期刊
MEDICINAL CHEMISTRY RESEARCH
卷 20, 期 6, 页码 661-669出版社
SPRINGER BIRKHAUSER
DOI: 10.1007/s00044-010-9368-4
关键词
Aldol condensation; Aromatase; Breast cancer; Indanone derivatives; Nonsteroidal aromatase inhibitors
资金
- University Grants Commission, India
The synthesis and aromatase inhibitory activity of a new series of 2-benzylidene indanones is presented. The imidazolyl-substituted indanones displayed potent aromatase inhibitory activity. The vanilloid-based derivative 2-[4-(3-imidazol-1-ylpropoxy)-3-methoxybenzylidene]-indan-1-one (26) exhibited maximum inhibition of human placental aromatase and was found to be 54 times more potent as compared to aminoglutethimide.
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