Article
Endocrinology & Metabolism
Kuang-Hua Huang, Chiu-Hsiang Lee, Yih-Dih Cheng, Shuo-Yan Gau, Tung-Han Tsai, Ning-Jen Chung, Chien-Ying Lee
Summary: This study investigated the correlation between metformin use and the incidence of nonalcoholic fatty liver disease (NAFLD) among patients with type 2 diabetes mellitus (T2DM). The results showed that patients with T2DM who received low-dose and low-intensity metformin treatment were at a higher risk of developing NAFLD.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Hyun Ho Choi, Giwoong Choi, Hojun Yoon, Kyoung Hwa Ha, Dae Jung Kim
Summary: The overall incidence rate of diagnosed diabetes in South Korean adults has been decreasing, but there has been a slight increase in the 20-39 age group. The proportion of obese young adults with diabetes has significantly increased.
DIABETES & METABOLISM JOURNAL
(2022)
Article
Oncology
Jingwei Wang, Xiaoyun Huang, Ruimin Ma, Qian Zhang, Na Wu, Xuqin Du, Qiao Ye
Summary: This prospective cohort study aimed to evaluate the incidence rate and potential risk factors in a cohort of asbestosis patients in China. The study found that the standardized incidence rates of patients with asbestosis-related malignancies were significantly increased, especially for lung cancer, mesothelioma, breast cancer, and endometrial carcinoma. Smoking and longer asbestos exposure increased the risk of lung cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Jun Cheng, Yanling Yu, Qiongjin Ma, Zhijian Wang, Qingrong Zhou, Guolong Zhang, Shuangyi Hou, Lin Zhou, Feiying Liu, Lan Xia, Lin Xu, Canyou Zhang, Yinyin Xia, Hui Chen, Hui Zhang, Lixia Wang
Summary: This study found a high prevalence and incidence of TB in DM patients in China, and suggested recommendations for public health practice.
Article
Endocrinology & Metabolism
Noreen Islam, Rebecca Nash, Qi Zhang, Leonidas Panagiotakopoulos, Tanicia Daley, Shalender Bhasin, Darios Getahun, J. Sonya Haw, Courtney McCracken, Michael J. Silverberg, Vin Tangpricha, Suma Vupputuri, Michael Goodman
Summary: The study found that transfeminine individuals are at higher risk for type 2 diabetes compared to cisgender females. However, no significant differences in prevalence or incidence of T2DM were observed across the remaining comparison groups, both overall and in transgender and gender diverse individuals with evidence of receiving gender-affirming hormone therapy.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Multidisciplinary Sciences
Luisa Castro, Luisa Brant, Maria de Fatima Diniz, Paulo Lotufo, Isabela Judith Bensenor, Dora Chor, Rosane Griep, Sandhi Maria Barreto, Antonio Luiz Ribeiro
Summary: Insulin resistance is associated with an increased risk of prehypertension and hypertension in the Brazilian population, independent of overweight or obesity. The presence of insulin resistance at baseline significantly increased the chances of developing prehypertension by 51% and hypertension by 150%. This association remained significant in individuals with a BMI less than 25 kg/m(2).
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Shih-Wei Lai, Chiu-Shong Liu, Yu-Hung Kuo, Cheng-Li Lin, Bing-Fang Hwang, Kuan-Fu Liao
Summary: The meta-analysis showed that patients with diabetes mellitus have a significantly higher risk of developing herpes zoster compared to those without diabetes. It is recommended that patients with diabetes mellitus consider getting vaccinated to prevent herpes zoster.
Article
Obstetrics & Gynecology
Tatiana A. Zaccara, Cristiane F. Paganoti, Fernanda C. F. Mikami, Rossana P. V. Francisco, Rafaela A. Costa
Summary: This study aimed to evaluate the differences and similarities between patients meeting the diagnostic criteria for gestational diabetes mellitus (GDM) or diabetes in pregnancy (DIP) according to the World Health Organization standards. Findings showed that diabetes in pregnancy is associated with an increased risk of adverse perinatal outcomes but does not necessarily equate to a post-pregnancy diabetes diagnosis.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Environmental Sciences
Johan N. Sommar, David Segersson, Erin Flanagan, Anna Oudin
Summary: This study aimed to assess the risk of diabetes incidence associated with source-specific air pollution. The results showed that air pollution related to particulate matter (PM10, PM2.5) and traffic emissions was associated with an increased incidence of diabetes. These findings are consistent with the current evidence on traffic pollution as an environmental risk factor for diabetes.
ENVIRONMENTAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Matias F. Martinez, Enzo Alveal, Tomas G. Soto, Eva Bustamante, Femanda Avila, Shrikant Bangdiwala, Ivonne Flores, Claudia Monterrosa, Ricardo Morales, Nelson M. Varela, Alison E. Fohner, Luis A. Quinones
Summary: This study established a pharmacogenetic-based algorithm to predict infections in patients undergoing chemotherapy, incorporating genetic polymorphisms and clinical/demographic variables into the predictive model, showing good goodness-of-fit and diagnostic accuracy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Florence Brellier, Mar Pujades-Rodriguez, Emma Powell, Kathleen Mudie, Eliana Mattos Lacerda, Luis Nacul, Kevin Wing
Summary: This study found that Lyme disease in the UK is associated with subsequent fatigue and ME/CFS. These effects persist beyond 6 months after diagnosis and should be taken into consideration by patients and healthcare providers.
