Article
Cardiac & Cardiovascular Systems
Maria Carmo P. Nunes, Lewis F. Buss, Jose Luiz P. Silva, Larissa Natany A. Martins, Claudia Di Lorenzo Oliveira, Clareci Silva Cardoso, Bruno Oliveira de Figueiredo Brito, Ariela Mota Ferreira, Lea Campos Oliveira, Ana Luiza Bierrenbach, Fabio Fernandes, Michael P. Busch, Viviane Tiemi Hotta, Luiz Mario Baptista Martinelli, Maria Carolina F. Almeida Soeiro, Adriana Brentegani, Vera M. C. Salemi, Marcia M. Menezes, Antonio Luiz P. Ribeiro, Ester Cerdeira Sabino
Summary: This study provides a comprehensive description of the natural history of T. cruzi seropositivity in a contemporary patient population, highlighting the central importance of anti-T. cruzi antibody titer as a marker of Chagas disease activity and risk of progression.
Article
Biochemistry & Molecular Biology
Naiara Dutra Barroso Gomes, Emanuel Paula Magalhaes, Lyanna Rodrigues Ribeiro, John Washington Cavalcante, Marcelo Morais Gomes Maia, Felipe Ramon Cunha da Silva, Arif Ali, Marcia Machado Marinho, Emmanuel Silva Marinho, Helcio Silva dos Santos, Alice Maria Costa Martins, Ramon Roseo Paula Pessoa Bezerra de Menezes
Summary: This study evaluated the activity of synthetic p-aminochalcones against T. cruzi and found that they have a trypanocidal effect by causing membrane damage and oxidative stress. Their mechanism of action may be related to inhibition of cruzain and TR.
BIOORGANIC CHEMISTRY
(2023)
Review
Immunology
Maria Gabriela Libisch, Natalia Rego, Carlos Robello
Summary: Chagas Disease is caused by the complex taxon T. cruzi, affecting nearly eight million people worldwide. T. cruzi has the ability to infect and interact with almost any nucleated cell, triggering molecular signaling cascades that depend on cell type, strain, and experimental variables. Host cell responses to infection, particularly in the respiratory chain and oxidative phosphorylation, vary depending on the T. cruzi strain and experimental model, while some responses remain consistent across strains, cell types, and conditions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Gabriela Venturini, Juliana M. Alvim, Kallyandra Padilha, Christopher N. Toepfer, Joshua M. Gorham, Lauren K. Wasson, Diogo Biagi, Sergio Schenkman, Valdemir M. Carvalho, Jessica S. Salgueiro, Karina H. M. Cardozo, Jose E. Krieger, Alexandre C. Pereira, Jonathan G. Seidman, Christine E. Seidman
Summary: This study reveals the molecular mechanisms and metabolic responses of Trypanosoma cruzi infection in cardiomyocytes. Infection activates the immune system and glycolysis pathway in cardiomyocytes, promoting intracellular infection and replication. These responses lead to heart dysfunction, cell death, and the development of cardiomyopathy.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Camila Victoria Sousa Oliveira, Oscar Moreno-Loaiza, Daniel Figueiredo-Vanzan, Isalira Peroba Ramos, Hilton Mata-Santos, Marcelo Torres Bozza, Claudia Neto Paiva, Emiliano Medei
Summary: This study investigated the role of IL-1 beta in chronic chagasic cardiomyopathy (CCC) using a mouse model. The results showed that the absence of functional IL-1 beta/IL-1R signaling did not prevent or reverse the decrease of cardiac function and the incidence of arrhythmias induced by CCC. Therefore, ruling out the IL-1 beta signaling pathway is an important step to discourage further attempts of IL-1 beta blockade as a therapeutic measure for CCC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Martha Alicia Ballinas-Verdugo, Rogelio Frank Jimenez-Ortega, Eduardo Martinez-Martinez, Nancy Rivas, Erick Abraham Contreras-Lopez, Roxana Carbo, Fausto Sanchez, Rafael Bojalil, Ricardo Marquez-Velasco, Fausto Sanchez-Munoz, Ricardo Alejandre-Aguilar
Summary: The expression levels of inflammatory microRNAs miR-21, miR-146a and miR-155 were up-regulated in both acutely and chronically infected mouse samples. Notably, miR-146a was consistently up-regulated in all samples from both phases, indicating its potential as a candidate biomarker for Chagas disease.
BIOLOGICAL RESEARCH
(2021)
Article
Immunology
Fernanda M. Frank, David H. Wagner Jr, Miriam Postan, Patricia B. Petray
Summary: The CD40/CD40L interaction plays a dual role in Trypanosoma cruzi infection, depending on the timing of treatment initiation. Early treatment with CD40-targeted peptide leads to uncontrolled acute infection and marked tissue damage, while late treatment improves myocardial and skeletal muscle damage.
