期刊
MEDICINAL CHEMISTRY
卷 8, 期 4, 页码 727-731出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157340612801216256
关键词
Dendrimer; Folic acid; PAMAM; Radiolabelled; Rhenium
资金
- Major Projects in National Science and Technology, Creation of major new drugs [2011ZX09501-001-05]
- National Nature Science Foundation of China [81071250]
Folic acid receptors (FR) are usually over expressed in many cancer cells and are considered as potential targeted therapy agent. Generation of five polyamido amine (PAMAM) dendrimer folic acid conjugate was synthesised and radiolabelled with Re-188, furthermore the in vitro/in vivo stability was evaluated accordingly. The labelling yield of the conjugate G5-FA-DTPA-Re-188 was 67.1 % and its radiochemical purity exceeded 95 %. The conjugate also showed high in vitro stability and potential value for further structure modifications and evaluations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据