Article
Pharmacology & Pharmacy
Manal Ali Buabeid, Hafiza Sidra Yaseen, Muhammad Asif, Ghulam Murtaza, El-Shaimaa A. Arafa
Summary: This study evaluates the anti-inflammatory and anti-angiogenic potential of Moringa olifera extract and Moringa-loaded nanoclay films. The results show that Moringa has anti-inflammatory and anti-angiogenic effects, indicating its therapeutic potential against chronic diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Manal Buabeid, El-Shaimaa A. Arafa, Hafiza Sidra Yaseen, Muhammad Ihtisham Umar, Ghulam Murtaza
Summary: This study evaluated the anti-inflammatory and antiangiogenic properties of simvastatin and its nanofilms containing silver nanoparticles. The results showed that simvastatin has significant anti-inflammatory and antiangiogenic effects, and can effectively reduce edema. These findings are important for the field of biomedicine, but further clinical studies are needed to validate their commercial use.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2022)
Review
Physiology
Emilio Badoer
Summary: Heart failure is a growing medical problem with common characteristics of increased sympathetic nerve activity, activated renin-angiotensin system, and inflammation. The mechanisms and role of central nervous system in heart failure are not fully understood.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Integrative & Complementary Medicine
Maryam Teimouri, Masoud Homayouni-Tabrizi, Arezoo Rajabian, Hamed Amiri, Hossein Hosseini
Summary: This study found through systematic review and meta-analysis that resveratrol can significantly decrease serum levels of CRP and TNF-alpha in patients with CVDs.
COMPLEMENTARY THERAPIES IN MEDICINE
(2022)
Article
Clinical Neurology
Bernadette Kirzinger, Andrea Stroux, Torsten Rackoll, Matthias Endres, Agnes Floeel, Martin Ebinger, Alexander Heinrich Nave
Summary: Elevated levels of IL-6 and fibrinogen in early subacute stroke were associated with worse outcomes up to 6 months post-stroke. However, exposure to aerobic physical fitness training did not alter the dynamics of inflammatory markers over time.
FRONTIERS IN NEUROLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Zhen Hui Peh, Adel Dihoum, Dana Hutton, J. Simon C. Arthur, Graham Rena, Faisel Khan, Chim C. C. Lang, Ify R. Mordi
Summary: HFpEF is a type of heart failure that accounts for around half of all cases and may become the dominant type in the future. Compared to heart failure with reduced ejection fraction, there are limited evidence-based treatment strategies available for HFpEF. Inflammation is believed to play a key role in the pathophysiology of HFpEF and could be a potential therapeutic target.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Hematology
Brandon G. Shokoples, Pierre Paradis, Ernesto L. Schiffrin
Summary: Chronic low-grade inflammation is closely linked to cardiovascular diseases. Targeting the purinergic receptor P2X7, which mediates inflammation and cellular death, shows potential in mitigating cardiovascular conditions. Inhibiting P2X7 activation and IL-1 beta/IL-18 release may reduce cardiovascular disease severity and occurrence of adverse cardiac events.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Irina Lousa, Flavio Reis, Alice Santos-Silva, Luis Belo
Summary: Chronic kidney disease is a global public health problem with high morbidity and mortality. Inflammation and inflammatory mediators, such as tumor necrosis factor-related biomarkers, play a role in the development and progression of CKD. Tumor necrosis factor receptors 1 and 2 have been associated with changes in kidney function and injury, and could potentially serve as biomarkers for CKD prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Timea Magdolna Szabo, Attila Frigy, Elod Erno Nagy
Summary: Inflammation plays a crucial role in the development and progression of heart failure, with chronic inflammation being a major cardiovascular risk factor. Anti-inflammatory treatments represent a novel approach to prevent and slow down the progression of heart failure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cardiac & Cardiovascular Systems
Konstantinos Prokopidis, Atiporn Therdyothin, Panagiotis Giannos, Jordi Morwani-Mangnani, Panagiotis Ferentinos, Alexandros Mitropoulos, Masoud Isanejad
Summary: This study aimed to evaluate the effect of n-3 fatty acid supplementation on circulating inflammatory cytokines in patients with heart failure. A systematic review and meta-analysis of 10 randomized controlled trials revealed that n-3 fatty acid supplementation had a beneficial effect on tumor necrosis factor-alpha and interleukin-6 levels, but no significant changes were observed in C-reactive protein levels. Therefore, n-3 fatty acid supplementation may be an effective strategy for reducing inflammation in patients with heart failure.
