Article
Cardiac & Cardiovascular Systems
A. M. Wegeberg, T. Okdahl, S. Riahi, N. Ejskjaer, F. Pociot, J. Storling, B. Brock, C. Brock
Summary: This study found that increased serum levels of IL-12/IL-23p40 and ICAM-1 were associated with decreased heart rate variability in type 2 diabetes patients, while VEGF-C levels were related to response to standing. The results suggest significant associations between neurocardiac regulation and serum markers, indicating potential systemic changes in inflammation, endothelial, and lymphatic function that collectively impact cardiovascular function. Further exploration of IL-12/IL-23p40, ICAM-1, and VEGF-C as cardiovascular biomarkers in type 2 diabetes is warranted for potential improvement in patient care strategies.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Oncology
Hansong Lee, Ji-Young Joo, Jae-Min Song, Hyun-Joo Kim, Yun Hak Kim, Hae Ryoun Park
Summary: Type 2 diabetes mellitus impairs the effector function and differentiation of T/NK cells. The RESISTIN pathway is a risk factor that makes periodontitis a precursor to type 2 diabetes mellitus.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Meiming Su, Wenqi Zhao, Suowen Xu, Jianping Weng
Summary: Diabetes mellitus (DM) is a common chronic disease with significant complications. Resveratrol, a plant-derived compound, has shown protective effects against diabetes and its cardiovascular complications. These effects are mediated through various signaling pathways.
Article
Cell Biology
Yuzhou Guo, Guangyao Wang, Jing Jing, Anxin Wang, Xiaoli Zhang, Xia Meng, Xingquan Zhao, Liping Liu, Hao Li, David Wang, Yongjun Wang, Yilong Wang
Summary: This study aimed to evaluate the risk of stroke recurrence among different types of diabetes patients and patients with stress hyperglycemia after minor stroke or TIA. The results showed that compared with diagnosed diabetes, patients with newly diagnosed diabetes-related hyperglycemia had a similar risk of stroke recurrence, while patients with stress hyperglycemia had a significantly increased risk of stroke recurrence.
Article
Endocrinology & Metabolism
Xinmei Huang, Bingbing Zha, Manna Zhang, Yue Li, Yueyue Wu, Rui Zhang, Li Sheng, Jiong Xu, Zhiyan Yu, Cuijun Gao, Zaoping Chen, Heyuan Ding, Ling Ma, Yanquan Zhang, Shufei Zang, Tie-Ning Zhang, Jun Liu
Summary: The study found that decreased monocyte count throughout pregnancy was closely associated with the development of gestational diabetes mellitus (GDM), macrosomia, and the chronic inflammatory state of GDM. First-trimester monocyte count performed better as a risk factor and diagnostic predictor of GDM and macrosomia compared to second and third trimester counts.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Clementine E. M. Verhulst, Julia I. P. van Heck, Therese W. Fabricius, Rinke Stienstra, Steven Teerenstra, Rory J. McCrimmon, Cees J. Tack, Ulrik Pedersen-Bjergaard, Bastiaan E. de Galan
Summary: Iatrogenic hypoglycemia activates the immune system and is associated with an increased risk of atherosclerotic disease. The study found that hypoglycemia induces a sustained inflammatory response at the cellular and protein level, which is present in both individuals with type 2 diabetes and control subjects.
Article
Endocrinology & Metabolism
Tingting Han, Ting Yuan, Xinyue Liang, Ningxin Chen, Jia Song, Xin Zhao, Yurong Weng, Yaomin Hu
Summary: This study examined the association between body composition and insulin resistance in elderly patients with type 2 diabetes mellitus. The results showed that elderly patients with both low muscle mass and high body fat had the most severe degree and highest risk of insulin resistance.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Nutrition & Dietetics
Hye-Yoom Kim, Jung-Joo Yoon, Hyeon-Kyoung Lee, Ai-Lin Tai, Yun-Jung Lee, Dae-Sung Kim, Dae-Gill Kang, Ho-Sub Lee
Summary: The study demonstrated that Bla.C extract effectively prevented diabetes-induced cardiovascular complications by reducing inflammation and cardiovascular fibrosis, and improving blood glucose metabolism.
