Review
Infectious Diseases
Harshad Lade, Hwang-Soo Joo, Jae-Seok Kim
Summary: MRSA is a drug-resistant pathogen with the ability to resist multiple antibiotics. It utilizes various resistance mechanisms to evade antibiotic action. This review discusses the molecular basis of MRSA resistance to non-beta-lactam antibiotics, providing insights for the development of new treatment approaches and detection methods for antibiotic resistance.
Article
Infectious Diseases
Carlton Poindexter, Andrea Yarberry, Clifford Rice, Stephanie Lansing
Summary: This study developed a uniform method to extract four classes of antibiotics from different types of manure, providing more accurate data for assessing the risk of antibiotic transport in liquid or solid manure waste.
Review
Biochemistry & Molecular Biology
Marco Fiore, Lorenzo Peluso, Fabio Silvio Taccone, Maya Hites
Summary: In critically ill patients undergoing continuous renal replacement therapy (CRRT), optimizing antibiotic therapy dosage can be challenging due to potential inadequate or excessive serum drug concentrations. Individualized therapy based on therapeutic drug monitoring results is recommended to avoid undertreatment or toxicity. Despite efforts to identify optimal antibiotic dosage regimens, target achievement for hydrophilic antibiotics remains low in many patients.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2021)
Review
Pharmacology & Pharmacy
Adam Foxfire, Andrew Riley Buhrow, Ravi S. Orugunty, Leif Smith
Summary: The genus Burkholderia consists of Gram-negative, non-sporulating bacteria that mainly dwell in soil, with some virulent species like Burkholderia mallei, Burkholderia pseudomallei, and the Burkholderia cepacia complex. Research on natural products isolated from Burkholderia and the drug discovery efforts have shown promise in developing novel therapeutics against infectious diseases, which is urgent due to the increasing prevalence of antibiotic-resistant pathogens.
EXPERT OPINION ON DRUG DISCOVERY
(2021)
Review
Infectious Diseases
Federico Giovagnorio, Andrea De Vito, Giordano Madeddu, Saverio Giuseppe Parisi, Nicholas Geremia
Summary: This review delves into the intricate resistance mechanisms employed by Pseudomonas aeruginosa and emphasizes the complexities encountered in clinical management. It highlights the need for innovative combination therapies and explores the role of accurate antibiogram interpretation in guiding antibiotic use and mitigating antibiotic resistance.
Article
Chemistry, Multidisciplinary
Yalong Zhang, Jian Bai, Le Zhang, Chen Zhang, Bingyu Liu, Youcai Hu
Summary: A unique self-resistance mechanism for fungal antibiotics was discovered, utilizing an oxidative-reductive cycle to prevent self-harm. This work contributes to the understanding of antibiotic biosynthesis and resistance mechanisms.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Infectious Diseases
Caterina Aurilio, Pasquale Sansone, Manlio Barbarisi, Vincenzo Pota, Luca Gregorio Giaccari, Francesco Coppolino, Alfonso Barbarisi, Maria Beatrice Passavanti, Maria Caterina Pace
Summary: Carbapenem antibiotics are highly effective for the treatment of infections caused by resistant bacteria. The widespread use of these antibiotics has resulted in carbapenem resistance, which can occur through both intrinsic and acquired mechanisms.
Article
Chemistry, Medicinal
Anka Lucic, Philip Hinchliffe, Tika R. Malla, Catherine L. Tooke, Jurgen Brem, Karina Calvopina, Christopher T. Lohans, Patrick Rabe, Michael A. McDonough, Timothy Armistead, Allen M. Orville, James Spencer, Christopher J. Schofield
Summary: Penems have shown potential as antibacterials and beta-lactamase inhibitors, but their clinical use is limited compared to carbapenems. Faropenem, with a C-2 tetrahydrofuran ring, is resistant to some beta-lactamases. Studies on reactions of faropenem with beta-lactamases demonstrate different outcomes, suggesting further research is needed for optimizing the interactions between penems and beta-lactamases.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Immunology
Lais Pessanha de Carvalho, Sara Groeger-Otero, Andrea Kreidenweiss, Peter G. Kremsner, Benjamin Mordmueller, Jana Held
Summary: Boromycin is a boron-containing macrolide antibiotic that is highly potent against certain viruses, bacteria, and protozoan parasites. It shows strong antiplasmodial activity against different types of Plasmodium species, including multidrug-resistant strains. Boromycin is a promising candidate for antimalarial treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Miao He, Ernane Souza, Aleksas Matvekas, Ryan L. Crass, Manjunath P. Pai
Summary: In mouse experiments, the dose of vancomycin (VAN) was found to be associated with the development of acute kidney injury (AKI). The risk of AKI can be reduced by combining VAN with piperacillin/tazobactam (TZP) or imipenem-cilastatin/relebactam (IMP-C/REL).
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Plant Sciences
Sara Freitas, Raquel Castelo-Branco, Arlette Wenzel-Storjohann, Vitor M. Vasconcelos, Deniz Tasdemir, Pedro N. Leao
Summary: In this study, two new lipoglycopeptides were discovered from the cyanobacterium Desmonostoc muscorum LEGE 12446 isolated from a cycad coralloid root. The chemical structures of the compounds were determined, and their potential role in root endosymbiosis was proposed.
JOURNAL OF NATURAL PRODUCTS
(2022)
Review
Pharmacology & Pharmacy
Khashayar Afshari, Nazanin Momeni Roudsari, Naser-Aldin Lashgari, Nazgol-Sadat Haddadi, Arvin Haj-Mirzaian, Malihe Hassan Nejad, Hamed Shafaroodi, Mehdi Ghasemi, Ahmad Reza Dehpour, Amir Hossein Abdolghaffari
Summary: This review paper discusses the therapeutic effects of antibiotics on spinal cord injury, which include anti-inflammatory and neuroprotective effects. Different families of antibiotics have been found to improve the sequels and complications of spinal cord injury by targeting similar signaling pathways. The mechanisms include reducing inflammatory microglial activity, promoting autophagy, inhibiting neuronal apoptosis, and modulating SCI-related mitochondrial dysfunction.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Samer S. Daher, Miseon Lee, Xiao Jin, Christiana N. N. Teijaro, Pamela R. R. Barnett, Joel S. S. Freundlich, Rodrigo B. B. Andrade
Summary: The increasing bacterial drug resistance calls for the development of novel antibacterials with new mechanisms of action. This study explores the design and synthesis of a novel series of solithromycin analogs, with a focus on their structure-activity relationship. Two analogs are found to exhibit improved activity against resistant strains, showing potential for further pre-clinical studies.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Thomas P. Lodise, Laura A. Puzniak, Lie H. Chen, Yun Tian, Rong Wei, Theresa M. Im, Sara Y. Tartof
Summary: This study evaluated the impact of anti-pseudomonal beta-lactam resistance on outcomes in patients with P. aeruginosa HABP/VABP. Patients resistant to at least 1 APBL had a higher 30-day mortality and were less likely to be discharged home compared to those with no APBL resistance.
Article
Environmental Sciences
Can Wang, Yinxue Jia, Jianpeng Li, Yu Wang, Huan Niu, Hang Qiu, Xing Li, Weizhen Fang, Zhongping Qiu
Summary: In this study, contaminated chicken manure composting was conducted to investigate the effect of bioaugmentation on tetracycline residue and antibiotics resistance genes (ARGs). The bioaugmented composting efficiently removed most of the antibiotics in just 7 days. It also resulted in changes in microbial community structure and increased the abundance of certain bacterial genera. However, further research is needed to determine the ability of bioaugmentation to remove ARGs.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)