期刊
MEDICINAL RESEARCH REVIEWS
卷 28, 期 5, 页码 688-714出版社
WILEY
DOI: 10.1002/med.20123
关键词
natural products; TRAIL; apoptosis; Curcuma parviflora; myxomycete
资金
- Grant-in-Aid from the Ministry of Education, Culture, Sports, Science, and Technology of Japan
- Grants-in-Aid from the Kampou Science Foundation, from the Shorai Foundation for Science and Technology
- Futaba Electronics Memorial Foundation
- Research for Promoting Technological Seed, Japan Science and Technology Agency
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces apoptosis in many transformed cells but not in normal cells and, hence, has been expected as a new anticancer strategy. During our studies on search for bioactive natural products from various natural resources such as plants and microorganisms, we recently indetified several natural products which exhibited activities related to TRAIL signaling. Dimeric sesquiterpenoids isolated from Zingiberaceous plant, Curcuma parviflora, showed enhancement activity of gene expression of TRAIL-receptor and TRAIL-receptor protein level. Several new isoflavone natural products, named brandisianins, were isolated from Leguminosaeous plant. Millettia brandisiana, by our screening study targeting TRAIL-receptor expression enhancement activity. A dihydroflavonol (BB1) that was extracted from Compositaeous plant, Blumea balsamifera, and fuligocandin B, a new anthranilylproline-indole alkaloid isolated from myxomycete were found to exhibit reversal effect of-TRAIL resistance activity. (C) 2008 Wiley Periodicals, Inc.
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