Article
Endocrinology & Metabolism
Xinmei Huang, Yue Li, Xiaoxu Tong, Yueyue Wu, Rui Zhang, Li Sheng, Jiong Xu, Zhiyan Yu, Zaoping Chen, Tiange Sun, Fang Wang, Qian Yang, Zhangyan Li, Cuijun Gao, Ling Ma, Heyuan Ding, Shufei Zang, Ni Yang, Tie-Ning Zhang, Jun Liu
Summary: Increased circulating IL-32 throughout pregnancy is closely associated with placenta macrophage-derived IL-32 expression and GDM. First trimester IL-32 level in peripheral blood may serve to predict the development of GDM.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Integrative & Complementary Medicine
Jianhua Li, Lin Lu, Xinping Xie, Xiaofeng Dai, Shan Zheng, Lihong Chen
Summary: This study identified 41 serum proteins with differential expression between pregnant women with GDM and healthy pregnant women, providing new candidate molecules for elucidating GDM pathogenesis and screening therapeutic targets. The differentially expressed proteins are involved in multiple biological processes and signaling pathways related to lipid metabolism, glycan degradation, immune response, and platelet aggregation, as revealed by bioinformatics analysis. The subsequent PRM assay validated the expression levels of 12 out of 41 differentially expressed proteins, confirming the findings.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Endocrinology & Metabolism
Shanhu Qiu, Xue Cai, Bo Xie, Yang Yuan, Zilin Sun, Tongzhi Wu
Summary: This study found that a high normalized creatinine-to-cystatin C ratio is associated with a reduced risk of diabetes in middle-aged and older adults. Muscle strength plays a moderating role in this relationship. The risk reduction in diabetes is more significant in individuals with normal weight and a high normalized creatinine-to-cystatin C ratio. Insulin resistance and inflammation are key mediators accounting for the observed relationship between the ratio and diabetes risk.
DIABETES & METABOLISM JOURNAL
(2022)
Article
Multidisciplinary Sciences
Shaza B. Zaghlool, Anna Halama, Nisha Stephan, Valborg Gudmundsdottir, Vilmundur Gudnason, Lori L. Jennings, Manonanthini Thangam, Emma Ahlqvist, Rayaz A. Malik, Omar M. E. Albagha, Karsten Suhre, Abdul Badi Abou-Samra
Summary: This study translates T2D subtypes previously identified in European individuals to an Arab population and identifies specific metabolic and proteomic signatures for each subtype, providing further understanding of the pathogenesis of these subtypes.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Colm J. McElwain, Fergus P. McCarthy, Cathal M. McCarthy
Summary: Gestational diabetes mellitus is a pregnancy complication that can lead to maternal hyperglycemia and immune dysregulation, impacting fetal health and increasing the risk of developing diabetes. Understanding the origins and evolution of these pathways is crucial for improving therapeutic interventions and outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Poorani Rengachar, Sailaja Polavarapu, Undurti N. Das
Summary: Our previous studies have identified certain endogenous low molecular weight lipids, particularly arachidonic acid (AA) and lipoxin A4 (LXA4), as potent anti-diabetic molecules. In addition to LXA4, protectin DX also exhibited similar anti-diabetic actions. Protectin DX prevented the development of type 1 and type 2 diabetes in mice and showed anti-inflammatory, antioxidant, and anti-apoptotic actions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Jisun Bang, Sang Ah Lee, Gwanpyo Koh, Soyeon Yoo
Summary: This study investigated the association between glucagon to insulin ratio and metabolic syndrome in patients with type 2 diabetes. The results showed that the fasting glucagon to insulin ratio was inversely associated with metabolic syndrome, indicating a higher risk of metabolic syndrome with lower fasting glucagon to insulin ratio.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Endocrinology & Metabolism
Min-Kyung Lee, Kyungdo Han, Hyuk-Sang Kwon
Article
Endocrinology & Metabolism
Ji-Yeon Park, Kyungdo Han, Hun-Sung Kim, Jae-Hyoung Cho, Kun-Ho Yoon, Mee Kyoung Kim, Seung-Hwan Lee
Summary: This study found a linear relationship between cumulative exposure to high gamma-GTP level and risk of diabetes, suggesting that monitoring and lowering gamma-GTP level should be considered for prevention of diabetes in the general population.
ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Endocrinology & Metabolism
Jinyoung Kim, Jeonghoon Ha, Chaiho Jeong, Jeongmin Lee, Yejee Lim, Kwanhoon Jo, Mee Kyoung Kim, Hyuk-Sang Kwon, Ki-Ho Song, Ki-Hyun Baek
Summary: This study investigated the relationship between lipid profiles and bone mineral density (BMD) in older adults. The results showed a significant inverse association between serum triglycerides and BMD, and this relationship is thought to correlate with vitamin D status among older adults.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Hyunah Kim, Da Young Jung, Seung-Hwan Lee, Jae-Hyoung Cho, Hyeon Woo Yim, Hun-Sung Kim
Summary: This study examined the relationship between glycemic control and cardiovascular disease risk in patients with type 2 diabetes. The results suggest that controlling glucose levels during early diabetes may be more important than reducing glycemic variability.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Gastroenterology & Hepatology
Han Hee Lee, Kyu-na Lee, Jin Su Kim, Dae Young Cheung, Hyuk-Sang Kwon, Bo-In Lee, Young-Seok Cho, Soo-Heon Park, Kyungdo Han, Jin Il Kim
Summary: This study investigated the association between changes in physical activity status and the development of colorectal cancer in patients with diabetes. The results showed that patients with diabetes who remained physically active had the lowest risk of developing colorectal cancer, while those who changed from inactive to active also had a reduced risk.
COLORECTAL DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Oak-Kee Hong, Eun Sook Kim, Jang-Won Son, Sung-Rae Kim, Soon Jib Yoo, Hyuk-Sang Kwon, Seong-Su Lee
Summary: Alcohol consumption exacerbates liver abnormalities and induces liver injury in early diabetic or prediabetic rats. However, the response to alcohol differs between prediabetic and diabetic rats. In prediabetic rats, alcohol induced liver steatosis and hepatitis, but had mild effects on inflammation.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Editorial Material
Endocrinology & Metabolism
Jin Yu, Jae-Hyoung Cho, Seung-Hwan Lee
JOURNAL OF DIABETES INVESTIGATION
(2023)
Article
Medicine, General & Internal
Jinyoung Kim, Kyungdo Han, Mee Kyoung Kim, Ki-Hyun Baek, Ki-Ho Song, Hyuk-Sang Kwon
Summary: Despite a similar examination rate, there has been a re-increasing trend in thyroid cancer since 2015, especially among young adults. A study using data from the Korean National Health Insurance Service found that cumulative exposure to metabolic syndrome was associated with an increased risk of thyroid cancer in young adults. The risk increased with the number of diagnoses of metabolic syndrome across multiple health examinations.
KOREAN JOURNAL OF INTERNAL MEDICINE
(2023)
Letter
Endocrinology & Metabolism
Se-Won Lee, Kyungdo Han, Hyuk-Sang Kwon
DIABETES & METABOLISM JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Hee Yeon Lee, Kyung-Do Han, In Sook Woo, Hyuk-Sang Kwon
Summary: The aim of this study was to determine the association of metabolic syndrome (MetS) with kidney cancer and the impact of age and gender on such an association. The study used the Korean National Health Insurance Service database to follow up 9,932,670 subjects who had check-ups in 2009 until the diagnosis of kidney cancer or death or until 2019. The results showed that kidney cancer was significantly associated with MetS, with a higher association in younger age groups and higher associations with obesity and central obesity in younger aged male population.
Article
Endocrinology & Metabolism
Seung-Hwan Lee, Jin Yu, Kyungdo Han, Seung Woo Lee, Sang Youn You, Hun -Sung Kim, Jae-Hyoung Cho, Kun-Ho Yoon, Mee Kyoung Kim
Summary: A risk model for predicting insulin-requiring GDM before pregnancy in Korean women was developed using data from 417,210 women. Six risk factors were identified and incorporated into a risk nomogram. The model showed a concordance index of 0.783, indicating its accuracy in predicting insulin-requiring GDM.
ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Endocrinology & Metabolism
Jin Hwa Kim, Young Sang Lyu, Mee Kyoung Kim, Sang Yong Kim, Ki-Hyun Baek, Ki-Ho Song, Kyungdo Han, Hyuk-Sang Kwon
Summary: This study found that repeated detection of non-alcoholic fatty liver disease (NAFLD) increases the risk of type 2 diabetes in young adults, and the risk increases with the number of repeated detections.
