Article
Agriculture, Dairy & Animal Science
Marina Loch, Tarmo Niine, Elisabeth Dorbek-Kolin, Kristel Peetsalu, Toomas Orro
Summary: This study investigated the immune system of newborn ruminants during the first 3 weeks of life and found some markers that are associated with future lactation performance.
JOURNAL OF DAIRY SCIENCE
(2023)
Review
Cell Biology
Tammy Speelman, Lieke Dale, Ann Louw, Nicolette J. D. Verhoog
Summary: Acute phase proteins (APPs) such as PAI-1, SAA, and CRP are elevated in type-2 diabetes and may be the causal link between stress, inflammation, and the development of insulin resistance.
Article
Immunology
Aracely A. Perez A. Gomez, Meichen Wang, Kelli Kochan, Katia Amstalden, Colin R. R. Young, C. Jane Welsh, Timothy D. D. Phillips, Candice L. L. Brinkmeyer-Langford
Summary: Neurological diseases can be caused by environmental influences such as viral infections and exposure to toxicants, triggering immune responses and resulting in neurological symptoms. Theiler's murine encephalomyelitis virus (TMEV) is used to model human neurological conditions associated with viral infections, and perfluorooctanoic acid (PFOA) can affect pathologies related to neurological diseases. This study explored the effects of co-exposure to TMEV and PFOA on immune responses and susceptibility to viral-induced neurological disease in mice.
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Oncology
Sergei Kusmartsev
Summary: The study demonstrates a positive association between AKI induced by ischemia-reperfusion injury and the formation of clear-cell renal cell carcinoma in genetically modified mice, with blockade of CXCL1 signaling inhibiting kidney tumor emergence. This provides a new experimental approach to prevent and reduce kidney cancer incidence through modulation of the AKI-induced inflammatory response.
Letter
Medicine, General & Internal
Theoharis C. Theoharides, Irene Tsilioni
Summary: The article points out that mast cells, as a unique tissue immune cell, can orchestrate the immune response by secreting proinflammatory molecules. It highlights the degranulation of mast cells in the lungs of deceased patients with severe Covid-19, as well as the elevated levels of mast cell-derived proteolytic enzymes in patients' serum.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Veterinary Sciences
Ali Arbaga, Hany Hassan, Anis Anis, Naemaa Othman, Ahmed Kamr
Summary: The study aimed to investigate the serum protein fractions, acute phase proteins, and inflammatory cytokine concentrations in sheep with pneumonia. A total of 50 adult sheep were divided into control healthy and acute pneumonia groups. The results showed increased levels of globulins, immunoglobulins, haptoglobin, serum amyloid A, and inflammatory cytokines in the pneumonia group, while albumin and Interleukin-10 were decreased. Phagocytic activity and index were also significantly lower in diseased sheep. Histopathological examination revealed various lung tissue abnormalities. In conclusion, acute pneumonia in sheep is associated with a severe pro-inflammatory condition and organ dysfunction, and serum haptoglobin and serum amyloid A concentrations can serve as diagnostic biomarkers.
PAKISTAN VETERINARY JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Gokul Raj Kathamuthu, Perumal Kannabiran Bhavani, Manjula Singh, Jitendra Kumar Saini, Ashutosh Aggarwal, Mohammed Soheb S. Ansari, Rajiv Garg, Subash Babu
Summary: High-dose rifampicin has the potential to improve the immunity of pulmonary tuberculosis patients by modulating different immune and inflammatory markers.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Infectious Diseases
Anuradha Rajamanickam, Nathella Pavan Kumar, Chandrasekaran Padmapriyadarsini, Arul Nancy, Nandhini Selvaraj, Kushiyasri Karunanithi, Saravanan Munisankar, Shrinivasa Bm, Rachel Mariam Renji, T. C. Ambu, Vijayalakshmi Venkataramani, Subash Babu
Summary: Individuals with LTBI who are seropositive for SARS-CoV-2 infection exhibit heightened levels of humoral, cytokine, and acute phase responses compared to LTBI-negative individuals. LTBI is associated with modulation of antibody and cytokine responses as well as systemic inflammation in individuals seropositive for SARS-CoV-2 infection.
