Article
Biochemistry & Molecular Biology
Paulo H. C. Mesquita, Donald A. Lamb, Joshua S. Godwin, Shelby C. Osburn, Bradley A. Ruple, Johnathon H. Moore, Christopher G. Vann, Kevin W. Huggins, Andrew D. Fruge, Kaelin C. Young, Andreas N. Kavazis, Michael D. Roberts
Summary: The study found that 6 weeks of resistance training reduced oxidative damage and increased antioxidant enzyme activities in skeletal muscle of older adults. The responses of older adults to resistance training involve multi-level control (transcriptional, post-transcriptional, and post-translational) of the redox status of skeletal muscle.
Review
Biochemistry & Molecular Biology
Sara Mendes, Diogo V. V. Leal, Luke A. A. Baker, Anibal Ferreira, Alice C. C. Smith, Joao L. Viana
Summary: Chronic Kidney Disease (CKD) is a global health burden with high mortality and health costs. CKD patients exhibit lower cardiorespiratory and muscular fitness, strongly associated with morbidity/mortality, which is exacerbated when they reach the need for renal replacement therapies (RRT). Muscle wasting in CKD has been associated with an inflammatory/oxidative status affecting the resident cells' microenvironment, decreasing repair capacity and leading to atrophy. Exercise may help counteracting such effects; however, the molecular mechanisms remain uncertain. This review will start with a general background about myogenesis, followed by an overview of the impact of redox imbalance as a mechanism of muscle wasting in CKD, with focus on the modulatory effect of exercise on the skeletal muscle microenvironment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biology
Denise de Melo-Marins, Juliano Boufleur Farinha, Josianne Rodrigues-Krause, Orlando Laitano, Alvaro Reischak-Oliveira
Summary: The study shows that acute exercise in the heat promotes oxidative stress at both tissue and circulatory levels. However, exercising in the heat also enhances endogenous antioxidant defense systems, reducing oxidative damage. Additionally, sweat-induced dehydration leads to oxidative stress but can be attenuated by rehydration.
JOURNAL OF THERMAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Elena Obrador, Rosario Salvador-Palmer, Rafael Lopez-Blanch, ALi Jihad-Jebbar, Soraya L. Valles, Jose M. Estrela
Summary: Amyotrophic lateral sclerosis (ALS) is a common neurodegenerative disease characterized by motor neuron degeneration leading to muscle weakness and paralysis. Mitochondrial dysfunction plays a significant role in ALS pathophysiology, affecting disease progression. Research indicates that targeting mitochondrial biology may offer potential therapeutic approaches to slow down ALS progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Sport Sciences
Josh Thorley, Craig Thomas, Stephen J. Bailey, Neil R. W. Martin, Nicolette C. Bishop, Tom Clifford
Summary: This study examined the impact of eccentric exercise on NRF2 activity in PBMCs. The results showed that eccentric exercise increased NRF2/ARE binding in PBMCs compared to resting.
JOURNAL OF SPORTS SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ahmet Tuncay, Daniel R. Crabtree, David J. Muggeridge, Holger Husi, James N. Cobley
Summary: The antibody-linked oxi-state assay (ALISA) is a useful tool for quantifying target-specific cysteine oxidation. It benefits both specialists and non-specialists, with its time-efficient analysis and high-throughput capacities. However, more benchmarking is needed before it can be widely adopted.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Tim J. M. Wallis, Magdalena Minnion, Anna Freeman, Andrew Bates, James M. Otto, Stephen A. Wootton, Sophie V. Fletcher, Michael P. W. Grocott, Martin Feelisch, Mark G. Jones, Sandy Jack
Summary: A study found that individualized aerobic interval training can improve exercise capacity and redox status in idiopathic pulmonary fibrosis (IPF) patients. After an 8-week training program, patients showed significant improvements in exercise capacity and redox status.
Review
Biochemistry & Molecular Biology
Zhanyi Zhou, Chaoyi Chen, Ee-Chon Teo, Yan Zhang, Jialu Huang, Yining Xu, Yaodong Gu
Summary: Exercise programs can improve an individual's antioxidative capacity, but inappropriate programs can induce oxidative stress. The severity of oxidative stress depends on the intensity and volume of exercise, as well as the individual's health condition. Recommendations include continuous aerobic exercise under moderate intensity or high-intensity interval training to enhance the body's redox balance, especially for unhealthy individuals.