MICROBIAL PATHOGENESIS
(2023)
Review
Immunology
Concepcion J. Puerta, Adriana Cuellar, Paola Lasso, Jose Mateus, John M. Gonzalez
Summary: Trypanosoma cruzi, the causal agent of Chagas disease, has developed mechanisms of antigenic variability to evade the host immune response. CD8(+) T cells play a key role in chronic Chagas cardiomyopathy, and specific peptide stimulation can activate multifunctional immune responses. Anti-parasitic treatment improves CD8(+) T cell response, and the quality of CD8(+) T cell responses correlates with the outcome of chronic infection. These findings provide valuable resources for discovering new biomarkers, vaccines, and immunotherapy strategies.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Chemistry, Medicinal
Ruben Martin-Escolano, Mikel Etxebeste-Mitxeltorena, Javier Martin-Escolano, Daniel Plano, Maria J. Rosales, Socorro Espuelas, Esther Moreno, Manuel Sanchez-Moreno, Carmen Sanmartin, Clotilde Marin
Summary: Chagas disease, caused by Trypanosoma cruzi, is a global public health concern with limited treatment options. Selenium and its derivatives have emerged as an interesting strategy for the treatment of various protozoan diseases, including Chagas disease. Further research on selenium compounds shows potential for the development of new antichagasic agents.
ACS INFECTIOUS DISEASES
(2021)
Article
Immunology
Priscila Silva Grijo Farani, Khodeza Begum, Glaucia Vilar-Pereira, Isabela Resende Pereira, Igor C. Almeida, Sourav Roy, Joseli Lannes-Vieira, Otacilio Cruz Moreira
Summary: Research explored the immune response-related gene expression changes in heart tissues of C57BL/6 mice chronically infected with T. cruzi and treated with benznidazole (Bz) or Bz+pentoxifylline (PTX). The study found that treatment could mitigate the Th1-driven response in cardiac remodeling processes of CCC patients by restoring the expression of genes related to inflammatory response, cellular development, growth, proliferation, and tissue development pathways.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Parasitology
Mercedes Rubio-Hernandez, Veronica Alcolea, Silvia Perez-Silanes
Summary: Current treatment for Chagas disease is limited to two drugs, but compounds containing sulfur have shown potential against the parasite. Isosteric replacement of sulfur by selenium may be a promising strategy for the development of new compounds. Further studies are needed to confirm the efficacy of selenium compounds, and researchers propose potential new selenium compounds for future drug development.
Article
Microbiology
Sergio Castaneda, Marina Munoz, Peter J. Hotez, Maria Elena Bottazzi, Alberto E. Paniz-Mondolfi, Kathryn M. Jones, Rojelio Mejia, Cristina Poveda, Juan David Ramirez
Summary: Chagas disease is caused by Trypanosoma cruzi and has a profound impact on the gastrointestinal tract. Alterations in the gut microbiome caused by the parasite may play a crucial role in host-parasite interactions and immune responses. Understanding this interaction could provide valuable insights into the pathophysiology of the disease and the development of new treatments.
MICROBIOLOGY SPECTRUM
(2023)
Article
Medicine, Research & Experimental
Gregorio Guilherme Almeida, Inga Rimkute, Isabela Natalia Pascoal Campos Do Vale, Thomas Liechti, Priscilla Miranda Henriques, Ester Roffe, Fernanda Fortes de Araujo, Manoel Otavio da Costa Rocha, Silvana Maria Eloi Santos, Olindo Assis Martins-Filho, Dragana Jankovic, Alan Sher, Andrea Teixeira-Carvalho, Mario Roederer, Lis Ribeiro do Valle Antonelli
Summary: In this study, high-dimensional flow cytometry was used to evaluate CD4(+) T cells in patients with different clinical forms. The results showed that activated CD4(+) T cells were increased in patients, while functional regulatory T cells were reduced. These findings provide evidence for the involvement of these cells in the development of Chagas cardiomyopathy and their potential as biomarkers for disease progression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Maykon Tavares de Oliveira, Andre Schmidt, Maria Claudia da Silva, Eduardo Antonio Donadi, Joao Santana da Silva, Jose Antonio Marin-Neto
Summary: The study revealed that the blood parasite load in patients with CCC is highly variable and appears to be directly linked to the reduction of LVEF, an important prognostic indicator in CCC patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Leonardo da Silva Lara, Guilherme Curty Lechuga, Lorraine Martins Rocha Orlando, Byanca Silva Ferreira, Bernardo Araujo Souto, Mauricio Silva dos Santos, Mirian Claudia de Souza Pereira
Summary: Chagas disease is a long-standing disease that primarily affects impoverished populations in Latin America. The available drugs have limited effectiveness and intense side effects. This study explores the biological activity of two new series of pyrazole-thiazoline derivatives with potential therapeutic options against Trypanosoma cruzi. These derivatives show potent activity with good oral bioavailability and low cytotoxicity, making them potential candidates for Chagas disease therapy.
