Article
Health Care Sciences & Services
Tadashi Ito, Yoshihito Sakai, Hideshi Sugiura, Keitaro Kawai, Yoshifumi Morita, Kazunori Yamazaki
Summary: This study explored the relationship between back muscle strength and fall risk in older adults with lumbar spondylosis, finding that both back and abdominal muscle strength were associated with fall scores. Furthermore, the study discovered differences in the factors related to fall risks between men and women in this population.
Article
Medicine, General & Internal
Oscar Bergens, Andreas Nilsson, Fawzi Kadi
Summary: The study found that in older women, there was a negative association between skeletal muscle index and pro-inflammatory markers independent of lifestyle factors, while no such associations were observed in older men. This highlights the importance of considering biological sex in the interaction between systemic inflammation and muscle health.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Paula C. Nahas, Luana T. Rossato, Flavia M. S. de Branco, Catarina M. Azeredo, Ana Elisa M. Rinaldi, Erick P. de Oliveira
Summary: This study found that serum uric acid is positively associated with muscle strength in older men and women, with the findings supporting this relationship after adjusting for potential confounders.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Natalia Maira da Cruz Alves, Karina Pfrimer, Priscila Carvalho Santos, Ellen Cristini de Freitas, Thiago Neves, Rodrigo Antonio Pessini, Marcia Varella Morandi Junqueira-Franco, Marcello H. Nogueira-Barbosa, Carolyn Anne Greig, Eduardo Ferriolli
Summary: This study found that fish oil supplementation can enhance the response of sarcopenic older women to exercise, increasing muscle strength and physical performance.
Article
Geriatrics & Gerontology
Ana C. M. de Carvalho, Cristiano S. Gomes, Karla V. R. S. Menezes, Juliana Fernandes, Ingrid G. Azevedo, Luana C. A. C. Correa, Ricardo O. Guerra
Summary: This study evaluated the effects of hospitalization on handgrip strength in older adults and found a significant decline in handgrip strength during the hospitalization period, particularly more pronounced in men. Undergoing surgery and the basal values of the Katz Index were associated with worse handgrip strength performance at discharge.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Geriatrics & Gerontology
Hyunkyu Kim, Seung Hoon Kim, Wonjeong Jeong, Sung-In Jang, Eun-Cheol Park, Youseok Kim
Summary: This study identified a relationship between changing handgrip strength and cognitive function, with decreasing handgrip strength associated with decline in cognitive function over time.
Article
Public, Environmental & Occupational Health
Hui Liu, Zhenmei Zhang, Yan Zhang
Summary: The study provides insight into the association between trajectories of marital quality and cognitive functioning among older adults, with a focus on gender differences. Initial positive marital quality correlated with better initial cognition in older adults, while negative marital quality correlated with worse cognition. An increase in positive marital quality was associated with a slower rate of cognitive decline in men, emphasizing the importance of maintaining a good marital relationship for cognitive health in later life.
SOCIAL SCIENCE & MEDICINE
(2021)
Article
Geriatrics & Gerontology
William Evans, Mahalakshmi Shankaran, Edna Nyangau, Tyler Field, Hussein Mohammed, Robert Wolfe, Scott Schutzler, Marc Hellerstein
Summary: This study examined the effects of Fortetropin supplementation on muscle protein FSR in older individuals, finding that Fortetropin increased FSR compared to a placebo group. The difference in FSR between Fortetropin and placebo was 18% and affected multiple gene ontologies, suggesting that Fortetropin supplementation may be effective for promoting muscle protein synthesis in older populations.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Geriatrics & Gerontology
Hideyoshi Kaga, Yoshifumi Tamura, Yuki Someya, Hitoshi Naito, Hiroki Tabata, Saori Kakehi, Nozomu Yamasaki, Motonori Sato, Satoshi Kadowaki, Ruriko Suzuki, Daisuke Sugimoto, Ryuzo Kawamori, Hirotaka Watada
Summary: In this cross-sectional study of older adults in Tokyo, Japan, it was found that prediabetes and diabetes are independent risk factors for sarcopenia in men, while only diabetes is an independent risk factor for sarcopenia in women. Additionally, age, higher body fat percentage, and lower body mass index were identified as independent risk factors for sarcopenia in both sexes.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Geriatrics & Gerontology
Hyo-jung Lee, Ju-Young Choi, Dongui Hong, Donghoon Kim, Jin-Young Min, Kyoung-Bok Min
Summary: This study investigated the sex differences in the association between sarcopenia and mild cognitive impairment (MCI). The results showed a significant relationship between sarcopenia and MCI in women, but not in men. Additionally, sarcopenia was found to be associated with memory decline in women. Therefore, maintaining muscle function and mass may be more crucial for cognitive function in women than in men.
