Article
Peripheral Vascular Disease
Julian E. Mariampillai, Erik E. Prestgaard, Sverre E. Kjeldsen, Knut Liestol, Irene Grundvold, Johan Bodegard, Knut Gjesdal, Jan E. Erikssen, Per T. Skretteberg
Summary: The study revealed that in healthy middle-aged men, an increase in blood pressure during maximal exercise is positively associated with the risk of stroke. An exaggerated blood pressure response to physical exercise may independently predict the risk of stroke.
JOURNAL OF HYPERTENSION
(2021)
Review
Biochemistry & Molecular Biology
Bashar Saad
Summary: Obesity is a chronic condition caused by an imbalance between energy consumption and expenditure. It is associated with premature mortality and contributes to a significant portion of chronic diseases worldwide. Lifestyle changes and dietary adjustments are the main strategies for managing obesity, but medication may be necessary in some cases. However, drug options are limited due to potential side effects, highlighting the need for safe and effective alternative treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Adam S. Vaughan, Fatima Coronado, Michele Casper, Fleetwood Loustalot, Janet S. Wright
Summary: This study examines trends in county-level hypertension-related cardiovascular disease (CVD) death rates and finds significant increases, particularly among adults aged 35 to 64 years. The study highlights the need for intensified clinical and public health actions to improve hypertension prevention, detection, and control in order to reduce CVD deaths across counties.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Yuta Suzuki, Hidehiro Kaneko, Yuichiro Yano, Akira Okada, Hidetaka Itoh, Satoshi Matsuoka, Isao Yokota, Takahiro Imaizumi, Katsuhito Fujiu, Nobuaki Michihata, Taisuke Jo, Norifumi Takeda, Hiroyuki Morita, Koichi Node, Hideo Yasunaga, Issei Komuro
Summary: This study found that hypertension and hyperglycemia have a synergistic effect on the development of cardiovascular disease (CVD). However, as glycemic status deteriorates, the relative risk of hypertension developing into CVD decreases, and the relative risk of hyperglycemia developing into CVD is attenuated with increasing blood pressure. The results suggest a potential interaction between hypertension and hyperglycemia in the development of CVD.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Arnaud D. Kaze, Sebhat Erqou, Prasanna Santhanam, Alain G. Bertoni, Rexford S. Ahima, Gregg C. Fonarow, Justin B. Echouffo-Tcheugui
Summary: This study found that greater variability in adiposity indices in individuals with type 2 diabetes was associated with a higher risk of incident heart failure, independently of traditional risk factors and baseline adiposity levels.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Endocrinology & Metabolism
Karine Suissa, Sebastian Schneeweiss, Antonios Douros, Kristian B. Filion, Hui Yin, Elisabetta Patorno, Laurent Azoulay
Summary: The study found that, compared with metformin, sulphonylureas did not increase the risk of major adverse cardiovascular events overall, but were associated with an increased risk of cardiovascular and all-cause mortality, particularly among obese patients. These results suggest that adiposity may modify the effects of sulphonylureas on cardiovascular safety and mortality compared with metformin.
DIABETES OBESITY & METABOLISM
(2021)
Article
Public, Environmental & Occupational Health
Ryan G. Wagner, Nigel J. Crowther, Lisa K. Micklesfield, Palwende Romauld Boua, Engelbert A. Nonterah, Felistas Mashinya, Shukri F. Mohamed, Gershim Asiki, Stephen Tollman, Michele Ramsay, Justine Davies
Summary: In sub-Saharan Africa, the prevalence of cardiovascular disease (CVD) risk factors is on the rise, but the impact of these factors on future CVD outcomes remains poorly understood. This study analyzed modifiable risk factors and estimated future CVD risk using various algorithms across four African countries. The results showed significant variations in risk levels between sites and highlighted the need for context-specific risk algorithms to accurately assess population risk and guide CVD treatment in Africa.
Article
Cardiac & Cardiovascular Systems
Junayd Hussain, Haris Imsirovic, Mark Canney, Edward G. Clark, Meghan J. Elliott, Pietro Ravani, Peter Tanuseputro, Ayub Akbari, Gregory L. Hundemer, Tim Ramsay, Navdeep Tangri, Greg A. Knoll, Manish M. Sood
Summary: This study found that subclinical reductions in kidney function in young adults are associated with an increased cardiovascular risk. The relative risk of major adverse cardiovascular events (MACE) and MACE plus heart failure (MACE+) was higher in young adults with eGFR below age-expected values. Age-appropriate risk stratification, proactive monitoring, and timely intervention are warranted.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Eva Nordendahl, Michael Fored, Barbro Kjellstrom, Anders Ekbom, Anna Norhammar, Anders Gustafsson
Summary: Using data from national registries in Sweden, this study found no association between periodontitis and a first myocardial infarction. Although cases received less scaling/root planing and/or periodontal surgery treatment than controls, there was no significant impact on the risk of a first myocardial infarction.
