Article
Multidisciplinary Sciences
Wonyoung Jung, Junhee Park, Hye Ryoun Jang, Junseok Jeon, Kyungdo Han, Bongseong Kim, Je Moon Yoon, Dong Hui Lim, Dong Wook Shin
Summary: This study investigated the association between age-related macular degeneration (AMD) and end-stage renal disease (ESRD) risk using a large cohort in Korea. The results showed that people with AMD had a 33% increased risk of ESRD, and the risk was even higher when accompanied by visual disability.
SCIENTIFIC REPORTS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Min Gul Kim, Min Gu Kang, Min Gyu Lee, Seong J. Yang, Sang Woo Yeom, Jong Hwan Lee, Sang Moon Choi, Ji Hyun Yoon, Eun Jung Lee, Sang Jae Noh, Min-Su Kim, Jong Seung Kim
Summary: The aim of this study was to investigate the effect of periodontitis on the incidence of fungal sinusitis. The study found that the risk of sinonasal fungal balls (SFBs) and invasive fungal sinusitis (IFS) increased after a diagnosis of periodontitis. Additionally, this trend was more severe in patients with diabetes mellitus (DM), chronic obstructive pulmonary disease (COPD), or chronic kidney disease (CKD).
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ziad M. El-Zaatari, Luan D. Truong
Summary: Renal cell carcinoma (RCC) occurring in the setting of end-stage renal disease (ESRD) shows unique clinicopathological characteristics, with acquired cystic kidney disease-associated renal cell carcinoma (ACKD-RCC) and clear-cell papillary renal cell carcinoma (ccpRCC) being the most frequent types. Other types of RCC also occur in ESRD, albeit with different frequencies from the non-ESRD general population. While the histological features of RCC do not vary in the setting of ESRD vs. non-ESRD, other findings, such as multifocality and multiple tumor types, are more frequent in ESRD. Studies have generated novel and important knowledge of the etiology, epidemiology, diagnosis, treatment, immunophenotype, and molecular characteristics of ESRD-associated RCC.
Article
Biochemistry & Molecular Biology
Yu-Hsien Liu, Yu-Hsuan Chen, Chi-Hua Ko, Chia-Wen Kuo, Chih-Ching Yen, Wei Chen, Kowit-Yu Chong, Chuan-Mu Chen
Summary: ESRD patients experience increased cardiovascular events and hospitalizations due to oxidative stress and inflammation. This study identifies SOD3 and IL-18 as strong predictors for the first kidney disease-related hospitalization or death in ESRD patients.
Article
Multidisciplinary Sciences
Jong Joo Moon, Yong Woo Kim, Baek-Lok Oh, Kyungdo Han, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Ki Ho Park, Hajeong Lee, Yong Chul Kim, Jin Wook Jeoung
Summary: This nationwide cohort study found that the incidence of primary open-angle glaucoma (POAG) was higher in patients with end stage renal disease (ESRD) and kidney transplantation recipients (KTRs) compared to healthy controls, but adjusting for confounding factors did not show a significant increase in risk. The incidence of primary angle-closure glaucoma (PACG) was higher in ESRD patients compared to healthy controls, while KTRs had a lower risk of PACG compared to ESRD patients.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Courtney L. Millar, Alyssa B. Dufour, Nitin Shivappa, Daniel Habtemariam, Joanne M. Murabito, Emelia J. Benjamin, James R. Hebert, Douglas P. Kiel, Marian T. Hannan, Shivani Sahni
Summary: This study found that a proinflammatory diet is associated with an increased incidence of frailty, suggesting that increasing the intake of anti-inflammatory foods may help prevent frailty.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Jhao-Yang Peng, Ying-Hui Yu, Wan-Ming Chen, Ben-Chang Shia, Mingchih Chen, Szu-Yuan Wu
Summary: Esophageal cancer has a low survival rate, so finding safe and effective medications to reduce its risk is crucial. This study found a significant association between the use of H1-antihistamines and an increased risk of esophageal squamous cell carcinoma, particularly at high doses.
Article
Clinical Neurology
Sung Hoon Kang, Yunjin Choi, Su Jin Chung, Chi Kyung Kim, Ji Hyun Kim, Kyungmi Oh, Joon Shik Yoon, Geum Joon Cho, Seong-Beom Koh
Summary: This study aimed to investigate the incidence rate of Parkinson's disease dementia (PDD) according to age and disease duration by sex. The results showed that age and disease duration were associated with the incidence of PDD, and hypertension, diabetes, dyslipidemia, and depression independently increased the risk for PDD.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Kyungdo Han, Jun-Beom Park
Summary: The study suggests an association between oral health, depicted by number of natural teeth, and the increased risk of kidney diseases. The risk of end-stage renal disease was found to be higher with lower number of natural teeth and longer follow-up periods. Factors such as age, body mass index, and smoking status were also significantly associated with this relationship.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Urology & Nephrology
Aurelie Lavergne, Adelaide Pladys, Cecile Couchoud, Mathilde Lassalle, Cecile Vigneau
Summary: The study found that the prognosis of SSc patients requiring RRT is still poor, with significantly higher mortality and lower likelihood of being listed for kidney transplantation waiting list compared to matched controls.
