期刊
MEMORIAS DO INSTITUTO OSWALDO CRUZ
卷 103, 期 6, 页码 549-553出版社
FUNDACO OSWALDO CRUZ
DOI: 10.1590/S0074-02762008000600007
关键词
Chagas disease; benznidazole; nifurtimox; nitroreduction; cardiopathy
资金
- FONCyT Argentina [PICT/005-9941]
- UNSAM Argentina [SP06/090]
Benznidazole (Bz) and Nifurtimox (Nfx) have been used to treat Chagas disease. As recent studies have demonstrated cardiotoxic effects of Nfx, we attempted to determine whether Bz behaves similarly. Bz reached the heart tissue of male rats after intragastric administration. No cytosolic Bz nitroreductases were detected, although microsomal NADPH-dependent Bz nitroreductase activity was observed, and appeared to be mediated by P450 reductase. No ultrastructurally observable deleterious effects of Bz were detected, in contrast to the overt cardiac effects previously reported for Nfx. In conclusion, when these drugs are used in chagasic patients, Bz may pose a lesser risk to heart function than Nfx when any cardiopathy is present.
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