Article
Cardiac & Cardiovascular Systems
Xintao Li, Shi Peng, Bo Guan, Songwen Chen, Genqing Zhou, Yong Wei, Chao Gong, Juan Xu, Xiaofeng Lu, Xiaoyu Zhang, Shaowen Liu
Summary: The study did not find convincing evidence to support that CRP and fibrinogen, together with their upstream IL-1-IL-6 signaling pathway, were causally associated with heart failure risk.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Endocrinology & Metabolism
Maria Krajewska, Ewelina Witkowska-Sedek, Malgorzata Ruminska, Anna Stelmaszczyk-Emmel, Maria Sobol, Anna Majcher, Beata Pyrzak
Summary: The study found that vitamin D supplementation had beneficial effects in overweight and obese children, reducing inflammation levels and stabilizing anti-inflammatory cytokines.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Mahsima Shabani, Hooman Bakhshi, Mohammad R. Ostovaneh, Xiaoyang Ma, Colin O. Wu, Bharath Ambale-Venkatesh, Michael J. Blaha, Matthew A. Allison, Matthew J. Budoff, Mary Cushman, Russell P. Tracy, David M. Herrington, Moyses Szklo, Christopher Cox, David A. Bluemke, Joao A. C. Lima
Summary: In individuals without a history of prior cardiovascular disease, temporal changes in CRP were found to be associated with heart failure in women and statin users, as well as other cardiovascular diseases in both women and men, and statin users. Annual changes in fibrinogen and IL-6 were not predictive of cardiovascular outcomes in either sex. Men with sustained high values of IL-6 had a significantly higher risk of all-cause mortality compared to those with sustained low values.
Review
Immunology
Joshua H. Cho, Saumya Bhutani, Carole H. Kim, Michael R. Irwin
Summary: This review examined the potential of exogenous melatonin in reducing inflammatory markers in humans. Results showed significant anti-inflammatory effects of melatonin on certain markers, suggesting its potential as a preventative and adjunct treatment for inflammatory disorders in older populations.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Geriatrics & Gerontology
Betty Manrique-Espinoza, Rosa Palazuelos-Gonzalez, Victoria Pando-Robles, Oscar Rosas-Carrasco, Aaron Salinas-Rodriguez
Summary: This study analyzed the association between tumor necrosis factor-alpha (TNF-alpha), Interleukin-10 (IL-10), C-reactive protein (CRP) and physical performance in a sample of older adults in rural Mexico. The results showed a significant association between higher CRP levels and low physical performance, while IL-10 and TNF-alpha did not show a significant association.
Article
Immunology
Jean-Francois Rossi, Hao-Chun Chiang, Zhao-Yang Lu, Kalle Levon, Frits van Rhee, Karan Kanhai, David C. Fajgenbaum, Bernard Klein
Summary: Standard doses of anti-IL-6 therapy were found to inadequately inhibit IL-6 signaling in patients with COVID-19 or iMCD, resulting in partial inhibition of CRP production. In situations of high IL-6 production, repeated administration of anti-IL-6 therapy was shown to effectively inhibit IL-6 activity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Wei-Ju Chang, Luke C. Jenkins, Peter Humburg, Valerie Wasinger, David M. Walton, Siobhan M. Schabrun
Summary: The study aimed to investigate the changes in pro- and anti-inflammatory molecules in patients with acute low back pain (LBP) and their association with long-term outcome. The results showed that the concentrations of systemic inflammatory molecules remained unchanged over a period of six months, regardless of recovery status. At three months, the unrecovered group had higher levels of IL-8 and IL-10 compared to the recovered group. Acute-stage psychological factors were not related to systemic inflammatory molecules. Further research is needed to understand the contribution of these molecules to long-term LBP outcome.
Article
Multidisciplinary Sciences
Thomas Bochaton, Jules Lassus, Alexandre Paccalet, Francois Derimay, Gilles Rioufol, Cyril Prieur, Eric Bonnefoy-Cudraz, Claire Crola Da Silva, Hugo Bernelin, Camille Amaz, Sylvie Espanet, Charles de Bourguignon, Nathalie Dufay, Regine Cartier, Pierre Croisille, Michel Ovize, Nathan Mewton
Summary: This study found a closer relationship between myocardial hemorrhage and inflammatory biomarker release in STEMI patients, suggesting that attenuating myocardial hemorrhage may be a novel target for future adjunctive STEMI treatments.
