Review
Cardiac & Cardiovascular Systems
Ahmad Sabbahi, Justin M. Canada, Abraham Samuel Babu, Richard Severin, Ross Arena, Cemal Ozemek
Summary: Cardiac rehabilitation programs are standard-of-care in cardiovascular medicine. Aerobic exercise training is crucial for improving cardiorespiratory fitness.
PROGRESS IN CARDIOVASCULAR DISEASES
(2022)
Review
Cardiac & Cardiovascular Systems
Ray W. Squires, Amanda R. Bonikowske
Summary: Heart transplantation is the preferred treatment for end-stage chronic heart failure. Although many patients experience improved functional ability after transplantation, they still face the challenges of acute rejection and other comorbidities. Exercise training, recommended before and after transplantation, can improve exercise capacity and skeletal muscle strength without altering immunosuppression.
PROGRESS IN CARDIOVASCULAR DISEASES
(2022)
Article
Cardiac & Cardiovascular Systems
Kyle Gobeil, Kevin White, Anusha Bhat, Heidi Szalai, Tara C. Lagu, Quinn R. Pack
Summary: The study found that utilization of cardiac rehabilitation in Takotsubo cardiomyopathy patients is inconsistent, despite the potential benefits of exercise for improving exercise capacity.
Review
Cardiac & Cardiovascular Systems
Susan Marzolini, Che-Yuan Wu, Rowaida Hussein, Lisa Y. Xiong, Suban Kangatharan, Ardit Peni, Christopher R. Cooper, Kylie S. K. Lau, Ghislaine Nzodjou Makhdoom, Maureen Pakosh, Stephanie A. Zaban, Michelle M. Nguyen, Mohammad Amin Banihashemi, Walter Swardfager
Summary: Exercise training initiated within 3 months after stroke may lead to better mobility outcomes, including improved walking distance and speed, but may not have as significant impact on cardiorespiratory fitness.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Rehabilitation
Matthew R. Ely, Grant D. Schleifer, Tamanna K. Singh, Aaron L. Baggish, J. Andrew Taylor
Summary: This study aimed to investigate the effects of different exercise training modes on cardiac atrophy and loss of function in patients with acute spinal cord injury (SCI). The results showed that neither upper-body exercise alone nor a combination of upper-body exercise with lower-body electrical stimulation had a significant impact on cardiac structure and function. This suggests that current rehabilitative aerobic exercise practices are not effective in preventing cardiac decline in individuals with SCI and further interventions are needed.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2023)
Article
Multidisciplinary Sciences
Shaan Khurshid, Julieta Lazarte, James P. Pirruccello, Lu-Chen Weng, Seung Hoan Choi, Amelia W. Hall, Xin Wang, Samuel F. Friedman, Victor Nauffal, Kiran J. Biddinger, Krishna G. Aragam, Puneet Batra, Jennifer E. Ho, Anthony A. Philippakis, Patrick T. Ellinor, Steven A. Lubitz
Summary: A genome-wide association study on 43,000 UK Biobank participants using cardiac magnetic resonance-derived left ventricular mass index identified 12 associations, including 11 novel ones, related to cardiac contractility and cardiomyopathy. The study demonstrates the association between indexed left ventricular mass and incident cardiomyopathy, as well as implantable cardioverter-defibrillator implant. The findings highlight the importance of cardiac magnetic resonance in assessing cardiovascular risk.
NATURE COMMUNICATIONS
(2023)
Review
Rehabilitation
Stian Hammer, Michel Toussaint, Maria Vollsaeter, Marianne Nesbjorg Tvedt, Ola Drange Roksund, Gregory Reychler, Hans Lund, Tiina Andersen
Summary: Exercise training may be beneficial for patients with Duchenne muscular dystrophy, but the evidence remains uncertain, further research is needed. A meta-analysis on muscular strength and endurance showed significant differences in favor of exercise training compared to no training and placebo.
JOURNAL OF REHABILITATION MEDICINE
(2022)
Article
Critical Care Medicine
David R. Schieffelers, Dorien Dombrecht, Cynthia Lafaire, Lieve De Cuyper, Thomas Rose, Martijn Vandewal, Jill Meirte, Nick Gebruers, Eric van Breda, Ulrike Van Daele
Summary: Exercise training during the acute phase of burns can reduce muscle wasting and improve muscle strength. This multicenter trial shows that providing additional exercise training to burn patients has significant benefits in improving muscle condition and quality of life.
