Review
Chemistry, Multidisciplinary
Mike Jeon, Mackenzie Halbert, Zachary R. Stephen, Miqin Zhang
Summary: Gadolinium-based chelates are commonly used contrast agents for MRI, but their toxicity and potential retention in patients' bodies have raised safety concerns. Iron oxide nanoparticles have emerged as a promising alternative due to their non-toxic and biodegradable nature, but their development as T-1 contrast agents is complex and challenging. Progress is being made in exploring IONPs as safe and improved alternatives, but there are still many hurdles to overcome before they can be used clinically.
ADVANCED MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Shengxiang Fu, Zhongyuan Cai, Li Liu, Xiaomin Fu, Changqiang Wu, Liang Du, Chunchao Xia, Su Lui, Qiyong Gong, Bin Song, Hua Ai
Summary: Compared to traditional branched polymers, branched polymers with Gd(III) chelates as the internal skeleton show higher kinetic stability and better relaxivity enhancement for MRI contrast agents. Different poly-DOTA branched polymers were synthesized and the Gd(III) chelates displayed excellent stability and high T1 relaxivities. In vivo studies showed that P4-Gd had the best performance in terms of MRA effect, vascular stenosis detection, and longer observation window compared to Gd-DOTA. Overall, poly-DOTA branched polymers with Gd(III) chelates are promising candidates for MRI probes with improved relaxivity enhancement.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Chemistry, Physical
Huan Zhang, Xiao Li Liu, Hai Ming Fan
Summary: Magnetic resonance imaging (MRI) has revolutionized medical imaging diagnostics. However, the clinical use of Gd-based contrast agents (CAs) still has limitations, making the development of magnetic nanoparticle-based CAs a promising avenue for research.
Article
Biotechnology & Applied Microbiology
Xiaoming Wang, Shiwei Guo, Zhiqian Li, Qiang Luo, Yan Dai, Hu Zhang, Yun Ye, Qiyong Gong, Kui Luo
Summary: The concept of non-metallic MRI contrast agents has emerged to address the potential toxicity of metal-based contrast agents. Paramagnetic nitroxides are being studied for their stability and imaging mechanisms similar to metal-based agents, with the challenge of lower relaxivity and rapid in vivo metabolism. Macromolecular nitroxides contrast agents have been shown to increase stability and improve water relaxation, with the potential for expanding application in tumor, liver, kidney, and cardiovascular imaging.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Shi-Hui Chen, Lu-Yao Huang, Biao Huang, Mingxi Zhang, Hao Li, Dai-Wen Pang, Zhi-Ling Zhang, Ran Cui
Summary: This study synthesizes ultrasmall MnSe nanoparticles and demonstrates their potential as T-1-MRI contrast agents for clinical tumor imaging. The nanoparticles exhibit high relaxivity and a long MRI acquisition window, while also showing no appreciable toxicity to cells and organisms.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Nanoscience & Nanotechnology
Ghazaleh Jamalipour Soufi, Ali Hekmatnia, Siavash Iravani, Rajender S. Varma
Summary: Magnetic resonance imaging (MRI) is a widely used noninvasive clinical imaging modality in bio- and nanomedicine, especially for tumor detection and high-quality three-dimensional imaging. The design of efficient nanoscale contrast agents (NCAs) is crucial for specific detection and imaging of tumors. However, there are still challenges to be addressed in the clinical applications of these agents, including nanotoxicology and biosafety issues.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Physical
Haiyang Jia, Fen Zhang, Chen Zhu, Jiawei Sun, Xiao Xie
Summary: This study synthesized amino-grafted ferromagnetic nanoparticles with highly stable dispersion using deep-eutectic-solvent electrolysis, and successfully applied them in magnetic resonance imaging. These nanoparticles exhibited high biocompatibility and had high longitudinal and transverse relaxation efficiencies, enabling prominent weighted imaging of T1 and T2 of the liver, as well as significant distinction between normal tissue and liver tumors.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Nanoscience & Nanotechnology
Tingting Zhang, Zhijie Wang, Huijing Xiang, Xue Xu, Jing Zou, Chichong Lu
Summary: This study successfully synthesized water-soluble and biocompatible EuIO NCs with enhanced contrast enhancement in MRI, as well as functionalized EuIO NCs exhibiting excellent fluorescence imaging performance in vivo. The research provides a simple strategy for the design and construction of a novel multifunctional magnetic nanoplatform, offering solutions for the development of multimodal imaging probes and disease diagnosis.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Medicine, Research & Experimental
Beatriz Brito, Thomas W. Price, Juan Gallo, Manuel Banobre-Lopez, Graeme J. Stasiuk
Summary: This review introduces smart theranostics that integrate multiple functions, especially responsive agents for MRI, aiming to improve cancer therapy efficiency and diagnostic accuracy. The challenges and obstacles in the design and application are also discussed.