Review
Nutrition & Dietetics
Stefan Zivkovic, Gorica Maric, Natasa Cvetinovic, Danijela Lepojevic-Stefanovic, Bojana Bozic Cvijan
Summary: Cardiovascular diseases (CVD) are the leading cause of death worldwide. Lipid-lowering agents used in the treatment of CVD may also have anti-inflammatory and immunomodulatory properties. This review aims to evaluate the anti-inflammatory properties of currently available lipid-lowering medications, dietary supplements, and novel drugs.
Article
Endocrinology & Metabolism
Anniek J. Sluiman, Stela McLachlan, Rachel B. Forster, Mark W. J. Strachan, Ian J. Deary, Jackie F. Price
Summary: In older individuals with type 2 diabetes, higher baseline levels of inflammatory markers such as plasma IL-6, fibrinogen, and C-reactive protein were associated with subsequent cognitive decline. This association appeared to be specific to certain cognitive domains and independent of vascular and diabetes-related risk factors.
Article
Medicine, General & Internal
Eun-Hwa Lee, Kyoung-Hwa Lee, Young-Goo Song, Sang-Hoon Han
Summary: C-reactive protein (CRP) or procalcitonin (PCT) alone have limitations in the early detection of infection or inflammation. Interleukin (IL)-6 has been assessed recently, and this study reveals considerable discrepancies among CRP, PCT, and IL-6 levels. Relying solely on CRP tests may lead to misinterpretation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Hong Xu, Jinwei Xie, Xufeng Wan, Li Liu, Duan Wang, Zongke Zhou
Summary: This study aimed to investigate the effective methods for screening PJI in patients with inflammatory diseases before revision arthroplasty. The results showed that CRP and FIB had higher accuracy in screening PJI, and the combination of CRP and FIB may further improve the diagnostic values.
CHINESE MEDICAL JOURNAL
(2022)
Article
Neurosciences
Qing-Qing Yang, Hao-Nan Li, Yu-Tong Xia, Xue Tian, Fan Feng, Jian Yang, Ya-Li Xu, Juan Guo, Xiao-Qi Li, Jun-Yang Wang, Xiao-Yan Zeng
Summary: Our study reveals that rubral interleukin-6 (IL-6) plays a role in descending facilitation and pain sensation through the activation of JAK2/STAT3 and/or ERK pathways, resulting in the upregulation of spinal pro-inflammatory cytokines and downregulation of spinal anti-inflammatory cytokines. These findings provide potential therapeutic targets for the treatment of pathological pain.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Sport Sciences
Simone J. J. M. Verswijveren, Jo Salmon, Robin M. Daly, Paul A. Della Gatta, Lauren Arundell, David W. Dunstan, Kylie D. Hesketh, Ester Cerin, Nicola D. Ridgers
Summary: In this study, replacing sedentary time with vigorous physical activity (VPA) was beneficially associated with inflammatory biomarkers, while replacing it with moderate physical activity (MPA) bouts was detrimentally associated. Other activity intensities did not show significant associations with inflammatory biomarkers. Further longitudinal research is needed to explore the long-term impacts of reallocating sedentary time with physical activity on markers of systemic inflammation in children.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2021)
Review
Cardiac & Cardiovascular Systems
Yifei Liu, Suzhen Guan, Haiming Xu, Na Zhang, Min Huang, Zhihong Liu
Summary: This meta-analysis assessed the association between fibrinogen, interleukin-6, C-reactive protein, and galectin-3 and the risk of cardiovascular disease. The results showed that these four inflammatory biomarkers are significantly associated with the development of cardiovascular disease and can be used as biomarkers to predict its development to some extent.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Transplantation
Xinting Cai, Barbara Thorand, Simon Hohenester, Wolfgang Koenig, Wolfgang Rathmann, Annette Peters, Jana Nano
Summary: This German cohort study aimed to evaluate the relationship between fatty liver and kidney function/chronic kidney disease (CKD). The study found that fatty liver is associated with kidney function and CKD, and this association is partially mediated by metabolic factors such as inflammation, diabetes, and hypertension.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Geriatrics & Gerontology
Marie-Theres Huemer, Alexander Kluttig, Beate Fischer, Wolfgang Ahrens, Stefanie Castell, Nina Ebert, Sylvia Gastell, Karl-Heinz Joeckel, Rudolf Kaaks, Andre Karch, Thomas Keil, Yvonne Kemmling, Lilian Krist, Michael Leitzmann, Wolfgang Lieb, Claudia Meinke-Franze, Karin B. Michels, Rafael Mikolajczyk, Ilais Moreno Velasquez, Tobias Pischon, Sabine Schipf, Boerge Schmidt, Ben Schoettker, Matthias B. Schulze, Hannah Stocker, Henning Teismann, Kerstin Wirkner, Michael Drey, Annette Peters, Barbara Thorand
Summary: This study compared the cut-off points for low grip strength in assessing sarcopenia between the European Working Group on Sarcopenia in Older People (EWGSOP) and a large German sample. The results showed that the German sample had cut-off points that were 2 kg higher than the EWGSOP2 cut-off points. Using higher cut-off points increased the sensitivity, suggesting intervention for more patients at risk, but also potentially leading to unnecessary diagnostics/treatment for others without immediate need.