Article
Genetics & Heredity
Saori Sakaue, Masahiro Kanai, Yosuke Tanigawa, Juha Karjalainen, Mitja Kurki, Seizo Koshiba, Akira Narita, Takahiro Konuma, Kenichi Yamamoto, Masato Akiyama, Kazuyoshi Ishigaki, Akari Suzuki, Ken Suzuki, Wataru Obara, Ken Yamaji, Kazuhisa Takahashi, Satoshi Asai, Yasuo Takahashi, Takao Suzuki, Nobuaki Shinozaki, Hiroki Yamaguchi, Shiro Minami, Shigeo Murayama, Kozo Yoshimori, Satoshi Nagayama, Daisuke Obata, Masahiko Higashiyama, Akihide Masumoto, Yukihiro Koretsune, Kaoru Ito, Chikashi Terao, Toshimasa Yamauchi, Issei Komuro, Takashi Kadowaki, Gen Tamiya, Masayuki Yamamoto, Yusuke Nakamura, Michiaki Kubo, Yoshinori Murakami, Kazuhiko Yamamoto, Yoichiro Kamatani, Aarno Palotie, Manuel A. Rivas, Mark J. Daly, Koichi Matsuda, Yukinori Okada
Summary: The study conducted deep-phenotype genome-wide association studies in BioBank Japan, identifying approximately 5,000 new loci and improving the resolution of the genomic map of human traits. By decomposing matrices of phenome-wide summary statistics, responsible variants and biological mechanisms underlying current disease classifications across populations were pinpointed.
Article
Physiology
Guilherme F. Fonseca, Adrian W. Midgley, Sandra A. Billinger, Andre C. Michalski, Victor A. B. Costa, Walace Monteiro, Paulo Farinatti, Felipe A. Cunha
Summary: This study aims to investigate whether a single bout of mixed circuit training can induce a reduction in blood pressure in chronic hemiparetic stroke patients. The results show that a single bout of mixed circuit training can elicit prolonged post-exercise hypotension in these patients, accompanied by increased sympathovagal balance and lowered systemic vascular resistance.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Neurosciences
Meng-Yuan Shang, Chu-Yi Zhang, Yong Wu, Lu Wang, Chuang Wang, Ming Li
Summary: This study utilized genome-wide association studies to investigate the polygenic overlap between bipolar disorder (BD) and brain structural phenotypes. It discovered shared genomic loci and identified novel risk genes. These findings provide insights into the genetic basis of BD and its developmental origins.
Article
Rehabilitation
Meghan Fahey, Gabrielle Brazg, Christopher E. Henderson, Abbey Plawecki, Emily Lucas, Darcy S. Reisman, Brian D. Schmit, T. George Hornby
Summary: Research in animal models and patients with stroke or iSCI suggests that specific physical training variables, including exercise intensity, can have a significant impact on neurological recovery and locomotor function. Properly defining and ensuring appropriate levels of exercise intensity is crucial for maximizing rehabilitation outcomes in patients with neurologic injury.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Cardiac & Cardiovascular Systems
Biykem Bozkurt, Gregg C. Fonarow, Lee R. Goldberg, Maya Guglin, Richard A. Josephson, Daniel E. Forman, Grace Lin, JoAnn Lindenfeld, Chris O'Connor, Gurusher Panjrath, Ileana L. Pina, Tina Shah, Shashank S. Sinha, Eugene Wolfel
Summary: Cardiac rehabilitation, which includes exercise training, risk factor modification, and outcomes assessment, is safe and beneficial for patients with HF. Despite its effectiveness and cost-efficiency, it is currently underused and should be prioritized as part of standard care for HF patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Martin Schoenfelder, Hubert Oberreiter, Andreas Egger, Marcus Tschentscher, Silke Droese, Josef Niebauer
Summary: This study aimed to assess the effect of different types of endurance training during outpatient cardiac rehabilitation on patients' health-related quality of life. The results showed that all 3 types of endurance training led to significant increases in physical work capacity, which was associated with an increase in HRQL independent of the type of training. These findings support further individualization of training regimes, potentially leading to better compliance during life-long home-based exercise training.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Cell Biology