JOURNAL OF INFECTION
(2021)
Article
Medical Laboratory Technology
Mina Yekani, Mohammad Yousef Memar
Summary: Meningitis is a severe inflammation of the meninges, caused by bacteria or viruses, with high mortality rates. Immunologic biomarkers, such as cytokines and acute phase proteins, have been identified as significant indicators for diagnosing bacterial meningitis. However, the sensitivity and specificity of these biomarkers are influenced by various factors. This study provides an overview of different immunologic biomarkers and their efficiency in diagnosing bacterial meningitis and differentiating it from viral meningitis.
CLINICA CHIMICA ACTA
(2023)
Article
Infectious Diseases
Joseph D. Thiriot, Yuejin Liang, Casey Gonzales, Jiaren Sun, Xiaoying Yu, Lynn Soong
Summary: Scrub typhus, caused by Orientia tsutsugamushi (Ot), is a leading cause of febrile illness in endemic countries. Pulmonary involvement associated with vascular parasitism is common and can become life threatening. The antigenicity and genome content of Ot genotypes are connected to varied virulence and clinical outcomes. This study investigated the pulmonary immune responses of two prevalent bacterial strains (Karp and Gilliam) and identified potential biomarkers of disease severity.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Review
Physiology
H. L. Notbohm, F. Moser, J. Goh, J. F. Feuerbacher, W. Bloch, M. Schumann
Summary: The immune system's role in exercise responses and adaptations is important, but the impact of fluctuating hormone concentrations across the menstrual cycle on these processes is unknown. This systematic review with meta-analysis compared immune and inflammatory parameters between menstrual cycle phases. The findings suggest that certain parameters of innate immunity, such as leukocytes, monocytes, granulocytes, neutrophils, and leptin concentrations, are higher in the luteal phase compared to the follicular phase at rest. The exercise-induced response of these parameters also indicate a higher pro-inflammatory response in the luteal phase. However, more research is needed to understand the exercise responses in different hormonal profiles.
Article
Gastroenterology & Hepatology
Nathalie van den Berghe, Dahham Alsoud, Bram Verstockt, Severine Vermeire, Paul Declerck, Debby Thomas
Summary: This study investigated the dynamics of serum biomarker concentrations during ustekinumab treatment in Crohn's disease (CD) patients. The results showed that lower concentrations of serum amyloid A protein (SAA), interleukin-6 (IL-6), serum albumin (AGP), interferon-γ (IFN-γ), lipopolysaccharide binding protein (LBP), and interleukin-22 (IL-22) were associated with better endoscopic remission. Therefore, monitoring the concentrations of these biomarkers may be helpful for evaluating the response to ustekinumab treatment in CD patients.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2023)
Article
Cell Biology
Anastasiia D. Shcherbitskaia, Dmitrii S. Vasilev, Yulia P. Milyutina, Natalia L. Tumanova, Anastasiia Mikhel, Irina Zalozniaia, Alexander Arutjunyan
Summary: This study found that prenatal hyperhomocysteinemia can lead to neuroinflammation, glial activation, and neuronal death in the hippocampus of infant rats, potentially leading to cognitive disorders later in life.
Article
Pharmacology & Pharmacy
Sonia Shastri, Tanvi Shinde, Krystel L. Woolley, Jason A. Smith, Nuri Gueven, Rajaraman Eri
Summary: Ulcerative colitis (UC) is characterized by chronic, relapsing, idiopathic, and multifactorial colon inflammation. Recent evidence suggests that mitochondrial dysfunction plays a critical role in the onset and recurrence of this disease. The study found that UTA77 could be a promising novel therapeutic approach for the treatment of human UC, as it improved UC symptoms and pathology in mouse models.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Oncology
Mudassier Ahmad, Anupam Dhasmana, Prateek Suresh Harne, Asif Zamir, Bilal Bin Hafeez
Summary: Tumor heterogeneity is a crucial factor in the resistance to chemotherapy and limited efficacy in hepatocellular carcinoma (HCC). Chemokines, a sub-family of cytokines, play a key role in HCC heterogeneity by affecting cell survival, growth, migration, and angiogenesis. Understanding the impact of chemokines on genetic, epigenetic, metabolic, immune cell composition, and tumor microenvironment levels can contribute to the development of personalized medicine strategies for HCC.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Cell Biology
Larissa Daniele Bobermin, Fernanda Becker Weber, Tiago Marcon dos Santos, Adriane Bello-Klein, Angela T. S. Wyse, Carlos-Alberto Goncalves, Andre Quincozes-Santos
Summary: Sulforaphane, a natural compound, has anti-inflammatory and antioxidant properties. This study found that sulforaphane protects astroglial cells by inhibiting inflammation and oxidative stress, through modulation of multiple molecular mechanisms.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Andrea Gisiane Kurek Ferreira, Helena Biasibetti-Brendler, Daniele Susana Volkart Sidegum, Samanta Oliveira Loureiro, Fabricio Figueiro, Angela T. S. Wyse
Summary: High concentrations of proline may favor signaling pathways towards cell proliferation by inhibiting acetylcholinesterase, which may act as a tumor suppressor. Proline can induce oxidative stress, but it appears to be insufficient to cause a significant change in cell cycle progression.
