Article
Nutrition & Dietetics
Keiko Namma-Motonaga, Emi Kondo, Takuya Osawa, Keisuke Shiose, Akiko Kamei, Motoko Taguchi, Hideyuki Takahashi
Summary: Daily muscle glycogen recovery is crucial for athletes. This study used C-13-MRS to investigate the impact of carbohydrate intake on muscle glycogen recovery for 24 hours after exercise. The findings suggest that a carbohydrate intake of 5 g/kg BM/d is insufficient for Japanese athletes to recover muscle glycogen stores within 24 hours.
Article
Nutrition & Dietetics
Sergej M. Ostojic
Summary: Low tissue creatine is a characteristic of many diseases, and non-invasive monitoring with MRS can be a valuable tool for evaluating and utilizing tissue creatine as a relevant target in clinical nutrition.
Article
Multidisciplinary Sciences
Haidong Li, Xiuchao Zhao, Yujin Wang, Xin Lou, Shizhen Chen, He Deng, Lei Shi, Junshuai Xie, Dazhong Tang, Jianping Zhao, Louis-S Bouchard, Liming Xia, Xin Zhou
Summary: The recovery process of COVID-19 patients remains unclear, with some experiencing ongoing respiratory issues. Xe-129 MRI analysis reveals higher ventilation defects and longer gas-blood exchange time in COVID-19 patients, indicating lung function impairment during recovery.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jameen Arm, Georg Oeltzschner, Oun Al-iedani, Rod Lea, Jeannette Lechner-Scott, Saadallah Ramadan
Summary: This study revealed that fatigue in patients with relapse remitting multiple sclerosis is associated with alterations in GABA and Glx levels in different brain regions, indicating a potential dysregulation of GABAergic and glutamatergic neurotransmission in the pathophysiological mechanism of central fatigue in MS.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rex E. Jeffries, Shawn M. Gomez, Jeffrey M. Macdonald, Michael P. Gamcsik
Summary: Nuclear magnetic resonance (NMR) spectroscopy was used to monitor the metabolism of glutathione in alginate-encapsulated JM-1 hepatoma cells. The results showed that the C-13-labeled glutathione signal provided a high-intensity spectrum, allowing for the monitoring of the detailed kinetics of glutathione metabolism. Additionally, the effects of the thiol alkylating agent on glutathione metabolism were observed, and the regeneration of intracellular glutathione was studied through the restoration of the C-13-glutathione signal and the wash-out of the conjugate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Endocrinology & Metabolism
Harald E. Moeller
Summary: Long-lasting activities with high demand in cognitive control result in cognitive fatigue, and the reason for control cost inflation is the necessity of recycling potentially toxic substances, specifically glutamate, which can accumulate extracellularly.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Review
Chemistry, Multidisciplinary
Florence Franconi, Laurent Lemaire, Jean-Christophe Gimel, Samuel Bonnet, Patrick Saulnier
Summary: NMR-based diffusion methods are valuable tools for nanomedicine characterization and understanding interactions with the biological environment. They provide insights into diffusion phenomena and measurement of self-diffusion and mutual diffusion coefficients. NMR diffusometry spectroscopic and imaging methods have broad applications in nanomedicine, aiding in elucidating important issues.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Physics, Multidisciplinary
C. Munuera-Javaloy, A. Tobalina, J. Casanova
Summary: Ensembles of nitrogen-vacancy centers are used to detect nuclear magnetic resonance signals from micron-sized samples. The large magnetic field regime is of particular interest due to the high thermal polarization and accessibility of chemical shifts and J couplings. However, coupling NV-based sensors with high-frequency nuclear signals has been challenging. This Letter presents a method that overcomes this obstacle and achieves high spectral resolutions, limited only by the coherence of the nuclear spin signal.
PHYSICAL REVIEW LETTERS
(2023)
Article
Physics, Multidisciplinary
A. J. Healey, S. C. Scholten, T. Yang, J. A. Scott, G. J. Abrahams, I. O. Robertson, X. F. Hou, Y. F. Guo, S. Rahman, Y. Lu, M. Kianinia, I Aharonovich, J-P Tetienne
Summary: A versatile quantum microscope is demonstrated using point defects embedded in a thin layer of hexagonal boron nitride, allowing for real-time observation of temperature and magnetic field near the Curie temperature of a van der Waals ferromagnet, as well as mapping of charge currents and Joule heating in a graphene device. The integration of hexagonal boron nitride quantum sensor with other van der Waals materials will have significant practical benefits for the design and measurement of 2D devices.
Article
Gastroenterology & Hepatology
Jan-Luca Reichardt, Meike Dirks, Ann-Katrin Wirries, Henning Pflugrad, Patrick Noesel, Kim Haag, Heinrich Lanfermann, Heiner Wedemeyer, Andrej Potthoff, Karin Weissenborn, Xiao-Qi Ding
Summary: Neuropsychiatric symptoms in patients with HCV, AIH, and PBC exhibit similar alterations in brain proton density and metabolites compared to healthy controls, suggesting potential shared pathophysiological mechanisms among these conditions. However, correlations between MRI/MRS observations and neuropsychological dysfunction were not significant.