Article
Immunology
Dazhi Zhao, Kezia Lizardo, Min Hui Cui, Kamalakar Ambadipudi, Jose Lora, Linda A. Jelicks, Jyothi F. Nagajyothi
MICROBES AND INFECTION
(2016)
Article
Parasitology
Lygia M. Malvestio, Mara Rubia N. Celes, Linda A. Jelicks, Herbert B. Tanowitz, Cibele M. Prado
PARASITOLOGY RESEARCH
(2017)
Article
Immunology
Romain A. Colas, Anthony W. Ashton, Shankar Mukherjee, Jesmond Dalli, Oscar B. Akide-Ndunge, Huan Huang, Mahalia S. Desruisseaux, Fangxia Guan, Linda A. Jelicks, Fabiane Matos dos Santos, Jyothi Nagajyothi, Michael A. Zingman, Jinet Reyes, Louis M. Weiss, Charles N. Serhan, Herbert B. Tanowitz
INFECTION AND IMMUNITY
(2018)
Review
Pathology
Linda A. Jelicks, Michael P. Lisanti, Fabiana S. Machado, Louis M. Weiss, Herbert B. Tanowitz, Mahalia S. Desruisseaux
AMERICAN JOURNAL OF PATHOLOGY
(2013)
Editorial Material
Pathology
Linda A. Jelicks, Herbert B. Tanowitz, Chris Albanese
AMERICAN JOURNAL OF PATHOLOGY
(2013)
Review
Pathology
Wade Koba, Linda A. Jelicks, Eugene J. Fine
AMERICAN JOURNAL OF PATHOLOGY
(2013)
Article
Endocrinology & Metabolism
Pasha Apontes, Zhongbo Liu, Kai Su, Outhiriaradjou Benard, Dou Y. Youn, Xisong Li, Wei Li, Raihan H. Mirza, Claire C. Bastie, Linda A. Jelicks, Jeffrey E. Pessin, Radhika H. Muzumdar, Anthony A. Sauve, Yuling Chi
Article
Immunology
Cibele M. Prado, Mara R. N. Celes, Lygia M. Malvestio, Erica C. Campos, Joao S. Silva, Linda A. Jelicks, Herbert B. Tanowitz, Marcos A. Rossi
MICROBES AND INFECTION
(2012)
Article
Immunology
Lygia M. Malvestio, Mara R. N. Celes, Cristiane Milanezi, Joao S. Silva, Linda A. Jelicks, Herbert B. Tanowitz, Marcos A. Rossi, Cibele M. Prado
MICROBES AND INFECTION
(2014)
Review
Radiology, Nuclear Medicine & Medical Imaging
Eugene J. Fine, Lawrence Herbst, Linda A. Jelicks, Wade Koba, Daniel Theele
SEMINARS IN NUCLEAR MEDICINE
(2014)
Article
Infectious Diseases
Fnu Nagajyothi, Louis M. Weiss, Dazhi Zhao, Wade Koba, Linda A. Jelicks, Min-Hui Cui, Stephen M. Factor, Philipp E. Scherer, Herbert B. Tanowitz
PLOS NEGLECTED TROPICAL DISEASES
(2014)
Article
Oncology
Yuanxin Liang, Jinwu Zeng, Linda Jelicks, Shengwei Ma, Jing Liu, Jingsong Mei, Roman Perez-Soler, Yiyu Zou
CURRENT CANCER DRUG TARGETS
(2017)
Meeting Abstract
Obstetrics & Gynecology
Hye Heo, Yelena Kogelman, Wade Koba, Linda Jelicks, Kamalakar Ambadipudi, Min-Hui Cui, Scarlett Karakash, Eugene Fine, Francine Einstein
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2014)
Meeting Abstract
Clinical Neurology
Fernando Pereira Bruno, Brandi D. Freeman, Wade R. Koba, Minxian Dai, Linda A. Jelicks, Eugene J. Fine, Mahalia S. Desruisseaux
ANNALS OF NEUROLOGY
(2013)
Meeting Abstract
Biochemistry & Molecular Biology
Cibele M. Prado, Valdecir Blefari, Mayara S. Ribeiro, Mara R. N. Celes, Ana C. S. Freitas, Lygia M. Malvestio, Erica C. Campos, Patricia Ferezin, Linda A. Jelicks, Herbert B. Tanowitz, Marcos A. Rossi