Article
Endocrinology & Metabolism
Ana Pereira, Pedro Ferrer, Alexandra Binder, Joanna Rojas, Karin B. Michels, Camila Corvalan, Veronica Mericq
Summary: This study evaluated the association between different adiposity markers during childhood and the timing of different pubertal milestones in girls. The results showed that waist circumference, percentage of fat mass, and fat mass index were associated with the timing of breast development, pubic hair development, menarche, and peak height velocity, while body mass index was only associated with menarche and peak height velocity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Emmie N. Upners, Lars Lau Raket, Jorgen H. Petersen, Ajay Thankamony, Edna Roche, Guftar Shaikh, Jeremy Kirk, Hilary Hoey, Sten-A Ivarsson, Olle Soder, Anders Juul, Rikke Beck Jensen
Summary: GH treatment improves adult height in short SGA children, with decreased peak height velocity, and earlier pubertal onset in SGA boys.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Psychology, Clinical
Abigail Emma Russell, Carol Joinson, Elystan Roberts, Jon Heron, Tamsin Ford, David Gunnell, Paul Moran, Caroline Relton, Matthew Suderman, Becky Mars
Summary: The study found that exposure to multiple types of early childhood adversity does not increase the risk of self-harm through early pubertal timing, but both childhood adversity and early puberty are risk factors for later self-harm. Identification of mechanisms linking childhood adversity and later self-harm is needed for interventions to be effective.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Sport Sciences
Tejal Sarika Patel, Alex McGregor, Karen Williams, Sean P. Cumming, Sean Williams
Summary: The study found that competitive trampoline gymnasts are at increased risk of injury during the adolescent growth spurt or with higher training loads, with the highest injury risk estimated around 90% predicted adult height (%PAH). Coaches should monitor growth periods and adjust training loads to reduce the risk of injury.
JOURNAL OF SPORTS SCIENCES
(2021)
Article
Endocrinology & Metabolism
Marco Antonio Cossio-Bolanos, Ruben Vidal-Espinoza, Juan Minango-Negrete, Pedro R. Olivares, Luis Urzua-Alul, Luis Felipe Castelli Correia de Campos, Jose Fuentes-Lopez, Lucila Sanchez-Macedo, Edilberto Diaz-Bonilla, Claudia Torres-Galvis, Rossana Gomez-Campos
Summary: Through a cross-sectional study in schoolchildren from Bogota, Colombia, it was found that boys reached a final height of 170.8 cm and girls at 157.9 cm; boys reached peak height velocity at 12.71 years, while girls at 10.4 years, 2.2 years earlier than boys. Boys had a higher growth speed in height (7.4 cm/y) compared to girls (7.0 cm/y).
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Tianyuan Lu, Vincenzo Forgetta, Haoyu Wu, John R. B. Perry, Ken K. Ong, Celia M. T. Greenwood, Nicholas J. Timpson, Despoina Manousaki, J. Brent Richards
Summary: A polygenic risk score capturing 71.1% of the total variance in adult height in the UK Biobank and identifying children with short stature with an AUROC of 0.84 in the ALSPAC cohort shows potential as an alternative or adjunct to mid-parental height for screening children at risk of developing short stature in adulthood in European ancestry populations. Combining the polygenic risk score with mid-parental height or one parent's height can further improve its predictive ability.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, General & Internal
Izzuddin M. Aris, Wei Perng, Dana Dabelea, Jody M. Ganiban, Chang Liu, Kristine Marceau, Olivia C. Robertson, Christine W. Hockett, Nicole L. Mihalopoulos, Xiangrong Kong, Megan M. Herting, T. Michael O'Shea, Elizabeth T. Jensen, Marie-France Hivert, Emily Oken
Summary: This study showed that faster gains in weight, height, or BMI in early life were associated with earlier pubertal onset, indicating that children who experience rapid early growth should be closely monitored for early puberty and provided with appropriate support services.
