期刊
MEMORIAS DO INSTITUTO OSWALDO CRUZ
卷 108, 期 7, 页码 928-931出版社
FUNDACO OSWALDO CRUZ
DOI: 10.1590/0074-0276130112
关键词
Chagas disease; lytic anti-alpha-Gal antibodies; Trypanosoma cruzi
资金
- NIH [R01AI070655-A5, R01AI070655-A5S1, 5G12RR008124-16A1, 5G12RR008124-16A1S1, G12MD007592]
- AGAUR [2009SGR385]
The disappearance of lytic, protective antibodies (Abs) from the serum of patients with Chagas disease is accepted as a reliable indicator of parasitological cure. The efficiency of a chemiluminescent enzyme-linked immunosorbent assay based on a purified, trypomastigote-derived glycosylphosphatidylinositol-anchored mucin antigen for the serologic detection of lytic Abs against Trypanosoma cruzi was evaluated in a nonendemic setting using a panel of 92 positive and 58 negative human sera. The technique proved to be highly sensitive [100%; 95% confidence interval (CI) = 96-100] and specific (98.3%; 95% CI = 90.7-99.7), with a kappa score of 0.99. Therefore, this assay can be used to detect active T. cruzi infection and to monitor trypanosomicidal treatment.
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