NEUROTOXICITY RESEARCH
(2021)
Article
Neurosciences
Angela T. S. Wyse, Tiago M. dos Santos, Bianca Seminotti, Guilhian Leipnitz
Summary: Phenylketonuria is a metabolic disorder caused by phenylalanine hydroxylase deficiency, leading to neurological dysfunction and hepatic damage in severe cases. Studies have shown that phenylalanine and its metabolites may induce toxicity by affecting mitochondrial bioenergetics and oxidative status.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Neurosciences
Angela T. S. Wyse, Larissa Daniele Bobermin, Tiago Marcon dos Santos, Andre Quincozes-Santos
Summary: Hyperhomocysteinemia can result from dietary intake, lifestyle factors, or enzyme deficiency, leading to tissue accumulation of the amino acid and potential neurological symptoms. The link between homocysteine and neurodegenerative/neuropsychiatric disorders has been suggested, with astrocyte dysfunction possibly playing a role in the neurotoxicity.Understanding the impact of homocysteine on gliotoxicity may lead to novel preventive/therapeutic strategies for these diseases.
NEUROTOXICITY RESEARCH
(2021)
Article
Cell Biology
Tiago Marcon dos Santos, Cassiana Siebert, Larissa Daniele Bobermin, Andre Quincozes-Santos, Angela T. S. Wyse
Summary: The study revealed that mild hyperhomocysteinemia may lead to anxiety-like behavior and alterations in locomotion/exploration in rats. Glutamate uptake remained unchanged, but the activities of glutamine synthetase and ATPases were increased. Cell viability was not affected.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Larissa Daniele Bobermin, Romulo Rodrigo de Souza Almeida, Fernanda Becker Weber, Lara Scopel Medeiros, Livia Medeiros, Angela T. S. Wyse, Carlos-Alberto Goncalves, Andre Quincozes-Santos
Summary: The study showed that resveratrol can protect aged astrocytes from LPS-induced toxicity, reduce inflammatory response, and improve astroglial functions. The glioprotective effects of resveratrol on aged astrocytes may be associated with molecular mechanisms such as SIRT1, Nrf2, and HO-1.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Josiane Silva Silveira, Osmar Vieira Ramires Junior, Felipe Schmitz, Fernanda Silva Ferreira, Fabiana Cristina Rodrigues, Robson Coutinho Silva, Luiz Eduardo Baggio Savio, Angela T. S. Wyse
Summary: Supplementing with 4 mg/kg of folic acid during pregnancy can negatively affect the behavior and biochemical indicators of offspring.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Osmar Vieira Ramires Junior, Tiago Marcon dos Santos, Josiane Silva Silveira, Raissa Leite-Aguiar, Robson Coutinho-Silva, Luiz Eduardo Baggio Savio, Angela T. S. Wyse
Summary: This study evaluated the effects of mild hyperhomocysteinemia on behavior and neurochemical parameters in male rats, and investigated the therapeutic effects of ibuprofen and rivastigmine. The results showed that mild hyperhomocysteinemia caused cognitive deficits and impaired motor coordination, but treatment with ibuprofen and rivastigmine reduced these damages.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Fernanda Silva Ferreira, Tiago Marcon Dos Santos, Osmar Vieira Ramires Junior, Josiane Silva Silveira, Felipe Schmitz, Angela T. S. Wyse
Summary: Quinolinic acid (QUIN) is an important agonist of NMDA receptors that are found at high levels in cases of brain injury and neuroinflammation. This study found that coenzyme Q(10) (CoQ(10)) can mitigate the toxicity caused by QUIN in the brain, including reducing the generation of reactive oxygen species, alleviating oxidative stress, preserving the activity of antioxidant enzymes, maintaining glutathione levels, reducing protein and lipid damage, and preventing alterations in electron transport chain complex activity and ATP levels. CoQ(10) may be a promising therapeutic alternative for neuroprotection against QUIN neurotoxicity.