Article
Geriatrics & Gerontology
Quan Zhang, Xinyi Zhao, Huiying Liu, Nan Yu, Danyu Li
Summary: The study found an association between metabolic syndrome and muscle weakness in older Chinese adults, which was more prominent in men.
Article
Biochemistry & Molecular Biology
Renata R. Bruno, Fernanda C. Rosa, Paula C. Nahas, Flavia M. S. de Branco, Erick P. de Oliveira
Summary: Aging is associated with decreased muscle strength and increased reactive oxygen species. This cross-sectional study found that serum levels of alpha-carotene were positively associated with muscle strength in older adults, while other antioxidants were not. This suggests that alpha-carotene may have a beneficial effect on muscle strength in aging individuals.
Article
Environmental Sciences
San Lee, Jae Won Oh, Nak-Hoon Son, Woojin Chung
Summary: This study found that baseline handgrip strength may be positively associated with later cognitive function, but the association may be non-linear and differ between sexes. Sex-specific preventive assessment of handgrip strength may help identify older adults at risk for cognitive impairment.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Geriatrics & Gerontology
Fatima Nari, Bich Na Jang, Selin Kim, Wonjeong Jeong, Sung-In Jang, Eun-Cheol Park
Summary: This study examined the longitudinal association between changes in successful aging status and depressive symptoms in Korean older adults. The results showed that older adults who continuously failed to attain or maintain successful aging status had the highest risk of depressive symptoms, highlighting the importance of promoting successful aging to protect mental health.
Article
Environmental Sciences
Mingyang Wu, Linfei Dou, Aisimila Abudoula, Yanling Shu, Youjie Wang
Summary: This study aimed to evaluate the relationship between blood and urine cadmium levels and muscle strength. The study found that there was a linear dose-response relationship between cadmium concentrations in blood and urine and muscle strength, with lower levels of cadmium associated with decreased muscle strength. This association was more evident among male participants.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Geriatrics & Gerontology
Gihwan Byeon, Sung Ok Kwon, Jin Hyeong Jhoo, Jae-Won Jang, Jong Bin Bae, Ji Won Han, Tae Hui Kim, Kyung Phil Kwak, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Seok Woo Moon, Joon Hyuk Park, Seung-Ho Ryu, Jong Chul Youn, Dong Woo Lee, Seok Bum Lee, Jung Jae Lee, Dong Young Lee, Ki Woong Kim
Summary: This study aimed to determine the differences in risk factors for dangerous driving between older adults with normal cognition and those with cognitive impairment. The driving risk questionnaire (DRQ) and accident/violation records were analyzed. Significant associations were found between risky driving and crash history, safety concern, reduced mileage, and aggressive driving in the normal cognition group. In the cognitive impairment group, only crash history was significantly associated. These findings contribute to evaluating and predicting risky driving and providing advice on whether to continue driving in clinics.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Health Care Sciences & Services
Hae-Yeon Park, Kyung Eun Nam, Jae-Young Lim, Seung Mi Yeo, Jong In Lee, Ji Hye Hwang
Summary: This study aimed to investigate the effect of an augmented reality (AR)-based digital health care system in postoperative patients with breast cancer. The results showed significant improvements in shoulder range of motion, shoulder pain, functional outcomes, and quality of life in both the intervention and control groups, with no significant differences between the two groups.