Luiz Alexandre Medrado de Barcellos, William Antonio Goncalves, Marcos Paulo Esteves de Oliveira, Juliana Bohnen Guimaraes, Celso Martins Queiroz-Junior, Carolina Braga de Resende, Remo Castro Russo, Candido Celso Coimbra, Albena Nunes Silva, Mauro Martins Teixeira, Barbara Maximino Rezende, Vanessa Pinho
Summary: Acute high intensity exercise induces inflammation, but physical training can attenuate exercise-induced inflammation. Training enhances immune adaptations and decreases inflammatory response post-exercise.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Emiel A. De Jaeghere, Sandra Tuyaerts, An M. T. Van Nuffel, Ann Belmans, Kris Bogaerts, Regina Baiden-Amissah, Lien Lippens, Peter Vuylsteke, Stephanie Henry, Xuan Bich Trinh, Peter A. van Dam, Sandrine Aspeslagh, Alex De Caluwe, Eline Naert, Diether Lambrechts, An Hendrix, Olivier De Wever, Koen K. Van de Vijver, Frederic Amant, Katrien Vandecasteele, Hannelore G. Denys
Summary: The PRIMMO study conducted a phase II trial on patients with pretreated persistent/recurrent/metastatic cervical or endometrial cancer. The study found that pembrolizumab, radiotherapy, and an immunomodulatory five-drug cocktail had modest but durable antitumor activity, with acceptable but not negligible toxicity.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Correction
Oncology
Yichao Hua, Gerlanda Vella, Florian Rambow, Elizabeth Allen, Asier Antoranz Martinez, Marie Duhamel, Akira Takeda, Sirpa Jalkanen, Steffie Junius, Ann Smeets, David Nittner, Stefanie Dimmeler, Thomas Hehlgans, Adrian Liston, Francesca Maria Bosisio, Giuseppe Floris, Damya Laoui, Maija Hollmen, Diether Lambrechts, Pascal Merchiers, Jean-Christophe Marine, Susan Schlenner, Gabriele Bergers
Article
Cell & Tissue Engineering
Florian Hermans, Lara Hemeryck, Celine Bueds, Marc Torres Pereiro, Steffie Hasevoets, Hiroto Kobayashi, Diether Lambrechts, Ivo Lambrichts, Annelies Bronckaers, Hugo Vankelecom
Summary: Organoid models have been successfully established to study tissue biology and development in a dish. In this study, tooth organoids (TOs) were developed from mouse molar and incisor, which express dental epithelium stem cell markers and recapitulate key properties of dental epithelium. These TOs can differentiate into ameloblast-resembling cells and co-differentiate into different cell types in the presence of dental mesenchymal stem cells. Furthermore, the TOs can also survive and differentiate in vivo. These organoid models provide new tools to study mouse tooth biology and development and may have implications for future human tooth repair and replacement.
Article
Multidisciplinary Sciences
Baptiste Lamarthee, Jasper Callemeyn, Yannick Van Herck, Asier Antoranz, Dany Anglicheau, Patrick Boada, Jan Ulrich Becker, Tim Debyser, Frederik De Smet, Katrien De Vusser, Maeva Eloudzeri, Amelie Franken, Wilfried Gwinner, Priyanka Koshy, Dirk Kuypers, Diether Lambrechts, Pierre Marquet, Virginie Mathias, Marion Rabant, Minnie M. Sarwal, Aleksandar Senev, Tara K. Sigdel, Ben Sprangers, Olivier Thaunat, Claire Tinel, Thomas Van Brussel, Amaryllis Van Craenenbroeck, Elisabet Van Loon, Thibaut Vaulet, Francesca Bosisio, Maarten Naesens
Summary: Although kidney allograft failure is classified as either T cell- or antibody-mediated, this distinction is not always clear in all patients, emphasizing the need for better characterization of allograft tissue. The authors used single-cell RNA sequencing and multiplex imaging to analyze the transcriptomes and spatial profiles of allograft tissue from patients with different degrees of rejection severity. The study identified specific cell types and gene expression signatures associated with rejection, highlighting the involvement of innate immune cells in allograft rejection and suggesting potential therapeutic targets to improve graft longevity.