HEART FAILURE REVIEWS
(2023)
Article
Cell Biology
Irina Lousa, Luis Belo, Maria Joao Valente, Susana Rocha, Ines Preguica, Petronila Rocha-Pereira, Idalina Beirao, Filipe Mira, Rui Alves, Flavio Reis, Alice Santos-Silva
Summary: Inflammation plays an important role in chronic kidney disease (CKD). This study found that inflammatory biomarkers in the blood were associated with kidney function and injury parameters, and could potentially be used as early markers for diagnosis and staging of CKD.
INFLAMMATION RESEARCH
(2022)
Article
Peripheral Vascular Disease
Michael A. Francisco, Joshua F. Lee, Zachary Barrett-O'Keefe, H. Jonathan Groot, Stephen M. Ratchford, Kanokwan Bunsawat, Jeremy K. Alpenglow, John J. Ryan, Jose N. Nativi, Russell S. Richardson, D. Walter Wray
Summary: The study revealed a significant decline in lower limb microvascular function in patients with HFpEF compared to healthy controls, possibly associated with systemic inflammation and oxidative damage. However, disease-related biomarkers of inflammation and oxidative damage were not correlated with responses to passive leg movement.
Review
Biochemistry & Molecular Biology
Faizeaab Hashmi, Sana Aqeel, Umra Fatima Zuberi, Wajihullah Khan
Summary: Inflammatory biomarkers CRP, IL-6, and TNF-alpha are associated with disease severity in malaria patients, with higher levels observed in complicated cases. However, individual biomarkers lack specificity and do not have sufficient diagnostic accuracy for malaria.
Article
Geriatrics & Gerontology
Nikolas Wada, Elizabeth C. Breen, Wendy S. Post, Valentina Stosor, Bernard J. Macatangay, Joseph B. Margolick
Summary: This study observed higher concentrations of CRP in men living with HIV compared to HIV-negative men at different ages, and men with detectable HIV RNA showed faster increases in CRP with age.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ewa Rudnicka, Katarzyna Suchta, Monika Grymowicz, Anna Calik-Ksepka, Katarzyna Smolarczyk, Anna M. Duszewska, Roman Smolarczyk, Blazej Meczekalski
Summary: Polycystic ovary syndrome (PCOS) is characterized by chronic anovulation, hyperandrogenism, and polycystic ovarian morphology, often leading to health issues like obesity and insulin resistance. Studies suggest a link between PCOS and chronic inflammation, which may contribute to cardiovascular diseases and other complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Letter
Cardiac & Cardiovascular Systems
Jorge Sanz-Sanchez, Dimitrios A. Vrachatis, Bernhard Reimers, Spyridon G. Deftereos, Marinos Kallikourdis, Marco Vicenzi, George Giannopoulos, Sotiria G. Giotaki, Dimitrios Tousoulis, Giuseppe Ferrante, Gianluigi Condorelli, Giulio G. Stefanini
HELLENIC JOURNAL OF CARDIOLOGY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Dimitrios A. Vrachatis, Georgios V. Giannopoulos, Spyridon G. Deftereos
Summary: This commentary reviews studies on the time-to-treatment initiation of colchicine and cardiovascular outcomes after myocardial infarction, as well as the adoption of colchicine for secondary prevention in coronary artery disease.
EUROPEAN HEART JOURNAL
(2021)
Review
Cardiac & Cardiovascular Systems
Ioannis Anagnostopoulos, Maria Kousta, Charalampos Kossyvakis, Eleni Lakka, Nikolaos Taxiarchis Paraskevaidis, Nikolaos Schizas, Spyridon Deftereos, Georgios Giannopoulos
Summary: Left atrial peak systolic longitudinal strain (LA-PLSsys) is considered a useful predictor for post-ablation atrial fibrillation (AF) recurrence, but substantial heterogeneity was noted in related studies; the study indicated that LA-PLSsys was negatively correlated with baseline LA volume index, and further uniform methodologies are needed to determine the reference range for LA-PLSsys.
