Review
Pharmacology & Pharmacy
Maoying Wei, Xingxing Liu, Mingdi Li, Xiaochan Tian, Mingyue Feng, Boxian Pang, Zeyang Fang, Junping Wei
Summary: Diabetic nephropathy (DN) is a common complication of diabetes mellitus and a major cause of end-stage renal disease in developed countries. Current clinical interventions for DN include lifestyle changes, blood glucose regulation, blood pressure reduction, lipid management, and avoiding nephrotoxic medications. However, many patients still progress to end-stage renal disease, highlighting the need for additional therapeutic strategies. The endoplasmic reticulum stress response has been implicated in the pathogenesis of DN, and Chinese herbal medicine has shown promise in regulating this stress. This review explores the involvement of endoplasmic reticulum stress in DN and the advancements in Chinese herbal medicine for its regulation, aiming to inspire new clinical strategies for the prevention and management of DN.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Environmental Sciences
Sallam K. Tony, Mohamed SH. Hassan, Hamadi A. Ismail, Gamal F. Abd El-Naem, Hanaa S. S. Gazwi
Summary: This study investigates the effects of blackberry juice on glucose metabolism, oxidative stress, inflammation, and endoplasmic reticulum stress in diabetic rats. The results showed that blackberry juice prevented weight loss and reduced food intake in diabetic rats. Additionally, it improved glucose metabolism, antioxidant status, and reduced ER stress and inflammation in diabetic rats.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Medicine, Research & Experimental
Maolin Zhu, Huiyang Wang, Jiawei Chen, Huang Zhu
Summary: The study showed that sinomenine nanoliposomes have therapeutic effects on nephropathy in diabetic rats by inhibiting oxidative stress, reducing renal cell apoptosis and fibrosis, and regulating the JAK2/STAT3/SOCS1 pathway to protect renal tissues.
Article
Medicine, Research & Experimental
Shuang Wei, Jianwu Fan, Xin Zhang, Yaping Jiang, Siliang Zeng, Xin Pan, Minjie Sheng, Yihui Chen
Summary: This study investigated the physiological and pathological changes in the corneas of diabetic rats by intervening in Sirt1 expression. It found that Sirt1 can regulate ERS activation and reduce corneal epithelial cell apoptosis under high glucose conditions.
Article
Cell Biology
Jinfei Yang, Li Li, Chenrui Li, Wei Chen, Yan Liu, Shilu Luo, Chanyue Zhao, Yachun Han, Ming Yang, Hao Zhao, Na Jiang, Yiyun Xi, Chengyuan Tang, Juan Cai, Li Xiao, Huafeng Liu, Lin Sun
Summary: In diabetic kidney disease (DKD), impaired ER-phagy of renal tubular cells worsens tubular injury. It has been found that the deficiency of PACS-2 aggravates tubular injury in DKD by inhibiting ER-phagy via the TFEB/FAM134B pathway.
CELL DEATH & DISEASE
(2023)
Article
Urology & Nephrology
Teng Liu, Yu-qing Jin, Qi Wang, Cong-hui Jia, Wei-yan Ren, Jia-yi Liu, Lei Yang, Hong-min Luo
Summary: IL-33/ST2 signaling pathway plays a role in mitigating renal damage in diabetic nephropathy (DN) by suppressing endoplasmic reticulum (ER) stress and apoptosis. IL-33 levels are increased in the kidneys of patients and mice with DN. Treatment with IL-33 attenuates kidney injury in streptozotocin (STZ)-treated mice and reduces ER stress and apoptosis in glomerular endothelial cells. However, sST2 treatment reverses these effects.
Article
Chemistry, Medicinal
Ling Guo, Bei Jiang, Dengren Li, Xiaoyan Xiao
Summary: Adropinin exhibited significant nephroprotective effects in STZ-induced diabetic nephropathy rats, primarily through anti-inflammatory and antioxidant pathways.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Andrology
Zheng Ruan, Haoran Wang, Keqin Zhang, Zhen Xu, Zhenjie Zang, Qiang Fu
Summary: The study found that Probucol improves erectile function in STZ-induced diabetic rats by reducing endothelial dysfunction and inhibiting the PERK/ATF4/CHOP pathway. In the probucol group, the expression of endoplasmic reticulum stress-related proteins decreased, while the levels of alpha-SMA and vWF increased. Additionally, the levels of Bax and Caspase3 were higher and Bcl-2 was lower in the diabetic group, but reversed in the probucol group.
