期刊
MEDICINAL CHEMISTRY RESEARCH
卷 21, 期 12, 页码 3929-3939出版社
SPRINGER BIRKHAUSER
DOI: 10.1007/s00044-012-9972-6
关键词
Imidazole; Antiepileptic agent; Denzimol; Nafimidone
资金
- All India Council for Technical Education, New Delhi, India
Imidazole is incorporated into many important biological molecules. The major revolution in the field of imidazole derivatives with antiepileptic properties came with the synthesis of Denzimol and Nafimidone, which leads in its effectiveness among other molecules. The pharmacophore and substitution necessary to elevate the pharmacological effect of these derivatives in curing epilepsy are presented in this review, which can serve the medicinal chemist working on epileptic research to focus on this untouched class of molecules and enlarge its category and synthesize more active and potent anticonvulsant agents.
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