Article
Oncology
Sarah Ward, Anya Burton, Rulla M. Tamimi, Ana Pereira, Maria Luisa Garmendia, Marina Pollan, Norman Boyd, Isabel dos-Santos-Silva, Gertraud Maskarinec, Beatriz Perez-Gomez, Celine Vachon, Hui Miao, Martin Lajous, Ruy Lopez-Ridaura, Kimberly Bertrand, Ava Kwong, Giske Ursin, Eunjung Lee, Huiyan Ma, Sarah Vinnicombe, Sue Moss, Steve Allen, Rose Ndumia, Sudhir Vinayak, Soo-Hwang Teo, Shivaani Mariapun, Beata Peplonska, Agnieszka Bukowska-Damska, Chisato Nagata, John Hopper, Graham Giles, Vahit Ozmen, Mustafa Erkin Aribal, Joachim Schuez, Carla H. Van Gils, Johanna O. P. Wanders, Reza Sirous, Mehri Sirous, John Hipwell, Jisun Kim, Jong Won Lee, Caroline Dickens, Mikael Hartman, Kee-Seng Chia, Christopher Scott, Anna M. Chiarelli, Linda Linton, Anath Arzee Flugelman, Dorria Salem, Rasha Kamal, Valerie McCormack, Jennifer Stone
Summary: Late age at menarche is positively associated with higher mammographic density, while taller stature is also related to higher mammographic density. The study reveals a complex relationship between growth and development, mammographic density, and breast cancer risk.
BREAST CANCER RESEARCH
(2022)
Article
Sport Sciences
John M. Radnor, Jon L. Oliver, Ian Dobbs, Megan Wong, Thomas W. Brown, Rhodri S. Lloyd, Adam L. Kelly
Summary: The study aimed to examine the distribution of birth quartile and maturity status among male academy cricketers. A total of 213 junior cricket players aged 9 to 18 years participated in the study. The players were separated into birth quartiles and categorized as early, average, or late maturers. The findings revealed a bias towards early maturers in the birth quartile 4 group and among U10 and U11 age groups, indicating the presence of selection biases and relative age effects in academy cricket pathways.
JOURNAL OF SPORTS SCIENCES
(2023)
Article
Physiology
Dorsaf Sariati, Raouf Hammami, Hassane Zouhal, Cain C. T. Clark, Ammar Nebigh, Mokhtar Chtara, Sabri Gaied Chortane, Anthony C. Hackney, Nizar Souissi, Urs Granacher, Omar Ben Ounis
Summary: The study on 30 youth male soccer players showed that a 6-week CoD training intervention improved balance, horizontal jump, and CoD without the ball, with greater improvements seen in post-PHV players. The maturity status of the athletes should be considered when programming CoD training for soccer players.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Oncology
Jimmy Celind, Maria Bygdell, Jari Martikainen, Johan Styrke, Jan-Erik Damber, Jenny M. Kindblom, Claes Ohlsson
Summary: This study aimed to evaluate the association between age at the pubertal growth spurt, an objective marker of pubertal timing, and the risk of prostate cancer and high-risk prostate cancer. The findings suggest that late pubertal timing is associated with a lower risk of prostate cancer, especially high-risk prostate cancer.
Article
Endocrinology & Metabolism
Emese Boros, Diana-Alexandra Ertl, Jugurtha Berkenou, Christelle Audrain, Anne Lise Lecoq, Peter Kamenicky, Karine Briot, Cyril Amouroux, Volha Zhukouskaya, Iva Gueorguieva, Brigitte Mignot, Barbara Girerd, Valerie Porquet Bordes, Jean Pierre Salles, Thomas Edouard, Regis Coutant, Justine Bacchetta, Agnes Linglart, Anya Rothenbuhler
Summary: This study aimed to analyze the height after cessation of growth (final height [FH]) and its evolution over the last decades in X-linked hypophosphatemia (XLH) patients in France. The study found that the FH of XLH patients in France has significantly increased over the last decades. However, men with XLH remain shorter than women, indicating a more severe disease phenotype. These findings provide important insights into the growth and development of XLH patients and can guide clinical treatment.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Biology
Hamza Marzouki, Samar Sbai, Ibrahim Ouergui, Okba Selmi, Marilia S. S. Andrade, Ezdine Bouhlel, Mabliny Thuany, Katja Weiss, Pantelis T. T. Nikolaidis, Beat Knechtle
Summary: This study examined the effects of combined plyometric and sprint with change of direction (COD) training on youth soccer players and found that it can improve explosive performances during the season. The importance of this study lies in providing a safe and effective training method to enhance the explosive power and technical abilities of youth soccer players.
