Article
Nutrition & Dietetics
Jin Zhang, Rui Chi, Yunpeng Zhang, Yi Xie, Yunxia Liu, Qun Bao, Hengyu Lv, Bo Han, Haipeng Sun, Peng Sun
Summary: This study demonstrates that preoperative supplementation of BCAA can lower blood glucose levels by reducing liver gluconeogenesis without significant elevation of insulin levels. This provides a novel approach for preventing postoperative insulin resistance.
NUTRITION & METABOLISM
(2022)
Article
Agriculture, Dairy & Animal Science
Mohammad Habibi, Cedrick Shili, Julia Sutton, Parniyan Goodarzi, Excel Rio Maylem, Leon Spicer, Adel Pezeshki
Summary: The study found that increasing the intake of BCAA in protein-restricted diets can partially mitigate the negative effects on pig growth by improving IGF-I concentration and feed intake, which is associated with changes in serotonin receptors, blood amino acids, and hypothalamic NPY.
Article
Medicine, Research & Experimental
Yasuyuki Tamai, Zhen Chen, Yue Wu, Jun Okabe, Yoshinao Kobayashi, Hitoshi Chiba, Shu-Ping Hui, Akiko Eguchi, Motoh Iwasa, Masaaki Ito, Yoshiyuki Takei
Summary: The combined treatment of BCAA and L-carnitine significantly improved hepatocellular function, reduced lipid deposition and adipophilin expression, and protected the liver by maintaining mitochondrial integrity in cirrhotic rats, supporting their therapeutic potential in human chronic liver diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Nutrition & Dietetics
Imran Ramzan, Moira Taylor, Beth Phillips, Daniel Wilkinson, Kenneth Smith, Kate Hession, Iskandar Idris, Philip Atherton
Summary: The study successfully designed and evaluated a diet aimed at reducing circulating branched-chain amino acids (BCAAs) in humans, achieving a 50% reduction while maintaining energy balance and overall energy/protein intake.
Review
Genetics & Heredity
Can Chen, Hassan Naveed, Keping Chen
Summary: This article introduces the important role of branched-chain amino acid aminotransferases in cellular metabolism, summarizes the related research in animals, plants, microorganisms, and humans, and analyzes the molecular mechanism. It has been found that disorders in branched-chain amino acid metabolism are closely related to various diseases, especially tumor development.
FRONTIERS IN GENETICS
(2023)
Article
Nutrition & Dietetics
Despoina D. Aspragkathou, Martha G. Spilioti, Anastasia Gkampeta, Efterpi Dalpa, Vasiliki Holeva, Maria T. Papadopoulou, Aspasia Serdari, Vaios Dafoulis, Dimitrios I. Zafeiriou, Athanasios E. Evangeliou
Summary: The branched-chain amino acid (BCAA) is essential for maintaining energy balance and neurotransmitter systems in the human body. Low levels of BCAA have been found in autism patients, and a study was conducted to investigate the use of BCAA in children with autistic behavior. After administering BCAA for more than 10 weeks, improvements in social behavior, speech, cooperation, stereotypy, and hyperactivity were observed in 26 out of 55 children. These preliminary results suggest that BCAA may be used as an adjunctive treatment for autism.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Nutrition & Dietetics
Ziyun Li, Ranran Zhang, Hongna Mu, Wenduo Zhang, Jie Zeng, Hongxia Li, Siming Wang, Xianghui Zhao, Wenxiang Chen, Jun Dong, Ruiyue Yang
Summary: This study found that dietary BCAA supplementation can attenuate HFD-induced atherosclerosis in ApoE(-/-) mice through improved dyslipidemia and inflammation, mechanisms involving the intestinal microbiota, and promotion of BA excretion.