TELEMEDICINE AND E-HEALTH
(2023)
Article
Nutrition & Dietetics
Soo Lim, Minji Sohn, Jose C. Florez, Michael A. Nauck, Jiyoung Ahn
Summary: This study aimed to compare the effects of gemigliptin-metformin and glimepiride-metformin combination therapies on gut microbiota and glucose homeostasis. The results showed that gemigliptin-metformin achieved better glycemic control without hypoglycemia or weight gain compared to glimepiride-metformin. Changes in gut microbiota were associated with treatment outcomes.
Article
Neuroimaging
Jun Sung Kim, Jong Bin Baeb, Ji Won Han, Dae Jong Oh, Seung Wan Suh, Jae Hyoung Kim, Ki Woong Kim
Summary: This study investigated the effects of controlled hypertension (cHT) and white matter hyperintensity (WMH) on cognitive function, as well as the mediating role of WMH in the relationship between cHT and cognitive impairment. The results showed that older WMH age was associated with a faster decline in cognitive function, and WMH age mediated the effects of cHT on cognitive function. Therefore, older individuals with cHT and older WMH age may be at a higher risk of cognitive decline.
NEUROIMAGE-CLINICAL
(2023)
Article
Endocrinology & Metabolism
Minji Sohn, Hyeyoung Jung, Woo Shun Lee, Tai Hoon Kim, Soo Lim
Summary: This study investigated the potential use of Lactobacillus plantarum strain LMT1-48 as a probiotic supplement for overweight individuals. A randomized, double-blind, placebo-controlled clinical trial was conducted on 100 volunteers with a body mass index (BMI) of 25 to 30 kg/m2. The results showed that administration of LMT1-48 significantly reduced body weight, abdominal visceral fat area, insulin resistance, and leptin levels.
DIABETES & METABOLISM JOURNAL
(2023)
Article
Endocrinology & Metabolism
Seon Mee Kang, Han Mi Yun, Minji Sohn, Soo Lim
Summary: In patients with inadequately controlled type 2 diabetes treated with metformin and sulphonylurea, ipragliflozin showed better glycemic control and metabolic benefits compared to sitagliptin. Ipragliflozin treatment resulted in a significant decrease in glycated hemoglobin levels, improved glucose and fat metabolism, and enhanced vascular function. Both ipragliflozin and sitagliptin were found to be safe.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Seung Min Chung, Jun Sung Moon, Jun Hwa Hong, In-Chang Hwang, Soo Lim
Summary: The aim of this study was to investigate the effects of gemigliptin on cardiac function and compare its effects with glimepiride in patients with type 2 diabetes. The results showed that gemigliptin and glimepiride both significantly reduced HbA1c levels without a significant difference between the groups. Gemigliptin also had positive effects on insulin resistance, inflammatory markers, lipid profiles, and body composition. No significant changes in cardiac biomarkers were observed. The study received a score of 8 out of 10.
DIABETES OBESITY & METABOLISM
(2023)
Article
Orthopedics
Eun Sil Koh, Jae-Young Lim
Summary: Whole-body vibration was evaluated for its effects on denervated skeletal muscle atrophy. The results showed that whole-body vibration led to a decrease in inclination angle and muscle weight, but not muscle fiber cross-sectional area. Changes in myosin heavy chain isoform composition were observed in denervated muscle after whole-body vibration. However, there were no significant changes in denervated slow-twitch muscle.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Medicine, General & Internal
Mun Jeong Kang, Bo Ryun Kim, Sang Yoon Lee, Jaewon Beom, Jun Hwan Choi, Jae-Young Lim
Summary: This is a retrospective cohort study that aimed to determine the predictors of functional outcomes and quality of life for patients who underwent surgery for fragility hip fracture. The study was conducted in three tertiary rehabilitation facilities and followed up with 165 patients for six months postoperatively. The study found that age, fracture site, operation type, comorbidities, and initial physical and cognitive function significantly influenced the recovery of function and quality of life at six months.