LIVER INTERNATIONAL
(2022)
Article
Physics, Multidisciplinary
Ainitze Biteri-Uribarren, Pol Alsina-Bolivar, Carlos Munuera-Javaloy, Ricardo Puebla, Jorge Casanova
Summary: This study tackles the detection of individual molecules by combining a hybrid sensor-a nitrogen vacancy center (NV) and a dangling bond on the diamond surface-with a multi-tone dynamical decoupling sequence. Via numerical simulations, the authors prove that the sequence minimizes the impact of decoherence, which allows using the dangling-bond as a signal amplifier.
COMMUNICATIONS PHYSICS
(2023)
Article
Neurosciences
Thomas J. Hureau, Ryan M. Broxterman, Joshua C. Weavil, Matthew T. Lewis, Gwenael Layec, Markus Amann
Summary: This study investigated the relationship between intramuscular metabolites and neuromuscular function during exercise. The results suggest that intramuscular inorganic phosphate is the primary cause of peripheral fatigue, and muscle acidosis contributes to central fatigue.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Multidisciplinary Sciences
K. S. Cujia, K. Herb, J. Zopes, J. M. Abendroth, C. L. Degen
Summary: The study extends nuclear magnetic resonance imaging to large nuclear spin clusters by combining weak quantum measurements, phase encoding, and simulated annealing. This method allows for the simultaneous detection of three-dimensional positions from multiple nuclei, with spatial selectivity and successful imaging of clusters containing multiple nuclear spins at room temperature.
NATURE COMMUNICATIONS
(2022)
Correction
Biochemical Research Methods
Melissa M. Wu, Katherine Perdue, Suk-Tak Chan, Kimberly A. Stephens, Bin Deng, Maria Angela Franceschini, Stefan A. Carp
Summary: This sentence states that there are errata for the associated article.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Neuroimaging
Wenli Li, Jiale Xu, Qiong Xiang, Kaiming Zhuo, Yaoyu Zhang, Dengtang Liu, Yao Li
Summary: This study examined the association between the alterations in default mode network (DMN) functional connectivity, changes in neurometabolites levels in the medial prefrontal cortex (MPFC), and improvements in psychopathology in drug-naive first-episode psychosis (FEP) patients, finding a correlation between these changes and symptom improvement.
NEUROIMAGE-CLINICAL
(2022)
Article
Emergency Medicine
Helen Anwander, Fabian Fuhrer, Gaelle Diserens, Beat Kaspar Moor, Chris Boesch, Peter Vermathen, Waldo Valenzuela, Matthias A. Zumstein
Summary: The study showed that muscle fat content in the healthy infraspinatus muscle correlates with age and BMI, but not with CSA. The measurement of muscle fat content in the entire muscle and slice Y demonstrated high reliability.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2021)
Article
Medicine, Legal
Thomas Widek, Pia Genet, Thomas Ehammer, Thorsten Schwark, Martin Urschler, Eva Scheurer
Summary: The study aimed to use MRI images of hand and wrist to estimate age of hand bones, and found good agreement with X-ray studies. The age estimates based on MRI images showed small differences with chronological age, indicating relatively low error rates.
FORENSIC SCIENCE INTERNATIONAL
(2021)
Article
Medicine, Legal
Melanie Bauer, Nikolaus Deigendesch, Holger Wittig, Eva Scheurer, Claudia Lenz
Summary: The post mortem evaluation of brain edema can be performed using various methods such as histology, wet-dry weight, and normalized cerebral weight. Results show limited benefits for the histological and wet-dry weight methods in classifying brain edema, with histology analysis being highly observer dependent. In contrast, the normalized cerebral weight method reveals a significant effect in classifying edematous and nonedematous cases according to the gold standard, suggesting its value as an objective and rater independent assessment tool.
FORENSIC SCIENCE INTERNATIONAL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Claudia Lenz, Celine Berger, Melanie Bauer, Eva Scheurer, Christoph Birkl
Summary: This study evaluated differences in fiber orientation dependent R2* between in vivo and post mortem in situ examinations, finding lower orientation dependency post mortem, likely attributed to lower brain temperature.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Biographical-Item
Radiology, Nuclear Medicine & Medical Imaging
Chris Boesch
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Manuela Carla Monti, Eva Scheurer, Katja Mercer-Chalmers-Bender
Summary: The study revealed that CUMYL-THPINACA and ADAMATYL-THPINACA both exhibit a variety of metabolites, with a specific di-hydroxylated metabolite identified as a potential in vivo biomarker. Mainly, CYP3A4 and CYP3A5 were found to be the primary metabolizing enzymes for both substances, with additional involvement of CYP2C8, CYP2C9, and CYP2C19 observed for CUMYL-THPINACA. The results suggest that ADAMANTYL-THPINACA may have a higher risk of metabolic drug-drug interactions compared to CUMYL-THPINACA when co-administered with strong CYP3A4 inhibitors.
