Review
Gastroenterology & Hepatology
Virginia Solitano, Sudheer K. Vuyyuru, John K. MacDonald, Alexa Zayadi, Claire E. Parker, Neeraj Narula, Laurent Peyrin-Biroulet, Silvio Danese, Brian G. Feagan, Siddharth Singh, Christopher Ma, Vipul Jairath
Summary: This systematic review and meta-analysis summarized the efficacy and safety of JAK inhibitors and S1P receptor modulators in the treatment of ulcerative colitis and Crohn's disease. The results showed that these treatments are effective in inducing clinical and endoscopic remission in IBD.
JOURNAL OF CROHNS & COLITIS
(2023)
Review
Medicine, General & Internal
Bo Qiu, Jia-Xu Liang, Cong Li
Summary: This study evaluated the efficacy and safety of vedolizumab in the treatment of inflammatory bowel disease. The meta-analysis results showed that vedolizumab was more effective than placebo in inducing and maintaining clinical response, clinical remission, and mucosal healing. Vedolizumab was also found to be safe and did not increase the risk of serious adverse reactions.
Review
Medicine, General & Internal
Gustavo Drugg Hahn, Petra Anna Golovics, Panu Wetwittayakhlang, Dirlene Melo Santa Maria, Usiara Britto, Gary Edward Wild, Waqqas Afif, Alain Bitton, Talat Bessissow, Peter Laszlo Lakatos
Summary: This study conducted a systematic review and meta-analysis to evaluate the safety of biologics in elderly patients with inflammatory bowel disease (IBD). The results showed that there were no differences in adverse events and infection rates among different biologics in elderly patients. However, infusion/injection reactions were more common with anti-TNFs, and malignancy rates were higher with VDZ and UST.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Gastroenterology & Hepatology
Ole Haagen Nielsen, John Mark Gubatan, Carsten Bogh Juhl, Sarah Elizabeth Streett, Cynthia Maxwell
Summary: Adverse pregnancy outcomes among pregnant IBD women using biologics are comparable with that of the general population.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Biology
Ivet A. Yordanova, Friederike Ebner, Axel Ronald Schulz, Svenja Steinfelder, Berit Rosche, Anna Bolze, Friedemann Paul, Henrik E. Mei, Susanne Hartmann
Summary: Studies have shown that multiple sclerosis patients receiving Trichuris suis ova treatment establish a specific T- and B-cell response, but there are variations in T cell responses and cellular functionality across individuals, potentially accounting for the diverse clinical efficacy observed in the studied patients.
Review
Microbiology
Mark Hsu, Kyaw Min Tun, Kavita Batra, Lubaba Haque, Tahne Vongsavath, Annie S. Hong
Summary: This systematic review and meta-analysis investigates the safety and efficacy of fecal microbiota transplantation (FMT) in a pediatric inflammatory bowel disease (IBD) population. The results suggest that FMT can be a safe and effective treatment option for pediatric IBD patients, and may have improved safety and efficacy compared to the adult population.
Article
Oncology
Ruth Gabriela Herrera-Gomez, Miruna Grecea, Claire Gallois, Valerie Boige, Patricia Pautier, Barbara Pistilli, David Planchard, David Malka, Michel Ducreux, Olivier Mir
Summary: This study retrospectively evaluated the safety and efficacy of combining bevacizumab and chemotherapy in adult cancer patients with inflammatory bowel disease. The results showed that the combination treatment was safe in patients with quiescent or moderately active inflammatory bowel disease.
Article
Medicine, General & Internal
Marta Vernero, Cristina Bezzio, Davide G. Ribaldone, Stefania Costa, Davide Scalvini, Elisa Tribocco, Gianpiero Manes, Simone Saibeni
Summary: This study evaluated the effectiveness and safety of GP2017, a biosimilar drug, in the treatment of inflammatory bowel disease (IBD). The results showed that GP2017 is an effective and safe therapy for IBD patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Parasitology
Tokio Hoshina, Tatsuya Sakurai, Hidetoshi Ichimura, Kenji Ishiwata, Shitan En, Takahiro Yamada, Lee Kwangyole, Akihiro Shimizu, Koji Hase, Hirotaka Kanuka
Summary: The study demonstrated that healthy Japanese individuals tolerated all doses of TSO without any severe adverse events. However, mild to moderate abdominal symptoms were observed in some participants, and higher doses of TSO led to elevated eosinophil count. Close follow-up is recommended for sustainable medicinal use of TSO in Japan.
PARASITOLOGY INTERNATIONAL
(2021)
Review
Gastroenterology & Hepatology
Conor Bell, Parul Tandon, Eric Lentz, John K. Marshall, Neeraj Narula
Summary: The study showed that pregnancies of women with inflammatory bowel disease exposed to vedolizumab may have increased adverse outcomes, including preterm births and early loss of pregnancy. However, these findings may be confounded by disease activity, and further prospective cohort studies are needed to confirm these results.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Medicine, Research & Experimental
Ines Silva, Joao Estarreja, Rui Pinto, Vanessa Mateus
Summary: Inflammatory Bowel Disease (IBD) is a group of chronic inflammatory disorders without known cure. Current pharmacological approaches have significant toxicity. Erythropoietin (EPO), known for its erythropoietic effect, has been found to also have anti-inflammatory properties. This study evaluated the efficacy and safety of EPO treatment in a chronic colitis model in rodents. EPO demonstrated significant anti-inflammatory effect and was deemed safe for extraintestinal manifestations.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Geriatrics & Gerontology
Nanyang Liu, Yi Wang, Lanye He, Jiahui Sun, Xing Wang, Hao Li
Summary: The study found that a previous diagnosis of inflammatory bowel disease (IBD) does not seem to increase the risk of subsequent all-cause dementia and AD-dementia. Cohort studies show a positive association between IBD patients and all-cause dementia, but it is not related to age and gender.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Integrative & Complementary Medicine
Xinyue Yang, Min He, Qingqing Tang, Zhihong Wang, De Jin, Xingquan Wu, Yonggang Yang, Dehui Ma, Mengmeng Sun, Tie Li
Summary: This study systematically evaluated the regulatory effects of acupuncture on inflammatory factors in inflammatory bowel disease (IBD) patients. The meta-analysis of selected studies showed that acupuncture has a positive therapeutic impact on IBD and can effectively regulate inflammatory factors in IBD patients, with TNF-a, IL-8, and IL-10 being more appropriate indicators for clinically evaluating the anti-inflammatory response in the blood of IBD patients treated with acupuncture.
COMPLEMENTARY THERAPIES IN MEDICINE
(2023)
Review
Clinical Neurology
Andrea Ballesio, Andrea Zagaria, Flavia Baccini, Federica Micheli, Giovanni Di Nardo, Caterina Lombardo
Summary: This study found that patients with inflammatory bowel disease have poorer subjective sleep quality compared to controls, with even worse sleep quality in those with active IBD. However, there were no differences within IBD subtypes. These results highlight the importance of considering sleep quality as a relevant comorbidity in IBD.
SLEEP MEDICINE REVIEWS
(2021)
Review
Medicine, General & Internal
Yuan-Fang Zhou, Ning Sun, Shi-Rui Cheng, Xiao-Dong Deng, Xiang-Yin Ye, Zheng-Jie Li, Jun Zhou, Gui-Xing Xu, Yu-Zhu Qu, Liu-Yang Huang, Rui-Rui Sun, Fan-Rong Liang
Summary: This study will conduct a systematic review on the effectiveness of acupuncture for inflammatory bowel disease (IBD) by evaluating relevant clinical data. The results will be published in a peer-reviewed journal or presented at relevant conferences.