Article
Environmental Sciences
Niklas Westblad, Henrik Petre, Andreas Karstrom, Niklas Psilander, Glenn Bjorklund
Summary: This study compared the effects of autoregulated flywheel resistance training (FRT) with traditional strength training (TST) on youth athletes and found that both methods resulted in similar load progression and motor skill development, with FRT having lower perceived exertion.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Multidisciplinary Sciences
Miha Mlakar, Anton Gradisek, Mitja Lustrek, Gregor Jurak, Maroje Soric, Bojan Leskosek, Gregor Starc
Summary: Understanding growth patterns is crucial for child and adolescent development. We developed a novel method called Growth Curve Comparison (GCC) for height prediction, which outperformed other methods in accuracy and is applicable in various fields. This method can be used for assessment and monitoring of somatic and motor development in children and youth.
Article
Sport Sciences
Diogo Martinho, Manuel J. Coelho-e-Silva, Joao Goncalves Santos, Tomas G. Oliveira, Claudia S. Minderico, Andre Seabra, Joao Valente-Dos-Santos, Lauren B. Sherar, Robert M. Malina
Summary: This study examined the body size and adiposity differences among adolescent girls participating in competitive age group youth soccer based on their maturity levels. It found that the number of skeletally mature players increased with competitive age groups, and early maturing girls tended to be heavier compared to their age group peers and late maturing players.
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2023)
Review
Surgery
Marco Quaranta, Nicola Poeta, Francesco Oliva, Nicola Maffulli
Summary: This study aims to evaluate the outcomes of conservative and surgical management for muscle herniae and determine the most appropriate management based on the etiology and size of the fascial defect. The findings suggest that fasciotomy should be considered for congenital muscle herniae to prevent complications, while direct suture repair can be used for small fascial defects in post-traumatic muscle herniae, and mesh repair and autologous graft repair are recommended to avoid severe complications.
SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND
(2023)
Article
Surgery
Nikolaos Malliaropoulos, Georgios Bikos, Ioannis Tsifountoudis, Dimosthenis Alaseirlis, Dimitrios Christodoulou, Nat Padhiar, Nicola Maffulli
Summary: This study used therapeutic ultrasound (TUS) as a primary diagnostic tool to assess tibial stress injuries and compared its sensitivity with magnetic resonance imaging (MRI). The results showed that TUS has a sensitivity of 79.2% related to MRI, making it a useful tool for clinicians to initially assess suspected tibial stress injuries in high-level track and field athletes.
SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND
(2023)
Article
Orthopedics
Lorenzo Giordano, Nicola Maffulli, Giulia Carimati, Emanuela Morenghi, Piero Volpi
Summary: This study aimed to assess the incidence of meniscal tears in ACL-deficient knees in a large sample of female patients and to evaluate the effects of surgery timing, age, and BMI on the rate of meniscal repair or meniscectomy. The results showed that a delay in surgery greater than 12 months increased the risk of nonrepairable medial meniscal tear, especially between 24 and 60 months after injury. Increasing age up to 30-50 years was associated with a greater prevalence of meniscal tears, while BMI had no clear association with associated lesions. The findings highlight the importance of timely ACL reconstruction for female patients to reduce the risk of meniscal tears.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2023)
Article
Orthopedics
Nicola Maffulli, Nikolaos Gougoulias, Panagiotis Christidis, Gayle D. Maffulli, Francesco Oliva
Summary: The study investigated the clinical outcomes of using percutaneous repair and FHL tendon augmentation to manage acute Achilles tendon ruptures, showing that this treatment method can reduce tendon elongation and improve functional recovery.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Review
Medicine, General & Internal
Filippo Migliorini, Francesco Oliva, Joerg Eschweiler, Ernesto Torsiello, Frank Hildebrand, Nicola Maffulli
Summary: Patients with ACL rupture can choose conservative management or reconstruction surgery. However, surgical management may increase the risk of early-onset knee osteoarthritis.