Article
Microbiology
Ranran Zhang, Hongna Mu, Ziyun Li, Jie Zeng, Qi Zhou, Hongxia Li, Siming Wang, Xianghui Li, Xianghui Zhao, Liang Sun, Wenxiang Chen, Jun Dong, Ruiyue Yang
Summary: BCAA supplementation has significant beneficial effects on MAFLD mouse model, reducing hepatic lipid accumulation and serum cholesterol levels, regulating the expression of lipogenesis and lipolysis-related enzymes in the liver, and improving gut microbiota diversity and composition.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhongxin Li, Liren Ding, Chunlong Mu, Weiyun Zhu, Suqin Hang
Summary: This study found that increased levels of soy protein hydrolysate (SPH) in the small intestine of pigs can promote the synthesis of dopamine and acetylcholine in the hypothalamus. This is achieved through the activation of the cAMP signaling pathway and results in increased production of brain-derived neurotrophic factor (BDNF), which is important for cognitive function.
Article
Pharmacology & Pharmacy
Tiangang Wu, Mengling Wang, Fengling Ning, Shilin Zhou, Xuetao Hu, Hong Xin, Svetlana Reilly, Xuemei Zhang
Summary: Fibrosis, characterized by excessive production of extracellular matrix, is a common pathological feature of organ diseases. Metabolic alterations, especially in the regulation of branched-chain amino acids (BCAAs), have been found to play significant roles in fibrogenesis. Dysregulation of BCAAs metabolism has been implicated in various diseases. This review summarizes the metabolic regulation of fibrosis, changes in BCAAs metabolism associated with fibrosis, and the effects and mechanisms of BCAAs intervention in hepatic, renal, and cardiac fibrosis, with a focus on liver fibrosis and associated hepatocellular carcinoma.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Cell Biology
Michaela E. Trautman, Nicole E. Richardson, Dudley W. Lamming
Summary: The proportion of people suffering from age-related diseases is increasing worldwide. Recent research has shown that low protein diets, particularly those low in branched-chain amino acids (BCAAs), can reduce mortality and promote metabolic health and extended lifespan in both humans and rodents. This article discusses the emerging evidence that BCAAs play a crucial role in healthy metabolism and longevity, and explores the physiological and molecular mechanisms behind the benefits of restricting dietary BCAAs. The findings suggest that the quality of protein, specifically the composition of dietary protein, may be a previously overlooked factor in metabolic dysfunction and reducing dietary BCAAs could be a promising new approach to delaying and preventing age-related diseases.
Review
Biotechnology & Applied Microbiology
Yoichi Toyokawa, Jirasin Koonthongkaew, Hiroshi Takagi
Summary: BCAT catalyzes transamination between BCAAs and BCKAs in the cell. Eukaryotic cells have mitochondrial BCAT (BCATm) and cytosolic BCAT (BCATc) isozymes, which have similar enzymatic functions but differences in physiological functions and regulatory mechanisms. The variations of BCAT could have significant implications for research into the relationship between their primary structures and protein functions.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Review
Oncology
Xiazhen Nong, Caiyun Zhang, Junmin Wang, Peilun Ding, Guang Ji, Tao Wu
Summary: This article reviews the role and mechanism of BCAT in different diseases, as well as the recent biomedical research progress, providing new research ideas for the treatment, prognosis, and prevention of certain diseases.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Sonia Ravanelli, Qiaochu Li, Andrea Annibal, Aleksandra Trifunovic, Adam Antebi, Thorsten Hoppe
Summary: Using genetics and multi-omics analyses, researchers have found a link between branched-chain amino acid metabolism and the regulation of the ubiquitin-proteasome system. This sheds light on the role of branched-chain amino acids in the aging process and opens up possibilities for future therapeutic interventions.
Article
Nutrition & Dietetics
Huan Xu, Xuanyang Wang, Xiaoqing Xu, Lin Liu, Yuntao Zhang, Xuemin Yan, Yingfeng Zhang, Keke Dang, Ying Li
Summary: This study using Mendelian randomization analysis found that increased circulating levels of BCAAs were associated with an increased risk of squamous cell lung cancer, but no causal link was found between BCAAs and other types of cancer.
CLINICAL NUTRITION
(2023)
