Perspectives and Potential Applications of Mitochondria-Targeted Antioxidants in Cardiometabolic Diseases and Type 2 Diabetes

Mitochondria-Targeted Antioxidants Protect Against Amyloid-β Toxicity in Alzheimer's Disease Neurons

(2017) Maria Manczak et al.   JOURNAL OF ALZHEIMERS DISEASE

Human Leukocyte/Endothelial Cell Interactions and Mitochondrial Dysfunction in Type 2 Diabetic Patients and Their Association With Silent Myocardial Ischemia

(2013) A. Hernandez-Mijares et al.   DIABETES CARE

Adverse Alterations in Mitochondrial Function Contribute to Type 2 Diabetes Mellitus–Related Endothelial Dysfunction in Humans

(2012) Tinoy J. Kizhakekuttu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Evidence for a relationship between mitochondrial Complex I activity and mitochondrial aldehyde dehydrogenase during nitroglycerin tolerance: Effects of mitochondrial antioxidants

(2012) Remedios Garcia-Bou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Lipid Metabolism and Toxicity in the Heart

(2012) Ira J. Goldberg et al.   Cell Metabolism

The Heart in Friedreich Ataxia

(2012) Frank Weidemann et al.   CIRCULATION

Free radical biology of the cardiovascular system

(2012) Alex F. Chen et al.   CLINICAL SCIENCE

Oxidative Stress and Mitochondrial Dysfunction in Type 2 Diabetes

(2012) Victor M. Victor et al.   CURRENT PHARMACEUTICAL DESIGN

GSH or Palmitate Preserves Mitochondrial Energetic/Redox Balance, Preventing Mechanical Dysfunction in Metabolically Challenged Myocytes/Hearts From Type 2 Diabetic Mice

(2012) C. G. Tocchetti et al.   DIABETES

Coenzyme Q10 prevents GDP-sensitive mitochondrial uncoupling, glomerular hyperfiltration and proteinuria in kidneys from db/db mice as a model of type 2 diabetes

(2012) M. Friederich Persson et al.   DIABETOLOGIA

Nitrite activates AMP kinase to stimulate mitochondrial biogenesis independent of soluble guanylate cyclase

(2012) Li Mo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Physical Activity Is the Key Determinant of Skeletal Muscle Mitochondrial Function in Type 2 Diabetes

(2012) F. H. J. van Tienen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Sporadic myopathy, myoclonus, leukoencephalopathy, neurosensory deafness, hypertrophic cardiomyopathy and insulin resistance associated with the mitochondrial 8306 T>C MTTK mutation

(2012) Elena Cardaioli et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Diabetes and hypertension: the bad companions

(2012) Ele Ferrannini et al.   LANCET

Exercise-induced AMPK activity in skeletal muscle: Role in glucose uptake and insulin sensitivity

(2012) Martin Friedrichsen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

PTEN, a widely known negative regulator of insulin/PI3K signaling, positively regulates neuronal insulin resistance

(2012) Amit Gupta et al.   MOLECULAR BIOLOGY OF THE CELL

Engineering of blended nanoparticle platform for delivery of mitochondria-acting therapeutics

(2012) S. Marrache et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New insights into ER stress-induced insulin resistance

(2012) Mélissa Flamment et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Resolution of Mitochondrial Oxidative Stress Rescues Coronary Collateral Growth in Zucker Obese Fatty Rats

(2011) Yuh Fen Pung et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mitochondria-targeted Antioxidants Protect Pancreatic β-cells against Oxidative Stress and Improve Insulin Secretion in Glucotoxicity and Glucolipotoxicity

(2011) Sangbin Lim et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Mitochondrial Dysfunction and Targeted Drugs: A Focus on Diabetes

(2011) Victor M Victor et al.   CURRENT PHARMACEUTICAL DESIGN

Mitochondrial complex I impairment in leukocytes from type 2 diabetic patients

(2011) Antonio Hernandez-Mijares et al.   FREE RADICAL BIOLOGY AND MEDICINE

Uncoupling proteins and the control of mitochondrial reactive oxygen species production

(2011) Ryan J. Mailloux et al.   FREE RADICAL BIOLOGY AND MEDICINE

The mitochondria-targeted antioxidant MitoQ decreases features of the metabolic syndrome in ATM+/–/ApoE–/– mice