Review
Immunology
Xiaokang Wang, Jingqian Zhao, Yuanqing Li, Jiaoyu Rao, Gengrui Xu
Summary: Proteinuria and nephrotic syndrome are symptoms of kidney diseases caused by direct or indirect damage to podocytes. Inflammation plays a crucial role in the development and progression of diabetic nephropathy, the leading cause of end-stage renal disease worldwide. The impact of podocyte damage on metabolic and inflammatory disorders has been documented. Epigenetic and endoplasmic reticulum stress are also observed in diabetic nephropathy. Targeting inflammation pathway and endoplasmic reticulum stress in podocytes may offer potential therapies to prevent the progression of diabetic nephropathy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Mona F. El-Azab, Ahmed A. Al-Karmalawy, Samar A. Antar, Pierre A. Hanna, Karim M. Tawfik, Reem M. Hazem
Summary: The study investigated the effects of nano selenium, sildenafil, and their combination on inflammation, oxidative stress, and apoptosis in streptozotocin-induced diabetic nephropathy in rats. The results showed that both nano selenium and sildenafil had beneficial effects on kidney function and histopathological changes, and these effects were supported by biochemical and molecular docking assays. The study highlighted the potential anti-inflammatory pathway of sildenafil as a high-mobility group box (HMGB1) inhibitor.
Article
Multidisciplinary Sciences
Lina Dong, Lei Yu, Aiqin Liu, Tahani Awad Alahmadi, Hesham S. Almoallim, Kaliannan Durairaj
Summary: The therapeutic properties of ononin against streptozotocin-challenged diabetic nephropathy (DN) in rats were investigated in this study. The results revealed that ononin significantly improved bodyweight and various renal function markers, reduced inflammatory and fibrosis factors, decreased ROS level, and enhanced antioxidant biomarkers in DN animals. Histological analysis further confirmed the therapeutic roles of ononin in protecting renal tissues against STZ-induced changes.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Environmental Sciences
Rami M. Mosaoa, Soonham S. Yaghmoor, Said S. Moselhy
Summary: This study investigated the antioxidant, anti-inflammatory, and antiglycation effects of pomegranate hexane extract (PHE) in diabetic rats. The results showed that PHE increased serum aldose reductase and total antioxidant activity, reduced the production of malondialdehyde (MDA), and inhibited the production of inflammatory factors in the diabetic rats. These findings suggest that pomegranate has potential as a functional biomolecule for the treatment and prevention of diabetic complications.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Endocrinology & Metabolism
Ming Yang, Chongbin Liu, Na Jiang, Yan Liu, Shilu Luo, Chenrui Li, Hao Zhao, Yachun Han, Wei Chen, Li Li, Li Xiao, Lin Sun
Summary: The endoplasmic reticulum (ER) is an active organelle involved in various physiological processes. Recent studies have shown that dysfunction of the ER plays a role in the progression of kidney disease, particularly diabetic nephropathy (DN). This review discusses the function of the ER, the regulation of homeostasis through the unfolded protein response (UPR) and ER-phagy, as well as the impact of abnormal ER homeostasis in renal cells in DN. Additionally, potential therapeutic targets for DN related to maintaining ER homeostasis are also explored.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shuqiang An, Yang Li, Xiaojing Jia, Yaqin Yang, Xiaojuan Jia, Xiaozhao Jia, Wujun Xue
Summary: The study demonstrated that ponicidin has therapeutic potential in ameliorating diabetic nephropathy by reducing oxidative stress, inflammation, and renal injury. Its benefits include weight reduction, improved blood glucose control, and modulation of lipid metabolism.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Environmental Sciences
Maryam A. Al-Ghamdi, Said S. Moselhy
