Article
Psychology, Clinical
Joseph M. Boden, James A. Foulds, Giles Newton-Howes, Rebecca McKetin
Summary: This study found that methamphetamine use is associated with an increased risk of psychotic symptoms in the general population, especially among those who have used regularly and recently.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Xinyue Hu, Ping Jiang, Yingxue Gao, Jiayu Sun, Xiaobo Zhou, Lianqing Zhang, Hui Qiu, Hailong Li, Lingxiao Cao, Jing Liu, Qiyong Gong, Xiaoqi Huang
Summary: This study investigated the brain morphometry differences in abstinent males with methamphetamine use disorder (MUD) and found hypergyrification in multiple brain regions as well as a smaller volume of the left nucleus accumbens in MUD individuals compared to healthy controls. The hypergyrification in the right inferior parietal gyrus was positively associated with the severity of depression and anxiety symptoms in MUDs.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Leanne Hides, Gary Chan, Sharon Dawe, Rebecca McKetin, David J. Kavanagh, Ross McD Young, Maree Teesson, John B. Saunders
Summary: A 12-month study found a bidirectional relationship between methamphetamine use and positive psychotic symptoms, with similar strength in each direction. The presence of methamphetamine dependence or a lifetime psychotic disorder did not impact this relationship. Integrated treatments targeting both methamphetamine use and psychotic symptoms may be most beneficial.
BRITISH JOURNAL OF PSYCHIATRY
(2021)
Article
Psychiatry
Tao Luo, Meng Xiao, Chang Qi, Qiuxia Wu, Jinsong Tang, Yanhui Liao
Summary: This study found that patients with methamphetamine use disorder are more likely to experience psychotic symptoms, especially positive and negative symptoms, compared to patients with ketamine use disorder.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Pharmacology & Pharmacy
Baeksun Kim, Sung Hyun Tag, Eunjoo Nam, Suji Ham, Sujin Ahn, Juhwan Kim, Doo-Wan Cho, Sangjoon Lee, Young-Su Yang, Seung Eun Lee, Yong Sik Kim, Il-Joo Cho, Kwang Pyo Kim, Su-Cheol Han, Heh-In Im
Summary: Abstinence from prolonged psychostimulant use leads to stimulant withdrawal syndrome characterized by molecular adaptations within the dorsal striatum. This study reveals that circulating miR-137 could serve as a potential blood-based marker for reflecting the changes in the striatal miR-137/SYNCRIP axis in methamphetamine-induced abstinence. The downregulation of SYNCRIP in the dorsal striatum may contribute to the cognitive dysfunction associated with methamphetamine withdrawal syndrome.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Neurosciences
Jordan L. Hopkins, Sarah T. Goldsmith, Samuel K. Wood, Katharine H. Nelson, Jordan S. Carter, Dylan L. Freels, Stacia I. Lewandowski, Benjamin M. Siemsen, Adam R. Denton, Michael D. Scofield, Carmela M. Reichel
Summary: Return to methamphetamine use is associated with cognitive sequela and cortical dysfunction. This study reveals the crucial role of the perirhinal cortex-medial prefrontal cortex circuit in novel object recognition memory.
Article
Substance Abuse
Rebecca McKetin, Philip J. Clare, David Castle, Alyna Turner, Peter J. Kelly, Dan I. Lubman, Shalini Arunogiri, Victoria Manning, Michael Berk
Summary: This study aimed to determine whether the risk of psychotic symptoms during methamphetamine use was dependent on, increased by, or independent of having a family history of psychosis. The findings showed that both methamphetamine use and family history of psychosis were independently associated with psychotic symptoms in the past week, and the joint risk was even larger when they occurred together. There was no significant interaction between family history of psychosis and methamphetamine use in predicting psychotic symptoms, but family history of psychosis was an independent risk factor for the absolute risk of psychotic symptoms in this population.
Article
Psychiatry
Weijun Liu, Yu Tian, Xinyu Yan, Jiemin Yang
Summary: This study found that long-term abstinence is more effective in improving impulse inhibition with methamphetamine dependents, as it can enhance both accuracy and reaction time delay, compared to short-term abstinence. In addition, with the prolongation of abstinence duration, the impulse inhibition ability of methamphetamine dependents improves.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Neuroimaging
Lili Nie, Xiantao Wen, Wei Luo, Tao Ju, Anlian Ren, Binbin Wu, Jing Li, Jinsheng Hu
Summary: This study found that chronic MA use is associated with specific regional disruption of ReHo, which is relatively independent of structural and functional alterations and does not recover after long-term abstinence.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Psychology, Multidisciplinary
Petr Bob, Tereza Petraskova Touskova, Ondrej Pec, Jiri Raboch, Nash Boutros, Paul Lysaker
Summary: This study found a significant correlation between hair cortisol levels and stress symptoms as well as complex partial seizure-like symptoms in patients experiencing their initial episode of psychosis. However, there was no significant correlation between hair cortisol levels and symptoms of anxiety and depression. These findings suggest a potential relationship between epileptic-like symptoms and stress responses in patients during their first psychotic episode.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yu Chen, Mingchao Li, Qiuming Ji, Zou Su, Ziyu Yang, Yin Xu, Qian Chen, Dan Liao, Jihua Zeng, Yuhong Yang
Summary: The combination of paliperidone palmitate long-acting injection and electroacupuncture is more effective in treating methamphetamine addicts compared to electroacupuncture alone. It significantly improves withdrawal symptoms, anxiety, depression, and brain waves, leading to a reduced risk of relapse.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Clinical Neurology
Maya Kuperberg, Douglas Katz, Sophie L. A. Greenebaum, Nevita George, Louisa G. Sylvia, Gustavo Kinrys, Astrid Desrosiers, Andrew A. Nierenberg
Summary: This study examined the relationship between psychotic symptoms during bipolar depressive episodes and suicidal ideation among outpatients with bipolar disorder. The results indicated that patients with psychotic symptoms were more likely to report active suicidal thoughts, including specific plans and methods.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Biochemistry & Molecular Biology
Di Zhao, Mingming Zhang, Weiwen Tian, Xinyu Cao, Lu Yin, Yi Liu, Tian-Le Xu, Wenbo Luo, Ti-Fei Yuan
Summary: Previous studies have shown that abstinence can lead to an increase in cue-induced drug craving, including for nicotine, alcohol, cocaine, and methamphetamine. However, research on methamphetamine craving incubation has not fully explored the neuropsychological and electrophysiological dynamics associated with this process. This study utilized EEG signals to track cue-induced craving in individuals with methamphetamine use disorder, finding that craving peaked at 1-3 months of abstinence along with changes in sleep quality and specific brain wave frequencies, suggesting potential neurophysiological signatures for identifying those at risk for relapse and guiding future therapeutic interventions.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Ruben Garcia-Cabrerizo, Cristian Bis-Humbert, M. Julia Garcia-Fuster
Summary: Studies on rats have shown that combining methamphetamine and electroconvulsive therapy can effectively alleviate the neurotoxic effects induced by methamphetamine, providing a potential option for treating methamphetamine toxicity.
Article
Neurosciences
Baeksun Kim, Sung Hyun Tag, Yong Sik Kim, Sung Nam Cho, Heh-In Im
Summary: The expression of miR-137 in the circulating extracellular vesicles was significantly reduced in patients under methamphetamine abstinence, suggesting its potential as a blood-based marker for methamphetamine abstinence. In addition, cEV miR-137 showed age-dependent differences in its diagnostic power, more effectively discriminating methamphetamine abstinence in the younger population.
PSYCHOPHARMACOLOGY
(2022)