(2011) John R. Mercer et al.   FREE RADICAL BIOLOGY AND MEDICINE

Induction of Oxidative Stress and Human Leukocyte/Endothelial Cell Interactions in Polycystic Ovary Syndrome Patients with Insulin Resistance

(2011) Victor M. Victor et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome

(2011) Matthew D. Hirschey et al.   MOLECULAR CELL

Novel Therapies Targeting Inner Mitochondrial Membrane—From Discovery to Clinical Development

(2011) Hazel H. Szeto et al.   PHARMACEUTICAL RESEARCH

Mitochondria-targeted antioxidant peptide SS31 attenuates high glucose-induced injury on human retinal endothelial cells

(2010) Jianqiao Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Prevention of diabetic nephropathy in Ins2+/−AkitaJmice by the mitochondria-targeted therapy MitoQ

(2010) Balu K. Chacko et al.   BIOCHEMICAL JOURNAL

Rapid uptake of lipophilic triphenylphosphonium cations by mitochondria in vivo following intravenous injection: Implications for mitochondria-specific therapies and probes

(2010) Carolyn M. Porteous et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Targeting Mitochondria: A New Promising Approach for the Treatment of Liver Diseases

(2010) G. Serviddio et al.   CURRENT MEDICINAL CHEMISTRY

A Novel Intronic Peroxisome Proliferator-activated Receptor γ Enhancer in the Uncoupling Protein (UCP) 3 Gene as a Regulator of Both UCP2 and -3 Expression in Adipocytes

(2010) Anne Bugge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diacylglycerol-mediated insulin resistance

(2010) Derek M Erion et al.   NATURE MEDICINE

Mitochondria-Penetrating Peptides: Sequence Effects and Model Cargo Transport

(2009) Lema F. Yousif et al.   CHEMBIOCHEM

Targeting Mitochondria with Organelle-Specific Compounds: Strategies and Applications

(2009) Lema F. Yousif et al.   CHEMBIOCHEM

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

(2009) Carles Cantó et al.   CURRENT OPINION IN LIPIDOLOGY

Protective Effect of Perindopril on Diabetic Retinopathy Is Associated With Decreased Vascular Endothelial Growth Factor-to-Pigment Epithelium-Derived Factor Ratio: Involvement of a Mitochondria-Reactive Oxygen Species Pathway

(2009) Z. Zheng et al.   DIABETES

Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice

(2009) Sergio Rodriguez-Cuenca et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial Complex I Impairment in Leukocytes from Polycystic Ovary Syndrome Patients with Insulin Resistance

(2009) Victor M. Victor et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Synthesis of N-arylpyridinium salts bearing a nitrone spin trap as potential mitochondria-targeted antioxidants

(2009) Linsey Robertson et al.   TETRAHEDRON

Mitochondrial drug delivery systems for macromolecule and their therapeutic application to mitochondrial diseases☆

(2008) Yuma Yamada et al.   ADVANCED DRUG DELIVERY REVIEWS

Rapid and extensive uptake and activation of hydrophobic triphenylphosphonium cations within cells

(2008) Meredith F. Ross et al.   BIOCHEMICAL JOURNAL

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

An attempt to prevent senescence: A mitochondrial approach

(2008) Vladimir P. Skulachev et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Development of mitochondria-targeted derivatives of resveratrol

(2008) Lucia Biasutto et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A mitochondria-targeted nitroxide is reduced to its hydroxylamine by ubiquinol in mitochondria

(2008) Jan Trnka et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reactivity of ubiquinone and ubiquinol with superoxide and the hydroperoxyl radical: implications for in vivo antioxidant activity

(2008) A MAROZ et al.   FREE RADICAL BIOLOGY AND MEDICINE

Multifunctional envelope-type nano device (MEND) as a non-viral gene delivery system

(2007) Kentaro Kogure et al.   ADVANCED DRUG DELIVERY REVIEWS

Do Mitochondriotropic Antioxidants Prevent Chlorinative Stress-Induced Mitochondrial and Cellular Injury?

(2007) Matthew Whiteman et al.   ANTIOXIDANTS & REDOX SIGNALING