BRITISH MEDICAL BULLETIN
(2023)
Review
Medicine, General & Internal
Filippo Migliorini, Gianluca Vecchio, Riccardo Giorgino, Joerg Eschweiler, Frank Hildebrand, Nicola Maffulli
Summary: Micro RNAs (miRNAs), short non-coding RNAs, play a primary role in posttranscriptional gene silencing and have attracted increasing interest in musculoskeletal conditions. Recent studies have postulated the potential of miRNAs as biomarkers for the diagnosis and treatment of meniscal injuries. However, the evaluation of miRNAs in patients with meniscal tears remains controversial. A systematic review was conducted to explore the potential of miRNAs in the diagnosis and management of meniscal damage.
BRITISH MEDICAL BULLETIN
(2023)
Letter
Orthopedics
Nicola Maffulli
JOURNAL OF FOOT & ANKLE SURGERY
(2023)
Review
Orthopedics
Sergio R. Piedade, Bruno P. Leite Arruda, Rodrigo A. de Vasconcelos, David A. Parker, Nicola Maffulli
Summary: ACL insufficiency is disabling and requires surgery, but successful ACL reconstruction depends on proper preoperative and postoperative rehabilitation. Advances in surgery and understanding of biological concepts have influenced ACL postoperative rehabilitation protocols, but new technologies may introduce inconsistency. Rehabilitation protocols should consider accurate diagnosis, patient expectations, and geographical differences in ACL rehabilitation.
JOURNAL OF ISAKOS JOINT DISORDERS & ORTHOPAEDIC SPORTS MEDICINE
(2023)
Article
Medicine, General & Internal
Attilio Basile, Riccardo Maria Lanzetti, Alessio Giai Via, Teresa Venditto, Marco Spoliti, Pasquale Sessa, Mauro Tortora, Nicola Maffulli
Summary: The study aimed to assess the effect of delaying operative fixation through the sinus tarsi approach on wound complications and the quality of reduction in subjects with displaced intra-articular calcaneus fractures. Two groups were compared: Group A, treated within 21 days after injury; Group B, treated more than 21 days after injury. The study found no significant differences between the groups in terms of wound complications or quality of reduction.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Sathish Muthu, Madhan Jeyaraman, Aditya Narula, V. R. Ravi, Avinash Gandi, Manish Khanna, Nicola Maffulli, Ashim Gupta
Summary: This study aimed to determine the influence of subjective factors (age, sex, and comorbidities) and procedure-specific factors (aspiration volume) on the yield of progenitor cells in bone marrow aspiration concentrate (BMAC) harvested from the iliac crest. A retrospective analysis on 58 patients undergoing BMAC therapy revealed that age, comorbidities, and aspirate volume significantly affected progenitor cell yield, while sex did not have a significant impact. These findings highlight the importance of considering individual and procedural factors when assessing the effectiveness of BMAC therapy.
Editorial Material
Biochemistry & Molecular Biology
Madhan Jeyaraman, Nicola Maffulli, Ashim Gupta
Review
Medicine, General & Internal
Daryl Poku, Rifat Hassan, Filippo Migliorini, Nicola Maffulli
Summary: This systematic review evaluates the efficacy of hydrodilatation for the management of frozen shoulder compared with other conservative management modalities. The study found that hydrodilatation leads to more marked short-term improvements in shoulder disability and passive external rotation compared with intra-articular corticosteroid injections. However, the clinical relevance of hydrodilatation remains unclear, and further research is necessary to establish its role in the management of frozen shoulder.
BRITISH MEDICAL BULLETIN
(2023)
Review
Medicine, General & Internal
Giuseppe Gargano, Giovanni Asparago, Filippo Spiezia, Francesco Oliva, Nicola Maffulli
Summary: Small interfering RNAs (siRNAs) have potential therapeutic applications in osteoporosis and can be used to study metabolic processes and identify new drug targets. However, it is challenging to predict the in vivo response of siRNAs and drugs based on in vitro studies.
BRITISH MEDICAL BULLETIN
(2023)
Review
Orthopedics
Rocco Aicale, Nicola Maffulli
Summary: Ankle sprains are common and understanding the recovery process is important for effective management decisions and identifying potential risk factors for chronic problems and recurrent sprains. Delayed diagnosis can result in untreated ligament tears and chronic ankle instability. Conservative treatment is preferred, with surgery as an option for special cases. Ankle arthroscopy is increasingly used to address ligament insufficiency and intra-articular pathologies.
JOURNAL OF ORTHOPAEDIC SURGERY
(2023)