Review
Cardiac & Cardiovascular Systems
Ioannis Anagnostopoulos, Maria Kousta, Charalampos Kossyvakis, Eleni Lakka, Nikolaos Taxiarchis Paraskevaidis, Nikolaos Schizas, Nikolaos Alexopoulos, Spyridon Deftereos, Georgios Giannopoulos
Summary: LGE on CMR is strongly associated with ADT and cardiac death in patients with NICM and reduced LVEF, but not with SCD. Contrast enhancement is a sensitive marker for future ADT and cardiac death, but has moderate specificity.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Dimitrios A. Vrachatis, Konstantinos A. Papathanasiou, Charalampos Kossyvakis, Dimitrios Kazantzis, Sotiria G. Giotaki, Gerasimos Deftereos, Jorge Sanz-Sanchez, Konstantinos Raisakis, Andreas Kaoukis, Dimitrios Avramides, Vaia Lambadiari, Gerasimos Siasos, George Giannopoulos, Spyridon Deftereos
Summary: This study investigates the association between early and late arrhythmia recurrence after atrial fibrillation cryoablation. The findings suggest that early recurrence is predictive of late outcomes.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2022)
Review
Medicine, General & Internal
Georgios Giannopoulos, Ioannis Anagnostopoulos, Maria Kousta, Stavros Vergopoulos, Spyridon Deftereos, Vassilios Vassilikos
Summary: Moderate alcohol consumption significantly reduces the risk of developing new-onset atrial fibrillation (AF), while heavy drinking increases the risk. The relationship between alcohol consumption and incident AF appears to be J-shaped.
Article
Cardiac & Cardiovascular Systems
Ioannis Anagnostopoulos, Charalampos Kossyvakis, Maria Kousta, Christina Verikokkou, Eleni Lakka, Asterios Karakanas, Gerasimos Deftereos, Polixeni Spanou, Sotiria Giotaki, Dimitrios Vrachatis, Dimitrios Avramidis, Spyridon Deftereos, Georgios Giannopoulos
Summary: In this study, the safety and efficacy of cephalic vein cutdown (CVC), subclavian vein puncture (SVP), and axillary vein puncture (AVP) for cardiac device implantation were compared. The results showed that both CVC and AVP were associated with lower incidence of pneumothorax and lead failure compared to SVP. There were no significant differences between AVP and CVC. Limited data suggests that different approaches did not have a major impact on infectious and bleeding complications. The initial use of CVC required more frequent alternate/additional venous access compared to AVP and SVP. Further clinical testing is suggested for AVP based on these results.
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Dimitrios Tachmatzidis, Anastasios Tsarouchas, Dimitrios Mouselimis, Dimitrios Filos, Antonios P. Antoniadis, Dimitrios N. Lysitsas, Nikolaos Mezilis, Antigoni Sakellaropoulou, Georgios Giannopoulos, Constantinos Bakogiannis, Konstantinos Triantafyllou, Nikolaos Fragakis, Konstantinos P. Letsas, Dimitrios Asvestas, Michael Efremidis, Charalampos Lazaridis, Ioanna Chouvarda, Vassilios P. Vassilikos
Summary: The study validates a novel index based on beat-to-beat P-wave morphology and wavelet analysis, which predicts the risk of atrial fibrillation recurrence within a year after successful catheter ablation. This index, along with other factors, serves as an independent predictor.
