Article
Clinical Neurology
Jiaxiong Wang, Hanqiang Jiang, Jinwei Tang, Chi Lin, Wei Ni, Yuxiang Gu
Summary: This study analyzed the causes and risk factors for postoperative cerebral infarction in patients with moyamoya disease (MMD) undergoing surgical revascularization. The results showed that initial presentation as infarction and first revascularization surgery performed on the left hemisphere were independent risk factors for postoperative cerebral infarction, while initial presentation as hemorrhage was a protective factor.
FRONTIERS IN NEUROLOGY
(2022)
Article
Oncology
T. O. S. H. M. I. T. S. U. TANAKA, H. I. R. O. Y. U. K. I. SUZUKI, K. E. I. S. U. K. E. MIWA, T. O. M. O. Y. U. K. I. USHIJIMA, S. A. C. H. I. K. O. NAGASU, M. A. S. A. R. U. FUKAHORI, K. A. I. T. O. ISHII, T. O. R. U. NAKAMURA, H. I. D. E. K. I. IWAMOTO, A. T. S. U. T. A. K. A. MASUDA, T. A. K. A. H. I. K. O. SAKAUE, H. I. R. O. N. O. R. I. KOGA, Y. O. S. H. I. T. O. AKAGI, K. E. N. T. A. MUROTANI, T. A. K. U. J. I. TORIMURA
Summary: Trousseau syndrome-related cerebral infarction is rare during chemotherapy for gastrointestinal cancer, and hyperlipidemia may predict its occurrence.
Article
Medicine, General & Internal
Rosa Fores, Josep M. Manresa, Victor M. Lopez-Lifante, Antonio Heras, Pilar Delgado, Xose Vazquez, Susana Ruiz, Maria Teresa Alzamora, Pere Toran
Summary: This study aimed to analyze the role of artery-vein ratio (AVR) assessment using VesselMap 2 software and cardiovascular risk evaluation through REGICOR in predicting silent brain infarction (SBI) in middle-age hypertensive patients. The study found that AVR and REGICOR scores significantly impact the prediction of SBI in hypertensive patients.
Article
Medicine, General & Internal
David Suran, Tadej Zavrsnik, Peter Kokol, Marko Kokol, Andreja Sinkovic, Franjo Naji, Jernej Zavrsnik, Helena Blazun Vosner, Vojko Kanic
Summary: Lp(a) is a risk factor for ischemic heart disease and calcific aortic valve stenosis. A retrospective observational study found that Lp(a) was strongly associated with the risk of hospitalization for IHD and AVS in cardiovascular disease patients. Higher levels of Lp(a) increased the risk of IHD in women of all ages and in men aged <= 75 years, and the risk of AVS in women aged <= 75 years.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Jiaming Huang, Foqiang Liao, Jianhua Tang, Xu Shu
Summary: This study investigated the risk factors for gastrointestinal bleeding in patients with cerebral infarction after dual antiplatelet therapy. Cerebral infarction patients who received dual antiplatelet therapy between January 2019 and December 2021 in Nanchang University Affiliated Ganzhou Hospital were included. Propensity score matching was used to compare the bleeding and nonbleeding groups. Conditional logistic regression analysis identified long-term use of aspirin and severity of cerebral infarction as risk factors for gastrointestinal bleeding, while the use of PPIs was found to be a protective factor.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Article
Clinical Neurology
R. Sky Jones, Manus J. Donahue, L. Taylor Davis, Sumit Pruthi, Spencer L. Waddle, Chelsea Custer, Niral J. Patel, Michael R. DeBaun, Adetola A. Kassim, Mark Rodeghier, Lori C. Jordan
Summary: This study evaluated the reduction of gray matter volume (GMV) and white matter volume (WMV) in children and young adults with sickle cell disease (SCD) using high-resolution MRI. The results showed an association between anemia, low arterial oxygen content, and decreased GMV and WMV. Increased gray matter cerebral blood flow and infarct burden were also associated with reduced volume in subcortical structures. This highlights the potential of brain volume as a biomarker of brain injury in SCD.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Ji Man Hong, Mun Hee Choi, Geun Hwa Park, Hee Sun Shin, Seong-Joon Lee, Jin Soo Lee, Yong Cheol Lim
Summary: The efficacy and safety of cranial MBH procedures under local anesthesia for augmenting transdural revascularization after EPO treatment in stroke patients were investigated. Results showed that the combination of MBH and EPO significantly improved revascularization success and perfusion parameters.