JOURNAL OF PERIODONTOLOGY
(2021)
Review
Cell Biology
Karsten Konigstein, Konstantina Dipla, Andreas Zafeiridis
Summary: Accelerated biological vascular ageing is a major driver of cardiovascular disease and mortality. Exercise training can delay early vascular ageing, but its effectiveness is often limited due to a lack of understanding of specific adaptations. This review summarizes the current knowledge on molecular and clinical vascular adaptations to acute and chronic exercise, and provides practical recommendations for maintaining and improving vascular health.
Article
Endocrinology & Metabolism
Danielle Newby, Victoria Garfield
Summary: Individuals with comorbid diabetes and hypertension have poorer brain and cognitive health compared to those with only one of these diseases. These findings suggest that prevention of both diabetes and hypertension may delay changes in brain structure, as well as the onset of cognitive decline and dementia.
DIABETES OBESITY & METABOLISM
(2022)
Article
Sport Sciences
Mark Hamer, Joanna M. Blodgett, Emmanuel Stamatakis
Summary: This study examined the dose-response associations between step count and classical cardiovascular disease risk markers and found that there is a linear risk reduction up to around 10,000 steps a day. Controlling for stepping intensity did not materially alter the results.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2022)
Article
Cell Biology
Susanne Kristine Aune, Joanna Cwikiel, Arnljot Flaa, Harald Arnesen, Svein Solheim, Ayodeji Awoyemi, Marius Troseid, Ingebjorg Seljeflot, Ragnhild Helseth
Summary: Elevated levels of gut leakage markers were observed in CAD patients after strenuous exercise, with TLR4 gene expression decreased as a possible feedback to the increase in LPS. The exercise-induced changes in gut leakage were independent of the presence of CAD.
Review
Cardiac & Cardiovascular Systems
Nicola Riccardo Pugliese, Pierpaolo Pellicori, Francesco Filidei, Nicolo De Biase, Pasquale Maffia, Tomasz J. Guzik, Stefano Masi, Stefano Taddei, John G. F. Cleland
Summary: Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome mainly affecting older people with many comorbidities. The management of HFpEF currently focuses on symptom control and treatment of comorbid conditions. Inflammation may play a key role in the development and progression of HFpEF.
CARDIOVASCULAR RESEARCH
(2023)
Article
Multidisciplinary Sciences
Navin Suthahar, Laura M. G. Meems, Coenraad Withaar, Thomas M. Gorter, Lyanne M. Kieneker, Ron T. Gansevoort, Stephan J. L. Bakker, Dirk J. van Veldhuisen, Rudolf A. de Boer
Summary: This study investigated the association between various anthropometric indices of adiposity and incident heart failure, and found that relative fat mass displayed the strongest association with heart failure risk.
SCIENTIFIC REPORTS
(2022)
Article
Public, Environmental & Occupational Health
Alice Sullivan, Matt Brown, Mark Hamer, George B. Ploubidis
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Nutrition & Dietetics
Elif Inan-Eroglu, Bo-Huei Huang, Peter Sarich, Natasha Nassar, Emmanuel Stamatakis
Summary: Obesity and alcohol consumption are important modifiable risk factors for cancer. This study found that individuals who were both in the higher adiposity groups and exceeded the alcohol guidelines had the highest risk of cancer. Additionally, regardless of alcohol consumption, higher adiposity was associated with an increased risk of obesity-related cancer in a dose-response manner.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Clinical Neurology
Peter J. Johansson, Patrick Crowley, John Axelsson, Karl Franklin, Anne Helene Garde, Pasan Hettiarachchi, Andreas Holtermann, Goran Kecklund, Eva Lindberg, Mirjam Ljunggren, Emmanuel Stamatakis, Jenny Theorell Haglow, Magnus Svartengren
Summary: Accelerometers placed on the thigh provide accurate measures of daily physical activity types, postures, and sedentary behaviors. However, their ability to estimate sleep duration or quality has not been thoroughly evaluated. This study developed an algorithm to estimate sleep using thigh-worn accelerometers and compared it with polysomnography. The algorithm had good sensitivity and specificity in estimating sleep periods, although sleep intervals and total sleep time were slightly underestimated.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Hugues Sampasa-Kanyinga, Jean-Philippe Chaput, Bo-Huei Huang, Mitch J. Duncan, Mark Hamer, Emmanuel Stamatakis
Summary: This study examined the bidirectional association between discretionary screen time (DST) and sleep patterns in adults. The findings suggest that high DST is associated with poor sleep, and poor sleep is associated with high DST.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Psychology, Multidisciplinary
Aiden J. Chauntry, Nicolette C. Bishop, Mark Hamer, Nicola J. Paine
Summary: Sitting for long periods without interruption and the way we respond to short-term stress are linked to heart disease risk. Breaking up sitting with light activity can lower heart disease risk.