Summary: Ferulic acid (FA) has anti-inflammatory, antioxidant, and antiglycation effects against streptozotocin-induced diabetic nephropathy. It reduces the release of inflammatory intermediates, improves kidney structure, and acts as a DPP4 inhibitor.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Endocrinology & Metabolism
Emilie Steinbach, Davide Masi, Agnes Ribeiro, Patricia Serradas, Tiphaine Le Roy, Karine Clement
Summary: The study of the gut microbiome is crucial for understanding and treating metabolic diseases. While research on the fecal microbiome has provided valuable insights, relying solely on this may not be enough to draw comprehensive conclusions. The microbiome in the proximal part of the small intestine may play a significant role in metabolic regulation, but further exploration is needed due to limited accessibility.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Evangelia Chavdoula, Vollter Anastas, Alessandro La Ferlita, Julian Aldana, Giuseppe Carota, Mariarita Spampinato, Burak Soysal, Ilaria Cosentini, Sameer Parashar, Anuvrat Sircar, Giovanni Nigita, Lalit Sehgal, Michael A. Freitas, Philip N. Tsichlis
Summary: This study reveals the important role of KDM2B in triple-negative breast cancer (TNBC). KDM2B affects cellular resistance to oxidative stress by regulating a network of genes and metabolic enzymes, in collaboration with ATF4 and MYC. Additionally, high expression of KDM2B is associated with poor prognosis in patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Joongmin Kim, Hyeongsoo Kim, Sang Hyun Park, Yura Kang, Kyungdo Han, Sang-Hak Lee
Summary: This study aimed to investigate the optimal LDL-C level after statin therapy in individuals with intermediate cardiovascular risk. The results showed that achieving LDL-C levels <120 mg/dL after statin therapy could lower the event risk.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Ze Chen, Li -Ping Xia, Lang Shen, Dan Xu, Yu Guo, Hui Wang
Summary: Accumulating evidence suggests that NAFLD has an intrauterine origin, with adverse prenatal environments and glucocorticoid exposure playing a crucial role in the developmental programming of fetal hepatic lipid metabolism. The offspring's glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis is programmed in utero, leading to postnatal catch-up growth and disrupted glucose and lipid metabolism, increasing susceptibility to NAFLD. Mismatch between intrauterine and postnatal environments can further disturb the programmed endocrine axes and accelerate the onset of NAFLD.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Fuwen Zuo, Youzhao Wang, Xinlei Xu, Ruihao Ding, Wei Tang, Yu Sun, Xiaojie Wang, Yan Zhang, Jichao Wu, Yusheng Xie, Min Liu, Ziying Wang, Fan Yi
Summary: This study investigates the role of CCDC92 in the pathogenesis of diabetic kidney disease (DKD). The expression of CCDC92 was found to increase in kidney biopsies from patients with DKD and was correlated with glomerular lipid accumulation. Animal studies further confirmed the induction of CCDC92 in the kidney, particularly in podocytes, and the podocyte-specific deletion of Ccdc92 ameliorated podocyte injury and lipid deposition. CCDC92 was shown to promote podocyte lipotoxicity through ABCA1 signaling-mediated lipid homeostasis. Therefore, CCDC92 may serve as a potential biomarker of podocyte injury in DKD and targeting CCDC92 could be an innovative therapeutic strategy for DKD patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Khanyisani Ziqubu, Phiwayinkosi Dludla, Sihle E. Mabhida, Babalwa U. Jack, Susanne Keipert, Martin Jastroch, Sithandiwe E. Mazibuko-Mbeje
Summary: The discovery and revival of brown adipose tissue (BAT) in adult humans have opened up new possibilities for treating obesity and metabolic diseases. BAT not only plays a role in generating heat, but also secretes signaling molecules known as batokines, which regulate overall metabolism. This review highlights the importance of BAT-derived metabolites in controlling thermogenesis, substrate metabolism, and other biological processes, as well as their potential to alleviate obesity and related metabolic complications.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)