JOURNAL OF NEPHROLOGY
(2021)
Article
Oncology
Yen-Po Lin, Pei-Ming Wang, Ching-Hui Chuang, Chee-Chen Yong, Yueh-Wei Liu, Pao-Yuan Huang, Chih-Chien Yao, Ming-Chao Tsai
Summary: In recent years, the risk of MAFLD, obesity, diabetes, and hypertension in patients with early-stage NBNC-HCC has significantly increased, indicating the need for monitoring metabolic syndrome in this specific population. Moreover, NBNC-HCC tends to have a better prognosis than CHB-HCC, possibly due to their distinct clinicopathological features.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Chih-Hsiang Chang, Pei-Chun Fan, Yu-Sheng Lin, Shao-Wei Chen, Michael Wu, Ming-Shyan Lin, Cheng-Hui Lu, Po-Cheng Chang, Ming-Jer Hsieh, Chao-Yung Wang, Chun-Li Wang, Pao-Hsien Chu, Victor Chien-Chia Wu
Summary: The study found that compared to hemodialysis, patients with end-stage renal disease and atrial fibrillation undergoing peritoneal dialysis had significantly lower risks of intracranial hemorrhage, major bleeding, and ischemic stroke/systemic embolism at 1-year, 3-year, and 5-year follow-ups.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Medicine, General & Internal
Sang Heon Suh, Jin Hyung Jung, Tae Ryom Oh, Eun Mi Yang, Hong Sang Choi, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Kyung-Do Han, Soo Wan Kim
Summary: This study aimed to investigate the association between rheumatoid arthritis (RA) and the risk of end-stage renal disease (ESRD). The results showed that patients with RA had an increased risk of ESRD compared to those without RA, and the risk was higher in relatively young and healthy individuals. Therefore, kidney-protective treatment, such as biologic agents, should be preferred for these patients with RA.
FRONTIERS IN MEDICINE
(2023)
Article
Hospitality, Leisure, Sport & Tourism
Lars Gabrys, Jens Baumert, Christin Heidemann, Markus Busch, Jonas David Finger
Summary: This study found that even a low weekly quantity (1-2 hours) of regular sports activity is associated with health benefits. Formerly active but currently inactive individuals were not associated with an increased disease incidence, but were associated with a higher risk-factor development. Becoming active was shown to be preventive for risk-factor development but not for disease incidence, highlighting the importance of promoting and committing to regular sports activity early in the lifespan for optimal health benefits.
JOURNAL OF SPORT AND HEALTH SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Todd A. Johnson, Shigekatsu Maekawa, Masashi Fujita, Jisong An, Young-Seok Ju, Kazuhiro Maejima, Yuki Kanazashi, Ryosuke Jikuya, Yuki Okawa, Shota Sasagawa, Ken Yagi, Yasushi Okazaki, Naoto Kuroda, Ryo Takata, Wataru Obara, Hidewaki Nakagawa
Summary: Patients with end-stage renal disease (ESRD) or receiving dialysis have a higher risk for renal cell carcinoma (RCC). This study aimed to identify the genomic features of ESRD RCC and their association with tumor histology and dialysis exposure. The study found that ESRD or dialysis may induce cellular stress leading to specific types of genomic damage.
HUMAN MOLECULAR GENETICS
(2022)
Article
Urology & Nephrology
Chia-Ter Chao, Jenq-Wen Huang, Chih-Kang Chiang, Kuan-Yu Hung
Article
Cell Biology
Peir-Haur Hung, Chien-Hung Lin, Kuan-Yu Hung, Chih-Hsin Muo, Mu-Chi Chung, Chao-Hsiang Chang, Chi-Jung Chung
Article
Endocrinology & Metabolism
C-T Chao, J. Wang, J-W Huang, D-C Chan, K-Y Hung, K-L Chien
OSTEOPOROSIS INTERNATIONAL
(2020)
Article
Endocrinology & Metabolism
Chia-Ter Chao, Jui Wang, Jenq-Wen Huang, Kuan-Yu Hung, Kuo-Liong Chien
BMJ OPEN DIABETES RESEARCH & CARE
(2020)
Article
Endocrinology & Metabolism
Hui-Teng Cheng, Xiaoqi Xu, Paik Seong Lim, Kuan-Yu Hung
Summary: The study compared the incidence of diabetes-related end-stage renal disease globally from 2000 to 2015, finding significant geographic variation in the risk of diabetic patients reaching ESRD in different regions during the study period.