Article
Clinical Neurology
Song Yu-Huan, Cai Guang-Yan, Xiao Yue-Fei
Summary: In patients undergoing hemodialysis, intracerebral hemorrhage (ICH) is the main cause of mortality among stroke subtypes. This study found that, in addition to traditional cardiovascular risk factors, factors unique to the uraemic environment, such as abnormal metabolism of intact parathyroid hormone (iPTH), may contribute to the risk of ICH. Higher systolic blood pressure and abnormal iPTH metabolism may be associated with ICH in patients undergoing hemodialysis.
FRONTIERS IN NEUROLOGY
(2023)
Article
Medicine, General & Internal
Peter Wohlfahrt, Dominik Jenca, Vojtech Melenovsky, Janka Franekova, Antonin Jabor, Marek Sramko, Vladimir Stanek, Michael Zelizko, Rudolf Poledne, Jan Pitha, Vera Adamkova, Josef Kautzner
Summary: This study found that both high and low concentrations of Lp(a) were associated with an increased risk of total mortality and recurrent cardiovascular events after MI. The association was partially weakened after adjusting for heart failure signs at the time of hospitalization.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Review
Endocrinology & Metabolism
Paul Nestel, Wann Jia Loh, Natalie C. Ward, Gerald F. Watts
Summary: The status of lipoprotein (a) as a cardiovascular risk factor has been confirmed by genetic studies. Measurement analysis and RNA therapy offer new directions for research and management of this disease. In addition, further research is needed on the increased risk of diabetes associated with low levels of lipoprotein (a).
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Cardiac & Cardiovascular Systems
Catarina Schiborn, Daniela Weber, Tilman Grune, Ronald Biemann, Susanne Jager, Natascha Neu, Marie Muller von Blumencron, Andreas Fritsche, Cornelia Weikert, Matthias B. Schulze, Clemens Wittenbecher
Summary: This study found differences in the association of retinol and RBP4 (retinol binding protein 4) with cardiovascular diseases and type 2 diabetes. The association was modified by hypertension state, liver function, kidney function, and sex. These findings suggest a complex relationship between retinol, RBP4, and cardiometabolic risk.
CIRCULATION RESEARCH
(2022)
Article
Health Care Sciences & Services
Zilong Hao, Yiping Chen, Neil Wright, Haiqiang Qin, Iain Turnbull, Yu Guo, Christiana Kartsonaki, Sam Sansome, Pei Pei, Canqing Yu, Qijun Gu, Jianming Hu, Jun Lv, Liming Li, Ming Liu, Yongjun Wang, Robert Clarke, Zhengming Chen
Summary: This study compared the 5-year risks of recurrent stroke and all-cause mortality for silent lacunar infarct (LACI) vs symptomatic LACI in Chinese adults with no history of stroke or ischemic heart disease. The results showed that the prognosis of cases with silent LACI was comparable to symptomatic LACI, highlighting the need for further randomized trials to assess the efficacy and safety of established treatments for ischemic stroke in cases with silent LACI.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2021)
Article
Clinical Neurology
Jinghao Zhao, Yubo Lei, Na Hu, Lang Xia, Liyang Zeng, Yongheng Zhang, Wei Qin
Summary: This article reports a very rare and serious complication, massive cerebral infarction, following a tonsillectomy procedure. The patient experienced bleeding during the operation, which ultimately developed into cerebral infarction. Fortunately, with active treatment and rehabilitation, the patient's condition stabilized.
Article
Multidisciplinary Sciences
Shih-Yuan Hung, Tsun-Mei Lin, Hung-Hsiang Liou, Ching-Yang Chen, Wei-Ting Liao, Hsi-Hao Wang, Li-Chun Ho, Ching-Fang Wu, Yi-Che Lee, Min-Yu Chang
Summary: Chronic HD patients have significantly lower ADAMTS13 activity than normal subjects, and ADAMTS13 deficiency is independently associated with an increased risk for cardiovascular events in these patients. ADAMTS13 activity is positively correlated with diabetes, triglyceride, and hemoglobin A1c, and negatively correlated with high-density lipoprotein cholesterol levels in HD patients. Cox proportional hazards model demonstrated that low ADAMTS13, comorbid diabetes, and coronary heart diseases have independent correlations with the development of cardiovascular events.