Article
Engineering, Biomedical
Gary Stinnett, Nasim Taheri, Jake Villanova, Arash Bohloul, Xiaoting Guo, Edward P. Esposito, Zhen Xiao, Deanna Stueber, Carolina Avendano, Paolo Decuzzi, Robia G. Pautler, Vicki L. Colvin
Summary: This study introduces shape-engineered plate-like nanocrystals with sulfonated surface polymers that promote second-sphere relaxation processes, providing remarkable contrast even at high fields. These noncytotoxic materials release no detectable free Gadolinium even under mild acidic conditions, and have a circulation half-life in the liver 50% longer than commercial agents. These features enable the first-time application of T-1 MRI contrast agents to the ex vivo detection of nonalcoholic fatty liver disease in mice.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Organic
Anfeng Li, Xingxing Peng, Mou Jiang, Tingjuan Wu, Kexin Chen, Zhigang Yang, Shizhen Chen, Xin Zhou, Xing Zheng, Zhong-Xing Jiang
Summary: This research synthesized a series of tetra-trifluoromethylated aza-boron dipyrromethenes and systematically studied their physicochemical properties. It identified one compound with 12 symmetrical fluorines as a dual-imaging photosensitizer for photodynamic therapy.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Review
Nanoscience & Nanotechnology
Can Chen, Jianxian Ge, Yun Gao, Lei Chen, Jiabin Cui, Jianfeng Zeng, Mingyuan Gao
Summary: USPIO nanoparticles, with their excellent MRI performance and remarkable biosafety profile, have shown considerable applications in developing T-1 contrast agents and T-2/T-1 switchable contrast agents, and have been widely used in the diagnosis of vascular pathological changes, inflammations, and malignant tumors.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Inorganic & Nuclear
Camille Gosee, Juliette Moreau, Cyril Cadiou, Maite Callewaert, Celine Henoumont, Lionel Larbanoix, Michael Molinari, Sorina N. Voicu, Christophe Portefaix, Sophie Laurent, Francoise Chuburu
Summary: The challenge of imaging is to combine resolution and sensitivity in order to gain accuracy in diagnosis. No single modality can provide comprehensive information. Then, the solution is to design probes that are able to gather on a single platform the best features of the different imaging modalities. To achieve this objective, we have combined two types of probes, one associated with photoacoustic imaging (PAI) and the other with magnetic resonance imaging (MRI), within polysaccharide-based nanohydrogels.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Inorganic & Nuclear
Camille Gosee, Juliette Moreau, Cyril Cadiou, Maite Callewaert, Celine Henoumont, Lionel Larbanoix, Michael Molinari, Sorina N. Voicu, Christophe Portefaix, Sophie Laurent, Francoise Chuburu
Summary: The challenge in imaging is to achieve accurate diagnosis by combining resolution and sensitivity. To overcome the limitations of single modality imaging, a solution is to design probes that combine the best features of different imaging modalities. In this study, we successfully combined photoacoustic imaging and magnetic resonance imaging within polysaccharide-based nanohydrogels to create an 'all in one' bimodal imaging system. The nanohydrogels showed significant signals in both MSOT and MRI experiments, demonstrating their potential for accurate imaging.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Multidisciplinary
Xiaoqing Wei, Dan Mu, Yingping Li, Jingya Zhao, Shaobing Zhou
Summary: Researchers have developed a magnetic exosome that responds to bacteria associated with tumors, enabling sensitive tumor imaging. The magnetic exosome can rapidly respond in the tumor microenvironment and release iron oxide nanoparticles for dynamic MRI of tumors. After MRI, the iron oxide nanoparticles can be eliminated through renal clearance to avoid potential toxicity.