Article
Urology & Nephrology
Wan-Chuan Tsai, Hon-Yen Wu, Yen-Ling Chiu, Ju-Yeh Yang, Mei-Fen Pai, Yong-Ru Wu, Wan-Yu Lin, Kuan-Yu Hung, Kuo-Liong Chien, Shih-Ping Hsu, Yu-Sen Peng
Summary: The study found that increased dietary phosphorus intake rapidly increases serum phosphate, iPTH, and iFGF23 levels, and decreases serum calcium levels, highlighting the important role of daily fluctuations in dietary habits in disturbed mineral homeostasis in hemodialysis patients.
Article
Cardiac & Cardiovascular Systems
Chia-Ter Chao, Szu-Ying Lee, Jui Wang, Kuo-Liong Chien, Kuan-Yu Hung
Summary: Patients with incident diabetes and subsequently developed chronic kidney disease had a significantly higher risk of mortality, heart failure, acute myocardial infarction, and peripheral vascular disease compared to those without CKD. The risk of mortality, heart failure, and acute myocardial infarction associated with CKD became significant soon after diabetes occurred and remained significant throughout follow-up, indicating the need for early cardiovascular care strategies for newly diagnosed diabetic patients.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Urology & Nephrology
Chia-Ter Chao, Ching- Chang, Pa-Chun Wang, Ching-Feng Chiang, Chia-Pei Chen, Hui-Shu Hsu, Kuan-Yu Hung
Summary: This study found that a kidney-care DSC certification program significantly improved multiple performance indicators of participating institutes, including patients' haemoglobin, albumin, and shunt re-creation probability among patients with end-stage renal disease.
Article
Cardiac & Cardiovascular Systems
Peir-Haur Hung, Chih-Ching Yeh, Chih-Yen Hsiao, Chih-Hsin Muo, Kuan-Yu Hung, Kuen-Jer Tsai
Summary: For patients receiving hemodialysis, the use of erythropoietin is not associated with an increased risk of stroke or any of its subtypes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Medicine, Research & Experimental
Jia-Huang Chen, Chia-Ter Chao, Jenq-Wen Huang, Kuan-Yu Hung, Shing-Hwa Liu, Der-Cherng Tarng, Chih-Kang Chiang
Summary: The study reveals that the accumulation of IS is associated with renal fibrosis and upregulation of BiP and CHOP. Administration of indole, a precursor of IS, exacerbates renal fibrosis, SASP, and activation of ER stress, while AST-120 attenuates these effects.
Article
Biochemistry & Molecular Biology
Chong-Sun Khoi, Yu-Wen Lin, Jia-Huang Chen, Biing-Hui Liu, Tzu-Yu Lin, Kuan-Yu Hung, Chih-Kang Chiang
Summary: This study demonstrates that OTA induces nephrotoxicity through ER stress-related apoptosis in human renal cells, with a pathway mediated by ROS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Chong-Sun Khoi, Jia-Huang Chen, Tzu-Yu Lin, Chih-Kang Chiang, Kuan-Yu Hung
Summary: OTA is a mycotoxin widely found in various foods and feeds, causing harmful effects on humans and animals, with the kidneys being the main target. Recent research has focused on the intracellular molecular interactions and signaling pathways of OTA-induced nephrotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Chong-Sun Khoi, Cai-Qin Xiao, Kuan-Yu Hung, Tzu-Yu Lin, Chih-Kang Chiang
Summary: This study investigated the mechanism of vascular dysfunction induced by palmitic acid, and revealed the crucial roles of XBP1s and OSGIN1 in maintaining endothelial cell migration and regulating autophagy.
Article
Cell Biology
Jia-Huang Chen, Chia-Hsien Wu, Jia-Rong Jheng, Chia-Ter Chao, Jenq-Wen Huang, Kuan-Yu Hung, Shing-Hwa Liu, Chih-Kang Chiang
Summary: This study investigated the role of XBP1, a key regulator of the unfolded protein response (UPR), in the transition from acute kidney injury (AKI) to chronic kidney disease (CKD). The findings demonstrated that XBP1 expression was attenuated after AKI and inversely correlated with the severity of renal fibrosis. XBP1 deficiency in mice resulted in exacerbated renal fibrosis. Silencing XBP1 in human proximal tubular epithelial cells led to cell cycle arrest and increased TGF-beta 1 secretion. The study also identified TNF receptor associated protein 1 (Trap1) as a potential downstream target of XBP1, and showed that Trap1 overexpression alleviated the profibrotic effects of XBP1 deficiency.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Dermatology
Mei-Ju Ko, Jenq-Wen Huang, Hon-Yen Wu, Wan-Chuan Tsai, Le-Yin Hsu, Ping-Hsiu Tsai, Kuo-Liong Chien, Kuan-Yu Hung
Summary: A nationwide cohort study of patients with advanced chronic kidney disease in Taiwan found that UVB phototherapy does not increase the risk of developing skin cancer in these patients, indicating that it is a safe treatment for uraemic pruritus in this population.
ACTA DERMATO-VENEREOLOGICA
(2021)
