoula, Vollter Anastas, Alessandro La Ferlita, Julian Aldana, Giuseppe Carota, Mariarita Spampinato, Burak Soysal, Ilaria Cosentini, Sameer Parashar, Anuvrat Sircar, Giovanni Nigita, Lalit Sehgal, Michael A. Freitas, Philip N. Tsichlis
Summary: This study reveals the important role of KDM2B in triple-negative breast cancer (TNBC). KDM2B affects cellular resistance to oxidative stress by regulating a network of genes and metabolic enzymes, in collaboration with ATF4 and MYC. Additionally, high expression of KDM2B is associated with poor prognosis in patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Joongmin Kim, Hyeongsoo Kim, Sang Hyun Park, Yura Kang, Kyungdo Han, Sang-Hak Lee
Summary: This study aimed to investigate the optimal LDL-C level after statin therapy in individuals with intermediate cardiovascular risk. The results showed that achieving LDL-C levels <120 mg/dL after statin therapy could lower the event risk.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Ze Chen, Li -Ping Xia, Lang Shen, Dan Xu, Yu Guo, Hui Wang
Summary: Accumulating evidence suggests that NAFLD has an intrauterine origin, with adverse prenatal environments and glucocorticoid exposure playing a crucial role in the developmental programming of fetal hepatic lipid metabolism. The offspring's glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis is programmed in utero, leading to postnatal catch-up growth and disrupted glucose and lipid metabolism, increasing susceptibility to NAFLD. Mismatch between intrauterine and postnatal environments can further disturb the programmed endocrine axes and accelerate the onset of NAFLD.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Fuwen Zuo, Youzhao Wang, Xinlei Xu, Ruihao Ding, Wei Tang, Yu Sun, Xiaojie Wang, Yan Zhang, Jichao Wu, Yusheng Xie, Min Liu, Ziying Wang, Fan Yi
Summary: This study investigates the role of CCDC92 in the pathogenesis of diabetic kidney disease (DKD). The expression of CCDC92 was found to increase in kidney biopsies from patients with DKD and was correlated with glomerular lipid accumulation. Animal studies further confirmed the induction of CCDC92 in the kidney, particularly in podocytes, and the podocyte-specific deletion of Ccdc92 ameliorated podocyte injury and lipid deposition. CCDC92 was shown to promote podocyte lipotoxicity through ABCA1 signaling-mediated lipid homeostasis. Therefore, CCDC92 may serve as a potential biomarker of podocyte injury in DKD and targeting CCDC92 could be an innovative therapeutic strategy for DKD patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Khanyisani Ziqubu, Phiwayinkosi Dludla, Sihle E. Mabhida, Babalwa U. Jack, Susanne Keipert, Martin Jastroch, Sithandiwe E. Mazibuko-Mbeje
Summary: The discovery and revival of brown adipose tissue (BAT) in adult humans have opened up new possibilities for treating obesity and metabolic diseases. BAT not only plays a role in generating heat, but also secretes signaling molecules known as batokines, which regulate overall metabolism. This review highlights the importance of BAT-derived metabolites in controlling thermogenesis, substrate metabolism, and other biological processes, as well as their potential to alleviate obesity and related metabolic complications.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)