Article
Biochemistry & Molecular Biology
Maria Jose Lopez-Martinez, Damian Escribano, Alba Ortin-Bustillo, Lorena Franco-Martinez, Luis Guillermo Gonzalez-Arostegui, Jose Joaquin Ceron, Camila Peres Rubio
Summary: This study aimed to evaluate the changes in salivary biomarkers of redox status in pigs with experimentally induced sepsis. The results showed that sepsis caused significant changes in various antioxidant capacity markers in pig saliva, suggesting the potential use of these biomarkers for monitoring pig health.
Article
Biochemistry & Molecular Biology
Belinda J. Dunning, Arno R. Bourgonje, Marian L. C. Bulthuis, Jan Alexander, Jan O. Aaseth, Anders Larsson, Harry van Goor, Urban Alehagen
Summary: This study aimed to evaluate the effect of supplementation with selenium and coenzyme Q10 on serum free thiols and to study associations with the risk of cardiovascular mortality in elderly community-dwelling individuals. The results showed that supplementation with selenium and coenzyme Q10 significantly improved serum free thiol levels and reduced the risk of cardiovascular mortality in elderly individuals.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Engineering, Industrial
Megan J. Blakely, Samantha L. Smith, Paul N. Russell, William S. Helton
Summary: Performing kayaking and a cognitive task (tone counting) simultaneously led to dual-task interference, affecting both tasks compared to single task performance. These results have important implications for occupations involving demanding physical activities and cognitive tasks.
APPLIED ERGONOMICS
(2022)
Review
Biochemistry & Molecular Biology
Dawn S. Tuell, Evan A. Los, George A. Ford, William L. Stone
Summary: The worldwide prevalence of type 2 diabetes (T2D) and prediabetes is increasing rapidly, particularly in younger populations. Oxidative stress (OxS) has been identified as a potential factor in the development of T2D. Natural antioxidant products have the potential to prevent or slow down T2D through various mechanisms such as reducing oxidative stress in mitochondria, preventing damage from lipid peroxidation, and supporting antioxidant enzymes. The evaluation of these products should consider the complex physiological processes involved in T2D-OxS, including glycemic control, postprandial OxS, and lifestyle factors like diet, exercise, and sleep. Future research should also focus on pediatric populations to address the lack of studies in this age group.
Article
Biochemistry & Molecular Biology
Helen T. McKenna, Katie A. O'Brien, Bernadette O. Fernandez, Magdalena Minnion, Adam Tod, Ben D. McNally, James A. West, Julian L. Griffin, Michael P. Grocott, Michael G. Mythen, Martin Feelisch, Andrew J. Murray, Daniel S. Martin
Summary: This study demonstrates rapid, specific and coordinated changes in cellular respiratory machinery, intermediary metabolism, and redox response in critically ill patients, with different trajectories in survivors and non-survivors. Differences in survival rates and metabolic activities were observed between survivors and non-survivors at 48 hours and day 7. Increases in oxidative stress and reductive drive were evident in critically ill patients, with non-survivors showing greater oxidative pressure and vascular inflammation compared to survivors.
Review
Biochemistry & Molecular Biology
Jessica Bouviere, Rodrigo S. Fortunato, Corinne Dupuy, Joao Pedro Werneck-de-Castro, Denise P. Carvalho, Ruy A. Louzada
Summary: Physical exercise induces acute and adaptative responses at the cellular and systemic levels through the modulation of various signaling pathways in skeletal muscle. Antioxidants can blunt these adaptations, highlighting the crucial role of ROS in exercise. Understanding the balance between beneficial and harmful effects of ROS during and after exercise is a challenging question in exercise biology.
