期刊
MEDICINAL CHEMISTRY RESEARCH
卷 18, 期 3, 页码 221-230出版社
SPRINGER BIRKHAUSER
DOI: 10.1007/s00044-008-9121-4
关键词
Anti-inflammatory; Imidazole-carbaldehyde; Microwave irradiation
A series of N-substituted 2-butyl-5-chloro-3H-imidazole-4-carbaldehyde derivatives bearing potentially bioactive substituents were synthesized by microwave irradiation method in good yield compared with conventional method. The synthesized compounds were screened for their anti-inflammatory activity and were compared with a standard drug. The compounds demonstrated potent to weak anti-inflammatory activity. Of the compounds studied, compounds 6i and 6d showed potent activity comparable to the standard drug ibuprofen at the same dose in carrageenan-induced paw edema in rat model.
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