Letter
Cardiac & Cardiovascular Systems
Vassilikos P. Vassilios, Georgios Giannopoulos, Nikolaos Fragakis, Antonis Billis, Michalis Efremidis, Konstantinos Letsas, Themistoklis Maounis, Anna Kostopoulou, Georgios Andrikopoulos, Sokratis Pastromas, Apostolos Katsivas, Charalambos Kossyvakis, Eleftherios Kallergis, Emmanouel Kanoupakis, Panagiotis Ioannidis, Stelios Tzeis, Dimosthenis Avramidis, Ioannis Papagiannis, Spyridon Deftereos, Eftychia Symeonidou, Dimitrios Tsiachris, George Theodorakis, Ioannis Rassias, Dimitrios Lysitsas, Eleni Chatzinikolaou, Nikolaos Mezilis, Stylianos Paraskevaidis, Spyros Kourouklis, Theodoros Apostolopoulos, Dimosthenis Katritsis, Sophia Chatzidou, Lilian Mantziari, Georgios Leventopoulos, Ioannis Chiladakis, George Kourgiannidis, George Stavropoulos, Sotirios Xydonas, Charilaos Ginos, Athanasios Kotsakis, Giannis Baltogiannis, Antonis S. Manolis, Skevos Sideris, Konstantinos Gatzoulis
HELLENIC JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Andreas S. Papazoglou, Ioannis T. Farmakis, Stefanos Zafeiropoulos, Dimitrios V. Moysidis, Efstratios Karagiannidis, Nikolaos Stalikas, Anastasios Kartas, Konstantinos Stamos, Georgios Sofidis, Ioannis Doundoulakis, Georgios Giannopoulos, George Giannakoulas, Georgios Sianos
Summary: Among patients with ACS, the absence of SMuRFs is associated with increased odds for non-obstructive CAD and with increased short-term mortality rates.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Ioannis Anagnostopoulos, Maria Kousta, Charalampos Kossyvakis, Eleni Lakka, Dimitrios Vrachatis, Spyridon Deftereos, Vassilios P. Vassilikos, Georgios Giannopoulos
Summary: This study found a nonlinear inverse relationship between weekly physical activity (PA) and the risk for atrial fibrillation (AF) in females. The risk of AF decreases as PA levels increase up to 50 metabolic equivalents of task-hours per week (METs-h/w). This study provides recommendations for PA dose to reduce the risk of AF in females.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Georgios Sidiropoulos, Antonios Antoniadis, Athanasios Saplaouras, Georgios Bazoukis, Konstantinos P. Letsas, Theodoros D. Karamitsos, Georgios Giannopoulos, Nikolaos Fragakis
Summary: This meta-analysis examined the value of echocardiographic indices of RV function as potential predictors of CRT outcomes in patients with standard indications for CRT. The results showed that baseline tricuspid annular plane systolic excursion was consistently higher in CRT responders, suggesting its potential as an additional component in the selection process of CRT candidates.
HELLENIC JOURNAL OF CARDIOLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Nikolaos Stalikas, Efstratios Karagiannidis, Andreas S. Papazoglou, Eleftherios Panteris, Manthos Didagelos, Antonios Ziakas, Vasileios Vassilikos, George Giannakoulas, George Giannopoulos
HELLENIC JOURNAL OF CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Georgios Giannopoulos, Dimitrios Tachmatzidis, Dimitrios V. Moysidis, Dimitrios Filos, Magdalini Petridou, Ioanna Chouvarda, Vasileios P. Vassilikos
Summary: The P wave contains information about atrial electrical activity, but technical and biological reasons make it challenging to gather and utilize this information. However, simple ECG descriptors like P-wave dispersion have predictive value for assessing the risk of atrial fibrillation. More complex analysis methods and machine learning techniques may improve the accuracy and reliability of obtaining clinically useful information from the P wave.
CURRENT PROBLEMS IN CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Georgios C. Bompotis, Georgios Giannopoulos, Asterios I. Karakanas, Magdalini Meletidou, Dimitrios Vrachatis, Ioannis Lazaridis, Konstantinos P. Toutouzas, Ioannis Styliadis, Dimitrios Tziakas, Spyridon G. Deftereos
Summary: Using the left distal radial artery (ldRA) in the anatomical snuffbox as the default vascular access site for coronary catheterization is highly effective, feasible, and safe. The failure rate decreases sharply after the initial 200 cases, and the absence or weak pulse is the most important predictor of failure.
JOURNAL OF INVASIVE CARDIOLOGY
(2022)