Article
Biochemistry & Molecular Biology
Arno R. Bourgonje, Antonius T. Otten, Mehdi Sadaghian Sadabad, Julius Z. H. von Martels, Marian L. C. Bulthuis, Klaas Nico Faber, Harry van Goor, Gerard Dijkstra, Hermie J. M. Harmsen
Summary: Riboflavin supplementation did not significantly change the systemic redox status in healthy individuals. However, observed changes in albumin-adjusted free thiol levels were negatively associated with changes in C-reactive protein levels. Additionally, albumin-adjusted free thiols were independently associated with the relative abundances of faecal F. prausnitzii, suggesting a potential host redox-microbiota interaction.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Nutrition & Dietetics
Celia Regina Barbosa De Araujo, Karini Freire Rocha, Byanca Carneiro, Karla Danielly da Silva Ribeiro, Ines Lanca de Morais, Joao Breda, Patricia Padrao, Pedro Moreira
Summary: This study evaluated the nutritional value of processed food products for 0-36-month-old children in Portugal and Brazil. Results showed that many meat- or fish-based meals in Brazil exceeded the recommended levels of sodium and total fat, while fruit and vegetable purees, as well as juice and smoothie products in Portugal, contained excessive free sugars and fat. These findings highlight the importance of improving the nutritional profile of food products targeted at young children.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Chemistry, Applied
Katherine Gutierrez-Luna, Diana Ansorena, Rebeca Cruz, Iciar Astiasaran, Susana Casal
Summary: The impact of in vitro digestion, processing temperature, and gelling agent on the bioactive compounds and oxidation status of olive and echium oils gelled formulations was assessed. In vitro digestion was the most relevant variable, promoting oxidation regardless of the oil type, gelling agent or temperature applied. The use of alginate as a gelling agent reduced secondary oxidation products formation in comparison with carrageenan.
Article
Chemistry, Applied
Nuno Rodrigues, Fatima Peres, Susana Casal, Arantzazu Santamaria-Echart, Filomena Barreiro, Antonio M. Peres, Jose Alberto Pereira
Summary: Olive oils from different regions in Portugal were analyzed to study the effect of geographical origin on their composition. The results showed that the geographical origin significantly influenced the chemical composition and stability of the oils. Principal component analysis and Fourier transform infrared spectroscopy were used to establish markers and a discriminant model for identifying the origin of the oils.
Review
Food Science & Technology
Cinthia de Carvalho Couto, Caroline Correa de Souza Coelho, Edna Maria Moraes Oliveira, Susana Casal, Otniel Freitas-Silva
Summary: This Systematic Literature Review (SLR) aims to identify and evaluate different types of analytical techniques published in the last 20 years for detecting adulterants in roasted coffee. The presence of impurities in coffee affects its quality. The study was conducted in three stages using StArt software, and 83 studies were selected. Chromatographic, spectroscopic, and multi-adulterant techniques were the most commonly used methods. Suitable techniques for detecting and quantifying adulterations in coffee, especially multi-detection approaches, are crucial for improving coffee quality worldwide.
INTERNATIONAL JOURNAL OF FOOD PROPERTIES
(2023)
Article
Green & Sustainable Science & Technology
Dmitry D. Evtyugin, Antonio Prates, M. Rosario Domingues, Susana Casal, Dmitry V. Evtuguin
Summary: In this work, a new solvent-free and eco-friendly method for isolating ellagic acid (EA) from sulphite spent liquor and alkali extract of unbleached sulphite pulp is proposed. EA was recovered from sulphite pulping streams via crystallization from acidified solutions under preselected conditions. The purity of EA was significantly increased from approximately 55-70% (w/w) to 85-95% (w/w) through the washing process.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Sport Sciences
Ana M. Lopes, Manoel Rios, Jorge Beleza, Diogo D. Carvalho, Sofia Monteiro, Tiago Montanha, Sandra Martins, Joao T. Guimaraes, Ricardo J. Fernandes, Jose Magalhaes, Vitor H. Teixeira, Antonio Ascensao
Summary: A study on 10 middle-distance runners concluded that the addition of protein to a pre-exercise carbohydrate beverage does not significantly affect running performance and metabolic biomarkers.
JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
(2023)
Article
Andrology
Bruno M. Fonseca, Rebeca Cruz, Beatriz Pinto, Lia Costa, Eduarda Felgueira, Pedro Oliveira, Susana Casal, Irene Rebelo
Summary: Vitamins A and E play a role in female reproduction and embryonic development. This observational study found correlations between the concentrations of fat-soluble vitamins in follicular fluid samples and assisted reproductive technology characteristics and pregnancy outcomes. Furthermore, the effects of all-trans-retinoic acid and alpha-tocopherol on granulosa cell viability and hormonal production were evaluated.
SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE
(2023)
Article
Medicine, General & Internal
Beatriz Goncalves Teixeira, Ines Paciencia, Joao Cavaleiro Rufo, Francisca Mendes, Mariana Farraia, Patricia Padrao, Pedro Moreira, Andre Moreira
Summary: This study investigates the impact of overweight and obesity on the autonomic nervous system activity in children. The findings suggest an association between body mass and changes in the autonomic activity. This study provides evidence for interventions targeting the prevention/treatment of obesity in children.
ACTA MEDICA PORTUGUESA
(2023)
Article
Nutrition & Dietetics
Ana Machado, Carla Goncalves, Pedro Moreira, Olivia Pinho, Patricia Padrao, Tania Silva-Santos, Micaela Rodrigues, Pedro Norton, Adriano A. Bordalo
Summary: The aim of this study was to assess the iodine status among a Portuguese university staff. The results showed moderate iodine deficiency in Portuguese adults, especially among women. Public health strategies and monitoring programs are needed to ensure iodine adequacy in all population groups.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Review
Chemistry, Multidisciplinary
Monica Rodrigues, Francisca de Castro Mendes, Luis Delgado, Patricia Padrao, Ines Paciencia, Renata Barros, Joao Cavaleiro Rufo, Diana Silva, Andre Moreira, Pedro Moreira
Summary: Asthma, a chronic respiratory disease, is influenced by diet. Certain dietary factors have been identified as potential contributors to asthma development and severity due to their inflammatory and oxidative effects. Consumption of fruits and vegetables, whole grains, and healthy fats has been associated with a positive impact on asthma, while high intake of salt, saturated fats, and trans-fat has a negative effect. However, further research is needed on dietary patterns and their mechanisms of action.
APPLIED SCIENCES-BASEL
(2023)
Article
Food Science & Technology
Sofia Almeida Costa, Milton Severo, Daniela Correia, Catarina Carvalho, Vania Magalhaes, Sofia Vilela, Sara Cunha, Susana Casal, Carla Lopes, Duarte Torres
Summary: This study compares different methodological approaches to estimate daily Bisphenol A (BPA) exposure in Portuguese adolescents and adults, and examines the associations between exposure and sociodemographic characteristics. The results indicate that the Portuguese population is exposed to unsafe levels of BPA, exceeding the safety levels proposed by the European Food Safety Authority (EFSA).
FOOD RESEARCH INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Dmitry D. Evtyugin, Dmitry V. Evtuguin, Susana Casal, Maria Rosario Domingues
Summary: Plant sterols (PS) are cholesterol-like terpenoids widely spread in the kingdom Plantae. They have beneficial effects in healthy subjects and applications in various industries. However, there are still gaps in research on PS, and further studies are needed.
Article
Food Science & Technology
Marcio Meira, Isabel M. Afonso, Rebeca Cruz, Julio Cesar Lopes, Raquel S. Martins, Jessica Domingues, Virginia Ribeiro, Rui Dantas, Susana Casal, Nuno V. Brito
Summary: The present study characterizes the meat from different breeds of roosters, highlighting their nutritional composition and desirable amino and fatty acid profiles. The results show that the meat from these breeds is a wholesome dietary option, with elevated protein content, reduced lipid amounts, and favorable nutritional indices.
Article
Medicine, Research & Experimental
Maria Roriz, Joao Brito, Filipe J. Teixeira, Konstantinos Spyrou, Vitor Hugo Teixeira
Summary: This study aims to analyze the effects of a menthol mouth rinse on the physical, physiological, and perceptual performance of elite male football referees during a 90-min football protocol in the heat.
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Joana Coimbra-Gomes, Patricia J. M. Reis, Tania G. Tavares, Afonso A. Silva, Eulalia Mendes, Susana Casal, Francisco Xavier Malcata, Angela C. Macedo
Summary: The study aimed to validate the application of an endogenous lactic acid bacterium strain in Cobrancosa table olives, providing a more standardized process and increasing the commercial value of the olives. Through monitoring and assessment for 8 months, it was found that the best treatment protocol was the addition of Lpb. pentosus i106 as a supplementary additive, rather than a starter culture.
FERMENTATION-BASEL
(2023)