SCIENTIFIC REPORTS
(2021)
Article
Rheumatology
Fang Kong, Xu Huang, Li Su, Qiuju Liao, Chunxiu Wang, Yi Zhao
Summary: Hyperlipidaemia, higher ITAS 2010 score, larger number of involved arteries, and MCA involvement are independent risk factors for cerebral infarction in patients with Takayasu arteritis. ITAS 2010 score and number of involved arteries can be used to distinguish Takayasu arteritis patients at risk of cerebral infarction.
Article
Endocrinology & Metabolism
Emilie Steinbach, Davide Masi, Agnes Ribeiro, Patricia Serradas, Tiphaine Le Roy, Karine Clement
Summary: The study of the gut microbiome is crucial for understanding and treating metabolic diseases. While research on the fecal microbiome has provided valuable insights, relying solely on this may not be enough to draw comprehensive conclusions. The microbiome in the proximal part of the small intestine may play a significant role in metabolic regulation, but further exploration is needed due to limited accessibility.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Evangelia Chavdoula, Vollter Anastas, Alessandro La Ferlita, Julian Aldana, Giuseppe Carota, Mariarita Spampinato, Burak Soysal, Ilaria Cosentini, Sameer Parashar, Anuvrat Sircar, Giovanni Nigita, Lalit Sehgal, Michael A. Freitas, Philip N. Tsichlis
Summary: This study reveals the important role of KDM2B in triple-negative breast cancer (TNBC). KDM2B affects cellular resistance to oxidative stress by regulating a network of genes and metabolic enzymes, in collaboration with ATF4 and MYC. Additionally, high expression of KDM2B is associated with poor prognosis in patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Joongmin Kim, Hyeongsoo Kim, Sang Hyun Park, Yura Kang, Kyungdo Han, Sang-Hak Lee
Summary: This study aimed to investigate the optimal LDL-C level after statin therapy in individuals with intermediate cardiovascular risk. The results showed that achieving LDL-C levels <120 mg/dL after statin therapy could lower the event risk.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Ze Chen, Li -Ping Xia, Lang Shen, Dan Xu, Yu Guo, Hui Wang
Summary: Accumulating evidence suggests that NAFLD has an intrauterine origin, with adverse prenatal environments and glucocorticoid exposure playing a crucial role in the developmental programming of fetal hepatic lipid metabolism. The offspring's glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis is programmed in utero, leading to postnatal catch-up growth and disrupted glucose and lipid metabolism, increasing susceptibility to NAFLD. Mismatch between intrauterine and postnatal environments can further disturb the programmed endocrine axes and accelerate the onset of NAFLD.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Fuwen Zuo, Youzhao Wang, Xinlei Xu, Ruihao Ding, Wei Tang, Yu Sun, Xiaojie Wang, Yan Zhang, Jichao Wu, Yusheng Xie, Min Liu, Ziying Wang, Fan Yi
Summary: This study investigates the role of CCDC92 in the pathogenesis of diabetic kidney disease (DKD). The expression of CCDC92 was found to increase in kidney biopsies from patients with DKD and was correlated with glomerular lipid accumulation. Animal studies further confirmed the induction of CCDC92 in the kidney, particularly in podocytes, and the podocyte-specific deletion of Ccdc92 ameliorated podocyte injury and lipid deposition. CCDC92 was shown to promote podocyte lipotoxicity through ABCA1 signaling-mediated lipid homeostasis. Therefore, CCDC92 may serve as a potential biomarker of podocyte injury in DKD and targeting CCDC92 could be an innovative therapeutic strategy for DKD patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Khanyisani Ziqubu, Phiwayinkosi Dludla, Sihle E. Mabhida, Babalwa U. Jack, Susanne Keipert, Martin Jastroch, Sithandiwe E. Mazibuko-Mbeje
Summary: The discovery and revival of brown adipose tissue (BAT) in adult humans have opened up new possibilities for treating obesity and metabolic diseases. BAT not only plays a role in generating heat, but also secretes signaling molecules known as batokines, which regulate overall metabolism. This review highlights the importance of BAT-derived metabolites in controlling thermogenesis, substrate metabolism, and other biological processes, as well as their potential to alleviate obesity and related metabolic complications.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