DIABETES OBESITY & METABOLISM
(2023)
Editorial Material
Endocrinology & Metabolism
Seung-Hwan Lee
DIABETES & METABOLISM JOURNAL
(2023)
Editorial Material
Endocrinology & Metabolism
Seung-Hwan Lee
ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Endocrinology & Metabolism
Jinyoung Kim, Bongseong Kim, Mee Kyoung Kim, Ki-Hyun Baek, Ki-Ho Song, Kyungdo Han, Hyuk-Sang Kwon
Summary: This study aimed to investigate the association between weight change and diabetes remission in patients with new-onset type 2 diabetes mellitus. The study found that weight loss within the first 2 years of treating type 2 diabetes was associated with diabetes remission, and the likelihood of remission increased with greater weight loss. Physicians should pay more attention to weight management, particularly for young and obese individuals with new-onset type 2 diabetes.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Emilie Steinbach, Davide Masi, Agnes Ribeiro, Patricia Serradas, Tiphaine Le Roy, Karine Clement
Summary: The study of the gut microbiome is crucial for understanding and treating metabolic diseases. While research on the fecal microbiome has provided valuable insights, relying solely on this may not be enough to draw comprehensive conclusions. The microbiome in the proximal part of the small intestine may play a significant role in metabolic regulation, but further exploration is needed due to limited accessibility.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Evangelia Chavdoula, Vollter Anastas, Alessandro La Ferlita, Julian Aldana, Giuseppe Carota, Mariarita Spampinato, Burak Soysal, Ilaria Cosentini, Sameer Parashar, Anuvrat Sircar, Giovanni Nigita, Lalit Sehgal, Michael A. Freitas, Philip N. Tsichlis
Summary: This study reveals the important role of KDM2B in triple-negative breast cancer (TNBC). KDM2B affects cellular resistance to oxidative stress by regulating a network of genes and metabolic enzymes, in collaboration with ATF4 and MYC. Additionally, high expression of KDM2B is associated with poor prognosis in patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Joongmin Kim, Hyeongsoo Kim, Sang Hyun Park, Yura Kang, Kyungdo Han, Sang-Hak Lee
Summary: This study aimed to investigate the optimal LDL-C level after statin therapy in individuals with intermediate cardiovascular risk. The results showed that achieving LDL-C levels <120 mg/dL after statin therapy could lower the event risk.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Ze Chen, Li -Ping Xia, Lang Shen, Dan Xu, Yu Guo, Hui Wang
Summary: Accumulating evidence suggests that NAFLD has an intrauterine origin, with adverse prenatal environments and glucocorticoid exposure playing a crucial role in the developmental programming of fetal hepatic lipid metabolism. The offspring's glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis is programmed in utero, leading to postnatal catch-up growth and disrupted glucose and lipid metabolism, increasing susceptibility to NAFLD. Mismatch between intrauterine and postnatal environments can further disturb the programmed endocrine axes and accelerate the onset of NAFLD.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Fuwen Zuo, Youzhao Wang, Xinlei Xu, Ruihao Ding, Wei Tang, Yu Sun, Xiaojie Wang, Yan Zhang, Jichao Wu, Yusheng Xie, Min Liu, Ziying Wang, Fan Yi
Summary: This study investigates the role of CCDC92 in the pathogenesis of diabetic kidney disease (DKD). The expression of CCDC92 was found to increase in kidney biopsies from patients with DKD and was correlated with glomerular lipid accumulation. Animal studies further confirmed the induction of CCDC92 in the kidney, particularly in podocytes, and the podocyte-specific deletion of Ccdc92 ameliorated podocyte injury and lipid deposition. CCDC92 was shown to promote podocyte lipotoxicity through ABCA1 signaling-mediated lipid homeostasis. Therefore, CCDC92 may serve as a potential biomarker of podocyte injury in DKD and targeting CCDC92 could be an innovative therapeutic strategy for DKD patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Khanyisani Ziqubu, Phiwayinkosi Dludla, Sihle E. Mabhida, Babalwa U. Jack, Susanne Keipert, Martin Jastroch, Sithandiwe E. Mazibuko-Mbeje
Summary: The discovery and revival of brown adipose tissue (BAT) in adult humans have opened up new possibilities for treating obesity and metabolic diseases. BAT not only plays a role in generating heat, but also secretes signaling molecules known as batokines, which regulate overall metabolism. This review highlights the importance of BAT-derived metabolites in controlling thermogenesis, substrate metabolism, and other biological processes, as well as their potential to alleviate obesity and related metabolic complications.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