Article
Cardiac & Cardiovascular Systems
Kausik K. Ray, Frederick J. Raal, David G. Kallend, Mark J. Jaros, Wolfgang Koenig, Lawrence A. Leiter, Ulf Landmesser, Gregory G. Schwartz, David Lawrence, Andrew Friedman, Lorena Garcia Conde, R. Scott Wright
Summary: Exploratory findings from the ORION trials suggest that treatment with inclisiran is associated with reductions in major cardiovascular events, providing potential cardiovascular benefits.
EUROPEAN HEART JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Qiuling Dong, Sidra Sidra, Christian Gieger, Rui Wang-Sattler, Wolfgang Rathmann, Cornelia Prehn, Jerzy Adamski, Wolfgang Koenig, Annette Peters, Harald Grallert, Sapna Sharma
Summary: Obesity is closely related to insulin resistance and diabetes, but the specific molecular mechanism that links these conditions remains unclear. This study analyzed the metabolomic profiles of a cohort of 1715 participants and found significant associations between certain metabolites and both obesity and type 2 diabetes. Further analysis suggested that lipids such as sphingomyelin and diacylphosphatidylcholine may mediate the effect of obesity on diabetes. Additionally, genetic research and experiments with mice supported the hypothesis that changes in sphingolipid and phosphatidylcholine metabolism contribute to the development of early-stage type 2 diabetes.
Article
Endocrinology & Metabolism
Hong Luo, Alina Bauer, Jana Nano, Agnese Petrera, Wolfgang Rathmann, Christian Herder, Stefanie M. Hauck, Benjamin B. Sun, Annika Hoyer, Annette Peters, Barbara Thorand
Summary: This study aimed to investigate the role of plasma proteins in glucose metabolism and type 2 diabetes development. The study identified several novel proteins associated with glucose metabolism abnormalities and type 2 diabetes, as well as confirming previously reported proteins. These findings highlight the importance of proteins in the pathogenesis of type 2 diabetes and suggest potential targets for diabetes treatment and prevention.
Article
Biochemistry & Molecular Biology
Amen Keshawarz, Roby Joehanes, Jiantao Ma, Gha Young Lee, Ricardo Costeira, Pei-Chien Tsai, Olatz M. Masachs, Jordana T. Bell, Rory Wilson, Barbara Thorand, Juliane Winkelmann, Annette Peters, Jakob Linseisen, Melanie Waldenberger, Terho Lehtimaeki, Pashupati P. Mishra, Mika Kahonen, Olli Raitakari, Mika Helminen, Carol A. Wang, Phillip E. Melton, Rae-Chi Huang, Craig E. Pennell, Therese A. O'Sullivan, Carolina Ochoa-Rosales, Trudy Voortman, Joyce B. J. van Meurs, Kristin L. Young, Misa Graff, Yujie Wang, Douglas P. Kiel, Caren E. Smith, Paul F. Jacques, Daniel Levy
Summary: Through meta-analysis of epigenome-wide association studies, we found significant associations between dietary and supplemental intake of vitamins C and E with DNA methylation. Vitamin C intake was associated with 4,656 CpG sites, while vitamin E intake was associated with 160 CpG sites. Vitamin C intake was found to be related to systems development and the immune response, while no significant associations were found for vitamin E intake with any biological pathways investigated.
Article
Endocrinology & Metabolism
Cornelia Then, Christian Herder, Margit Heier, Christa Meisinger, Wolfgang Koenig, Wolfgang Rathmann, Chaterina Sujana, Michael Roden, Martin Bidlingmaier, Jochen Seissler, Barbara Thorand, Annette Peters, Martin Reincke
Summary: This study analyzed the association between plasma aldosterone concentrations and cardiovascular events, mortality, and biomarkers of inflammation in a population-based study. The results showed that aldosterone was associated with all-cause mortality, but not with cardiovascular mortality, incident cardiovascular events, or biomarkers of subclinical inflammation.