Article
Biochemistry & Molecular Biology
Chin-Hsiao Tseng
Summary: The use of metformin is associated with a reduced risk of benign brain tumors and cerebral meningiomas in patients with type 2 diabetes mellitus, with a dose-response pattern observed.
Article
Public, Environmental & Occupational Health
Panglin Sun, Haoyu Wen, Xiaoxue Liu, Yudiyang Ma, Jie Jang, Chuanhua Yu
Summary: The incidence rate of type 2 diabetes mellitus is increasing in the BRICS countries and is influenced by age and environmental factors. The trends in incidence rate vary across different countries and age groups.
Article
Gastroenterology & Hepatology
Timo U. U. Kosunen, Anna A. A. Nieminen, Arto Kokkola, Perttu Arkkila, Eero Pukkala, Hilpi Rautelin
Summary: Long-term Helicobacter pylori infection increases the risk of gastric malignancies. This study assessed the incidence of gastrointestinal and various other malignancies in individuals after eradication therapy for H. pylori infection. The results showed that although eradication of H. pylori may have a long-lasting protective effect against gastric cancer, H. pylori therapy may postpone the detection of malignancies possibly underlying unspecific gastrointestinal symptoms, highlighting the importance of continuing diagnostic work-up for malignancies even after detection and treatment of H. pylori infection.
Article
Oncology
Tao Thi Tran, Jeonghee Lee, Madhawa Gunathilake, Hyunsoon Cho, Jeongseon Kim
Summary: This study aimed to investigate the influence of different fasting glucose levels on gastric cancer incidence. Through long-term observation of over 41,837 participants, it was found that high fasting glucose is associated with an increased risk of gastric cancer.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Endocrinology & Metabolism
Emilie Steinbach, Davide Masi, Agnes Ribeiro, Patricia Serradas, Tiphaine Le Roy, Karine Clement
Summary: The study of the gut microbiome is crucial for understanding and treating metabolic diseases. While research on the fecal microbiome has provided valuable insights, relying solely on this may not be enough to draw comprehensive conclusions. The microbiome in the proximal part of the small intestine may play a significant role in metabolic regulation, but further exploration is needed due to limited accessibility.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Evangelia Chavdoula, Vollter Anastas, Alessandro La Ferlita, Julian Aldana, Giuseppe Carota, Mariarita Spampinato, Burak Soysal, Ilaria Cosentini, Sameer Parashar, Anuvrat Sircar, Giovanni Nigita, Lalit Sehgal, Michael A. Freitas, Philip N. Tsichlis
Summary: This study reveals the important role of KDM2B in triple-negative breast cancer (TNBC). KDM2B affects cellular resistance to oxidative stress by regulating a network of genes and metabolic enzymes, in collaboration with ATF4 and MYC. Additionally, high expression of KDM2B is associated with poor prognosis in patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Joongmin Kim, Hyeongsoo Kim, Sang Hyun Park, Yura Kang, Kyungdo Han, Sang-Hak Lee
Summary: This study aimed to investigate the optimal LDL-C level after statin therapy in individuals with intermediate cardiovascular risk. The results showed that achieving LDL-C levels <120 mg/dL after statin therapy could lower the event risk.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Ze Chen, Li -Ping Xia, Lang Shen, Dan Xu, Yu Guo, Hui Wang
Summary: Accumulating evidence suggests that NAFLD has an intrauterine origin, with adverse prenatal environments and glucocorticoid exposure playing a crucial role in the developmental programming of fetal hepatic lipid metabolism. The offspring's glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis is programmed in utero, leading to postnatal catch-up growth and disrupted glucose and lipid metabolism, increasing susceptibility to NAFLD. Mismatch between intrauterine and postnatal environments can further disturb the programmed endocrine axes and accelerate the onset of NAFLD.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Fuwen Zuo, Youzhao Wang, Xinlei Xu, Ruihao Ding, Wei Tang, Yu Sun, Xiaojie Wang, Yan Zhang, Jichao Wu, Yusheng Xie, Min Liu, Ziying Wang, Fan Yi
Summary: This study investigates the role of CCDC92 in the pathogenesis of diabetic kidney disease (DKD). The expression of CCDC92 was found to increase in kidney biopsies from patients with DKD and was correlated with glomerular lipid accumulation. Animal studies further confirmed the induction of CCDC92 in the kidney, particularly in podocytes, and the podocyte-specific deletion of Ccdc92 ameliorated podocyte injury and lipid deposition. CCDC92 was shown to promote podocyte lipotoxicity through ABCA1 signaling-mediated lipid homeostasis. Therefore, CCDC92 may serve as a potential biomarker of podocyte injury in DKD and targeting CCDC92 could be an innovative therapeutic strategy for DKD patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Khanyisani Ziqubu, Phiwayinkosi Dludla, Sihle E. Mabhida, Babalwa U. Jack, Susanne Keipert, Martin Jastroch, Sithandiwe E. Mazibuko-Mbeje
Summary: The discovery and revival of brown adipose tissue (BAT) in adult humans have opened up new possibilities for treating obesity and metabolic diseases. BAT not only plays a role in generating heat, but also secretes signaling molecules known as batokines, which regulate overall metabolism. This review highlights the importance of BAT-derived metabolites in controlling thermogenesis, substrate metabolism, and other biological processes, as well as their potential to alleviate obesity and related metabolic complications.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)