Article
Endocrinology & Metabolism
Kyuho Kim, Ji Hye Moon, Chang Ho Ahn, Soo Lim
Summary: This study suggests that olmesartan has beneficial effects on serum ACE2 and Ang-(1-7) levels, as well as kidney and vascular function in patients with type 2 diabetes and hypertension.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Endocrinology & Metabolism
Yingying Luo, Jun Xia, Zhan Zhao, Yaping Chang, Yong Mong Bee, Khue Thy Nguyen, Soo Lim, Daisuke Yabe, Margaret McGill, Alice Pik Shan Kong, Siew Pheng Chan, Marisa Deodat, Chaicharn Deerochanawong, Ketut Suastika, Chenchen Xu, Liming Chen, Wei Chen, Xiaoying Li, Weigang Zhao, Xiaomei Yao, Linong Ji
Summary: The study aimed to investigate the effectiveness, safety, optimal starting dose, optimal maintenance dose range, and target fasting plasma glucose of five basal insulins in insulin-naive patients with type 2 diabetes mellitus. Meta-analyses and network meta-analyses showed that glargine U-300 or degludec U-100 might be the most effective choices for injecting basal insulin regimens at bedtime, followed by glargine U-100 or detemir, and NPH. Injecting glargine U-100 in the morning may be more effective and result in fewer hypoglycemic events. The optimal starting dose for any basal insulin initiation can be 0.10-0.20 U/kg/day. There is no eligible evidence to determine the optimal maintenance dose for basal insulins.
JOURNAL OF DIABETES
(2023)
Review
Endocrinology & Metabolism
Linong Ji, Yingying Luo, Yong Mong Bee, Jun Xia, Khue Thy Nguyen, Weigang Zhao, Liming Chen, Siew Pheng Chan, Chaicharn Deerochanawong, Soo Lim, Daisuke Yabe, Margaret McGill, Ketut Suastika, Xiaoying Li, Alice Pik Shan Kong, Wei Chen, Zhan Zhao, Chenchen Xu, Marisa Deodat, Xiaomei Yao
Summary: The study aimed to provide recommendations on the use of five basal insulins in insulin-naive adults with type 2 diabetes in the Asia-Pacific region. Through a systematic review and guideline development process, clinical practice guidelines were formulated based on GRADE methods. The guidelines received high agreement rates, and strong and conditional recommendations were made. The recommendations and clinical thresholds set in the guidelines can be valuable references for clinicians worldwide.
JOURNAL OF DIABETES
(2023)
Review
Clinical Neurology
Suhyun Jang, Boram Lee, Eunji Lee, Jungbin Kim, Jong In Lee, Jae-Young Lim, Ji Hye Hwang, Sunmee Jang
Summary: Rehabilitation using digital healthcare (DHC) shows potential in enhancing treatment effectiveness for musculoskeletal disorders (MSDs) and associated pain. This systematic review and meta-analysis evaluated the effectiveness of DHC in musculoskeletal rehabilitation. The findings indicate that DHC offers a practical and flexible alternative, with greater pain reduction and improved quality of life compared to conventional rehabilitation. Further research is needed to understand the underlying mechanisms and variations in patient-reported outcomes.