NATURE COMMUNICATIONS
(2023)
Article
Clinical Neurology
Anna Matveeva, Orla Watters, Ani Rukhadze, Niraj Khemka, Debora Gentile, Ivan Fernandez Perez, Irene Llorente-Folch, Cliona Farrell, Elide Lo Cacciato, Joshua Jackson, Antonia Piazzesi, Lena Wischhof, Ina Woods, Luise Halang, Marion Hogg, Amaya Garcia Munoz, Eugene T. Dillon, David Matallanas, Ingrid Arijs, Diether Lambrechts, Daniele Bano, Niamh M. C. Connolly, Jochen H. M. Prehn
Summary: A study found that upregulation of ACSL3 and YARS2 in the cortical tissues of pre-symptomatic ALS/FTD were the most common changes, suggesting that fatty acid beta-oxidation and mitochondrial protein translation may be adaptive mechanisms in response to ALS/FTD pathology.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2023)
Article
Oncology
Anna Morra, Maartje A. C. Schreurs, Irene L. Andrulis, Hoda Anton-Culver, Annelie Augustinsson, Matthias W. Beckmann, Sabine Behrens, Stig E. Bojesen, Manjeet K. Bolla, Hiltrud Brauch, Annegien Broeks, Saundra S. Buys, Nicola J. Camp, Jose E. Castelao, Melissa H. Cessna, Jenny Chang-Claude, Wendy K. Chung, Sarah Colonna, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Mary B. Daly, Joe Dennis, Peter Devilee, Thilo Doerk, Alison M. Dunning, Miriam Dwek, Douglas F. Easton, Diana M. Eccles, Mikael Eriksson, D. Gareth Evans, Peter A. Fasching, Tanja N. Fehm, Jonine D. Figueroa, Henrik Flyger, Marike Gabrielson, Manuela Gago-Dominguez, Montserrat Garcia-Closas, Jose A. Garcia-Saenz, Jeanine A. Genkinger, Felix Grassmann, Melanie Guendert, Eric Hahnen, Christopher Haiman, Ute Hamann, Patricia A. Harrington, Jaana M. Hartikainen, Reiner Hoppe, John L. Hopper, Richard S. Houlston, Anthony Howell, Anna Jakubowska, Wolfgang Janni, Helena Jernstroem, Esther M. John, Nichola Johnson, Michael E. Jones, Vessela N. Kristensen, Allison Kurian, Diether Lambrechts, Loic Le Marchand, Annika Lindblom, Jan Lubinski, Michael P. Lux, Arto Mannermaa, Dimitrios Mavroudis, Anna Marie Mulligan, Taru A. Muranen, Heli Nevanlinna, Ines Nevelsteen, Patrick Neven, William G. Newman, Nadia Obi, Kenneth Offit, Andrew F. Olshan, Tjoung-Won Park-Simon, Alpa Patel, Paolo Peterlongo, Kelly-Anne Phillips, Dijana Plaseska-Karanfilska, Eric C. Polley, Nadege Presneau, Katri Pylkas, Brigitte Rack, Paolo Radice, Muhammad U. Rashid, Valerie Rhenius, Mark Robson, Atocha Romero, Emmanouil Saloustros, Elinor J. Sawyer, Rita K. Schmutzler, Sabine Schuetze, Christopher Scott, Mitul T. Shah, Snezhana Smichkoska, Melissa C. Southey, William J. Tapper, Lauren R. Teras, Rob A. E. M. Tollenaar, Katarzyna Tomczyk, Ian Tomlinson, Melissa Troester, Celine Vachon, Elke van Veen, Qin Wang, Camilla Wendt, Hans Wildiers, Robert A. Winqvist, Argyrios Ziogas, Per Hall, Paul D. P. Pharoah, Muriel Adank, Antoinette Hollestelle, Marjanka K. Schmidt, Maartje Hooning
Summary: Breast cancer patients with the CHEK2 c.1100delC variant have an increased risk of contralateral breast cancer and worse survival. Systemic therapy is associated with reduced contralateral breast cancer risk, regardless of CHEK2 c.1100delC status. Patients with the CHEK2 c.1100delC variant have shorter survival, which is not fully explained by their contralateral breast cancer risk.