NEUROTOXICITY RESEARCH
(2022)
Article
Clinical Neurology
Luiza N. Foschiera, Felipe Schmitz, Angela T. S. Wyse
Summary: Methylphenidate (MPH) is effective in treating Attention Deficit Hyperactivity Disorder (ADHD), but its unrestricted use can have neurological and psychiatric consequences. Animal studies show that MPH alters brain energy homeostasis, induces oxidative stress, causes inflammation, and alters the apoptosis pathway. Age, treatment time, administration route, and dose are important factors that influence the effects of MPH.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Review
Neurosciences
Alessandra S. Rieder, Bruna F. Deniz, Carlos Alexandre Netto, Angela T. S. Wyse
Summary: Since the emergence of SARS-CoV-2 and the COVID-19 pandemic, there has been a growing interest in using in silico approaches to identify potential therapeutic molecules for this disease. Molecular docking, a commonly used method, has been employed to find inhibitors for viral proteins of SARS-CoV-2, including the papain-like protease (PLpro). This systematic review focuses on in silico research of PLpro inhibitors and their potential therapeutic effects on COVID-19. Additionally, the neurological problems associated with COVID-19, particularly the similarities to neuroinflammation in Alzheimer's disease, are briefly discussed.
NEUROTOXICITY RESEARCH
(2022)
Article
Medicine, Research & Experimental
Josiane Silva Silveira, Osmar Vieira Ramires Junior, Felipe Schmitz, Fernanda Silva Ferreira, Fabiana Cristina Rodrigues, Marion Deon, Graziella Ribas, Robson Coutinho-Silva, Carmen Regla Vargas, Luiz Eduardo Baggio Savio, Angela T. S. Wyse
Summary: This study investigated the effects of a high-protein diet consumed during pregnancy on neurobiochemistry and behavioral performance in the offspring. The results showed that maternal consumption of a high-protein diet led to increased levels of homocysteine and neuroinflammatory mediators in the offspring's cerebral cortex, as well as decreased histidine levels in their serum. It also resulted in impaired memory and motricity, and increased anxiety-like behavior in the offspring.
Correction
Endocrinology & Metabolism
Felipe Schmitz, Paula Pierozan, Helena Biasibetti-Brendler, Fernanda Silva Ferreira, Fernanda dos Santos Petry, Vera Maria Treis Trindade, Regina Pessoa-Pureur, Angela T. S. Wyse
METABOLIC BRAIN DISEASE
(2023)
Article
Cell Biology
Julia Pramio, Mateus Grings, Amanda Gasparin da Rosa, Rafael Teixeira Ribeiro, Nicolas Manzke Glanzel, Marian Flores Signori, Manuela Bianchin Marcuzzo, Larissa Daniele Bobermin, Angela T. S. Wyse, Andre Quincozes-Santos, Moacir Wajner, Guilhian Leipnitz
Summary: Isolated sulfite oxidase (ISOD) and molybdenum cofactor (MoCD) deficiencies are genetic diseases characterized by the accumulation of toxic sulfite in the brain tissues, leading to neurological dysfunction and brain abnormalities in newborns. This study found that sulfite administration caused redox imbalance, mitochondrial dysfunction, and altered signaling proteins in the cerebral cortex of rat pups, which may contribute to the neuropathology of ISOD and MoCD.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Review
Endocrinology & Metabolism
Lucas Ferreira Teixeira, Gustavo R. Krupp Prauchner, Darlan Gusso, Angela T. S. Wyse
Summary: Classic galactosemia is a rare inborn error of metabolism caused by gene variants leading to absent or misfolded enzyme, resulting in galactose metabolite accumulation and cell damage. Its symptoms vary and prevalence differs among populations. Dairy restriction is a common treatment, but recent studies suggest its reconsideration in certain cases. Further preclinical trials are needed to understand the disease and propose new treatments.
METABOLIC BRAIN DISEASE
(2023)