Article
Biochemistry & Molecular Biology
Ali Alquraini
Summary: This study evaluated the efficacy of hexaconazole to bind with sex hormone-binding globulin (SHBG) and found that it has a stable molecular interaction with SHBG, leading to significant endocrine disruption during agricultural work.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Yutang Wang
Summary: This study established criteria for low SHBG among US adults and found the estimated national prevalence to be 3.3% in men and 2.7% in women. Risk factors for this condition include higher BMI, diabetes, ethnicity, COPD, coronary heart disease, and smoking.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Obstetrics & Gynecology
Z. N. Azene, S. R. Davis, J. J. McNeil, A. M. Tonkin, D. J. Handelsman, R. M. Islam
Summary: This study investigated the association between estrone and sex hormone binding globulin (SHBG) concentrations with lipid concentrations in older postmenopausal women. The results showed that estrone and SHBG are associated with lipid concentrations in older women, with SHBG providing additional clinical predictive utility for the assessment of cardiometabolic disease risk.
Article
Public, Environmental & Occupational Health
Nuozhou Liu, Ying Feng, Xinyao Luo, Xue Ma, Fang Ma
Summary: This study reveals an association between a proinflammatory diet and decreased levels of SHBG in women, particularly in premenopausal women.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Cardiac & Cardiovascular Systems
Wern Yew Ding, Majd B. Protty, Ian G. Davies, Gregory Y. H. Lip
Summary: Lipoproteins play a crucial role in the pathophysiology of atrial fibrillation by impacting hemostasis and promoting thrombus formation. Different types of lipoproteins contain various lipid species and proteins with distinct functions, potentially leading to thrombosis. There is a contradictory relationship between total cholesterol and LDL cholesterol levels with the incidence of atrial fibrillation.
CARDIOVASCULAR RESEARCH
(2022)
Article
Clinical Neurology
Rob Molenberg, Chris H. L. Thio, Marlien W. Aalbers, Maarten Uyttenboogaart, Susanna C. Larsson, Mark K. Bakker, Ynte M. Ruigrok, Harold Snieder, J. Marc C. van Dijk
Summary: Using a 2-sample MR study, we found that genetic predisposition to elevated SHBG levels, with secondary lower BioT levels, is associated with an increased risk of aSAH in women.
Article
Multidisciplinary Sciences
Asuka Minami-Takano, Hiroshi Iwata, Katsutoshi Miyosawa, Tomoyuki Shiozawa, Hidemori Hayashi, Takehiro Funamizu, Kai Ishii, Yui Nozaki, Haruna Tabuchi, Gaku Sekita, Kazunori Shimada, Masataka Sumiyoshi, Yuji Nakazato, Hiroyuki Daida, Tohru Minamino
Summary: The study found that the association between Non-ABCA1 CEC and left atrial enlargement was independent of traditional risk factors for AF, indicating a potential important role of Non-ABCA1 CEC in the pathophysiology of left atrial structural remodeling in patients with AF.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Bingyan Xu, Wei Mo, Xiangliang Tan, Peizhen Zhang, Junlin Huang, Chensihan Huang, Dan Guo, Xueyun Wei, Yating Liu, Xuzhen Lei, Weijuan Dou, Jiayang Lin, Deying Liu, Linjie Yang, Yan Huang, Huijie Zhang, Yunfei Liao
Summary: This study found that lower levels of testosterone and free testosterone were associated with an increased risk of atrial fibrillation and bradyarrhythmia in men. Higher levels of free testosterone were associated with an increased risk of atrial fibrillation and ventricular arrhythmia. Higher SHBG concentrations were associated with an increased risk of atrial fibrillation, ventricular arrhythmia, and bradyarrhythmia.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Bu B. Yeap, Ross J. Marriott, Leen Antonio, Yi X. Chan, Suchitra Raj, Girish Dwivedi, Christopher M. Reid, Bradley D. Anawalt, Shalender Bhasin, Adrian S. Dobs, Graeme J. Hankey, Alvin M. Matsumoto, Paul E. Norman, Terence W. O'Neill, Claes Ohlsson, Eric S. Orwoll, Dirk Vanderschueren, Gary A. Wittert, Frederick C. W. Wu, Kevin Murray
Summary: The study showed that lower serum testosterone levels were independently associated with higher all-cause and cancer-related mortality in middle-aged to older men, while lower SHBG levels were independently associated with lower all-cause, CVD-related, and cancer-related mortality. Confirmation of these associations and causality would require mechanistic studies and prospective trials.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Ke Xu, Yicheng Fu, Buzi Cao, Mingyi Zhao
Summary: This study aims to evaluate the association between sex hormones and sex hormone-binding globulin (SHBG) with bone mineral density (BMD) in adolescents. The results show differences in the association of sex hormones with BMD in boys and girls, where an appropriate increase in serum testosterone levels may be beneficial for skeletal development in girls and keeping estradiol levels below a certain level in boys may be considered.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Food Science & Technology
Laura Brianso-Llort, Olga Simo-Servat, Lorena Ramos-Perez, Javier Torres-Torronteras, Cristina Hernandez, Rafael Simo, David M. Selva
Summary: The study found that red wine rich in resveratrol can reduce total cholesterol in both men and women, and only increase SHBG levels in women, which may be beneficial for cardiovascular protection. Further research is needed to explore the potential enhancement of SHBG by resveratrol in cardiovascular protection between women and men.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Medicine, General & Internal
Haojie Zhang, Chi Chen, Xuan Zhang, Yuying Wang, Heng Wan, Yi Chen, Wen Zhang, Fangzhen Xia, Yingli Lu, Ningjian Wang
Summary: This study aimed to investigate the association between sex hormone-binding globulin (SHBG) and renal function in a community-based Chinese population. Lower levels of SHBG were significantly associated with lower estimated glomerular filtration rate (eGFR) and a higher prevalence of low eGFR in Chinese men, independent of demographics, lifestyle, metabolic-related risk factors, and testosterone.
CHINESE MEDICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Justin Harbs, Sabina Rinaldi, Pekka Keski-Rahkonen, Xijia Liu, Richard Palmqvist, Bethany Van Guelpen, Sophia Harlid
Summary: Endogenous sex hormones and DNA methylation have important roles in various diseases, but their interaction is largely unknown. This study investigated the associations between circulating sex hormones, sex hormone binding globulin (SHBG), and DNA methylation in blood samples from 77 men. The findings suggest a relationship between circulating sex hormones and DNA methylation, and several differentially methylated regions were associated with hormone-related genes and diseases.
Article
Cardiac & Cardiovascular Systems
Bisan Shweikialrefaee, Dennis T. Ko, Jiming Fang, Andrea Pang, Peter C. Austin, Paul Dorian, Sheldon M. Singh, Cynthia A. Jackevicius, Karen Tu, Douglas S. Lee, Husam Abdel-Qadir
Summary: This study found that statin use is associated with a lower stroke rate in patients with atrial fibrillation (AF), while higher levels of low-density lipoprotein are associated with a higher stroke rate.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Environmental Sciences
Hao Zhao, Wei Gui, Xin Tan, Ying Chen, Yao Ning, Xin Wang
Summary: This study investigated the relationship between neonicotinoid insecticides (NNIs) and their metabolites in urine with serum lipid profiles in adults. The results showed a significant positive correlation between N-desmethyl-acetamiprid and total cholesterol (TC) levels, especially in participants aged over 46 years. Body mass index (BMI) also modified the association between N-desmethyl-acetamiprid and LDL-C and Apo-B levels.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)