JOURNAL OF PAIN RESEARCH
(2023)
Article
Medicine, General & Internal
Seungwoo Cha, Won Kee Chang, Hee-Mun Cho, Kyungdo Han, Nam-Jong Paik, Sohyun Kwon, Won-Seok Kim
Summary: This study analyzed the prevalence and risk of Parkinson's disease (PD) and dysphagia in Korea from 2006 to 2015. The study found that both the prevalence of PD and dysphagia in PD patients increased continuously during the study period, with the highest prevalence among elderly individuals. Patients with PD had a three times higher risk of dysphagia compared to those without PD, emphasizing the importance of attention to this condition.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Engineering, Biomedical
Kwangsub Song, Sangui Choi, Jin-Hong Shin, Woo-Hyeon Son, Hyuntae Park, Hooman Lee, Nam-Jong Paik
Summary: We propose a digital biomarker (DB/MS and DB/ME) for diagnosing muscle disorders using a multi-layer perceptron (MLP) and stimulated muscle contraction. Traditional methods of measuring muscle strength and endurance related DBs are difficult and expensive. We introduce a non-volitional DB measurement technique using impact response signal (IRS) based on multi-frequency electrical stimulation (MFES) and an electromyography sensor. The DB estimation model learned through MLP accurately assesses muscle disorders causing decreased physical performance.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Article
Endocrinology & Metabolism
Emilie Steinbach, Davide Masi, Agnes Ribeiro, Patricia Serradas, Tiphaine Le Roy, Karine Clement
Summary: The study of the gut microbiome is crucial for understanding and treating metabolic diseases. While research on the fecal microbiome has provided valuable insights, relying solely on this may not be enough to draw comprehensive conclusions. The microbiome in the proximal part of the small intestine may play a significant role in metabolic regulation, but further exploration is needed due to limited accessibility.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Evangelia Chavdoula, Vollter Anastas, Alessandro La Ferlita, Julian Aldana, Giuseppe Carota, Mariarita Spampinato, Burak Soysal, Ilaria Cosentini, Sameer Parashar, Anuvrat Sircar, Giovanni Nigita, Lalit Sehgal, Michael A. Freitas, Philip N. Tsichlis
Summary: This study reveals the important role of KDM2B in triple-negative breast cancer (TNBC). KDM2B affects cellular resistance to oxidative stress by regulating a network of genes and metabolic enzymes, in collaboration with ATF4 and MYC. Additionally, high expression of KDM2B is associated with poor prognosis in patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Joongmin Kim, Hyeongsoo Kim, Sang Hyun Park, Yura Kang, Kyungdo Han, Sang-Hak Lee
Summary: This study aimed to investigate the optimal LDL-C level after statin therapy in individuals with intermediate cardiovascular risk. The results showed that achieving LDL-C levels <120 mg/dL after statin therapy could lower the event risk.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Ze Chen, Li -Ping Xia, Lang Shen, Dan Xu, Yu Guo, Hui Wang
Summary: Accumulating evidence suggests that NAFLD has an intrauterine origin, with adverse prenatal environments and glucocorticoid exposure playing a crucial role in the developmental programming of fetal hepatic lipid metabolism. The offspring's glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis is programmed in utero, leading to postnatal catch-up growth and disrupted glucose and lipid metabolism, increasing susceptibility to NAFLD. Mismatch between intrauterine and postnatal environments can further disturb the programmed endocrine axes and accelerate the onset of NAFLD.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Fuwen Zuo, Youzhao Wang, Xinlei Xu, Ruihao Ding, Wei Tang, Yu Sun, Xiaojie Wang, Yan Zhang, Jichao Wu, Yusheng Xie, Min Liu, Ziying Wang, Fan Yi
Summary: This study investigates the role of CCDC92 in the pathogenesis of diabetic kidney disease (DKD). The expression of CCDC92 was found to increase in kidney biopsies from patients with DKD and was correlated with glomerular lipid accumulation. Animal studies further confirmed the induction of CCDC92 in the kidney, particularly in podocytes, and the podocyte-specific deletion of Ccdc92 ameliorated podocyte injury and lipid deposition. CCDC92 was shown to promote podocyte lipotoxicity through ABCA1 signaling-mediated lipid homeostasis. Therefore, CCDC92 may serve as a potential biomarker of podocyte injury in DKD and targeting CCDC92 could be an innovative therapeutic strategy for DKD patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Khanyisani Ziqubu, Phiwayinkosi Dludla, Sihle E. Mabhida, Babalwa U. Jack, Susanne Keipert, Martin Jastroch, Sithandiwe E. Mazibuko-Mbeje
Summary: The discovery and revival of brown adipose tissue (BAT) in adult humans have opened up new possibilities for treating obesity and metabolic diseases. BAT not only plays a role in generating heat, but also secretes signaling molecules known as batokines, which regulate overall metabolism. This review highlights the importance of BAT-derived metabolites in controlling thermogenesis, substrate metabolism, and other biological processes, as well as their potential to alleviate obesity and related metabolic complications.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