Article
Computer Science, Interdisciplinary Applications
Viktor Puchnin, Viacheslav Ivanov, Mikhail Gulyaev, Yury Pirogov, Mikhail Zubkov
Summary: This paper presents the initial experimental investigation of a two-coil receive/transmit design for small animal imaging at 7T MRI. The system uses a butterfly-type coil for scanning H-1 nuclei and a non-resonant loop antenna with a metamaterial-inspired resonator for X-nuclei. Simulation and experimental results show that the system has sufficiently homogeneous RF fields and tuning capabilities.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2022)
Article
Physics, Multidisciplinary
D. S. Farrakhova, I. D. Romanishkin, D. Yakovlev, Yu S. Maklygina, T. A. Savelieva, L. Bezdetnaya, V. B. Loschenov
Summary: Spectroscopic approaches are useful for noninvasively determining important indicators of tissue state. Investigation of indocyanine green nanoparticles stability in human blood and plasma reveals that its transition to monomeric form results in increased circulation time, potentially enhancing fluorescent diagnosis of near-tumor tissues.
PHYSICS OF WAVE PHENOMENA
(2022)
Article
Chemistry, Multidisciplinary
Mariya S. Kopyeva, Serafima A. Filatova, Vladimir A. Kamynin, Anton Trikshev, Elizaveta Kozlikina, Vadim V. Astashov, Victor B. Loschenov, Vladimir B. Tsvetkov
Summary: In this study, the effects of ultrafast all-fiber Holmium laser system on porcine longissimus muscle tissues were investigated through ex vivo experiments with different exposure times. The results showed that ultrafast pulsed radiation led to destructive changes and ablation formation in the tissue, while continuous-wave radiation only caused tissue heating without ablation and coagulation traces. The ablation efficiency of ultrafast pulsed radiation was approximately 28%.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Analytical
Daria Pominova, Igor Romanishkin, Vera Proydakova, Sergei Kuznetsov, Pavel Grachev, Anastasia Ryabova, Natalya Tabachkova, Pavel Fedorov, Victor Loschenov
Summary: This study analyzed the effect of synthesis temperature on the efficiency and luminescence decay of beta-NaGd0.78Yb0.20Er0.02F4 upconversion nanoparticles. The results showed that synthesis temperature had a significant influence on the upconversion luminescence efficiency and decay time. Using the maximum entropy method for luminescence decay kinetics processing allowed for the evaluation of different distributions of rare-earth ions under different conditions.
METHODS AND APPLICATIONS IN FLUORESCENCE
(2022)
Article
Biochemistry & Molecular Biology
Olga A. Averina, Oleg A. Permyakov, Mariia A. Emelianova, Olga O. Grigoryeva, Mikhail Gulyaev, Olga S. Pavlova, Sofia S. Mariasina, Olga Yu Frolova, Marina Kurkina, Galina Baydakova, Ekaterina Yu Zakharova, Maria Marey, Dmitry A. Tsarev, Vadim N. Tashlitsky, Vladimir S. Popov, Maxim L. Lovat, Vladimir I. Polshakov, Mikhail Yu Vyssokikh, Petr Sergiev
Summary: Mitoregulin (Mtln) is a mitochondrial peptide that enhances the function of respiratory complex I by modulating lipid composition. Knockout mice deficient in Mtln gene showed obesity on a high fat diet, which was attributed to enhanced fat accumulation based on magnetic resonance imaging. In addition, these mice exhibited elevated serum triglycerides, exhaustion of tricarboxylic acids cycle intermediates, and suboptimal oxidation of respiration substrates by mitochondria lacking Mtln.
Article
Biophysics
Roman A. Barmin, Elizaveta A. Maksimova, Polina G. Rudakovskaya, Alexey Gayer, Evgeny A. Shirshin, Kirill S. Petrov, Daria A. Terentyeva, Olga Gusliakova, Olga A. Sindeeva, Oleg A. Klimenko, Roman N. Chuprov-Netochin, Alexander A. Solovev, Gaoshan Huang, Anastasia Ryabova, Victor B. Loschenov, Dmitry A. Gorin
Summary: Gas-liquid interfaces have gained interest in biomedicine, particularly in the use of microbubbles as theranostic platforms. In this study, two commercially available photosensitizers were conjugated to bovine serum albumin before microbubble synthesis to enhance photodynamic therapy. The conjugates increased microbubble concentration and stability compared to plain microbubbles. Agents based on one of the photosensitizers demonstrated higher photodynamic activity and microbubbles showed acoustic stability in human blood plasma. The study concludes that these microbubble platforms have potential for further applications in photodynamic therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Oncology
Evgeniya A. Kogan, Gennady A. Meerovich, Saida Sh. Karshieva, Elena A. Makarova, Igor D. Romanishkin, Ekaterina V. Akhlyustina, Irina G. Meerovich, Nikolai V. Zharkov, Tatiana A. Demura, Zhi-Long Chen, Elizaveta V. Koudan, Ivan P. Angelov, Victor B. Loschenov
Summary: Photosensitizers based on polycationic derivatives of synthetic bacteriochlorin show significant therapeutic effects against A549 lung cancer cells. These photosensitizers induce cell necrosis, apoptosis, reduce the number of cancer cells with stem cell characteristics, and decrease mitotic and proliferative activity.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Chemistry, Multidisciplinary
Dmitry Yakovlev, Ekaterina Kolesova, Svetlana Sizova, Kirill Annas, Marina Tretyak, Victor Loschenov, Anna Orlova, Vladimir Oleinikov
Summary: Fluorescent diagnostics and photodynamic therapy are promising methods for diagnosing and treating oncological diseases. In our study, we conjugated photosensitizers with triple quantum dots to enhance the luminescence response. The efficiency of the energy transfer depends on the ratio of the photosensitizers and quantum dots.
