期刊
METABOLISM-CLINICAL AND EXPERIMENTAL
卷 63, 期 10, 页码 1228-1237出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.metabol.2014.06.018
关键词
Kidneys; Type 2 diabetes mellitus; Sodium glucose co-transporter 2 (SGLT2) inhibitor
资金
- Janssen Pharmaceutica NV
The kidneys play an important role in regulating glucose homeostasis through utilization of glucose, gluconeogenesis, and glucose reabsorption via sodium glucose co-transporters (SGLTs) and glucose transporters. The renal threshold for glucose excretion (RTG) is increased in patients with type 2 diabetes mellitus (T2DM), possibly due to upregulation of SGLT2 and SGLT1 expression. The resulting increase in renal glucose reabsorption is thought to contribute to the maintenance of hyperglycemia in patients with T2DM. Selective SGLT2 inhibitors reduce the RTG, thereby increasing glucosuria, and have demonstrated favorable efficacy and safety in patients with T2DM inadequately controlled with diet and exercise and other glucose-lowering treatments. (C) 2014 The Author. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license,(http://creativecommons.org/licenses/by-nc-nd/3.0/).
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