Article
Biochemical Research Methods
Priska Frei, Stephanie Frauchiger, Eva Scheurer, Katja Mercer-Chalmers-Bender
Summary: Cannabis is the most commonly consumed illegal substance globally, but there is an increasing consumption of legal cannabis products with low levels of THC and high levels of CBD. This study presents a validated and automated method for quantifying THC, its metabolites, CBD, and CBN in whole blood and urine. The method allows sensitive and robust measurement of cannabinoids, and the detection of CBD provides additional information about consumed products.
DRUG TESTING AND ANALYSIS
(2022)
Article
Biochemical Research Methods
Manuela Carla Monti, Jill Zeugin, Konrad Koch, Natasa Milenkovic, Eva Scheurer, Katja Mercer-Chalmers-Bender
Summary: Since late 2019, Switzerland has frequently observed low-THC preparations adulterated with synthetic cannabinoids. Users' unawareness of the presence of synthetic cannabinoids and the higher potency and toxicity compared to THC can lead to increased health risks. This study collected and analyzed cannabis samples and user self-reports to gain insight into this phenomenon. The results showed that around 50% of the samples contained up to three different synthetic cannabinoids, with MDMB-4en-PINACA being the most commonly detected. Adverse effects were more profound in the group that consumed adulterated products, especially in psychological and cardiological aspects.
DRUG TESTING AND ANALYSIS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Celine Berger, Melanie Bauer, Holger Wittig, Eva Scheurer, Claudia Lenz
Summary: This study aimed to assess the effects of brain temperature on MRI parameters and develop linear models to correct for temperature in post mortem MRI. Linear positive temperature correlations were observed for T-1, T-2* and mean diffusivity in all tissue types.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2022)
Article
Medicine, Legal
Alina Senst, Eva Scheurer, Kathrin Gerlach, Iris Schulz
Summary: In forensic medicine, DNA genotyping is crucial for identifying deceased individuals, especially when bodies are severely altered. This study examined the success of DNA analysis in different tissue types from decomposed, skeletonised, burnt, and water-submerged bodies, revealing the challenges and uncertainties associated with DNA-based identification in altered human remains.
JOURNAL OF FORENSIC AND LEGAL MEDICINE
(2021)
Article
Biochemical Research Methods
Manuela Carla Monti, Priska Frei, Sophie Weber, Eva Scheurer, Katja Mercer-Chalmers-Bender
Summary: This study developed an analytical method for the elucidation of minor cannabinoid fingerprints in cannabis varieties. By using targeted and non-targeted metabolomics, it was possible to distinguish different cannabis varieties by their minor cannabinoid fingerprints and detect additional plant ingredients. This contributes to a better understanding of the chemical composition and diversity of cannabis.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Medicine, Legal
Alina Senst, Amke Caliebe, Eva Scheurer, Iris Schulz
Summary: The study evaluated the performance of MiSeq FGx system and ForenSeq (TM) DNA Signature Prep Kit on challenging DNA samples, such as degraded and inhibited samples, and found the system to be reliable in concordance to traditional CE-based genotyping but still had some limitations when dealing with highly degraded and inhibited remains samples.
JOURNAL OF FORENSIC SCIENCES
(2022)
Article
Multidisciplinary Sciences
Korbinian Lackermair, Florian Fischer, Johannes Manhart, Eva Scheurer, Matthias Graw, Diana Boy, Claudia Lenz, Bonnie Hartrampf, Antonia Kellnar, Lauren Sams, Heidi Estner, Stephanie Fichtner
Summary: Postmortal interrogation of cardiac implantable electrical devices (CIED) can contribute to determining time of death in forensic medicine. Combining findings from autopsy, CIED interrogation, and patients' medical history improves estimation accuracy. Certain types and manufacturers of CIED are associated with more successful time of death determination.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Legal
Melanie Bauer, Celine Berger, Kathrin Gerlach, Eva Scheurer, Claudia Lenz
Summary: This study examined the suitability of magnetic resonance imaging (MRI) as an objective, noninvasive, and quantitative method for differentiating edematous and nonedematous brains. The results showed that quantitative MRI, specifically the calculation of T2 and FA parameters, can effectively differentiate edematous brains from nonedematous brains. In addition to providing morphological information, post mortem in situ MRI scans can provide relevant and objective information on the edema status of the brain prior to autopsy or when no autopsy is ordered.
FORENSIC SCIENCE INTERNATIONAL
(2022)
Article
Medicine, Legal
Laura Egloff, Priska Frei, Kathrin Gerlach, Katja Mercer-Chalmers-Bender, Eva Scheurer
Summary: This prospective study aimed to determine cannabinoid levels in blood and driving-related ability after single and repetitive vaporization of CBD-rich cannabis. The results showed no significant differences in driving-related ability between low-THC/CBD-rich products and placebo. However, detection of THC after consumption of low-THC/CBD-rich cannabis could have legal consequences for drivers.
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
(2023)