Article
Oncology
Igor Romanishkin, Tatiana Savelieva, Alexandra Kosyrkova, Vladimir Okhlopkov, Svetlana Shugai, Arseniy Orlov, Alexander Kravchuk, Sergey Goryaynov, Denis Golbin, Galina Pavlova, Igor Pronin, Victor Loschenov
Summary: The study analyzed the Raman spectra of human brain glioblastoma multiforme tissue samples and proposed a new technique combining feature filtering and principal component analysis for dimensionality reduction. The support vector machine was applied for tissue classification, achieving high accuracy and sensitivity.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Vladimir Makarov, Daria Pominova, Anastasiya Ryabova, Igor D. Romanishkin, Arina V. Voitova, Rudolf W. Steiner, Victor B. Loschenov
Summary: The study focuses on the biomedical applications of phthalocyanine nanoparticles (AlPc NPs) as nanophotosensitizers. The research discovers that AlPc NPs can enter cells, localize in lysosomes, exhibit fluorescence, and achieve photodynamic therapy.
Article
Radiology, Nuclear Medicine & Medical Imaging
Olga S. Pavlova, Mikhail V. Gulyaev, Lev L. Gervits, Anna A. Hurshkainen, Anton V. Nikulin, Viktor M. Puchnin, Ekaterina D. Teploukhova, Tatyana A. Kuropatkina, Nikolay V. Anisimov, Nataliya A. Medvedeva, Yury A. Pirogov
Summary: The feasibility of using octafluorocyclobutane (OFCB) for T-1 mapping of lungs in F-19 MRI was demonstrated in this study. The study was conducted on healthy rats and rats with pulmonary hypertension using a bent-shaped RF coil with periodic metal strips structure to increase the sensitivity of F-19 MRI. The results showed that T-1 of OFCB was linearly dependent on its partial pressure in mixtures with different gases.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Chemistry, Medicinal
Lev L. Gervits, Andrey L. Sigan, Alina A. Markova, Mikhail V. Gulyaev, Olga S. Pavlova, Ratislav M. Ozhiganov, Yury A. Pirogov
Summary: F-19 MRI is a radiation-free technique for tracking and quantifying indicators in vivo. New F-19-MRI labels were developed, which showed high contrast properties and good biological inertness. These compounds, 1,2-bis(perfluoro-tert-butoxy)ethane and 1,3-bis(perfluoro-tert-butyl)propane, demonstrated promise for use in F-19 MRI applications.
Article
Biotechnology & Applied Microbiology
Elizaveta Kozlikina, Igor S. Trifonov, Mikhail Sinkin, Vladimir V. Krylov, Victor B. Loschenov
Summary: The treatment of glial brain tumors is a challenging problem in neuro-oncology. This case report demonstrates the potential of using a combination of two photosensitizers for fluorescence-guided resection and photodynamic therapy to achieve total tumor removal and additional treatment.
BIOENGINEERING-BASEL
(2022)
Article
Biotechnology & Applied Microbiology
Elizaveta I. Kozlikina, Kanamat T. Efendiev, Andrey Yu. Grigoriev, Olesia Y. Bogdanova, Igor S. Trifonov, Vladimir V. Krylov, Victor B. Loschenov
Summary: This paper presents the use of fluorescence diagnostics in the resection of pituitary adenomas. The study used chlorin e6 photosensitizer and a two-channel video system to detect high concentrations of chlorin e6 accumulation in tumor tissues, leading to a high degree of tumor resection.
BIOENGINEERING-BASEL
(2022)