Meeting Abstract
Oncology
Ian S. Miller, Valentina Thomas, Tom Venken, Ingrid Arijs, Ana Barat, Johannes Betge, Tianzuo Zhan, Timo Gaiser, Matthias P. Ebert, Jochen Prehn, Rut Klinger, Darran P. O'Connor, Brian Brian Moulton, Verena Murphy, Ray McDermott, Brian Bird, Gregory Leonard, Liam Grogan, Anne Horgan, Nadine Schulte, Markus Moehler, Nicole Prannikar, Judith Franz-Werner, Hans-Peter Feustel, Diether Lambrechts, Annette T. Byrne
Meeting Abstract
Oncology
Francesca Lodi, Sam Vanmassenhove, Elena Donders, Pierre Van Mol, Amelie Franken, Sarah Cappuyns, Ayse Bassez, Siel Olbrecht, Liselore Loverix, Michel Bila, Hanne Vos, Joanna Pozniak, Kevin Punie, Diether Lambrechts
Meeting Abstract
Oncology
Francois Richard, Tatjana Geukens, Giuseppe Marano, Wouter Van Den Bogaert, Maxim De Schepper, Marion Maetens, Amena Mahdami, Karen Van Baelen, Ha-Linh Nguyen, Anirudh Pabba, Sophia Leduc, Edoardo Isnaldi, Maysam Hajipirloo, Imane Bachir, Evy Vanderheyden, Bram Boeckx, Diether Lambrechts, Ann Smeets, Ines Nevelsteen, Kevin Punie, Patrick Neven, Hans Wildiers, Elia Biganzoli, Giuseppe Floris, Christine Desmedt
Meeting Abstract
Oncology
Francois Richard, Tatjana Geukens, Maxim De Schepper, Amena Mahdami, Karen Van Baelen, Marion Maetens, Ha-Linh Nguyen, Anirudh Pabba, Sophia Leduc, Edoardo Isnaldi, Maysam Hajipirloo, Emily Vanden Berghe, Imane Bachir, Sigrid Hatse, Peter Vermeulen, Evy Vanderheyden, Bram Boeckx, Diether Lambrechts, Ann Smeets, Ines Nevelsteen, Kevin Punie, Patrick Neven, Hans Wildiers, Wouter Van Den Bogaert, Elia Biganzoli, Giuseppe Floris
Meeting Abstract
Oncology
Marie Fongard, Chloe Steen, Salim Ghannoum, Marius Bjornstad, Barbro Holm, Tatjana Bosnjak, Laurens Reitsma, Stephanie Geisler, Kamilla Fjermeros, Johannes Bruteig, Manouchehr Seyedzadeh, Unn-Cathrin Buvarp, Marie Loeng, Aino Vuoriluoto, Torben Luders, Diether Lambrechts, Marianne Lyngra, Vessela Kristensen, Jurgen Geisler, Xavier Tekpli
Meeting Abstract
Gastroenterology & Hepatology
Lukas Van Melkebeke, Jef Verbeek, Dora Bihary, Markus Boesch, Hannelie Korf, Diether Lambrechts, Schalk van der Merwe
JOURNAL OF HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Sarah Cappuyns, Gino Philips, Vincent Vandecaveye, Bram Boeckx, Rogier Schepers, Thomas Van Brussel, Ingrid Arijs, Aurelie Mechels, Ayse Bassez, Francesca Lodi, Joris Jaekers, Halit Topal, Baki Topal, Orian Bricard, Junbin Qian, Eric Van Cutsem, Chris Verslype, Diether Lambrechts, Jeroen Dekervel
JOURNAL OF HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Sarah Cappuyns, Marta Pique-Gili, Roger Esteban-Fabro, Gino Philips, Roser Pinyol, Vincent Vandecaveye, Jordi Abril-Fornaguera, Philipp Haber, Chris Verslype, Eric Van Cutsem, Diether Lambrechts, Augusto Villanueva, Jeroen Dekervel, Josep Llovet
JOURNAL OF HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Rita Furtado Feio de Azevedo, Markus Boesch, Silvia Radenkovic, Marie Wallays, Lukas Van Melkebeke, Bram Boeckx, Gino Philips, Lena Smets, Wim Laleman, Philippe Meersseman, Alexander Wilmer, David Cassiman, Hannah Van Malenstein, Joan Claria, Frederik Nevens, Jef Verbeek, Richard Moreau, Vicente Arroyo, Dieter Lambrechts, Bart Ghesquiere, Hannelie Korf, Schalk van der Merwe
JOURNAL OF HEPATOLOGY
(2023)