ANNALS OF BEHAVIORAL MEDICINE
(2023)
Article
Psychology, Clinical
Verity Hailey, Abi Fisher, Mark Hamer, Daisy Fancourt
Summary: This study analyzed data from the COVID-19 lockdown period and found that social support played an important role in maintaining physical activity during the lockdown, while loneliness and social isolation did not show a significant association with physical activity.
INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Matthew N. Ahmadi, Elif Inan-Eroglu, Gita D. Mishra, Amanda Salis, Emmanuel Stamatakis
Summary: This study examined the association between changes in physical activity and diet with obesity development and changes in body fat percentage, body mass index, and waist circumference. The results showed that increasing physical activity combined with improving diet was most effective in reducing the risk of obesity. Improvements in physical activity or diet mutually attenuated the deleterious associations of the other behavior's deterioration.
PREVENTIVE MEDICINE
(2023)
Letter
Medicine, General & Internal
Borja del Pozo Cruz, Matthew Ahmadi, Emmanuel Stamatakis
JAMA INTERNAL MEDICINE
(2023)
Article
Medicine, General & Internal
Bo-Huei Huang, Borja del Pozo Cruz, Armando Teixeira-Pinto, Peter A. Cistulli, Emmanuel Stamatakis
Summary: This study found that poor sleep quality, both self-reported and doctor-diagnosed, is associated with increased risk of cardiovascular disease. Sleep-related breathing disorders are particularly pronounced in their negative impact on CVD-free life.
Article
Sport Sciences
Susan Paudel, Matthew Ahmadi, Philayrath Phongsavan, Mark Hamer, Emmanuel Stamatakis
Summary: This study examined whether individual-level and area-level socioeconomic status (SES) modify the associations between moderate-to-vigorous physical activity (MVPA), domain-specific physical activity, and sedentary behavior with all-cause mortality (ACM) and incident cardiovascular disease (CVD). The results showed that low physical activity and high sedentary behavior were associated with increased risk of ACM and incident CVD. There were statistically significant interactions between SES and all exposures in ACM analyses, indicating that the detrimental associations of low MVPA and high screen time with ACM and incident CVD are accentuated in low SES groups.
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Article
Sport Sciences
Le Wei, Matthew N. Ahmadi, Hsiu-Wen Chan, Sebastien Chastin, Mark Hamer, Gita D. Mishra, Emmanuel Stamatakis
Summary: This study aimed to examine the associations between different types and contexts of stepping behaviors and cardiometabolic risk. The results showed that all stepping behaviors were beneficial to cardiometabolic health, with higher stair steps and peak 30-min walking intensity associated with a steep decline of adiposity biomarkers. Purposeful steps showed more consistent associations with cardiometabolic biomarkers than incidental steps.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Sport Sciences
J. J. Mitchell, M. Hamer, J. M. Blodgett, G. S. Wannamethee, B. J. Jefferis
Summary: Evidence suggests that engaging in sporting leisure time physical activity (sporting-LTPA) is associated with healthy cognition in adults. This relationship may be due to the physiological effects of physical activity or other psychosocial factors related to sports. This study examined the association between sporting-LTPA and cognition, while controlling for device-measured physical activity volume, in both midlife and later-life participants. The results showed that there were positive associations between sporting-LTPA and cognition, and sports with team/partner elements were particularly beneficial.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Public, Environmental & Occupational Health
Jacqueline L. Mair, Elroy J. Aguiar, Emmanuel Stamatakis, Sarah M. Edney
JOURNAL OF PHYSICAL ACTIVITY & HEALTH
(2023)
Correction
Medicine, General & Internal
Borja del Pozo Cruz, Matthew Ahmadi, Emmanuel Stamatakis
JAMA INTERNAL MEDICINE
(2023)