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
(2023)
Article
Pathology
Gordon D. O. Lowe, Katie Harris, Wolfgang Koenig, Yoav Ben-Shlomo, Barbara Thorand, Annette Peters, Christa Meisinger, Armin Imhof, Hugh Tunstall-Pedoe, Sanne A. E. Peters, Mark Woodward
Summary: Plasma viscosity is significantly associated with CHD events and mortalities, while IgA, IgG, and IgM levels have no significant association, except for a borderline association between IgA and all-cause mortality.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Gastroenterology & Hepatology
Fiona Niedermayer, Yaqi Su, Ricarda von Kruechten, Barbara Thorand, Annette Peters, Wolfgang Rathmann, Michael Roden, Christopher L. Schlett, Fabian Bamberg, Johanna Nattenmueller, Susanne Rospleszcz
Summary: This study investigated the association between hepatic iron and fat content and markers of glucose metabolism over a 7-year period. The results showed that markers of glucose metabolism were correlated with hepatic iron and fat content, particularly in women. Monitoring changes in glycaemia in the sub-diabetic range may help identify hepatic iron overload and steatosis early.
LIVER INTERNATIONAL
(2023)
Article
Cardiac & Cardiovascular Systems
Paul M. Haller, Alina Gossling, Christina Magnussen, Hermann Brenner, Ben Schoettker, Licia Iacoviello, Simona Costanzo, Frank Kee, Wolfgang Koenig, Allan Linneberg, Chaterina Sujana, Barbara Thorand, Veikko Salomaa, Teemu J. Niiranen, Stefan Soederberg, Henry Voelzke, Marcus Doerr, Susana Sans, Teresa Padro, Stephan B. Felix, Matthias Nauck, Astrid Petersmann, Luigi Palmieri, Chiara Donfrancesco, Roberto De Ponti, Giovanni Veronesi, Marco M. Ferrario, Kari Kuulasmaa, Tanja Zeller, Francisco M. Ojeda, Stefan Blankenberg, Dirk Westermann
Summary: This study demonstrates the role of cardiac biomarkers in predicting cardiovascular events and death in both general population and individuals with known diabetes. The findings suggest that these biomarkers can help identify individuals at highest risk for cardiovascular events and improve early identification of high-risk individuals. Therefore, they should be considered for routine risk assessment and can enhance the initiation of preventive therapies.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Nutrition & Dietetics
Ava Arshadipour, Barbara Thorand, Birgit Linkohr, Karl-Heinz Ladwig, Margit Heier, Annette Peters
Summary: The coexistence of multiple chronic diseases in older adults is common. This study aimed to determine the prevalence of multimorbidity (MM) and common disease combinations, as well as their impact on mortality in men and women aged 65 years and older. The study found that although the prevalence of MM was similar in men and women, it had a greater overall effect on mortality in men.
FRONTIERS IN NUTRITION
(2023)
Article
Medicine, General & Internal
Jie-sheng Lin, Jana Nano, Agnese Petrera, Stefanie M. Hauck, Tanja Zeller, Wolfgang Koenig, Christian L. Mueller, Annette Peters, Barbara Thorand
Summary: This study investigated the associations of 233 plasma proteins with chronic kidney disease (CKD). The results identified 21 proteins associated with kidney function decline and incident CKD, with a potential causal association between higher levels of TNFRSF11A and kidney function decline.
Article
Cardiac & Cardiovascular Systems
Wolfgang Koenig, Elke S. Lorenz, Lea Beier, Ioanna Gouni-Berthold
Summary: This study investigated the real-world persistence and adherence to lipid-lowering therapies in German patients with cardiovascular disease. The findings showed low persistence and adherence rates, especially in women. The study also found that patients who discontinued treatment had a relatively short average treatment duration, and only about 10% of patients persisted in medication for more than 300 days. Overall, the persistence rates with lipid-lowering therapies were low at 36 months.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Julia Karady, Thomas Mayrhofer, James L. Januzzi, James E. Udelson, Jerome L. Fleg, Bela Merkely, Michael T. Lu, William F. Peacock, John T. Nagurney, Wolfgang Koenig, Maros Ferencik, Udo Hoffmann
Summary: This study aimed to determine the concordance of different high-sensitivity cardiac troponin (hs-cTn) assays in risk stratification for cardiovascular disease and compare the differences in patient management, cost, and predicted quality of care.
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2023)