期刊
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
卷 43, 期 9, 页码 1666-1674出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1249/MSS.0b013e318214679d
关键词
DYSANAPSIS; EXPIRATORY FLOW LIMITATION; GENDER; LUNG MECHANICS
资金
- Natural Science and Engineering Research Council of Canada (NSERC)
- British Columbia Lung Association
- Michael Smith Foundation for Health Research
- Sir James Lougheed Award of Distinction
- John Alexander Stewart Fellowship
- Canadian Institutes for Health Research
DOMINELLI, P. B., J. A. GUENETTE, S. S. WILKIE, G. E. FOSTER, and A. W. SHEEL. Determinants of Expiratory Flow Limitation in Healthy Women during Exercise. Med. Sci. Sports Exerc., Vol. 43, No. 9, pp. 1666-1674, 2011. Purpose: Expiratory flow limitation (EFL) can occur in healthy young women during exercise. We questioned whether the occurrence and severity of EFL were related to aerobic fitness or anatomical factors. Methods: Twenty-two healthy young (<40 yr) women performed a progressive cycle test to exhaustion. The subjects' maximum expiratory flow-volume curve was compiled from several effort-graded vital capacity maneuvers before and after exercise. The maximum expiratory flow-volume curve, along with inspiratory capacity maneuvers, was used to determine lung volumes and expiratory flows and to quantify EFL. To determine relative airway size, we used a ratio sensitive to both airway size and lung volume, called the dysanapsis ratio. The subjects were partitioned into two groups based upon the appearance of >5% EFL. Results: Ten subjects showed EFL during exercise. Forced vital capacities (4.4 +/- 0.4 vs 3.7 +/- 0.4 L, P < 0.001) and forced expiratory flows for any given lung volume were significantly larger in the non-expiratory flow-limited (NEFL) group. The NEFL group's dysanapsis ratio was significantly larger than that of the EFL group (0.27 +/- 0.06 vs 0.21 +/- 0.04, respectively, P < 0.05), indicating larger airways in the NEFL group. There was no difference between the NEFL and EFL groups with respect to maximal aerobic capacity (50.8 +/- 10.0 vs 46.7 +/- 5.9 mL.kg(-1).min(-1), respectively, P = 0.264). At peak exercise, the NEFL group had a significantly higher end-expiratory lung volume than the EFL group (40.1% +/- 4.8% vs 33.7% +/- 5.7% FVC, respectively, P < 0.05). Conclusions: We conclude that EFL in women can largely be explained by anatomical factors that influence the capacity to generate flow and volume during exercise rather than fitness per se.
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